Gene: Celsr3 (cadherin, EGF LAG seven-pass G-type receptor 3) Rattus norvegicus
Analyze
Symbol:
Celsr3
Name:
cadherin, EGF LAG seven-pass G-type receptor 3
Description:
Predicted to have G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in several processes, including neuron migration; plasma membrane bounded cell projection organization; and regulation of protein phosphorylation. Predicted to localize to integral component of membrane and plasma membrane. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3); INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
cadherin EGF LAG seven-pass G-type receptor 3; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); Megf2; multiple EGF-like domains protein 2; multiple epidermal growth factor-like domains 2; multiple epidermal growth factor-like domains protein 2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):
Celsr3 (cadherin, EGF LAG seven-pass G-type receptor 3) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Celsr3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Celsr3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Celsr3 (cadherin EGF LAG seven-pass G-type receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Celsr3 (cadherin, EGF LAG seven-pass G-type receptor 3)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
fmi-1
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
stan
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|InParanoid|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 8 117,620,293 - 117,648,034 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 117,620,317 - 117,648,028 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 116,964,621 - 116,991,771 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 113,882,883 - 113,923,950 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 8 113,902,337 - 113,943,405 (+) NCBI Celera 8 108,824,695 - 108,852,099 (+) NCBI Celera Cytogenetic Map 8 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
1,2-dichloroethane increases expression ISO RGD:732288 6480464 ethylene dichloride results in increased expression of CELSR3 mRNA CTD PMID:28960355 17alpha-ethynylestradiol multiple interactions ISO RGD:732288 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:732288 6480464 Ethinyl Estradiol results in increased expression of CELSR3 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1342685 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of CELSR3 mRNA CTD PMID:30165855 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:732288 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:732288 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732288 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR3 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732288 6480464 Tetrachlorodibenzodioxin affects the expression of CELSR3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732288 6480464 Tetrachlorodibenzodioxin results in increased expression of CELSR3 mRNA CTD PMID:17942748 2-methylcholine affects expression ISO RGD:1342685 6480464 beta-methylcholine affects the expression of CELSR3 mRNA CTD PMID:21179406 aflatoxin B2 increases methylation ISO RGD:1342685 6480464 aflatoxin B2 results in increased methylation of CELSR3 intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:1342685 6480464 Tretinoin results in decreased expression of CELSR3 mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CELSR3 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:1342685 6480464 Arsenic affects the methylation of CELSR3 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1342685 6480464 Arsenic affects the methylation of CELSR3 gene CTD PMID:25304211 benzo[a]pyrene affects methylation ISO RGD:1342685 6480464 Benzo(a)pyrene affects the methylation of CELSR3 intron CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:1342685 6480464 benzo(e)pyrene results in increased methylation of CELSR3 intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CELSR3 mRNA CTD PMID:31199487 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CELSR3 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:732288 6480464 bisphenol A results in increased expression of CELSR3 mRNA CTD PMID:29165653 bisphenol A decreases methylation ISO RGD:732288 6480464 bisphenol A results in decreased methylation of CELSR3 promoter CTD PMID:27312807 Butylbenzyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CELSR3 mRNA CTD PMID:31199487 cadmium dichloride increases expression ISO RGD:732288 6480464 Cadmium Chloride results in increased expression of CELSR3 mRNA CTD PMID:18974090 carbon nanotube increases expression ISO RGD:732288 6480464 Nanotubes, Carbon results in increased expression of CELSR3 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:732288 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CELSR3 mRNA more ... CTD PMID:20938992 cisplatin decreases expression ISO RGD:1342685 6480464 Cisplatin results in decreased expression of CELSR3 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1342685 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of CELSR3 mRNA CTD PMID:27392435 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of CELSR3 mRNA CTD PMID:26033743 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of CELSR3 mRNA CTD PMID:26033743 dexamethasone decreases expression ISO RGD:1342685 6480464 Dexamethasone results in decreased expression of CELSR3 mRNA CTD PMID:12782123 dibutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CELSR3 mRNA CTD PMID:31199487 dicrotophos increases expression ISO RGD:1342685 6480464 dicrotophos results in increased expression of CELSR3 mRNA CTD PMID:28302478 diethyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CELSR3 mRNA CTD PMID:31199487 diisobutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CELSR3 mRNA CTD PMID:31199487 Diisodecyl phthalate increases expression ISO RGD:732288 6480464 diisodecyl phthalate results in increased expression of CELSR3 mRNA CTD PMID:25270620 diisononyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CELSR3 mRNA CTD PMID:31199487 dimethylarsinic acid decreases expression EXP 6480464 Cacodylic Acid results in decreased expression of CELSR3 mRNA CTD PMID:16122865 dorsomorphin multiple interactions ISO RGD:1342685 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CELSR3 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1342685 6480464 Doxorubicin results in decreased expression of CELSR3 mRNA CTD PMID:29803840 emodin decreases expression ISO RGD:1342685 6480464 Emodin results in decreased expression of CELSR3 mRNA CTD PMID:16045814 ethanol increases expression ISO RGD:732288 6480464 Ethanol results in increased expression of CELSR3 mRNA CTD PMID:30319688 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of CELSR3 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:732288 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CELSR3 mRNA more ... CTD PMID:20938992 furan increases methylation EXP 6480464 furan results in increased methylation of CELSR3 gene CTD PMID:22079235 graphite affects expression EXP 6480464 Graphite affects the expression of CELSR3 mRNA CTD PMID:29933104 hydrogen peroxide affects expression ISO RGD:1342685 6480464 Hydrogen Peroxide affects the expression of CELSR3 mRNA CTD PMID:21179406 L-methionine multiple interactions ISO RGD:732288 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CELSR3 mRNA more ... CTD PMID:20938992 methapyrilene increases methylation ISO RGD:1342685 6480464 Methapyrilene results in increased methylation of CELSR3 intron CTD PMID:30157460 Niclosamide increases expression ISO RGD:1342685 6480464 Niclosamide results in increased expression of CELSR3 mRNA CTD PMID:28284560 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of CELSR3 mRNA CTD PMID:30723492 phenylmercury acetate decreases expression ISO RGD:1342685 6480464 Phenylmercuric Acetate results in decreased expression of CELSR3 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1342685 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CELSR3 mRNA CTD PMID:27188386 quercitrin increases expression ISO RGD:1342685 6480464 quercitrin results in increased expression of CELSR3 mRNA CTD PMID:25193878 SB 431542 multiple interactions ISO RGD:1342685 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CELSR3 mRNA CTD PMID:27188386 trichostatin A increases expression ISO RGD:1342685 6480464 trichostatin A results in increased expression of CELSR3 mRNA CTD PMID:26705709 tunicamycin increases expression ISO RGD:1342685 6480464 Tunicamycin results in increased expression of CELSR3 mRNA CTD PMID:29453283 valproic acid affects expression ISO RGD:1342685 6480464 Valproic Acid affects the expression of CELSR3 mRNA CTD PMID:25979313 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CELSR3 mRNA CTD PMID:29427782 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of CELSR3 mRNA CTD PMID:29427782 valproic acid increases expression ISO RGD:1342685 6480464 Valproic Acid results in increased expression of CELSR3 mRNA CTD PMID:23179753 more ... XL147 multiple interactions ISO RGD:732288 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CELSR3 mRNA CTD PMID:27935865 zinc atom increases expression ISO RGD:1342685 6480464 Zinc deficiency results in increased expression of CELSR3 mRNA CTD PMID:18356318 zinc(0) increases expression ISO RGD:1342685 6480464 Zinc deficiency results in increased expression of CELSR3 mRNA CTD PMID:18356318
Gene Ontology Annotations
Biological Process axonal fasciculation ISO RGD:732288 1624291 MGI:MGI:3578665 (MGI:MGI:3578066 , PMID:15778712) RGD MGI:MGI:3578066 , PMID:15778712 cell-cell adhesion IBA FB:FBgn0024836 more ... 13792537 PMID:21873635 GO_Central cilium assembly ISO RGD:732288 1624291 MGI:MGI:1858235 (MGI:MGI:4460066 , PMID:20473291) RGD MGI:MGI:4460066 , PMID:20473291 dopaminergic neuron axon guidance ISO RGD:732288 1624291 (MGI:MGI:4866939, PMID:21106844) RGD MGI:MGI:4866939 , PMID:21106844 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 1600115 GO_REF:0000043 UniProt GO_REF:0000043 homophilic cell adhesion via plasma membrane adhesion molecules IEA InterPro:IPR002126 1600115 GO_REF:0000002 InterPro GO_REF:0000002 neuron migration ISO RGD:732288 1624291 MGI:MGI:3578665 (MGI:MGI:4819311 , PMID:20631168) RGD MGI:MGI:4819311 , PMID:20631168 planar cell polarity pathway involved in axon guidance ISO RGD:732288 1624291 (MGI:MGI:4866939, PMID:21106844) RGD MGI:MGI:4866939 , PMID:21106844 regulation of protein localization ISO RGD:732288 1624291 MGI:MGI:1858235 (MGI:MGI:4460066 , PMID:20473291) RGD MGI:MGI:4460066 , PMID:20473291 regulation of protein phosphorylation ISO RGD:732288 1624291 (MGI:MGI:5529726, PMID:24305805) RGD MGI:MGI:5529726 , PMID:24305805 serotonergic neuron axon guidance ISO RGD:732288 1624291 (MGI:MGI:4866939, PMID:21106844) RGD MGI:MGI:4866939 , PMID:21106844 Cellular Component integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 plasma membrane IEA UniProtKB-SubCell:SL-0039 1600115 GO_REF:0000044 UniProt GO_REF:0000044 Molecular Function calcium ion binding IEA InterPro:IPR001881 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 G protein-coupled receptor activity IEA UniProtKB-KW:KW-0297 1600115 GO_REF:0000043 UniProt GO_REF:0000043 protein binding ISO RGD:1342685 1624291 UniProtKB:P16333 (PMID:17474147) RGD PMID:17474147
2313400 Anxrr25 Anxiety related response QTL 25 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 8 95963141 122354314 Rat 631650 Stl6 Serum triglyceride level QTL 6 4 0.0019 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 8 10938911 120496129 Rat 631653 Bp125 Blood pressure QTL 125 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 8 72849686 117849686 Rat 738011 Anxrr9 Anxiety related response QTL 9 6.1 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 8 102051964 133307652 Rat 738014 Anxrr15 Anxiety related response QTL 15 3.6 0.005 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 8 104682575 133307652 Rat 8694446 Bw170 Body weight QTL 170 12.07 0.001 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 8 78805083 123805083 Rat 9590292 Uminl3 Urine mineral level QTL 3 3.62 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 8 78805083 123805083 Rat 8694200 Abfw4 Abdominal fat weight QTL 4 9.07 0.001 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) 8 78805083 123805083 Rat 8694392 Bw161 Body weight QTL 161 8.06 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 8 78805083 123805083 Rat 1300171 Bp184 Blood pressure QTL 184 3.66 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) 8 76103982 127182642 Rat 1549909 Stresp11 Stress response QTL 11 6.83 0.0019 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 8 80697934 125697934 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 44458129 118087517 Rat 1358893 Bp263 Blood pressure QTL 263 5.01 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 100873811 133307652 Rat 1358903 Bp252 Blood pressure QTL 252 7 0.0001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 100873811 133307652 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 8 9531047 119211942 Rat 61437 Cia6 Collagen induced arthritis QTL 6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 8 89058229 132243842 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 50529480 128036471 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 8 50529480 128036471 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607) 8 50529480 128036471 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 8 50529480 128036471 Rat 631210 Bw3 Body weight QTL3 5.9 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight as a percentage of body weight (CMO:0000654) 8 74917593 121080545 Rat 2303171 Bp331 Blood pressure QTL 331 5.57 0.005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 8 65717449 128033050 Rat 2300182 Bmd56 Bone mineral density QTL 56 5.4 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 104682575 133307652 Rat 2300181 Bmd55 Bone mineral density QTL 55 5.7 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 83894304 128894304 Rat 724539 Cm19 Cardiac mass QTL 19 2.6 heart mass (VT:0007028) calculated heart weight (CMO:0000073) 8 107769005 129956433 Rat
Predicted Target Of
Count of predictions: 277 Count of miRNA genes: 149 Interacting mature miRNAs: 187 Transcripts: ENSRNOT00000040661 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
