Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Notch1 (notch receptor 1) Rattus norvegicus
Symbol: Notch1
Name: notch receptor 1
Description: Exhibits transmembrane signaling receptor activity. Involved in several processes, including nervous system development; positive regulation of transcription of Notch receptor target; and regulation of heart morphogenesis. Localizes to several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleus. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2-tert-butylhydroquinone.
Type: protein-coding
Also known as: Drosophila Notch homolog 1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); neurogenic locus notch homolog protein 1; NOTCH; notch 1; Notch gene homolog 1; Notch gene homolog 1 (Drosophila); Notch homolog 1, translocation-associated; Notch homolog 1, translocation-associated (Drosophila); TAN1
Homo sapiens (human) : NOTCH1 (notch receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Notch1 (notch 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notch1 (notch receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTCH1 (notch receptor 1)
Canis lupus familiaris (dog) : NOTCH1 (notch receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notch1 (notch receptor 1)
Sus scrofa (pig) : NOTCH1 (notch receptor 1)
Chlorocebus sabaeus (African green monkey) : NOTCH1 (notch receptor 1)
Heterocephalus glaber (naked mole-rat) : Notch1 (notch receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Celera34,097,915 - 4,143,369 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Notch1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3187
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.