Notch1 (notch receptor 1) - Rat Genome Database

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Gene: Notch1 (notch receptor 1) Ictidomys tridecemlineatus
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Symbol: Notch1
Name: notch receptor 1
RGD ID: 12475975
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); aortic valve morphogenesis (ortholog); apoptotic process involved in embryonic digit morphogenesis (ortholog); PARTICIPATES IN altered Notch signaling pathway involving the main players; Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 5 (ortholog); adenoid cystic carcinoma (ortholog); FOUND IN acrosomal vesicle (ortholog); adherens junction (ortholog); apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: neurogenic locus notch homolog protein 1; notch 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBI
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Adams-Oliver syndrome  (ISO)
Adams-Oliver Syndrome 5  (ISO)
adenoid cystic carcinoma  (ISO)
adenoiditis  (ISO)
adult T-cell leukemia  (ISO)
amyotrophic lateral sclerosis  (ISO)
aortic valve disease  (ISO)
aortic valve disease 1  (ISO)
Aortic Valve, Calcification of  (ISO)
ARTERIAL DISSECTION  (ISO)
autosomal dominant non-syndromic intellectual disability 8  (ISO)
bicuspid aortic valve disease  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
Colonic Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hypoplastic left heart syndrome  (ISO)
Kleefstra syndrome 1  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
microphthalmia  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Peritoneal Diseases  (ISO)
prion disease  (ISO)
scoliosis  (ISO)
SHONE COMPLEX  (ISO)
Skin Neoplasms  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
syndromic microphthalmia 5  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell lymphoblastic leukemia/lymphoma  (ISO)
tetralogy of Fallot  (ISO)
thoracic aortic aneurysm  (ISO)
Uterine Cervical Neoplasms  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
aortic valve morphogenesis  (ISO)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
astrocyte differentiation  (ISO)
atrioventricular node development  (ISO)
atrioventricular valve morphogenesis  (ISO)
auditory receptor cell fate commitment  (ISO)
axonogenesis  (ISO)
brain development  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium morphogenesis  (ISO)
cardiac chamber formation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle tissue morphogenesis  (ISO)
cardiac right atrium morphogenesis  (ISO)
cardiac right ventricle formation  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell differentiation  (ISO)
cell differentiation in spinal cord  (ISO)
cell fate commitment  (ISO)
cell fate specification  (ISO)
cell migration involved in endocardial cushion formation  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
collecting duct development  (ISO)
compartment pattern specification  (ISO)
coronary artery morphogenesis  (ISO)
coronary sinus valve morphogenesis  (ISO)
coronary vein morphogenesis  (ISO)
determination of left/right symmetry  (ISO)
distal tubule development  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
endocardial cell differentiation  (ISO)
endocardial cushion development  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardium development  (ISO)
endocardium morphogenesis  (ISO)
endoderm development  (ISO)
epidermis development  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
forebrain development  (ISO)
foregut morphogenesis  (ISO)
glial cell differentiation  (ISO)
glomerular mesangial cell development  (ISO)
growth involved in heart morphogenesis  (ISO)
hair follicle morphogenesis  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart trabecula morphogenesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
keratinocyte differentiation  (ISO)
left/right axis specification  (ISO)
liver development  (ISO)
lung development  (ISO)
mesenchymal cell development  (ISO)
mitral valve formation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of catalytic activity  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of extracellular matrix constituent secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of growth rate  (ISO)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of ossification  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of photoreceptor cell differentiation  (ISO)
negative regulation of pro-B cell differentiation  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neural tube development  (ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuronal stem cell population maintenance  (ISO)
Notch signaling involved in heart development  (ISO)
Notch signaling pathway  (ISO)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation  (ISO)
oligodendrocyte differentiation  (ISO)
outflow tract morphogenesis  (ISO)
pericardium morphogenesis  (ISO)
positive regulation of aorta morphogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic process involved in morphogenesis  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
positive regulation of transcription of Notch receptor target  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of viral genome replication  (ISO)
positive regulation of viral transcription  (ISO)
prostate gland epithelium morphogenesis  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of cardioblast proliferation  (ISO)
regulation of cell cycle  (ISO)
regulation of cell migration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of neurogenesis  (ISO)
regulation of Notch signaling pathway  (ISO)
regulation of somitogenesis  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  (ISO)
response to corticosteroid  (ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (ISO)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  (ISO)
skeletal muscle cell differentiation  (ISO)
somatic stem cell division  (ISO)
spermatogenesis  (ISO)
sprouting angiogenesis  (ISO)
tissue regeneration  (ISO)
tube formation  (ISO)
vasculogenesis involved in coronary vascular morphogenesis  (ISO)
venous blood vessel morphogenesis  (ISO)
venous endothelial cell differentiation  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Notch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBI
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9136,494,433 - 136,546,048 (-)EnsemblGRCh38hg38GRCh38
GRCh389136,494,433 - 136,546,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,388,885 - 139,440,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,508,717 - 138,560,059 (-)NCBINCBI36hg18NCBI36
Build 349136,664,733 - 136,716,075NCBI
Celera9109,903,340 - 109,955,631 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9108,848,155 - 108,928,442 (-)NCBIHuRef
CHM1_19139,537,619 - 139,588,846 (-)NCBICHM1_1
Notch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBImm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
Notch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.239,277,955 - 9,323,531 (-)NCBI
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Celera34,097,915 - 4,143,369 (-)NCBICelera
Cytogenetic Map3p13NCBI
Notch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBIChiLan1.0ChiLan1.0
NOTCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,544,639 - 136,595,511 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,544,639 - 136,598,740 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09107,568,670 - 107,621,032 (-)NCBIMhudiblu_PPA_v0panPan3
NOTCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,975,972 - 49,018,985 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,974,757 - 49,017,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,226,361 - 48,269,900 (+)NCBI
ROS_Cfam_1.0949,852,205 - 49,895,734 (+)NCBI
UMICH_Zoey_3.1948,633,237 - 48,676,758 (+)NCBI
UNSW_CanFamBas_1.0948,926,759 - 48,970,231 (+)NCBI
UU_Cfam_GSD_1.0948,974,423 - 49,017,941 (+)NCBI
NOTCH1
(Sus scrofa - pig)
No map positions available.
NOTCH1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,656,815 - 1,707,566 (+)NCBI
ChlSab1.1 Ensembl121,656,918 - 1,709,585 (+)Ensembl
Notch1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247601,636,331 - 1,676,398 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021734278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_021734278   ⟹   XP_021589953
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBI
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021589953 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_021589953   ⟸   XM_021734278
- Sequence:
Protein Domains
ANK_REP_REGION   EGF-like   LNR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005889 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000005319 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005945 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DUF3454_notch UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/TrEMBL
  Notch_1 UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
NCBI Gene Notch1 ENTREZGENE
Pfam Ank_2 UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PIRSF Notch UniProtKB/TrEMBL
PRINTS LNOTCHREPEAT UniProtKB/TrEMBL
  NOTCH1 UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF90193 UniProtKB/TrEMBL
UniProt I3M6Z8_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 Notch1  notch receptor 1    notch 1  Symbol and/or name change 5135510 APPROVED