Notch1 (notch receptor 1) - Rat Genome Database

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Gene: Notch1 (notch receptor 1) Rattus norvegicus
Symbol: Notch1
Name: notch receptor 1
RGD ID: 3187
Description: Enables transmembrane signaling receptor activity. Involved in several processes, including central nervous system development; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in acrosomal vesicle; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; altered Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: Drosophila Notch homolog 1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); neurogenic locus notch homolog protein 1; NOTCH; notch 1; Notch gene homolog 1; Notch gene homolog 1 (Drosophila); Notch homolog 1, translocation-associated; Notch homolog 1, translocation-associated (Drosophila); TAN1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.239,277,955 - 9,323,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,332,077 - 12,388,087 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,915,306 - 20,971,319 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0319,170,646 - 19,226,660 (-)NCBIRnor_WKY
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Celera34,097,915 - 4,143,369 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Adams-Oliver syndrome  (ISO)
Adams-Oliver Syndrome 2  (ISO)
Adams-Oliver Syndrome 5  (ISO)
adenoid cystic carcinoma  (ISO)
adenoiditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis  (ISO)
aortic valve disease  (ISO)
aortic valve disease 1  (ISO)
atherosclerosis  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant intellectual developmental disorder 8  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy 5  (ISO)
bicuspid aortic valve disease  (ISO)
Breast Neoplasms  (ISO)
calcification of aortic valve  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Colonic Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
Diabetic Foot  (ISO)
diabetic retinopathy  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Uveitis  (IEP)
Experimental Liver Neoplasms  (IEP)
Focal Nodular Hyperplasia  (ISO)
Folate-Responsive Megaloblastic Anemia  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hemangiopericytoma  (ISO)
hypoplastic left heart syndrome  (ISO)
Joubert syndrome  (ISO)
keratoacanthoma  (ISO)
Kleefstra syndrome 1  (ISO)
Leigh disease  (ISO)
lung adenocarcinoma  (IEP)
lung large cell carcinoma  (IEP)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (IEP)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
microphthalmia  (ISO)
myeloproliferative neoplasm  (ISO)
Myocardial Ischemia  (IEP)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
oral squamous cell carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Peritoneal Diseases  (IMP)
primary coenzyme Q10 deficiency 7  (ISO)
prion disease  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (ISO)
Rafiq syndrome  (ISO)
retinopathy of prematurity  (IEP)
scoliosis  (ISO)
Skin Neoplasms  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
Surgical Wound  (ISO)
syndromic microphthalmia 5  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (IEP)
tuberous sclerosis 1  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
aconitine  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Botulinum toxin type A  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
Cyclopamine  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP)
enzalutamide  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fluoxetine  (EXP)
folic acid  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
kaempferol 3-O-beta-D-glucoside  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (ISO)
mebendazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
miconazole  (ISO)
Mitotane  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinic acid  (EXP)
nocodazole  (ISO)
ochratoxin A  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
picropodophyllotoxin  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
poly(ethylene)  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propranolol  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
Salidroside  (ISO)
SB 203580  (ISO)
simvastatin  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trans-caffeic acid  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zalcitabine  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ regeneration  (IEP)
aortic valve morphogenesis  (ISO)
apoptotic process  (ISO)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
astrocyte differentiation  (IDA)
atrioventricular node development  (ISO)
atrioventricular valve morphogenesis  (ISO)
auditory receptor cell fate commitment  (ISO)
axonogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
calcium-ion regulated exocytosis  (ISO)
cardiac atrium morphogenesis  (ISO)
cardiac chamber formation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell myoblast differentiation  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle tissue morphogenesis  (ISO)
cardiac right atrium morphogenesis  (ISO)
cardiac right ventricle formation  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell differentiation  (IEA,ISO)
cell differentiation in spinal cord  (IEP)
cell migration involved in endocardial cushion formation  (ISO)
cell population proliferation  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to hypoxia  (ISO,ISS)
cellular response to tumor cell  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO,ISS)
cilium assembly  (ISS)
collecting duct development  (ISO)
compartment pattern specification  (ISO)
coronary artery morphogenesis  (ISO)
coronary sinus valve morphogenesis  (ISO)
coronary vein morphogenesis  (ISO)
determination of left/right symmetry  (ISO)
distal tubule development  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
endocardial cell differentiation  (ISO)
endocardial cushion development  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardium development  (ISO)
endocardium morphogenesis  (ISO)
endoderm development  (ISO)
epidermal cell fate specification  (ISO)
epidermis development  (ISO)
epithelial cell fate commitment  (ISO)
epithelial cell proliferation  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
forebrain development  (ISO)
foregut morphogenesis  (ISO)
gene expression  (ISO)
glial cell differentiation  (IBA,ISO)
glomerular mesangial cell development  (ISO)
growth involved in heart morphogenesis  (ISO)
hair follicle morphogenesis  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart trabecula morphogenesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
inhibition of neuroepithelial cell differentiation  (ISO)
interleukin-17-mediated signaling pathway  (ISO)
keratinocyte differentiation  (ISO)
left/right axis specification  (ISO)
liver development  (ISO)
lung development  (ISO)
luteolysis  (IEP)
mesenchymal cell development  (ISO)
mitral valve formation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of catalytic activity  (ISO,ISS)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of cell proliferation involved in heart valve morphogenesis  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO,ISS)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of extracellular matrix constituent secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO,ISS)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of neurogenesis  (ISO,ISS)
negative regulation of neuron differentiation  (IMP,ISO)
negative regulation of oligodendrocyte differentiation  (ISO,ISS)
negative regulation of ossification  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of photoreceptor cell differentiation  (ISO)
negative regulation of pro-B cell differentiation  (ISO,ISS)
negative regulation of programmed cell death  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
neural tube development  (ISO)
neuroendocrine cell differentiation  (ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuronal stem cell population maintenance  (ISO)
Notch signaling involved in heart development  (ISO,ISS)
Notch signaling pathway  (IDA,IEA,IMP,ISO)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation  (ISO)
oligodendrocyte differentiation  (IEP,ISO)
outflow tract morphogenesis  (ISO)
pericardium morphogenesis  (ISO)
positive regulation of aorta morphogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic process involved in morphogenesis  (ISO)
positive regulation of astrocyte differentiation  (ISO,ISS)
positive regulation of BMP signaling pathway  (ISO,ISS)
positive regulation of cardiac epithelial to mesenchymal transition  (IGI)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of endothelial cell differentiation  (IMP)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IGI,IMP,ISO)
positive regulation of glial cell differentiation  (IMP)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of neuroblast proliferation  (IBA,IMP)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IBA,IGI,IMP,ISO)
positive regulation of transcription of Notch receptor target  (IMP,ISO)
positive regulation of viral genome replication  (ISO)
positive regulation of viral transcription  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein catabolic process  (ISO)
protein import into nucleus  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of cardioblast proliferation  (IMP)
regulation of cell migration  (ISO)
regulation of cell population proliferation  (IMP)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (ISO)
regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of neurogenesis  (ISO)
regulation of Notch signaling pathway  (ISO)
regulation of somitogenesis  (ISO)
regulation of stem cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to lipopolysaccharide  (IEP)
response to muramyl dipeptide  (ISO)
retinal cone cell differentiation  (ISO)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  (ISO)
skeletal muscle cell differentiation  (ISO)
somatic stem cell division  (ISO)
spermatogenesis  (IMP)
sprouting angiogenesis  (ISO)
T-helper 17 type immune response  (ISO)
tissue regeneration  (IEP)
transcription by RNA polymerase II  (ISO)
tube formation  (ISO,ISS)
vasculogenesis involved in coronary vascular morphogenesis  (ISO)
venous blood vessel morphogenesis  (ISO)
venous endothelial cell differentiation  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Inhibitory role of Notch1 in calcific aortic valve disease. Acharya A, etal., PLoS One. 2011;6(11):e27743. doi: 10.1371/journal.pone.0027743. Epub 2011 Nov 16.
2. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Bi P, etal., Nat Med. 2014 Aug;20(8):911-8. doi: 10.1038/nm.3615. Epub 2014 Jul 20.
3. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. Bosse K, etal., J Mol Cell Cardiol. 2013 Jul;60:27-35. doi: 10.1016/j.yjmcc.2013.04.001. Epub 2013 Apr 11.
4. Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Cao Q, etal., Glia. 2008 Aug 15;56(11):1224-37.
5. Functional genomics and gene-environment interaction highlight the complexity of congenital heart disease caused by Notch pathway variants. Chapman G, etal., Hum Mol Genet. 2020 Mar 13;29(4):566-579. doi: 10.1093/hmg/ddz270.
6. Notch1 signaling stimulates proliferation of immature cardiomyocytes. Collesi C, etal., J Cell Biol. 2008 Oct 6;183(1):117-28. Epub 2008 Sep 29.
7. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. De La O JP, etal., Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18907-12. Epub 2008 Nov 21.
8. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
9. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
10. Mutations in NOTCH1 cause aortic valve disease. Garg V, etal., Nature. 2005 Sep 8;437(7056):270-4. Epub 2005 Jul 17.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Notch1 and Numb genes are inversely expressed as oligodendrocytes differentiate. Givogri MI, etal., Dev Neurosci. 2003 Jan-Feb;25(1):50-64.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma. Hanlon L, etal., Cancer Res. 2010 May 18.
15. Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. Hayashi T, etal., J Androl. 2001 Nov-Dec;22(6):999-1011.
16. Total Flavonoids in Caragana (TFC) Promotes Angiogenesis and Enhances Cerebral Perfusion in a Rat Model of Ischemic Stroke. He Q, etal., Front Neurosci. 2018 Sep 12;12:635. doi: 10.3389/fnins.2018.00635. eCollection 2018.
17. The Expression of Neuroepithelial Cell Fate Determinants in Rat Spinal Cord Development. Henley BM and McDermott KW, J Mol Neurosci. 2010 Mar 2.
18. Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat. Hernandez F, etal., Biol Reprod. 2011 May;84(5):859-65. doi: 10.1095/biolreprod.110.088708. Epub 2011 Jan 5.
19. Notch-1 activation and dendritic atrophy in prion disease. Ishikura N, etal., Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):886-91. doi: 10.1073/pnas.0408612101. Epub 2005 Jan 7.
20. Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis. Ishimura N, etal., Gastroenterology. 2005 May;128(5):1354-68.
21. Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice. Kimura K, etal., Cancer Sci. 2007 Feb;98(2):155-62.
22. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Kohler C, etal., Hepatology 2004 Apr;39(4):1056-65.
23. Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Kubu CJ, etal., Dev Biol 2002 Apr 1;244(1):199-214.
24. Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions. Kuo TM, etal., J Cell Physiol. 2019 Aug;234(8):13984-13993. doi: 10.1002/jcp.28084. Epub 2019 Jan 9.
25. Analysis of Molecular Mechanism of YiqiChutan Formula Regulating DLL4-Notch Signaling to Inhibit Angiogenesis in Lung Cancer. Li J, etal., Biomed Res Int. 2021 Feb 12;2021:8875503. doi: 10.1155/2021/8875503. eCollection 2021.
26. Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats. Li S, etal., Evid Based Complement Alternat Med. 2020 Feb 5;2020:5041629. doi: 10.1155/2020/5041629. eCollection 2020.
27. All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia. Lin JT, etal., Adv Ther. 2003 Nov-Dec;20(6):337-43.
28. Jagged: a mammalian ligand that activates Notch1. Lindsell CE, etal., Cell 1995 Mar 24;80(6):909-17.
29. Activation of the Notch signaling pathway in response to pulp capping of rat molars. Lovschall H, etal., Eur J Oral Sci. 2005 Aug;113(4):312-7.
30. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Malecki MJ, etal., Mol Cell Biol. 2006 Jun;26(12):4642-51.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage. Ozbey O, etal., Acta Histochem. 2009 May 28.
36. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. Patten BA, etal., J Neurosci 2003 Jul 9;23(14):6132-40.
37. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
38. Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. Pinlaor S, etal., World J Gastroenterol. 2005 Aug 14;11(30):4644-9.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- miceļ¼š An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Riley MF, etal., Biochim Biophys Acta. 2011 Jan;1812(1):121-9. doi: 10.1016/j.bbadis.2010.10.002. Epub 2010 Oct 14.
46. Activated Notch1 is a stronger astrocytic stimulus than leukemia inhibitory factor for rat neural stem cells. Rodriguez-Rivera NS, etal., Int J Dev Biol. 2009;53(7):947-53.
47. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
48. Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway. Sun W, etal., Med Sci Monit. 2019 Jan 17;25:492-499. doi: 10.12659/MSM.913828.
49. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
50. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. Sweeney C, etal., FASEB J. 2004 Sep;18(12):1421-3. Epub 2004 Jul 9.
51. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
52. Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Tryndyak VP, etal., Mol Carcinog. 2009 Jun;48(6):479-87.
53. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
54. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
55. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
56. A homolog of Drosophila Notch expressed during mammalian development. Weinmaster G, etal., Development 1991 Sep;113(1):199-205.
57. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Weng AP, etal., Science 2004 Oct 8;306(5694):269-71.
58. Alterations of Notch/Jagged mRNA and protein expression after partial hepatectomy in rats. Xu HY, etal., Scand J Gastroenterol. 2008;43(12):1522-8.
59. Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway. Xu J, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C535-43. Epub 2008 Dec 24.
60. MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway. Ye C, etal., Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F760-F768. doi: 10.1152/ajprenal.00528.2016. Epub 2017 Jan 18.
61. The expression levels of Notch-related signaling molecules in pulmonary microvascular endothelial cells in bleomycin-induced rat pulmonary fibrosis. Yin Q, etal., Physiol Res. 2017 May 4;66(2):305-315. doi: 10.33549/physiolres.933356. Epub 2016 Dec 16.
62. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
63. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
64. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
65. Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats. Zhu F, etal., Am J Pathol. 2010 Feb;176(2):650-9. Epub 2010 Jan 7.
66. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Zhu YM, etal., Clin Cancer Res. 2006 May 15;12(10):3043-9.
Additional References at PubMed
PMID:1295745   PMID:7789282   PMID:9102301   PMID:9111338   PMID:10205173   PMID:10206645   PMID:10713164   PMID:11076679   PMID:11182080   PMID:11306509   PMID:11438922   PMID:11997524  
PMID:12001066   PMID:12032823   PMID:12186854   PMID:12489191   PMID:12666205   PMID:12717450   PMID:12727209   PMID:12730124   PMID:12783854   PMID:12794108   PMID:14657333   PMID:14701881  
PMID:15064243   PMID:15068794   PMID:15081359   PMID:15082708   PMID:15107403   PMID:15156153   PMID:15226394   PMID:15509736   PMID:15525534   PMID:15574878   PMID:15598981   PMID:15689374  
PMID:15809373   PMID:15821257   PMID:15902259   PMID:15920012   PMID:15965470   PMID:15978571   PMID:16107537   PMID:16120638   PMID:16145673   PMID:16169548   PMID:16245338   PMID:16324690  
PMID:16360140   PMID:16378597   PMID:16452096   PMID:16501043   PMID:16510869   PMID:16607638   PMID:16618808   PMID:16680150   PMID:16838279   PMID:16949068   PMID:17079689   PMID:17091491  
PMID:17157832   PMID:17217625   PMID:17303760   PMID:17336907   PMID:17393108   PMID:17543552   PMID:17573339   PMID:17658278   PMID:17658279   PMID:17662764   PMID:17685488   PMID:17849174  
PMID:17855369   PMID:17984306   PMID:18299578   PMID:18311147   PMID:18411251   PMID:18593716   PMID:18662245   PMID:18685078   PMID:18927449   PMID:18952909   PMID:19080462   PMID:19143760  
PMID:19154718   PMID:19238999   PMID:19245366   PMID:19251639   PMID:19336246   PMID:19407245   PMID:19481073   PMID:19489437   PMID:19536070   PMID:19587430   PMID:19620969   PMID:19682396  
PMID:19695258   PMID:19698832   PMID:19828677   PMID:20007915   PMID:20333303   PMID:20547764   PMID:20613903   PMID:20616313   PMID:20730910   PMID:20890042   PMID:21156799   PMID:21191019  
PMID:21266778   PMID:21311046   PMID:21330605   PMID:21419176   PMID:21426641   PMID:21457232   PMID:21493891   PMID:21672385   PMID:21887253   PMID:22085497   PMID:22147266   PMID:22302604  
PMID:22334042   PMID:22474986   PMID:22525134   PMID:22713619   PMID:22833359   PMID:22833673   PMID:22964414   PMID:22989188   PMID:23056328   PMID:23132739   PMID:23160044   PMID:23232913  
PMID:23284756   PMID:23382219   PMID:23589286   PMID:23595520   PMID:23707238   PMID:23755752   PMID:23834718   PMID:23844238   PMID:23938602   PMID:23948289   PMID:24098462   PMID:24098939  
PMID:24217957   PMID:24223152   PMID:24397211   PMID:24406215   PMID:24563863   PMID:24667410   PMID:24677709   PMID:24715457   PMID:24751889   PMID:24866722   PMID:24974008   PMID:25342127  
PMID:25535395   PMID:25624721   PMID:25660475   PMID:25700513   PMID:26040933   PMID:26134952   PMID:26182882   PMID:26316699   PMID:26491108   PMID:26703474   PMID:26728369   PMID:26817817  
PMID:27011052   PMID:27057278   PMID:27107132   PMID:27259983   PMID:27655677   PMID:27804997   PMID:28025657   PMID:28129650   PMID:28210849   PMID:28273100   PMID:28677782   PMID:28695984  
PMID:28698260   PMID:28776666   PMID:29097792   PMID:29138545   PMID:29186476   PMID:29286063   PMID:29504377   PMID:29674611   PMID:29717517   PMID:30221657   PMID:30338818   PMID:30515819  
PMID:30653707   PMID:30714138   PMID:30768929   PMID:31002155   PMID:31035811   PMID:31209813   PMID:31210285   PMID:31433841   PMID:31476403   PMID:31585906   PMID:31640732   PMID:31718671  
PMID:31726181   PMID:31796120   PMID:31799679   PMID:31975567   PMID:32004541   PMID:32069075   PMID:32144600   PMID:32703409   PMID:32783102   PMID:32827575   PMID:33086033   PMID:33236068  
PMID:34018360   PMID:34646085   PMID:34739190   PMID:34755661   PMID:34795395   PMID:34975828   PMID:35306046   PMID:35355403   PMID:35545948   PMID:36602704  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.239,277,955 - 9,323,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,332,077 - 12,388,087 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,915,306 - 20,971,319 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0319,170,646 - 19,226,660 (-)NCBIRnor_WKY
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Celera34,097,915 - 4,143,369 (-)NCBICelera
Cytogenetic Map3p13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389136,494,433 - 136,546,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,494,433 - 136,546,048 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,388,885 - 139,440,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,508,717 - 138,560,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,664,733 - 136,716,075NCBI
Celera9109,903,340 - 109,955,631 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,848,155 - 108,928,442 (-)NCBIHuRef
CHM1_19139,537,630 - 139,588,846 (-)NCBICHM1_1
T2T-CHM13v2.09148,723,532 - 148,777,907 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)EnsemblGRCm39 Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBIMGSCv36mm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan192,840,709 - 2,893,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,568,670 - 107,621,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,544,639 - 136,595,511 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,544,639 - 136,598,740 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1948,975,972 - 49,018,985 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,974,757 - 49,017,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,226,361 - 48,269,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,852,205 - 49,895,734 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,851,628 - 49,894,186 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,633,237 - 48,676,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,926,759 - 48,970,231 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,974,423 - 49,017,941 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,292,088 - 1,332,428 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
No map positions available.
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1121,656,815 - 1,707,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,656,918 - 1,709,585 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,509,673 - 3,610,304 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247601,634,702 - 1,676,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,636,331 - 1,676,398 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Notch1
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:128
Interacting mature miRNAs:140
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,286,002 - 9,286,237 (+)MAPPERmRatBN7.2
Rnor_6.033,913,490 - 3,913,724NCBIRnor6.0
Rnor_5.039,274,591 - 9,274,825UniSTSRnor5.0
RGSC_v3.434,639,724 - 4,639,959RGDRGSC3.4
RGSC_v3.434,639,725 - 4,639,959UniSTSRGSC3.4
RGSC_v3.134,639,724 - 4,639,959RGD
Celera34,105,843 - 4,106,077UniSTS
SHRSP x BN Map32.4699RGD
SHRSP x BN Map32.4699UniSTS
Cytogenetic Map3p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,325,263 - 9,325,417 (+)MAPPERmRatBN7.2
Rnor_6.033,952,748 - 3,952,901NCBIRnor6.0
Rnor_5.039,313,308 - 9,313,453UniSTSRnor5.0
Celera34,145,102 - 4,145,255UniSTS
SHRSP x BN Map32.4499RGD
SHRSP x BN Map32.4499UniSTS
Cytogenetic Map3p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,285,189 - 9,285,550 (+)MAPPERmRatBN7.2
Rnor_6.033,912,677 - 3,913,037NCBIRnor6.0
Rnor_5.039,273,778 - 9,274,138UniSTSRnor5.0
RGSC_v3.434,638,912 - 4,639,272UniSTSRGSC3.4
Celera34,105,030 - 4,105,390UniSTS
Cytogenetic Map3p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,277,962 - 9,278,179 (+)MAPPERmRatBN7.2
Rnor_6.033,905,450 - 3,905,666NCBIRnor6.0
Rnor_5.039,266,551 - 9,266,767UniSTSRnor5.0
RGSC_v3.434,631,685 - 4,631,901UniSTSRGSC3.4
Celera34,097,803 - 4,098,019UniSTS
Cytogenetic Map3p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,279,595 - 9,279,775 (+)MAPPERmRatBN7.2
Rnor_6.033,907,083 - 3,907,262NCBIRnor6.0
Rnor_5.039,268,184 - 9,268,363UniSTSRnor5.0
RGSC_v3.434,633,318 - 4,633,497UniSTSRGSC3.4
Celera34,099,436 - 4,099,615UniSTS
Cytogenetic Map3p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,279,732 - 9,279,979 (+)MAPPERmRatBN7.2
Rnor_6.033,907,220 - 3,907,466NCBIRnor6.0
Rnor_5.039,268,321 - 9,268,567UniSTSRnor5.0
RGSC_v3.434,633,455 - 4,633,701UniSTSRGSC3.4
Celera34,099,573 - 4,099,819UniSTS
Cytogenetic Map3p13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,280,872 - 9,281,064 (+)MAPPERmRatBN7.2
Rnor_6.033,908,360 - 3,908,551NCBIRnor6.0
Rnor_5.039,269,461 - 9,269,652UniSTSRnor5.0
RGSC_v3.434,634,595 - 4,634,786UniSTSRGSC3.4
Celera34,100,713 - 4,100,904UniSTS
Cytogenetic Map3p13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 33 15 2 17 2 1 1 61 23 33 11 1
Low 1 10 42 39 2 39 7 10 13 12 8 7
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026212   ⟹   ENSRNOP00000026212
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)Ensembl
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104296   ⟹   ENSRNOP00000096802
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)Ensembl
RefSeq Acc Id: NM_001105721   ⟹   NP_001099191
Rat AssemblyChrPosition (strand)Source
mRatBN7.239,278,075 - 9,323,531 (-)NCBI
Rnor_6.033,905,562 - 3,951,015 (-)NCBI
Rnor_5.039,266,663 - 9,311,575 (-)NCBI
RGSC_v3.434,631,797 - 4,677,640 (-)RGD
Celera34,097,915 - 4,143,369 (-)RGD
RefSeq Acc Id: XM_039104374   ⟹   XP_038960302
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.239,277,955 - 9,303,898 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099191 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960302 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93491 (Get FASTA)   NCBI Sequence Viewer  
  Q07008 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099191   ⟸   NM_001105721
- Peptide Label: precursor
- UniProtKB: F1M9E7 (UniProtKB/Swiss-Prot),   Q07008 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026212   ⟸   ENSRNOT00000026212
RefSeq Acc Id: XP_038960302   ⟸   XM_039104374
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000096802   ⟸   ENSRNOT00000104296
Protein Domains
EGF-like   LNR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07008-F1-model_v2 AlphaFold Q07008 1-2531 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691908
Promoter ID:EPDNEW_R2433
Type:single initiation site
Description:notch 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.033,951,039 - 3,951,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3187 AgrOrtholog
BioCyc Gene G2FUF-50378 BioCyc
Ensembl Genes ENSRNOG00000019322 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026212 ENTREZGENE
  ENSRNOP00000026212.6 UniProtKB/Swiss-Prot
  ENSRNOP00000096802.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026212 ENTREZGENE
  ENSRNOT00000026212.8 UniProtKB/Swiss-Prot
  ENSRNOT00000104296.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.300.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454_notch UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_C UniProtKB/TrEMBL
  Notch_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25496 UniProtKB/Swiss-Prot
  PROTEIN SLIT UniProtKB/Swiss-Prot
  SLIT HOMOLOG UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Notch1 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AT84_RAT UniProtKB/TrEMBL
UniProt Secondary F1M9E7 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Notch1  notch receptor 1  Notch1  notch 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Notch1  notch 1  Notch1  Notch homolog 1, translocation-associated (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Notch1  Notch homolog 1, translocation-associated (Drosophila)  Notch1  Notch gene homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Notch1  Notch gene homolog 1, (Drosophila)      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains 36 epidermal growth factor (EGF)-like repeats 728926
gene_expression expressed only in ventricular proliferative zones of embryonic neuroepithelia 728926