Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ica1 (islet cell autoantigen 1) Rattus norvegicus
Analyze
Symbol: Ica1
Name: islet cell autoantigen 1
Description: Exhibits protein domain specific binding activity. Involved in regulation of protein homodimerization activity. Localizes to the Golgi apparatus; dendrite; and perinuclear region of cytoplasm. Used to study diabetes mellitus and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1); PARTICIPATES IN type 1 diabetes mellitus pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2-acetamidofluorene; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 69 kDa islet cell autoantigen; ICA69; ICAp69; islet cell autoantigen 1, 69 kDa; islet cell autoantigen p69; p69
Orthologs:
Homo sapiens (human) : ICA1 (islet cell autoantigen 1)  HGNC  Alliance
Mus musculus (house mouse) : Ica1 (islet cell autoantigen 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ica1 (islet cell autoantigen 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ICA1 (islet cell autoantigen 1)
Canis lupus familiaris (dog) : ICA1 (islet cell autoantigen 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ica1 (islet cell autoantigen 1)
Sus scrofa (pig) : ICA1 (islet cell autoantigen 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0434,635,509 - 34,780,187 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0434,493,594 - 34,639,924 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4433,680,878 - 33,830,443 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1433,799,417 - 33,948,647 (-)NCBI
Celera432,158,705 - 32,303,677 (-)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Ica1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621465
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.