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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3187
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch1
Name: notch receptor 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1decreases expressionEXP 6480464CTDGlyphosate results in decreased expression of NOTCH1 mRNAPMID:34953950
Notch1increases methylationEXP 6480464CTDGlyphosate results in increased methylation of NOTCH1 genePMID:31011160
Notch1increases activityISONOTCH1 (Homo sapiens)6480464CTDGlyphosate results in increased activity of NOTCH1 proteinPMID:35485992
Notch1increases expressionISONOTCH1 (Homo sapiens)6480464CTDGlyphosate results in increased expression of NOTCH1 mRNAPMID:31295307
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