(+)-catechin increases expression ISO NOTCH1 (Homo sapiens) 6480464 Catechin results in increased expression of NOTCH1 mRNA CTD PMID:15465739 (+)-dexrazoxane multiple interactions ISO Notch1 (Mus musculus) 6480464 Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of NOTCH1 protein] CTD PMID:30517846 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 MAPK1 protein promotes the reaction [o more ... CTD PMID:18791200 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of NOTCH1 mRNA CTD PMID:32387197 1,2-dimethylhydrazine decreases expression ISO Notch1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of NOTCH1 mRNA CTD PMID:22206623 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA]] and Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA] CTD PMID:35662665 17alpha-ethynylestradiol multiple interactions ISO Notch1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of NOTCH1 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of NOTCH1 mRNA and Estradiol promotes the reaction [NOTCH1 protein binds to CCND1 promoter] CTD PMID:19838210 and PMID:30165855 17beta-estradiol increases expression ISO NOTCH1 (Homo sapiens) 6480464 Estradiol results in increased expression of NOTCH1 mRNA CTD PMID:31614463 17beta-estradiol multiple interactions ISO Notch1 (Mus musculus) 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of NOTCH1 mRNA and Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein] CTD PMID:19693291 and PMID:35537655 17beta-estradiol affects expression ISO Notch1 (Mus musculus) 6480464 Estradiol affects the expression of NOTCH1 mRNA CTD PMID:15598610 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:21908764 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Notch1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of NOTCH1 mRNA CTD PMID:18343893 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NOTCH1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of NOTCH1 mRNA CTD PMID:29704546 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Notch1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA CTD PMID:10886394 more ... 2,3,7,8-tetrachlorodibenzodioxine affects activity ISO Notch1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the activity of NOTCH1 protein CTD PMID:25585350 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Notch1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNA CTD PMID:17586704 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Notch1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of NOTCH1 mRNA more ... CTD PMID:15667827 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO NOTCH1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNA CTD PMID:19684285 2,3,7,8-Tetrachlorodibenzofuran increases expression ISO Notch1 (Mus musculus) 6480464 2 more ... CTD PMID:20702594 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO Notch1 (Mus musculus) 6480464 2 more ... CTD PMID:18343893 2-acetamidofluorene increases expression ISO Notch1 (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA CTD PMID:21607683 2-tert-butylhydroquinone decreases expression EXP 6480464 2-tert-butylhydroquinone results in decreased expression of NOTCH1 protein CTD PMID:29663635 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Notch1 (Mus musculus) 6480464 3 more ... CTD PMID:18042819 more ... 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of NOTCH1 mRNA CTD PMID:32041402 3,3',5,5'-tetrabromobisphenol A increases expression ISO Notch1 (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of NOTCH1 mRNA CTD PMID:35230478 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of NOTCH1 mRNA CTD PMID:30071829 4,4'-sulfonyldiphenol multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [bisphenol S co-treated with Fulvestrant] results in decreased methylation of NOTCH1 gene CTD PMID:31601247 4-hydroxynon-2-enal decreases expression ISO Notch1 (Mus musculus) 6480464 4-hydroxy-2-nonenal results in decreased expression of NOTCH1 mRNA CTD PMID:19191707 5-aza-2'-deoxycytidine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Decitabine co-treated with trichostatin A] results in decreased expression of NOTCH1 mRNA CTD PMID:17185465 5-fluorouracil multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein CTD PMID:29917191 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of NOTCH1 mRNA CTD PMID:24780913 and PMID:25825206 6-propyl-2-thiouracil multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NOTCH1 protein] CTD PMID:36942326 7,12-dimethyltetraphene increases expression ISO Notch1 (Mus musculus) 6480464 9 more ... CTD PMID:32553695 aconitine increases expression EXP 6480464 Aconitine results in increased expression of NOTCH1 protein and Aconitine results in increased expression of NOTCH1 protein modified form CTD PMID:32234357 aconitine increases expression ISO NOTCH1 (Homo sapiens) 6480464 Aconitine results in increased expression of NOTCH1 protein modified form CTD PMID:32234357 aconitine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Aconitine promotes the reaction [NOTCH1 protein modified form binds to HCN4 promoter] more ... CTD PMID:32234357 aconitine multiple interactions EXP 6480464 Aconitine affects the reaction [NOTCH1 protein modified form binds to HCN4 promoter] and crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form] CTD PMID:32234357 aconitine affects expression ISO NOTCH1 (Homo sapiens) 6480464 Aconitine affects the expression of NOTCH1 protein CTD PMID:32234357 acrylamide decreases expression ISO Notch1 (Mus musculus) 6480464 Acrylamide results in decreased expression of NOTCH1 mRNA CTD PMID:30807115 aflatoxin B1 increases expression ISO Notch1 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of NOTCH1 mRNA CTD PMID:19770486 aflatoxin B1 multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Zearalenone co-treated with Aflatoxin B1] results in increased expression of NOTCH1 mRNA CTD PMID:28965971 all-trans-retinoic acid multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3 and 3-bis(2-aminoethyl)-1-triazene] results in increased expression of NOTCH1 protein CTD PMID:23284745 all-trans-retinoic acid increases expression ISO NOTCH1 (Homo sapiens) 6480464 Tretinoin results in increased expression of NOTCH1 mRNA and Tretinoin results in increased expression of NOTCH1 protein CTD PMID:28130038 and PMID:33167477 all-trans-retinoic acid decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of NOTCH1 mRNA CTD PMID:21934132 and PMID:22906706 alpha-D-galactose multiple interactions ISO Notch1 (Mus musculus) 6480464 [Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein more ... CTD PMID:35537655 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NOTCH1 mRNA CTD PMID:16483693 arecoline increases expression ISO Notch1 (Mus musculus) 151347668 arecoline cotreated with dimethyl sulfoxide increases expression of Notch1 protein in tongue RGD aristolochic acid A increases expression ISO NOTCH1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of NOTCH1 mRNA CTD PMID:33212167 arsane multiple interactions ISO Notch1 (Mus musculus) 6480464 arginyl-2 more ... CTD PMID:32647881 arsane increases expression ISO Notch1 (Mus musculus) 6480464 [Arsenic results in increased expression of NOTCH1 protein] which results in increased expression of DLL4 protein and Arsenic results in increased expression of NOTCH1 mRNA CTD PMID:32647881 arsenic atom multiple interactions ISO Notch1 (Mus musculus) 6480464 arginyl-2 more ... CTD PMID:32647881 arsenic atom increases expression ISO Notch1 (Mus musculus) 6480464 [Arsenic results in increased expression of NOTCH1 protein] which results in increased expression of DLL4 protein and Arsenic results in increased expression of NOTCH1 mRNA CTD PMID:32647881 arsenite(3-) multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to NOTCH1 mRNA] and RTKI cpd inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form] CTD PMID:18633435 and PMID:32406909 arsenite(3-) increases expression ISO NOTCH1 (Homo sapiens) 6480464 arsenite results in increased expression of NOTCH1 protein CTD PMID:22011395 arsenite(3-) decreases expression ISO NOTCH1 (Homo sapiens) 6480464 arsenite results in decreased expression of NOTCH1 protein modified form CTD PMID:18633435 arsenous acid multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein] more ... CTD PMID:23542114 more ... arsenous acid increases expression ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of NOTCH1 mRNA and Arsenic Trioxide results in increased expression of NOTCH1 protein CTD PMID:29738779 arsenous acid decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NOTCH1 more ... CTD PMID:22949821 more ... arsenous acid decreases response to substance ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22949821 arsenous acid decreases activity ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased activity of NOTCH1 protein CTD PMID:23542114 aspartame multiple interactions ISO Notch1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA CTD PMID:23783067 aspartame affects localization ISO NOTCH1 (Homo sapiens) 6480464 Aspartame affects the localization of NOTCH1 protein modified form CTD PMID:33992720 aspartame multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form] CTD PMID:33992720 azoxystrobin decreases expression ISO NOTCH1 (Homo sapiens) 6480464 azoxystrobin results in decreased expression of NOTCH1 mRNA CTD PMID:33512557 baicalein increases activity ISO NOTCH1 (Homo sapiens) 6480464 baicalein results in increased activity of NOTCH1 protein CTD PMID:19160421 baicalein increases expression ISO NOTCH1 (Homo sapiens) 6480464 baicalein results in increased expression of NOTCH1 mRNA CTD PMID:19160421 baicalin increases activity ISO NOTCH1 (Homo sapiens) 6480464 baicalin results in increased activity of NOTCH1 protein CTD PMID:19160421 baicalin increases expression ISO NOTCH1 (Homo sapiens) 6480464 baicalin results in increased expression of NOTCH1 mRNA CTD PMID:19160421 benzene increases expression ISO NOTCH1 (Homo sapiens) 6480464 Benzene results in increased expression of NOTCH1 mRNA CTD PMID:24993241 benzo[a]pyrene increases expression ISO Notch1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of NOTCH1 mRNA CTD PMID:19770486 more ... benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in increased expression of NOTCH1 mRNA] more ... CTD PMID:35378083 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of NOTCH1 mRNA and Benzo(a)pyrene results in increased expression of NOTCH1 protein CTD PMID:35378083 benzo[a]pyrene multiple interactions ISO Notch1 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA CTD PMID:27858113 benzo[b]fluoranthene multiple interactions ISO Notch1 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA CTD PMID:27858113 beta-naphthoflavone increases expression ISO Notch1 (Mus musculus) 6480464 beta-Naphthoflavone results in increased expression of NOTCH1 mRNA CTD PMID:23994337 bis(2-chloroethyl) sulfide decreases expression EXP 6480464 Mustard Gas results in decreased expression of NOTCH1 mRNA CTD PMID:28402575 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of NOTCH1 protein CTD PMID:29663635 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of NOTCH1 mRNA and Diethylhexyl Phthalate results in increased expression of NOTCH1 protein CTD PMID:36988346 bis(2-ethylhexyl) phthalate multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased expression of NOTCH1 protein CTD PMID:38042133 bisphenol A decreases expression ISO Notch1 (Mus musculus) 6480464 bisphenol A results in decreased expression of NOTCH1 mRNA CTD PMID:21932408 and PMID:35278557 bisphenol A increases expression ISO Notch1 (Mus musculus) 6480464 bisphenol A results in increased expression of NOTCH1 mRNA CTD PMID:32156529 bisphenol A multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of NOTCH1 gene CTD PMID:31601247 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NOTCH1 mRNA CTD PMID:32145629 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NOTCH1 mRNA and bisphenol A results in increased expression of NOTCH1 protein CTD PMID:29323181 and PMID:29438945 bisphenol A affects methylation ISO Notch1 (Mus musculus) 6480464 bisphenol A affects the methylation of NOTCH1 promoter CTD PMID:27334623 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of NOTCH1 gene CTD PMID:28505145 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of NOTCH1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO NOTCH1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of NOTCH1 mRNA CTD PMID:26363213 bisphenol F decreases expression ISO Notch1 (Mus musculus) 6480464 bisphenol F results in decreased expression of NOTCH1 mRNA CTD PMID:35278557 Botulinum toxin type A decreases response to substance ISO Notch1 (Mus musculus) 6480464 NOTCH1 results in decreased susceptibility to Botulinum Toxins and Type A CTD PMID:23884415 cadmium atom multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOTCH1 mRNA CTD PMID:36602393 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of NOTCH1 promoter CTD PMID:22457795 cadmium dichloride multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] more ... CTD PMID:25118938 and PMID:36602393 caffeine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]] CTD PMID:31597699 calciol increases expression ISO Notch1 (Mus musculus) 6480464 Cholecalciferol results in increased expression of NOTCH1 mRNA CTD PMID:17170073 calciol multiple interactions EXP 6480464 [Cholecalciferol co-treated with Dietary Fats co-treated with Particulate Matter] results in increased expression of NOTCH1 mRNA CTD PMID:36603807 captan decreases expression ISO Notch1 (Mus musculus) 6480464 Captan results in decreased expression of NOTCH1 mRNA CTD PMID:31558096 carbon nanotube decreases expression ISO Notch1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 chloroquine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein CTD PMID:29917191 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of NOTCH1 mRNA CTD PMID:18668222 chlorpyrifos increases expression ISO Notch1 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of NOTCH1 mRNA and Chlorpyrifos results in increased expression of NOTCH1 protein modified form CTD PMID:32715474 and PMID:37019170 chromium(6+) multiple interactions ISO Notch1 (Mus musculus) 6480464 MAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased expression of NOTCH1 mRNA] CTD PMID:19654923 chromium(6+) increases expression ISO Notch1 (Mus musculus) 6480464 chromium hexavalent ion results in increased expression of NOTCH1 mRNA CTD PMID:19654923 chrysene decreases expression ISO Notch1 (Mus musculus) 6480464 chrysene results in decreased expression of NOTCH1 mRNA CTD PMID:26377693 chrysene multiple interactions ISO Notch1 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA CTD PMID:27858113 cis-caffeic acid multiple interactions EXP 6480464 caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA] CTD PMID:29968957 cisplatin decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of NOTCH1 mRNA CTD PMID:27594783 clobetasol decreases expression ISO Notch1 (Mus musculus) 6480464 Clobetasol results in decreased expression of NOTCH1 mRNA CTD PMID:27462272 cobalt dichloride increases expression ISO NOTCH1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of NOTCH1 mRNA CTD PMID:22941251 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of NOTCH1 mRNA CTD PMID:24386269 cordycepin multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [cordycepin co-treated with thymoquinone] results in decreased expression of NOTCH1 protein CTD PMID:35774120 crocidolite asbestos decreases expression ISO Notch1 (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of NOTCH1 mRNA CTD PMID:23917077 Cuprizon multiple interactions EXP 6480464 Cuprizone results in increased cleavage of and results in increased activity of NOTCH1 protein CTD PMID:31168611 curcumin decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Curcumin results in decreased expression of NOTCH1 mRNA and Curcumin results in decreased expression of NOTCH1 protein CTD PMID:17927689 and PMID:18640131 curcumin multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein CTD PMID:18640131 Cyclopamine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [2-(2-(3 more ... CTD PMID:21498710 Cyclopamine decreases cleavage ISO NOTCH1 (Homo sapiens) 6480464 cyclopamine results in decreased cleavage of NOTCH1 protein CTD PMID:21498710 DAPT multiple interactions EXP 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 protein] CTD PMID:36988346 DAPT decreases expression EXP 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein CTD PMID:36988346 DAPT decreases expression ISO NOTCH1 (Homo sapiens) 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein modified form CTD PMID:18633435 DAPT multiple interactions ISO Notch1 (Mus musculus) 6480464 N-(N-(3 more ... CTD PMID:22115781 and PMID:24223152 DAPT multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 N-(N-(3 more ... CTD PMID:22039516 more ... DDT increases activity ISO NOTCH1 (Homo sapiens) 6480464 DDT results in increased activity of NOTCH1 protein CTD PMID:18791200 DDT multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 MAP2K6 protein promotes the reaction [DDT results in increased activity of NOTCH1 protein] CTD PMID:18791200 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of NOTCH1 mRNA CTD PMID:14618091 dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 mRNA] CTD PMID:18449946 diallyl trisulfide decreases expression ISO NOTCH1 (Homo sapiens) 6480464 diallyl trisulfide results in decreased expression of NOTCH1 mRNA and diallyl trisulfide results in decreased expression of NOTCH1 protein CTD PMID:23430952 diallyl trisulfide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 mutant form promotes the reaction [diallyl trisulfide results in decreased activity of MMP2 protein] more ... CTD PMID:23430952 diarsenic trioxide decreases response to substance ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22949821 diarsenic trioxide decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NOTCH1 more ... CTD PMID:22949821 more ... diarsenic trioxide decreases activity ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased activity of NOTCH1 protein CTD PMID:23542114 diarsenic trioxide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein] more ... CTD PMID:23542114 more ... diarsenic trioxide increases expression ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of NOTCH1 mRNA and Arsenic Trioxide results in increased expression of NOTCH1 protein CTD PMID:29738779 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of NOTCH1 mRNA and Dibutyl Phthalate results in increased expression of NOTCH1 protein CTD PMID:29438945 and PMID:35378083 dibutyl phthalate multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in increased expression of NOTCH1 mRNA] more ... CTD PMID:35378083 dicrotophos increases expression ISO NOTCH1 (Homo sapiens) 6480464 dicrotophos results in increased expression of NOTCH1 mRNA CTD PMID:28302478 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of NOTCH1 mRNA CTD PMID:22546817 diethyl maleate increases expression ISO NOTCH1 (Homo sapiens) 6480464 diethyl maleate results in increased expression of NOTCH1 mRNA CTD PMID:33545341 diethylstilbestrol decreases expression ISO Notch1 (Mus musculus) 6480464 Diethylstilbestrol results in decreased expression of NOTCH1 mRNA CTD PMID:21041162 dimethylarsinic acid affects expression EXP 6480464 Cacodylic Acid affects the expression of NOTCH1 mRNA CTD PMID:17720352 dioxygen multiple interactions ISO Notch1 (Mus musculus) 6480464 N-(N-(3 more ... CTD PMID:24223152 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of NOTCH1 mRNA and Oxygen deficiency results in increased expression of NOTCH1 protein CTD PMID:24223152 dioxygen affects localization EXP 6480464 Oxygen deficiency affects the localization of NOTCH1 protein modified form CTD PMID:24223152 dioxygen affects localization ISO Notch1 (Mus musculus) 6480464 Oxygen deficiency affects the localization of NOTCH1 protein modified form CTD PMID:24223152 dioxygen increases expression ISO Notch1 (Mus musculus) 6480464 Oxygen deficiency results in increased expression of NOTCH1 mRNA and Oxygen deficiency results in increased expression of NOTCH1 protein CTD PMID:24223152 doxorubicin multiple interactions EXP 6480464 paeonol affects the reaction [Doxorubicin results in decreased expression of NOTCH1 mRNA] CTD PMID:31307187 doxorubicin multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Doxorubicin inhibits the reaction [Nocodazole promotes the reaction [Hydroxyurea results in decreased expression of NOTCH1 protein]] and NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]] CTD PMID:31597699 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of NOTCH1 mRNA CTD PMID:31307187 doxorubicin increases expression ISO Notch1 (Mus musculus) 6480464 Doxorubicin results in increased expression of NOTCH1 protein CTD PMID:30517846 doxorubicin increases cleavage EXP 6480464 Doxorubicin results in increased cleavage of NOTCH1 protein CTD PMID:31307187 doxorubicin multiple interactions ISO Notch1 (Mus musculus) 6480464 Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of NOTCH1 protein] CTD PMID:30517846 emodin decreases expression EXP 6480464 Emodin results in decreased expression of NOTCH1 protein CTD PMID:27989784 emodin multiple interactions EXP 6480464 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]] more ... CTD PMID:27989784 emodin decreases response to substance EXP 6480464 NOTCH1 protein results in decreased susceptibility to Emodin CTD PMID:27989784 enzalutamide affects response to substance ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein affects the susceptibility to enzalutamide CTD PMID:30940724 enzalutamide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein CTD PMID:30940724 enzalutamide affects expression ISO NOTCH1 (Homo sapiens) 6480464 enzalutamide affects the expression of NOTCH1 mRNA CTD PMID:30940724 epoxiconazole increases expression ISO Notch1 (Mus musculus) 6480464 epoxiconazole results in increased expression of NOTCH1 mRNA CTD PMID:35436446 ethanol decreases activity EXP 6480464 Ethanol results in decreased activity of NOTCH1 protein CTD PMID:16770775 ethanol increases expression ISO Notch1 (Mus musculus) 6480464 Ethanol results in increased expression of NOTCH1 mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO NOTCH1 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of NOTCH1 mRNA CTD PMID:23649840 eugenol decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Eugenol results in decreased expression of NOTCH1 mRNA and Eugenol results in decreased expression of NOTCH1 protein CTD PMID:31926151 eugenol decreases expression ISO Notch1 (Mus musculus) 6480464 Eugenol results in decreased expression of NOTCH1 protein CTD PMID:31926151 fenamidone increases expression ISO Notch1 (Mus musculus) 6480464 fenamidone results in increased expression of NOTCH1 mRNA CTD PMID:27029645 fenofibrate multiple interactions ISO Notch1 (Mus musculus) 6480464 Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA] CTD PMID:31241159 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of NOTCH1 mRNA and Fluoxetine results in increased expression of NOTCH1 protein CTD PMID:19801843 folic acid increases expression EXP 6480464 Folic Acid results in increased expression of NOTCH1 mRNA and Folic Acid results in increased expression of NOTCH1 protein CTD PMID:20838574 folpet decreases expression ISO Notch1 (Mus musculus) 6480464 folpet results in decreased expression of NOTCH1 mRNA CTD PMID:31558096 formaldehyde increases expression ISO NOTCH1 (Homo sapiens) 6480464 Formaldehyde results in increased expression of NOTCH1 mRNA CTD PMID:23649840 FR900359 decreases phosphorylation ISO NOTCH1 (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of NOTCH1 protein CTD PMID:37730182 fulvestrant multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of NOTCH1 gene and [bisphenol S co-treated with Fulvestrant] results in decreased methylation of NOTCH1 gene CTD PMID:31601247 furan decreases expression EXP 6480464 furan results in decreased expression of NOTCH1 mRNA CTD PMID:25539665 galactose multiple interactions ISO Notch1 (Mus musculus) 6480464 [Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein more ... CTD PMID:35537655 gemcitabine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 sulforaphane inhibits the reaction [Gemcitabine results in increased expression of NOTCH1 protein] CTD PMID:20940707 gemcitabine increases expression ISO NOTCH1 (Homo sapiens) 6480464 Gemcitabine results in increased expression of NOTCH1 protein CTD PMID:20940707 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of NOTCH1 mRNA CTD PMID:22061828 and PMID:33387578 glycyrrhizinic acid decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Glycyrrhizic Acid results in decreased expression of NOTCH1 mRNA CTD PMID:35844403 glyphosate decreases expression EXP 6480464 Glyphosate results in decreased expression of NOTCH1 mRNA CTD PMID:34953950 glyphosate increases activity ISO NOTCH1 (Homo sapiens) 6480464 Glyphosate results in increased activity of NOTCH1 protein CTD PMID:35485992 glyphosate increases methylation EXP 6480464 Glyphosate results in increased methylation of NOTCH1 gene CTD PMID:31011160 glyphosate increases expression ISO NOTCH1 (Homo sapiens) 6480464 Glyphosate results in increased expression of NOTCH1 mRNA CTD PMID:31295307 hexadecanoic acid decreases expression EXP 6480464 Palmitic Acid results in decreased expression of NOTCH1 protein and Palmitic Acid results in decreased expression of NOTCH1 protein modified form CTD PMID:34897970 hexadecanoic acid multiple interactions EXP 6480464 MIR141 mRNA promotes the reaction [Palmitic Acid results in decreased expression of NOTCH1 protein modified form] and MIR141 mRNA promotes the reaction [Palmitic Acid results in decreased expression of NOTCH1 protein] CTD PMID:34897970 hydrogen peroxide increases cleavage ISO NOTCH1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased cleavage of NOTCH1 protein CTD PMID:25108166 hydrogen peroxide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 HIF1A protein affects the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein] more ... CTD PMID:25108166 hydroxyurea decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Hydroxyurea results in decreased expression of NOTCH1 protein CTD PMID:31597699 hydroxyurea multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Doxorubicin inhibits the reaction [Nocodazole promotes the reaction [Hydroxyurea results in decreased expression of NOTCH1 protein]] more ... CTD PMID:31597699 isoflavones multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein CTD PMID:18640131 isoflavones decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Isoflavones results in decreased expression of NOTCH1 protein CTD PMID:18640131 isoprenaline multiple interactions EXP 6480464 [Isoproterenol co-treated with POSTN protein] results in decreased expression of NOTCH1 mRNA CTD PMID:30303030 isoprenaline decreases expression EXP 6480464 Isoproterenol results in decreased expression of NOTCH1 mRNA CTD PMID:30303030 kaempferol 3-O-beta-D-glucoside multiple interactions ISO Notch1 (Mus musculus) 6480464 astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein] CTD PMID:35537655 Licochalcone B increases expression ISO NOTCH1 (Homo sapiens) 6480464 licochalcone B results in increased expression of NOTCH1 mRNA CTD PMID:33647349 lipopolysaccharide increases expression ISO Notch1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of NOTCH1 protein CTD PMID:18449946 lipopolysaccharide increases expression ISO NOTCH1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of NOTCH1 protein CTD PMID:35385713 lipopolysaccharide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 ITCH protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 protein] more ... CTD PMID:35385713 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of NOTCH1 mRNA and Lipopolysaccharides results in increased expression of NOTCH1 protein CTD PMID:18449946 lipopolysaccharide multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 mRNA] CTD PMID:18449946 lipopolysaccharide multiple interactions ISO Notch1 (Mus musculus) 6480464 NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of CSF1 mRNA] more ... CTD PMID:18449946 lithium chloride decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Lithium Chloride results in decreased expression of NOTCH1 mRNA CTD PMID:23527032 LY294002 multiple interactions ISO Notch1 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein] CTD PMID:17513037 LY294002 multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 mebendazole decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Mebendazole results in decreased expression of NOTCH1 protein CTD PMID:32277947 methoxyacetic acid decreases expression ISO Notch1 (Mus musculus) 6480464 methoxyacetic acid results in decreased expression of NOTCH1 mRNA CTD PMID:32496642 methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of NOTCH1 gene CTD PMID:35440735 methyl methanesulfonate increases expression ISO NOTCH1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of NOTCH1 mRNA CTD PMID:23649840 methylmercury chloride affects expression EXP 6480464 methylmercuric chloride affects the expression of NOTCH1 mRNA CTD PMID:20864626 methylmercury chloride multiple interactions ISO Notch1 (Mus musculus) 6480464 methylmercuric chloride affects the reaction [ITPR3 protein affects the expression of NOTCH1 mRNA] CTD PMID:33166615 miconazole increases expression ISO Notch1 (Mus musculus) 6480464 Miconazole results in increased expression of NOTCH1 mRNA CTD PMID:27462272 Mitotane increases activity ISO NOTCH1 (Homo sapiens) 6480464 Mitotane results in increased activity of NOTCH1 protein CTD PMID:18791200 mono(2-ethylhexyl) phthalate multiple interactions EXP 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 protein] CTD PMID:36988346 mono(2-ethylhexyl) phthalate increases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 mRNA and mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 protein CTD PMID:36988346 mono(2-ethylhexyl) phthalate increases expression ISO NOTCH1 (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 mRNA and mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 protein CTD PMID:38042133 mono(2-ethylhexyl) phthalate multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased expression of NOTCH1 protein CTD PMID:38042133 monocrotaline multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NOTCH1 protein] CTD PMID:36942326 monocrotaline increases expression ISO NOTCH1 (Homo sapiens) 6480464 Monocrotaline results in increased expression of NOTCH1 protein CTD PMID:36942326 monosodium L-glutamate multiple interactions ISO Notch1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA CTD PMID:23783067 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptonide results in increased degradation of NOTCH1 protein] CTD PMID:24801890 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO NOTCH1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOTCH1 mRNA CTD PMID:24497960 N-methyl-4-phenylpyridinium multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 KLF4 protein affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NOTCH1 protein] more ... CTD PMID:29611404 N-methyl-4-phenylpyridinium affects expression ISO NOTCH1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium affects the expression of NOTCH1 protein CTD PMID:29611404 N-nitrosodiethylamine multiple interactions ISO Notch1 (Mus musculus) 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NOTCH1 mRNA] CTD PMID:17854601 N-nitrosodiethylamine increases expression ISO Notch1 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of NOTCH1 mRNA CTD PMID:17854601 and PMID:21607683 nickel dichloride increases expression ISO NOTCH1 (Homo sapiens) 6480464 nickel chloride results in increased expression of NOTCH1 protein CTD PMID:26962057 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of NOTCH1 mRNA CTD PMID:22546817 niclosamide decreases activity ISO NOTCH1 (Homo sapiens) 6480464 Niclosamide results in decreased activity of NOTCH1 protein CTD PMID:19160421 niclosamide multiple interactions EXP 6480464 Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA] and Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] CTD PMID:32961231 nicotinic acid increases expression EXP 6480464 Niacin results in increased expression of NOTCH1 protein CTD PMID:19223914 nocodazole decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Nocodazole results in decreased expression of NOTCH1 protein CTD PMID:31597699 nocodazole multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 BI 2536 inhibits the reaction [Nocodazole results in decreased expression of NOTCH1 protein] more ... CTD PMID:31597699 ochratoxin A increases acetylation ISO NOTCH1 (Homo sapiens) 6480464 ochratoxin A results in increased acetylation of NOTCH1 promoter CTD PMID:29098329 omacetaxine mepesuccinate multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein] CTD PMID:31307525 omacetaxine mepesuccinate increases expression ISO NOTCH1 (Homo sapiens) 6480464 Homoharringtonine results in increased expression of NOTCH1 protein CTD PMID:31307525 oxaliplatin affects response to substance ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein affects the susceptibility to oxaliplatin CTD PMID:19147571 oxaliplatin multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 Sulfonamides inhibits the reaction [oxaliplatin results in increased expression of NOTCH1 protein modified form] CTD PMID:19147571 oxaliplatin increases expression ISO NOTCH1 (Homo sapiens) 6480464 oxaliplatin results in increased expression of NOTCH1 protein modified form CTD PMID:19147571 oxidopamine multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein] and PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]] CTD PMID:31778666 oxidopamine affects expression ISO NOTCH1 (Homo sapiens) 6480464 Oxidopamine affects the expression of NOTCH1 protein CTD PMID:31778666 oxidopamine multiple interactions EXP 6480464 MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein] and PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]] CTD PMID:31778666 oxidopamine affects expression EXP 6480464 Oxidopamine affects the expression of NOTCH1 protein CTD PMID:31778666 ozone multiple interactions ISO Notch1 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of NOTCH1 mRNA CTD PMID:34911549 ozone multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of NOTCH1 mRNA CTD PMID:35430440 paclitaxel multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in decreased expression of CASP9 protein modified form more ... CTD PMID:34048126 paclitaxel multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA]] and Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA] CTD PMID:35662665 paclitaxel decreases expression EXP 6480464 Paclitaxel results in decreased expression of NOTCH1 mRNA CTD PMID:35662665 paclitaxel decreases response to substance ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein results in decreased susceptibility to Paclitaxel CTD PMID:34048126 Paeonol increases expression EXP 6480464 paeonol results in increased expression of NOTCH1 mRNA CTD PMID:31307187 Paeonol increases cleavage EXP 6480464 paeonol results in increased cleavage of NOTCH1 protein CTD PMID:31307187 Paeonol multiple interactions EXP 6480464 paeonol affects the reaction [Doxorubicin results in decreased expression of NOTCH1 mRNA] CTD PMID:31307187 paracetamol increases expression ISO NOTCH1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of NOTCH1 mRNA CTD PMID:22230336 and PMID:29067470 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of NOTCH1 mRNA CTD PMID:33387578 paraquat affects expression ISO NOTCH1 (Homo sapiens) 6480464 Paraquat affects the expression of NOTCH1 mRNA CTD PMID:24053911 pentachlorophenol increases expression ISO Notch1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of NOTCH1 mRNA CTD PMID:23892564 phenethyl isothiocyanate multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 N-(N-(3 more ... CTD PMID:22039516 phenethyl isothiocyanate increases expression ISO NOTCH1 (Homo sapiens) 6480464 phenethyl isothiocyanate results in increased expression of NOTCH1 mRNA CTD PMID:22039516 picropodophyllotoxin multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 pirinixic acid increases expression ISO Notch1 (Mus musculus) 6480464 pirinixic acid results in increased expression of NOTCH1 mRNA CTD PMID:18301758 and PMID:23811191 pluronic P-123 multiple interactions EXP 6480464 Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] CTD PMID:32961231 Poloxamer multiple interactions EXP 6480464 Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] CTD PMID:32961231 poly(ethylene) decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Polyethylene results in decreased expression of NOTCH1 mRNA CTD PMID:23203475 potassium chromate increases expression ISO NOTCH1 (Homo sapiens) 6480464 potassium chromate(VI) results in increased expression of NOTCH1 mRNA CTD PMID:22714537 progesterone multiple interactions ISO Notch1 (Mus musculus) 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of NOTCH1 mRNA CTD PMID:19693291 propiconazole decreases expression ISO Notch1 (Mus musculus) 6480464 propiconazole results in decreased expression of NOTCH1 mRNA CTD PMID:21278054 propranolol decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Propranolol results in decreased expression of NOTCH1 protein CTD PMID:30130526 prostaglandin F2alpha decreases cleavage EXP 6480464 Dinoprost results in decreased cleavage of NOTCH1 protein CTD PMID:21209419 prostaglandin F2alpha decreases expression EXP 6480464 Dinoprost results in decreased expression of NOTCH1 mRNA CTD PMID:21209419 quercetin multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [2-(2-(3 more ... CTD PMID:20032413 more ... resveratrol multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 MRK 003 inhibits the reaction [Resveratrol results in increased activity of NOTCH1] more ... CTD PMID:21743969 and PMID:23594881 resveratrol affects expression ISO NOTCH1 (Homo sapiens) 6480464 resveratrol affects the expression of NOTCH1 mRNA and resveratrol affects the expression of NOTCH1 protein CTD PMID:25896424 resveratrol increases expression ISO NOTCH1 (Homo sapiens) 6480464 resveratrol results in increased expression of NOTCH1 mRNA and resveratrol results in increased expression of NOTCH1 protein CTD PMID:23594881 resveratrol decreases expression ISO NOTCH1 (Homo sapiens) 6480464 resveratrol results in decreased expression of NOTCH1 mRNA and resveratrol results in decreased expression of NOTCH1 protein CTD PMID:17868649 and PMID:25061499 resveratrol increases activity ISO NOTCH1 (Homo sapiens) 6480464 resveratrol results in increased activity of NOTCH1 CTD PMID:21743969 retinyl acetate increases expression ISO Notch1 (Mus musculus) 6480464 retinol acetate results in increased expression of NOTCH1 mRNA CTD PMID:16772331 rotenone decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Rotenone results in decreased expression of NOTCH1 mRNA CTD PMID:33512557 Salidroside decreases expression ISO Notch1 (Mus musculus) 6480464 rhodioloside results in decreased expression of NOTCH1 mRNA CTD PMID:24929042 SB 203580 multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 SB 203580 inhibits the reaction [o and p'-DDT results in increased activity of NOTCH1 protein] CTD PMID:18791200 simvastatin increases cleavage EXP 6480464 Simvastatin results in increased cleavage of NOTCH1 protein CTD PMID:19109527 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of NOTCH1 mRNA CTD PMID:19109527 sirolimus affects expression EXP 6480464 Sirolimus affects the expression of NOTCH1 protein CTD PMID:26676567 sodium arsenite affects expression ISO NOTCH1 (Homo sapiens) 6480464 sodium arsenite affects the expression of NOTCH1 mRNA CTD PMID:20056578 sodium arsenite decreases expression ISO Notch1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of NOTCH1 mRNA CTD PMID:30130555 sodium arsenite increases expression ISO NOTCH1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of NOTCH1 mRNA CTD PMID:17879257 sodium arsenite multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 sodium arsenite inhibits the reaction [BMP6 protein results in increased activity of NOTCH1 protein] and sodium arsenite inhibits the reaction [U 0126 results in increased activity of NOTCH1 protein] CTD PMID:23566955 sodium dichromate increases expression ISO NOTCH1 (Homo sapiens) 6480464 sodium bichromate results in increased expression of NOTCH1 protein CTD PMID:28624442 sodium dichromate multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 FBP1 protein inhibits the reaction [sodium bichromate results in increased expression of NOTCH1 protein] CTD PMID:28624442 sulforaphane multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 sulforaphane inhibits the reaction [Gemcitabine results in increased expression of NOTCH1 protein] CTD PMID:20940707 sunitinib increases expression ISO NOTCH1 (Homo sapiens) 6480464 Sunitinib results in increased expression of NOTCH1 mRNA CTD PMID:31533062 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of NOTCH1 mRNA CTD PMID:26141394 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of NOTCH1 protein CTD PMID:17343880 tamoxifen multiple interactions EXP 6480464 [Tamoxifen results in increased expression of MIR34A mRNA] which results in decreased expression of NOTCH1 protein CTD PMID:17343880 temozolomide increases expression ISO NOTCH1 (Homo sapiens) 6480464 Temozolomide results in increased expression of NOTCH1 mRNA CTD PMID:31758290 testosterone decreases expression ISO Notch1 (Mus musculus) 6480464 Testosterone results in decreased expression of NOTCH1 mRNA CTD PMID:19693291 testosterone decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Testosterone results in decreased expression of NOTCH1 mRNA CTD PMID:33359661 tetraphene multiple interactions ISO Notch1 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA CTD PMID:27858113 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of NOTCH1 mRNA CTD PMID:32961231 and PMID:34492290 thioacetamide multiple interactions EXP 6480464 Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA] and Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] CTD PMID:32961231 thymoquinone multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [cordycepin co-treated with thymoquinone] results in decreased expression of NOTCH1 protein CTD PMID:35774120 titanium dioxide affects expression ISO Notch1 (Mus musculus) 6480464 titanium dioxide affects the expression of NOTCH1 mRNA CTD PMID:17656681 titanium dioxide decreases methylation ISO NOTCH1 (Homo sapiens) 6480464 titanium dioxide results in decreased methylation of NOTCH1 gene and titanium dioxide results in decreased methylation of NOTCH1 promoter CTD PMID:34973136 toluene multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Toluene co-treated with Xylenes] results in decreased expression of NOTCH1 mRNA and [Toluene co-treated with Xylenes] results in increased methylation of NOTCH1 gene CTD PMID:33438815 trans-caffeic acid multiple interactions EXP 6480464 caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA] CTD PMID:29968957 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of NOTCH1 mRNA CTD PMID:33387578 trichostatin A multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [decitabine co-treated with trichostatin A] results in decreased expression of NOTCH1 mRNA CTD PMID:17185465 triclosan decreases expression ISO Notch1 (Mus musculus) 6480464 Triclosan results in decreased expression of NOTCH1 mRNA and Triclosan results in decreased expression of NOTCH1 protein CTD PMID:36243240 triphenylstannane decreases expression ISO NOTCH1 (Homo sapiens) 6480464 triphenyltin results in decreased expression of NOTCH1 mRNA CTD PMID:12788061 Triptolide increases expression ISO Notch1 (Mus musculus) 6480464 triptolide results in increased expression of NOTCH1 mRNA CTD PMID:31241159 and PMID:32835833 Triptolide decreases expression ISO NOTCH1 (Homo sapiens) 6480464 triptolide results in decreased expression of NOTCH1 mRNA more ... CTD PMID:30394310 Triptolide multiple interactions ISO Notch1 (Mus musculus) 6480464 Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA] more ... CTD PMID:30394310 and PMID:31241159 Triptolide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein] CTD PMID:30394310 triptonide multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptonide results in increased degradation of NOTCH1 protein] and triptonide results in increased ubiquitination of and results in increased degradation of NOTCH1 protein CTD PMID:31866380 tungsten decreases expression ISO Notch1 (Mus musculus) 6480464 Tungsten results in decreased expression of NOTCH1 mRNA CTD PMID:30912803 tunicamycin increases cleavage ISO Notch1 (Mus musculus) 6480464 Tunicamycin results in increased cleavage of NOTCH1 protein CTD PMID:22115781 tunicamycin multiple interactions ISO Notch1 (Mus musculus) 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased cleavage of NOTCH1 protein] CTD PMID:22115781 tyrphostin AG 1478 multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 RTKI cpd inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form] and RTKI cpd inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:18633435 and PMID:25118938 tyrphostin AG 1478 increases expression ISO NOTCH1 (Homo sapiens) 6480464 RTKI cpd results in increased expression of NOTCH1 protein modified form CTD PMID:18633435 uranium atom decreases expression EXP 6480464 Uranium results in decreased expression of NOTCH1 mRNA CTD PMID:27639536 urethane increases expression ISO NOTCH1 (Homo sapiens) 6480464 Urethane results in increased expression of NOTCH1 mRNA CTD PMID:28818685 valproic acid increases methylation ISO NOTCH1 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of NOTCH1 gene CTD PMID:29154799 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of NOTCH1 mRNA CTD PMID:34779009 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of NOTCH1 mRNA CTD PMID:29968957 valproic acid multiple interactions EXP 6480464 caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA] CTD PMID:29968957 valproic acid decreases expression ISO NOTCH1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of NOTCH1 mRNA CTD PMID:23179753 and PMID:23527032 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of NOTCH1 mRNA CTD PMID:19015723 wortmannin multiple interactions ISO Notch1 (Mus musculus) 6480464 wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein] and wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein] CTD PMID:17513037 zalcitabine increases mutagenesis ISO Notch1 (Mus musculus) 6480464 Zalcitabine results in increased mutagenesis of NOTCH1 gene CTD PMID:18798262 zearalenone multiple interactions ISO NOTCH1 (Homo sapiens) 6480464 [Zearalenone co-treated with Aflatoxin B1] results in increased expression of NOTCH1 mRNA CTD PMID:28965971 zinc atom multiple interactions ISO Notch1 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein] more ... CTD PMID:17513037 zinc atom affects localization ISO Notch1 (Mus musculus) 6480464 Zinc affects the localization of NOTCH1 protein CTD PMID:17513037 zinc atom decreases activity ISO Notch1 (Mus musculus) 6480464 Zinc results in decreased activity of NOTCH1 protein CTD PMID:17513037 zinc(0) multiple interactions ISO Notch1 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein] more ... CTD PMID:17513037 zinc(0) decreases activity ISO Notch1 (Mus musculus) 6480464 Zinc results in decreased activity of NOTCH1 protein CTD PMID:17513037 zinc(0) affects localization ISO Notch1 (Mus musculus) 6480464 Zinc affects the localization of NOTCH1 protein CTD PMID:17513037