Aen (apoptosis enhancing nuclease) - Rat Genome Database

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Gene: Aen (apoptosis enhancing nuclease) Chinchilla lanigera
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Symbol: Aen
Name: apoptosis enhancing nuclease
RGD ID: 9012396
Description: ENCODES a protein that exhibits DNA exonuclease activity (ortholog); exonuclease activity (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); response to ionizing radiation (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN nuclear membrane (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-enhancing nuclease
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,331,290 - 16,338,078 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,328,655 - 16,338,069 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Aen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,331,290 - 16,338,078 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,328,655 - 16,338,069 (-)NCBIChiLan1.0ChiLan1.0
AEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381588,604,683 - 88,632,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1588,621,337 - 88,632,281 (+)EnsemblGRCh38hg38GRCh38
GRCh371589,164,571 - 89,175,512 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,965,593 - 86,976,516 (+)NCBINCBI36Build 36hg18NCBI36
Celera1565,565,411 - 65,576,403 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,276,424 - 65,287,417 (+)NCBIHuRef
CHM1_11589,006,164 - 89,017,154 (+)NCBICHM1_1
T2T-CHM13v2.01586,359,390 - 86,386,993 (+)NCBIT2T-CHM13v2.0
Aen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,545,675 - 78,560,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl778,545,602 - 78,560,957 (+)EnsemblGRCm39 Ensembl
GRCm38778,895,927 - 78,911,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,895,854 - 78,911,209 (+)EnsemblGRCm38mm10GRCm38
MGSCv37786,040,813 - 86,053,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36778,769,440 - 78,782,346 (+)NCBIMGSCv36mm8
Celera776,301,311 - 76,311,341 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.83NCBI
Aen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,224,499 - 142,233,902 (+)NCBIGRCr8
mRatBN7.21132,815,094 - 132,824,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,815,142 - 132,824,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,728,011 - 140,737,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,897,432 - 147,906,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,815,119 - 140,824,512 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,584,328 - 140,593,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,584,380 - 140,593,745 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,559,299 - 141,568,695 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,615,998 - 134,625,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,687,039 - 134,703,710 (+)NCBI
Celera1124,884,104 - 124,893,474 (+)NCBICelera
Cytogenetic Map1q31NCBI
AEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,093,519 - 78,177,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,798,032 - 81,881,972 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01567,237,871 - 67,321,808 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11586,502,347 - 86,529,579 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,518,204 - 86,529,579 (+)Ensemblpanpan1.1panPan2
AEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,797,251 - 51,819,385 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,809,975 - 51,819,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,446,831 - 54,455,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,229,881 - 52,238,971 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,217,677 - 52,239,164 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,752,639 - 51,761,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,962,832 - 51,971,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,301,829 - 52,310,943 (+)NCBIUU_Cfam_GSD_1.0
Aen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,722,868 - 131,745,835 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648314,601,671 - 14,611,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,200,632 - 191,219,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,200,625 - 191,211,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,633,431 - 212,644,691 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,160,445 - 7,172,082 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,165,964 - 7,172,304 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605939,676,015 - 39,695,221 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476815,931,607 - 15,940,690 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000012882   ⟹   ENSCLAP00000012734
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541616,331,290 - 16,338,078 (-)Ensembl
RefSeq Acc Id: XM_005381572   ⟹   XP_005381629
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541616,328,655 - 16,338,069 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005381629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000012734
  ENSCLAP00000012734.1
RefSeq Acc Id: XP_005381629   ⟸   XM_005381572
- UniProtKB: A0A8C2YP07 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000012734   ⟸   ENSCLAT00000012882
Protein Domains
Exonuclease


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008791 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012882 ENTREZGENE
  ENSCLAT00000012882.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/TrEMBL
  REXO1/3/4-like UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
NCBI Gene Aen ENTREZGENE
PANTHER APOPTOSIS-ENHANCING NUCLEASE UniProtKB/TrEMBL
  RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED UniProtKB/TrEMBL
Pfam RNase_T UniProtKB/TrEMBL
SMART EXOIII UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/TrEMBL
UniProt A0A8C2YP07 ENTREZGENE, UniProtKB/TrEMBL