Gsta5 (glutathione S-transferase alpha 5) - Rat Genome Database

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Gene: Gsta5 (glutathione S-transferase alpha 5) Rattus norvegicus
Symbol: Gsta5
Name: glutathione S-transferase alpha 5
RGD ID: 1593189
Description: Enables glutathione binding activity and glutathione transferase activity. Involved in xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3); PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-Cyano-2-hydroxy-3-butene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GHS transferase; glutathione S-transferase alpha-2; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-2; glutathione transferase YA subunit; GST 1b-1b; GST A2-2; GST Ya2; Gsta2; LOC494499; MGC114217
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2879,105,561 - 79,117,472 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,105,661 - 79,117,472 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0885,553,659 - 85,564,914 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,553,734 - 85,565,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,111,369 - 85,122,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,202,554 - 83,211,997 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,852,562 - 78,862,243 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (ISO)
1-Cyano-2-hydroxy-3-butene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-imidazole  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (EXP)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
aminoguanidine  (ISO)
angelica lactone  (ISO)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoquinones  (ISO)
benzotriazole  (EXP)
benzyl isothiocyanate  (EXP)
benzylideneacetone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cafestol  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorambucil  (EXP)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
Dicyclohexyl phthalate  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl maleate  (EXP)
dimercaprol  (ISO)
diquat  (ISO)
diuron  (EXP)
doramapimod  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
etofenprox  (EXP)
fenofibrate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
Glutathione ethyl ester  (ISO)
glycine betaine  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP)
inulin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isopimpinellin  (ISO)
isothiocyanate  (ISO)
kahweol  (EXP)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
L-selenocysteine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Meclizine  (ISO)
melatonin  (EXP)
melphalan  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methyl methacrylate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (EXP)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (EXP)
ochratoxin A  (EXP)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
oxfendazole  (EXP)
oxybenzone  (EXP)
oxycodone  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
propanal  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
selenium atom  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sinigrin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
spermidine  (ISO)
stilbene oxide  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
tannic acid  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl ethyl ether  (EXP)
tetrachloromethane  (EXP,ISO)
thiazoles  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triadimefon  (EXP)
triazines  (ISO)
triazoles  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2645828   PMID:3025841   PMID:3766257   PMID:6292839   PMID:6325423   PMID:6547043   PMID:8144363   PMID:12477932   PMID:17086191   PMID:23012479   PMID:23533145   PMID:25931508  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2879,105,561 - 79,117,472 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,105,661 - 79,117,472 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0885,553,659 - 85,564,914 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,553,734 - 85,565,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,111,369 - 85,122,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,202,554 - 83,211,997 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,852,562 - 78,862,243 (+)NCBICelera
Cytogenetic Map8q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38652,831,692 - 52,846,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,831,655 - 52,840,843 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,696,490 - 52,711,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,804,499 - 52,818,852 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,804,498 - 52,818,852NCBI
Celera654,358,301 - 54,372,656 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,527,978 - 52,542,334 (-)NCBIHuRef
CHM1_1652,698,651 - 52,713,008 (-)NCBICHM1_1
T2T-CHM13v2.0652,671,168 - 52,685,725 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39978,137,951 - 78,149,965 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,137,938 - 78,149,966 (+)EnsemblGRCm39 Ensembl
GRCm38978,230,669 - 78,242,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,230,656 - 78,242,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,078,476 - 78,090,490 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36978,016,370 - 78,028,355 (+)NCBIMGSCv36mm8
Celera975,462,780 - 75,478,144 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI


Variants in Gsta5
94 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0926,213,561 - 26,213,684NCBIRnor5.0
RGSC_v3.4920,008,743 - 20,008,934UniSTSRGSC3.4
RGSC_v3.4920,008,711 - 20,009,109RGDRGSC3.4
RGSC_v3.1920,006,033 - 20,006,431RGD
Celera921,237,634 - 21,237,825UniSTS
RH 3.4 Map9229.5UniSTS
RH 3.4 Map9229.5RGD
RH 2.0 Map9201.3RGD
SHRSP x BN Map921.1098RGD
FHH x ACI Map914.0RGD
Cytogenetic Map8q31UniSTS
Cytogenetic Map9q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2923,711,413 - 23,711,630 (+)MAPPERmRatBN7.2
Rnor_6.0927,444,195 - 27,444,411NCBIRnor6.0
Rnor_6.0927,372,297 - 27,372,513NCBIRnor6.0
Rnor_5.0926,291,488 - 26,291,704UniSTSRnor5.0
Rnor_5.0926,222,128 - 26,222,344UniSTSRnor5.0
RGSC_v3.4920,059,439 - 20,059,655UniSTSRGSC3.4
Celera921,286,558 - 21,286,774UniSTS
RH 3.4 Map2052.92UniSTS
Cytogenetic Map9q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2879,112,440 - 79,112,544 (-)MAPPERmRatBN7.2
mRatBN7.2879,112,440 - 79,112,544 (+)MAPPERmRatBN7.2
mRatBN7.2879,189,476 - 79,189,580 (-)MAPPERmRatBN7.2
mRatBN7.2879,189,476 - 79,189,580 (+)MAPPERmRatBN7.2
Rnor_6.0885,644,665 - 85,644,768NCBIRnor6.0
Rnor_6.0885,559,883 - 85,559,986NCBIRnor6.0
Rnor_5.0885,117,591 - 85,117,694UniSTSRnor5.0
Rnor_5.0885,201,632 - 85,201,735UniSTSRnor5.0
RGSC_v3.4883,206,967 - 83,207,070UniSTSRGSC3.4
RGSC_v3.4883,304,715 - 83,304,818UniSTSRGSC3.4
Celera878,936,867 - 78,936,970UniSTS
Celera878,857,199 - 78,857,302UniSTS
RH 3.4 Map8927.59UniSTS
Cytogenetic Map8q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 1 41 31 13 31 28 12 8
Low 2 11 14 8 6 8 8 11 11 2 12 3 8
Below cutoff 18 2 2 2 31 4 13


RefSeq Acc Id: ENSRNOT00000044944   ⟹   ENSRNOP00000043510
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,105,661 - 79,117,472 (+)Ensembl
Rnor_6.0 Ensembl885,553,734 - 85,565,179 (+)Ensembl
RefSeq Acc Id: NM_001010921   ⟹   NP_001010921
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2879,108,060 - 79,117,471 (+)NCBI
Rnor_6.0885,556,115 - 85,564,913 (+)NCBI
Rnor_5.0885,111,369 - 85,122,622 (+)NCBI
RGSC_v3.4883,202,554 - 83,211,997 (+)RGD
Celera878,852,562 - 78,862,243 (+)RGD
RefSeq Acc Id: XM_017595811   ⟹   XP_017451300
Rat AssemblyChrPosition (strand)Source
mRatBN7.2879,105,561 - 79,117,472 (+)NCBI
Rnor_6.0885,553,659 - 85,564,914 (+)NCBI
RefSeq Acc Id: XM_017595812   ⟹   XP_017451301
Rat AssemblyChrPosition (strand)Source
mRatBN7.2879,105,639 - 79,117,472 (+)NCBI
Rnor_6.0885,553,662 - 85,564,914 (+)NCBI
RefSeq Acc Id: NP_001010921   ⟸   NM_001010921
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   Q4FZZ3 (UniProtKB/TrEMBL),   A0A096MIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451300   ⟸   XM_017595811
- Peptide Label: isoform X1
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   Q4FZZ3 (UniProtKB/TrEMBL),   A0A096MIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451301   ⟸   XM_017595812
- Peptide Label: isoform X1
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   Q4FZZ3 (UniProtKB/TrEMBL),   A0A096MIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043510   ⟸   ENSRNOT00000044944
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04903-F1-model_v2 AlphaFold P04903 1-222 view protein structure
AF-Q4FZZ3-F1-model_v2 AlphaFold Q4FZZ3 1-222 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696150
Promoter ID:EPDNEW_R6668
Type:multiple initiation site
Description:glutathione S-transferase alpha 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0885,553,724 - 85,553,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593189 AgrOrtholog
BioCyc Gene G2FUF-29768 BioCyc
Ensembl Genes ENSRNOG00000000201 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044944 ENTREZGENE
  ENSRNOT00000044944.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:494499 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gsta5 PhenoGen
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000201 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q63715 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-18 Gsta5  glutathione S-transferase alpha 5  LOC494499  LOC494499 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC494499  LOC494499 protein      Symbol and Name status set to provisional 70820 PROVISIONAL