Gene: Aen (apoptosis enhancing nuclease) Rattus norvegicus
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Symbol: Aen
Name: apoptosis enhancing nuclease
Description: Predicted to have exonuclease activity; predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation; predicted to localize to the nuclear membrane, nucleolus, and nucleoplasm; orthologous to human AEN (apoptosis enhancing nuclease); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-nitropropane; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: apoptosis-enhancing nuclease; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1; Isg20l1; LOC361594; RGD1305051; similar to hypothetical protein FLJ12484
Orthologs:
Homo sapiens (human) : AEN (apoptosis enhancing nuclease)  HGNC  Alliance
Mus musculus (house mouse) : Aen (apoptosis enhancing nuclease)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aen (apoptosis enhancing nuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : AEN (apoptosis enhancing nuclease)
Canis lupus familiaris (dog) : AEN (apoptosis enhancing nuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aen (apoptosis enhancing nuclease)
Sus scrofa (pig) : AEN (apoptosis enhancing nuclease)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01140,584,328 - 140,593,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01141,559,299 - 141,568,695 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,615,998 - 134,625,367 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,687,039 - 134,703,710 (+)NCBI
Celera1124,884,104 - 124,893,474 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Aen
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305051
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.