AEN (apoptosis enhancing nuclease) - Rat Genome Database

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Gene: AEN (apoptosis enhancing nuclease) Sus scrofa
Analyze
Symbol: AEN
Name: apoptosis enhancing nuclease
RGD ID: 14044069
Description: ENCODES a protein that exhibits DNA exonuclease activity (inferred); exonuclease activity (inferred); nuclease activity (inferred); INVOLVED IN DNA metabolic process (inferred); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (inferred); response to ionizing radiation (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN nuclear membrane (inferred); nucleolus (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-enhancing nuclease
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,200,632 - 191,219,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,200,625 - 191,211,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,633,431 - 212,644,691 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,200,632 - 191,219,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,200,625 - 191,211,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,633,431 - 212,644,691 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381588,604,683 - 88,632,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1588,621,337 - 88,632,281 (+)EnsemblGRCh38hg38GRCh38
GRCh371589,164,571 - 89,175,512 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,965,593 - 86,976,516 (+)NCBINCBI36Build 36hg18NCBI36
Celera1565,565,411 - 65,576,403 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,276,424 - 65,287,417 (+)NCBIHuRef
CHM1_11589,006,164 - 89,017,154 (+)NCBICHM1_1
T2T-CHM13v2.01586,359,390 - 86,386,993 (+)NCBIT2T-CHM13v2.0
Aen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,545,675 - 78,560,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl778,545,602 - 78,560,957 (+)EnsemblGRCm39 Ensembl
GRCm38778,895,927 - 78,911,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,895,854 - 78,911,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv37786,040,813 - 86,053,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36778,769,440 - 78,782,346 (+)NCBIMGSCv36mm8
Celera776,301,311 - 76,311,341 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.83NCBI
Aen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,224,499 - 142,233,902 (+)NCBIGRCr8
mRatBN7.21132,815,094 - 132,824,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,815,142 - 132,824,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,728,011 - 140,737,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,897,432 - 147,906,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,815,119 - 140,824,512 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,584,328 - 140,593,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,584,380 - 140,593,745 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,559,299 - 141,568,695 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,615,998 - 134,625,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,687,039 - 134,703,710 (+)NCBI
Celera1124,884,104 - 124,893,474 (+)NCBICelera
Cytogenetic Map1q31NCBI
Aen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,331,290 - 16,338,078 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,328,655 - 16,338,069 (-)NCBIChiLan1.0ChiLan1.0
AEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,093,519 - 78,177,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,798,032 - 81,881,972 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01567,237,871 - 67,321,808 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11586,502,347 - 86,529,579 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,518,204 - 86,529,579 (+)Ensemblpanpan1.1panPan2
AEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,797,251 - 51,819,385 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,809,975 - 51,819,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,446,831 - 54,455,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,229,881 - 52,238,971 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,217,677 - 52,239,164 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,752,639 - 51,761,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,962,832 - 51,971,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,301,829 - 52,310,943 (+)NCBIUU_Cfam_GSD_1.0
Aen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,722,868 - 131,745,835 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648314,601,671 - 14,611,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,160,445 - 7,172,082 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,165,964 - 7,172,304 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605939,676,015 - 39,695,221 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476815,931,607 - 15,940,690 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AEN
221 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000005624   ⟹   ENSSSCP00000005483
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,200,632 - 191,219,961 (-)Ensembl
RefSeq Acc Id: XM_003121858   ⟹   XP_003121906
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,200,625 - 191,211,884 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003121906   ⟸   XM_003121858
- UniProtKB: F1SRT3 (UniProtKB/TrEMBL),   A0A4X1WCN6 (UniProtKB/TrEMBL),   A0A8D0Q3B8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000005483   ⟸   ENSSSCT00000005624
Protein Domains
Exonuclease


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005102 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015076286 UniProtKB/TrEMBL
  ENSSSCG00025029525 UniProtKB/TrEMBL
  ENSSSCG00030001723 UniProtKB/TrEMBL
  ENSSSCG00035041018 UniProtKB/TrEMBL
  ENSSSCG00040021803 UniProtKB/TrEMBL
  ENSSSCG00045038558 UniProtKB/TrEMBL
  ENSSSCG00050048522 UniProtKB/TrEMBL
  ENSSSCG00055022104 UniProtKB/TrEMBL
  ENSSSCG00060061269 UniProtKB/TrEMBL
  ENSSSCG00065065617 UniProtKB/TrEMBL
  ENSSSCG00070030483 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005624 ENTREZGENE
  ENSSSCT00000005624.5 UniProtKB/TrEMBL
  ENSSSCT00015102873.1 UniProtKB/TrEMBL
  ENSSSCT00025040125.1 UniProtKB/TrEMBL
  ENSSSCT00030002208.1 UniProtKB/TrEMBL
  ENSSSCT00035054503.1 UniProtKB/TrEMBL
  ENSSSCT00040029251.1 UniProtKB/TrEMBL
  ENSSSCT00045066890.1 UniProtKB/TrEMBL
  ENSSSCT00050066082.1 UniProtKB/TrEMBL
  ENSSSCT00055043389.1 UniProtKB/TrEMBL
  ENSSSCT00060083616.1 UniProtKB/TrEMBL
  ENSSSCT00065090057.1 UniProtKB/TrEMBL
  ENSSSCT00070061368.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/TrEMBL
  REXO1/3/4-like UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
KEGG Report ssc:100522657 UniProtKB/TrEMBL
NCBI Gene AEN ENTREZGENE
PANTHER APOPTOSIS-ENHANCING NUCLEASE UniProtKB/TrEMBL
  RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED UniProtKB/TrEMBL
Pfam RNase_T UniProtKB/TrEMBL
SMART EXOIII UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/TrEMBL
UniProt A0A4X1WCN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Q3B8 ENTREZGENE, UniProtKB/TrEMBL
  F1SRT3 ENTREZGENE
UniProt Secondary F1SRT3 UniProtKB/TrEMBL
VGNC ID VGNC:85164 ENTREZGENE