Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3187
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch1
Name: notch receptor 1
Acc ID: CHEBI:2430
Term: aconitine
Definition: A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.
Chemical ID: MESH:D000157
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1increases expressionEXP 6480464CTDAconitine results in increased expression of NOTCH1 protein; Aconitine results in increased expression of NOTCH1 protein modified formPMID:32234357
Notch1multiple interactionsEXP 6480464CTDAconitine affects the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form]PMID:32234357
Notch1affects expressionISONOTCH1 (Homo sapiens)6480464CTDAconitine affects the expression of NOTCH1 proteinPMID:32234357
Notch1increases expressionISONOTCH1 (Homo sapiens)6480464CTDAconitine results in increased expression of NOTCH1 protein modified formPMID:32234357
Notch1multiple interactionsISONOTCH1 (Homo sapiens)6480464CTDAconitine promotes the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; Aconitine promotes the reaction [NOTCH1 protein modified form binds to KDM5A protein]; crenigacestat affects the reaction [Aconitine affects the expression of NOTCH1 protein]; crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form]PMID:32234357
Go Back to source page   Continue to Ontology report