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Gene: Rbbp8 (RB binding protein 8, endonuclease) Rattus norvegicus
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Symbol: Rbbp8
Name: RB binding protein 8, endonuclease
Description: Predicted to have several functions, including DNA binding activity; RNA polymerase II repressing transcription factor binding activity; and transcription corepressor activity. Involved in response to estradiol. Predicted to localize to the nucleoplasm; site of double-strand break; and transcriptional repressor complex. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; Notch signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ctBP-interacting protein; CtIP; DNA endonuclease RBBP8; LOC291787; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM); sporulation in the absence of SPO11 protein 2 homolog
Orthologs:
Homo sapiens (human) : RBBP8 (RB binding protein 8, endonuclease)  HGNC  Alliance
Mus musculus (house mouse) : Rbbp8 (retinoblastoma binding protein 8, endonuclease)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rbbp8 (RB binding protein 8, endonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : RBBP8 (RB binding protein 8, endonuclease)
Canis lupus familiaris (dog) : RBBP8 (RB binding protein 8, endonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rbbp8 (RB binding protein 8, endonuclease)
Sus scrofa (pig) : RBBP8 (RB binding protein 8, endonuclease)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0183,134,630 - 3,227,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,173,428 - 3,239,961 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,266,565 - 3,333,153 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,269,885 - 3,333,117 (+)NCBI
Celera182,790,129 - 2,855,180 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Rbbp8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308872
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.