Notch1 (notch receptor 1) - Rat Genome Database

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Gene: Notch1 (notch receptor 1) Chinchilla lanigera
Analyze
Symbol: Notch1
Name: notch receptor 1
RGD ID: 8733413
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); aortic valve morphogenesis (ortholog); apoptotic process (ortholog); PARTICIPATES IN altered Notch signaling pathway involving the main players; Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 2 (ortholog); Adams-Oliver Syndrome 5 (ortholog); FOUND IN acrosomal vesicle (ortholog); adherens junction (ortholog); apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neurogenic locus notch homolog protein 1; notch 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Adams-Oliver syndrome  (ISO)
Adams-Oliver Syndrome 2  (ISO)
Adams-Oliver Syndrome 5  (ISO)
adenoid cystic carcinoma  (ISO)
adenoiditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis  (ISO)
aortic valve disease  (ISO)
aortic valve disease 1  (ISO)
ARTERIAL DISSECTION  (ISO)
autosomal dominant intellectual developmental disorder 8  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy 5  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2N  (ISO)
bicuspid aortic valve disease  (ISO)
Breast Neoplasms  (ISO)
calcification of aortic valve  (ISO)
calcinosis  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
Colonic Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hypoplastic left heart syndrome  (ISO)
Immunodeficiency 103  (ISO)
Joubert syndrome  (ISO)
keratoacanthoma  (ISO)
Kleefstra syndrome 1  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
microphthalmia  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
oral squamous cell carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Peritoneal Diseases  (ISO)
prion disease  (ISO)
scoliosis  (ISO)
SHONE COMPLEX  (ISO)
Skin Neoplasms  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
syndromic microphthalmia 5  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thoracic aortic aneurysm  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
aortic valve morphogenesis  (ISO)
apoptotic process  (ISO)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
astrocyte differentiation  (ISO)
atrioventricular node development  (ISO)
atrioventricular valve morphogenesis  (ISO)
auditory receptor cell fate commitment  (ISO)
axonogenesis  (ISO)
brain development  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
calcium-ion regulated exocytosis  (ISO)
cardiac atrium morphogenesis  (ISO)
cardiac chamber formation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell myoblast differentiation  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle tissue morphogenesis  (ISO)
cardiac right atrium morphogenesis  (ISO)
cardiac right ventricle formation  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell differentiation  (ISO)
cell differentiation in spinal cord  (ISO)
cell migration involved in endocardial cushion formation  (ISO)
cell population proliferation  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to tumor cell  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
collecting duct development  (ISO)
compartment pattern specification  (ISO)
coronary artery morphogenesis  (ISO)
coronary sinus valve morphogenesis  (ISO)
coronary vein morphogenesis  (ISO)
determination of left/right symmetry  (ISO)
distal tubule development  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
endocardial cell differentiation  (ISO)
endocardial cushion development  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardium development  (ISO)
endocardium morphogenesis  (ISO)
endoderm development  (ISO)
epidermal cell fate specification  (ISO)
epidermis development  (ISO)
epithelial cell fate commitment  (ISO)
epithelial cell proliferation  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
forebrain development  (ISO)
foregut morphogenesis  (ISO)
gene expression  (ISO)
glial cell differentiation  (ISO)
glomerular mesangial cell development  (ISO)
growth involved in heart morphogenesis  (ISO)
hair follicle morphogenesis  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart trabecula morphogenesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
inhibition of neuroepithelial cell differentiation  (ISO)
interleukin-17-mediated signaling pathway  (ISO)
keratinocyte differentiation  (ISO)
left/right axis specification  (ISO)
liver development  (ISO)
lung development  (ISO)
mesenchymal cell development  (ISO)
mitral valve formation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of catalytic activity  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of extracellular matrix constituent secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of ossification  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of photoreceptor cell differentiation  (ISO)
negative regulation of pro-B cell differentiation  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube development  (ISO)
neuroendocrine cell differentiation  (ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuronal stem cell population maintenance  (ISO)
Notch signaling involved in heart development  (ISO)
Notch signaling pathway  (ISO)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation  (ISO)
oligodendrocyte differentiation  (ISO)
outflow tract morphogenesis  (ISO)
pericardium morphogenesis  (ISO)
positive regulation of aorta morphogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic process involved in morphogenesis  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription of Notch receptor target  (ISO)
positive regulation of viral genome replication  (ISO)
positive regulation of viral transcription  (ISO)
prostate gland epithelium morphogenesis  (ISO)
protein catabolic process  (ISO)
protein import into nucleus  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of cardioblast proliferation  (ISO)
regulation of cell migration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of neurogenesis  (ISO)
regulation of Notch signaling pathway  (ISO)
regulation of somitogenesis  (ISO)
regulation of stem cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to corticosteroid  (ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (ISO)
retinal cone cell differentiation  (ISO)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  (ISO)
skeletal muscle cell differentiation  (ISO)
somatic stem cell division  (ISO)
spermatogenesis  (ISO)
sprouting angiogenesis  (ISO)
T-helper 17 type immune response  (ISO)
tissue regeneration  (ISO)
transcription by RNA polymerase II  (ISO)
tube formation  (ISO)
vasculogenesis involved in coronary vascular morphogenesis  (ISO)
venous blood vessel morphogenesis  (ISO)
venous endothelial cell differentiation  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Notch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBIChiLan1.0ChiLan1.0
NOTCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,494,433 - 136,546,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,494,433 - 136,546,048 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,388,885 - 139,440,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,508,717 - 138,560,059 (-)NCBINCBI36hg18NCBI36
Build 349136,664,733 - 136,716,075NCBI
Celera9109,903,340 - 109,955,631 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9108,848,155 - 108,928,442 (-)NCBIHuRef
CHM1_19139,537,630 - 139,588,846 (-)NCBICHM1_1
T2T-CHM13v2.09148,723,532 - 148,777,907 (-)NCBI
Notch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBImm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
Notch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.239,277,955 - 9,323,531 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)Ensembl
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Celera34,097,915 - 4,143,369 (-)NCBICelera
Cytogenetic Map3p13NCBI
NOTCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,544,639 - 136,595,511 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,544,639 - 136,598,740 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09107,568,670 - 107,621,032 (-)NCBIMhudiblu_PPA_v0panPan3
NOTCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,975,972 - 49,018,985 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,974,757 - 49,017,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,226,361 - 48,269,900 (+)NCBI
ROS_Cfam_1.0949,852,205 - 49,895,734 (+)NCBI
ROS_Cfam_1.0 Ensembl949,851,628 - 49,894,186 (+)Ensembl
UMICH_Zoey_3.1948,633,237 - 48,676,758 (+)NCBI
UNSW_CanFamBas_1.0948,926,759 - 48,970,231 (+)NCBI
UU_Cfam_GSD_1.0948,974,423 - 49,017,941 (+)NCBI
Notch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBI
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH1
(Sus scrofa - pig)
No map positions available.
NOTCH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,656,815 - 1,707,566 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl121,656,918 - 1,709,585 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660583,509,673 - 3,610,304 (-)NCBIVero_WHO_p1.0
Notch1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,634,702 - 1,676,531 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247601,636,331 - 1,676,398 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009280   ⟹   ENSCLAP00000009151
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)Ensembl
RefSeq Acc Id: XM_013506704   ⟹   XP_013362158
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013362158 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013362158   ⟸   XM_013506704
- Sequence:
RefSeq Acc Id: ENSCLAP00000009151   ⟸   ENSCLAT00000009280
Protein Domains
EGF-like   LNR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006372 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000009151 ENTREZGENE
  ENSCLAP00000009151.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009280 ENTREZGENE
  ENSCLAT00000009280.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/TrEMBL
  Notch_1 UniProtKB/TrEMBL
  Notch_C UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
NCBI Gene Notch1 ENTREZGENE
Pfam Ank_2 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PIRSF Notch UniProtKB/TrEMBL
PRINTS LNOTCHREPEAT UniProtKB/TrEMBL
  NOTCH1 UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF90193 UniProtKB/TrEMBL
UniProt A0A8C2V4B7_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 Notch1  notch receptor 1    notch 1  Symbol and/or name change 5135510 APPROVED