Notch1 (notch 1) - Rat Genome Database

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Gene: Notch1 (notch 1) Mus musculus
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Symbol: Notch1
Name: notch 1
RGD ID: 10998
MGI Page MGI
Description: Enables several functions, including Notch binding activity; transcription coactivator activity; and transcription regulator activator activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and regulation of BMP signaling pathway. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and regulation of epithelial cell differentiation. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9930111A19Rik; lin; lin-12; major type A protein; Mi; Mis6; Motch A; mT14; N; N1; neurogenic locus notch homolog protein 1; Notch gene homolog 1; p300; Ta; Tan1; transmembrane receptor Notch1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)EnsemblGRCm39 Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBIMGSCv36mm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Adams-Oliver syndrome  (ISO)
Adams-Oliver Syndrome 2  (ISO)
Adams-Oliver Syndrome 5  (ISO)
adenoid cystic carcinoma  (ISO)
adenoiditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
amyotrophic lateral sclerosis  (IEP)
aortic valve disease  (ISO)
aortic valve disease 1  (ISO)
ARTERIAL DISSECTION  (ISO)
atherosclerosis  (IEP)
autism spectrum disorder  (ISO)
autosomal dominant intellectual developmental disorder 8  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy 5  (ISO)
bicuspid aortic valve disease  (ISO)
Breast Neoplasms  (ISO)
Calcification of Aortic Valve  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Colonic Neoplasms  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
diabetic retinopathy  (IMP)
Ehlers-Danlos syndrome classic type 1  (ISO)
Ehlers-Danlos syndrome hypermobility type  (ISO)
endometrial cancer  (ISO)
epilepsy  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Liver Neoplasms  (ISO)
Focal Nodular Hyperplasia  (ISO)
Folate-Responsive Megaloblastic Anemia  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hemangioma  (ISO)
hemangiopericytoma  (ISO)
hypoplastic left heart syndrome  (ISO)
Joubert syndrome 1  (ISO)
keratoacanthoma  (ISO)
Kleefstra syndrome 1  (ISO)
Leigh disease  (ISO)
lung adenocarcinoma  (ISO)
lung large cell carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
microphthalmia  (ISO)
myeloproliferative neoplasm  (ISO)
Myocardial Ischemia  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
oral squamous cell carcinoma  (IEP)
pancreatic cancer  (IMP)
pancreatic ductal carcinoma  (IMP,ISO)
Peritoneal Diseases  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prion disease  (IEP)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA)
Rafiq syndrome  (ISO)
retinopathy of prematurity  (ISO)
scoliosis  (ISO)
SHONE COMPLEX  (ISO)
Skin Neoplasms  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
Surgical Wound  (IMP)
syndromic microphthalmia 5  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (ISO)
tuberous sclerosis 1  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Malformations  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Botulinum toxin type A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
captan  (EXP)
carbon nanotube  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
chrysene  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
Cyclopamine  (ISO)
DAPT  (EXP,ISO)
DDT  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP,ISO)
fenamidone  (EXP)
fenofibrate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (EXP)
gemcitabine  (ISO)
gentamycin  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (EXP,ISO)
mebendazole  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
miconazole  (EXP)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinic acid  (ISO)
nocodazole  (ISO)
ochratoxin A  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
phenethyl isothiocyanate  (ISO)
picropodophyllotoxin  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(ethylene)  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propiconazole  (EXP)
propranolol  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
rotenone  (ISO)
Salidroside  (EXP)
SB 203580  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP)
zalcitabine  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ regeneration  (ISO)
aortic valve morphogenesis  (IGI,IMP,ISO)
apoptotic process  (IDA)
apoptotic process involved in embryonic digit morphogenesis  (IMP)
arterial endothelial cell differentiation  (IMP)
astrocyte differentiation  (ISO)
atrioventricular node development  (IMP)
atrioventricular valve morphogenesis  (IMP)
auditory receptor cell fate commitment  (IMP)
axon guidance  (IBA)
axonogenesis  (IDA,IMP)
branching morphogenesis of an epithelial tube  (IMP)
calcium-ion regulated exocytosis  (IMP)
cardiac atrium morphogenesis  (IMP)
cardiac chamber formation  (IMP)
cardiac epithelial to mesenchymal transition  (IMP)
cardiac left ventricle morphogenesis  (IMP)
cardiac muscle cell myoblast differentiation  (IMP)
cardiac muscle cell proliferation  (IMP)
cardiac muscle tissue morphogenesis  (IMP)
cardiac right atrium morphogenesis  (IMP)
cardiac right ventricle formation  (IMP)
cardiac septum morphogenesis  (IMP)
cardiac vascular smooth muscle cell development  (IMP)
cardiac ventricle morphogenesis  (IMP)
cell differentiation  (IMP)
cell differentiation in spinal cord  (ISO)
cell migration involved in endocardial cushion formation  (IMP)
cell population proliferation  (IGI)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to hypoxia  (IDA)
cellular response to tumor cell  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
chemical synaptic transmission, postsynaptic  (IDA,IMP)
collecting duct development  (IEP)
compartment pattern specification  (IMP)
coronary artery morphogenesis  (IMP)
coronary sinus valve morphogenesis  (IMP)
coronary vein morphogenesis  (IMP)
determination of left/right symmetry  (IMP)
distal tubule development  (IEP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IGI)
endocardial cell differentiation  (IMP)
endocardial cushion development  (IMP)
endocardial cushion morphogenesis  (IGI,IMP)
endocardium development  (IMP)
endocardium morphogenesis  (IEP,IMP)
endoderm development  (IMP)
epidermal cell fate specification  (IMP)
epidermis development  (IGI)
epithelial cell fate commitment  (IMP)
epithelial cell proliferation  (IGI,IMP)
epithelial to mesenchymal transition  (IMP,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
forebrain development  (IGI,IMP)
foregut morphogenesis  (IMP)
gene expression  (IDA)
glial cell differentiation  (IMP)
glomerular mesangial cell development  (IEP)
growth involved in heart morphogenesis  (IMP)
hair follicle morphogenesis  (IMP)
heart development  (ISO)
heart looping  (IGI)
heart trabecula morphogenesis  (IMP)
homeostasis of number of cells within a tissue  (IGI)
humoral immune response  (IGI)
in utero embryonic development  (IMP)
inflammatory response to antigenic stimulus  (IGI)
inhibition of neuroepithelial cell differentiation  (IMP)
interleukin-17-mediated signaling pathway  (IDA)
keratinocyte differentiation  (IGI,IMP)
left/right axis specification  (IGI)
liver development  (IMP)
lung development  (IMP)
luteolysis  (ISO)
mesenchymal cell development  (IMP)
mitral valve formation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of biomineral tissue development  (IDA,IMP)
negative regulation of BMP signaling pathway  (IMP)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of canonical Wnt signaling pathway  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy  (IMP)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (IDA,IMP)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (IDA,IMP)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of extracellular matrix constituent secretion  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (IDA)
negative regulation of inner ear auditory receptor cell differentiation  (IMP)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myotube differentiation  (IMP)
negative regulation of neurogenesis  (IMP)
negative regulation of neuron differentiation  (IGI,IMP,ISO)
negative regulation of oligodendrocyte differentiation  (IDA)
negative regulation of ossification  (IMP)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of photoreceptor cell differentiation  (IMP)
negative regulation of pro-B cell differentiation  (IMP)
negative regulation of programmed cell death  (IMP)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
neural tube development  (IMP)
neuroendocrine cell differentiation  (IMP)
neuron differentiation  (IGI,IMP)
neuron fate commitment  (IGI)
neuronal stem cell population maintenance  (ISO)
Notch signaling pathway  (IBA,IC,IDA,IGI,IMP,ISO)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation  (IMP)
oligodendrocyte differentiation  (IMP,ISO)
osteoblast fate commitment  (NAS)
outflow tract morphogenesis  (ISO)
pericardium morphogenesis  (IMP)
positive regulation of aorta morphogenesis  (IMP)
positive regulation of apoptotic process  (IDA,IGI)
positive regulation of apoptotic process involved in morphogenesis  (IDA)
positive regulation of astrocyte differentiation  (IDA)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of ephrin receptor signaling pathway  (IC)
positive regulation of epithelial cell proliferation  (IGI)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IGI,ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of keratinocyte differentiation  (IDA,IGI)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of Notch signaling pathway  (IDA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription of Notch receptor target  (IGI,ISO)
positive regulation of viral genome replication  (IMP)
positive regulation of viral transcription  (IMP)
prostate gland epithelium morphogenesis  (IMP)
protein catabolic process  (IDA)
protein import into nucleus  (IDA)
pulmonary valve morphogenesis  (IGI,IMP,ISO)
regulation of cardioblast proliferation  (ISO)
regulation of cell adhesion involved in heart morphogenesis  (IMP)
regulation of cell migration  (IMP)
regulation of cell population proliferation  (ISO)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IGI,IMP)
regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
regulation of extracellular matrix assembly  (IMP)
regulation of gene expression  (IMP)
regulation of inner ear auditory receptor cell differentiation  (IMP)
regulation of neurogenesis  (IMP)
regulation of Notch signaling pathway  (IGI)
regulation of somitogenesis  (IMP)
regulation of stem cell proliferation  (IMP)
regulation of transcription by RNA polymerase II  (IGI,IMP)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (IDA)
retinal cone cell differentiation  (IMP)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  (IMP)
skeletal muscle cell differentiation  (IMP)
somatic stem cell division  (IDA,IGI)
spermatogenesis  (ISO)
sprouting angiogenesis  (IMP)
T-helper 17 type immune response  (IDA)
tissue regeneration  (ISO)
transcription by RNA polymerase II  (IDA,IGI)
tube formation  (ISO)
vasculogenesis involved in coronary vascular morphogenesis  (IMP)
venous blood vessel morphogenesis  (IMP)
venous endothelial cell differentiation  (IMP)
ventricular septum morphogenesis  (IGI,IMP,ISO)
ventricular trabecula myocardium morphogenesis  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell morphology  (IAGP)
abnormal branching involved in pancreas development  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cell death  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocrine pancreas morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal left-right axis symmetry of the somites  (IAGP)
abnormal liver lobule morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic bud formation  (IAGP)
abnormal pericyte morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal somite development  (IAGP)
abnormal somite size  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell receptor beta chain V(D)J recombination  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular plexus formation  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vein morphology  (IAGP)
abnormal venule morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent coronary vessels  (IAGP)
absent hair follicle inner root sheath  (IAGP)
absent sebaceous gland  (IAGP)
absent vitelline blood vessels  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
aortic valve inflammation  (IAGP)
arrested T cell differentiation  (IAGP)
arteriovenous malformation  (IAGP)
bicuspid aortic valve  (IAGP)
calcified aortic valve cusp  (IAGP)
chronic liver inflammation  (IAGP)
corneal deposits  (IAGP)
corneal vascularization  (IAGP)
decreased angiogenesis  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased conjunctiva goblet cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased organ of Corti supporting cell number  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
delayed heart looping  (IAGP)
delayed somite formation  (IAGP)
dilated liver sinusoidal space  (IAGP)
diluted coat color  (IAGP)
disorganized inner root sheath cells  (IAGP)
disorganized myocardium  (IAGP)
distended pericardium  (IAGP)
dry eyes  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
hair follicle degeneration  (IAGP)
hemopericardium  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
impaired basement membrane formation  (IAGP)
incomplete embryo turning  (IAGP)
incomplete somite formation  (IAGP)
increased angiogenesis  (IAGP)
increased apoptosis  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased grip strength  (IEA)
increased hemangioma incidence  (IAGP)
increased hematopoietic cell number  (IAGP)
increased immature B cell number  (IAGP)
increased leukemia incidence  (IAGP)
increased neuron number  (IAGP)
increased single-positive T cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased startle reflex  (IEA)
increased T cell apoptosis  (IAGP)
internal hemorrhage  (IAGP)
kinked neural tube  (IAGP)
lacrimal gland degeneration  (IAGP)
Meibomian gland degeneration  (IAGP)
myocardium hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neural tube degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
notochord degeneration  (IAGP)
open neural tube  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
progressive hair loss  (IAGP)
renal hypoplasia  (IAGP)
scaly skin  (IAGP)
short hair  (IAGP)
small pancreas  (IAGP)
small pharyngeal arch  (IAGP)
small sebaceous gland  (IAGP)
small thymus  (IAGP)
thick aortic valve cusps  (IAGP)
thick epidermis  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thymus hypoplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
waved hair  (IAGP)
References

References - curated
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19. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
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23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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25. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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33. Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway. Sun W, etal., Med Sci Monit. 2019 Jan 17;25:492-499. doi: 10.12659/MSM.913828.
34. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
35. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. Sweeney C, etal., FASEB J. 2004 Sep;18(12):1421-3. Epub 2004 Jul 9.
36. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
37. Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Tryndyak VP, etal., Mol Carcinog. 2009 Jun;48(6):479-87.
38. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
39. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
40. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
41. A homolog of Drosophila Notch expressed during mammalian development. Weinmaster G, etal., Development 1991 Sep;113(1):199-205.
42. The expression levels of Notch-related signaling molecules in pulmonary microvascular endothelial cells in bleomycin-induced rat pulmonary fibrosis. Yin Q, etal., Physiol Res. 2017 May 4;66(2):305-315. doi: 10.33549/physiolres.933356. Epub 2016 Dec 16.
43. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
44. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
45. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
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47. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Zhu YM, etal., Clin Cancer Res. 2006 May 15;12(10):3043-9.
Additional References at PubMed
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PMID:32756905   PMID:32820046   PMID:32871474   PMID:32924017   PMID:32929274   PMID:32991757   PMID:33012268   PMID:33017398   PMID:33046701   PMID:33046710   PMID:33053343   PMID:33109684  
PMID:33148887   PMID:33189893   PMID:33195274   PMID:33210601   PMID:33227706   PMID:33237915   PMID:33284968   PMID:33303684   PMID:33309869   PMID:33314197   PMID:33315499   PMID:33332551  
PMID:33371813   PMID:33435713   PMID:33590845   PMID:33608670   PMID:33622250   PMID:33637728   PMID:33655333   PMID:33657078   PMID:33673337   PMID:33675998   PMID:33730615   PMID:33830085  
PMID:33846290   PMID:33892704   PMID:33898448   PMID:33956260   PMID:34004439   PMID:34099102   PMID:34107249   PMID:34257546   PMID:34278466   PMID:34320265   PMID:34389314   PMID:34408185  
PMID:34463756   PMID:34475389   PMID:34487959   PMID:34504875   PMID:34519339   PMID:34519870   PMID:34571841   PMID:34665379   PMID:34671097   PMID:34686881   PMID:34698766   PMID:34726809  
PMID:34737300   PMID:34757798   PMID:34824237   PMID:34838591   PMID:34854382   PMID:34921404   PMID:34998785   PMID:35013223   PMID:35020836   PMID:35064244   PMID:35084365   PMID:35103284  
PMID:35126469   PMID:35211114   PMID:35247391   PMID:35263603   PMID:35273151   PMID:35297995   PMID:35303432   PMID:35349492   PMID:35429490   PMID:35508126   PMID:35521669   PMID:35575074  
PMID:35617425   PMID:35623385   PMID:35652338   PMID:35682851   PMID:35803280   PMID:35815610   PMID:35821235   PMID:35831318   PMID:35832093   PMID:35906071   PMID:35942101   PMID:36006534  
PMID:36064547   PMID:36082581   PMID:36183290   PMID:36218069   PMID:36239412   PMID:36253375   PMID:36273888   PMID:36316479   PMID:36325906   PMID:36376768   PMID:36414704   PMID:36418183  
PMID:36456828   PMID:36580262   PMID:36657722   PMID:36658434   PMID:36672468   PMID:36797416   PMID:36834623   PMID:36840628   PMID:36899896   PMID:36973704   PMID:37023750   PMID:37068229  
PMID:37168577   PMID:37249327   PMID:37260223   PMID:37272771   PMID:37317851   PMID:37329502   PMID:37330998   PMID:37369584   PMID:37385754   PMID:37414855   PMID:37494420   PMID:37573008  
PMID:37632963   PMID:37669937   PMID:37702066   PMID:37723064   PMID:37818607   PMID:37921375   PMID:38095642   PMID:38111957   PMID:38149979   PMID:38284891   PMID:38289520   PMID:38345319  
PMID:38374152   PMID:38512983   PMID:38538986  


Genomics

Comparative Map Data
Notch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,347,915 - 26,406,675 (-)EnsemblGRCm39 Ensembl
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBIMGSCv36mm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
NOTCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,494,433 - 136,546,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,494,433 - 136,546,048 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,388,885 - 139,440,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,508,717 - 138,560,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,664,733 - 136,716,075NCBI
Celera9109,903,340 - 109,955,631 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,848,155 - 108,928,442 (-)NCBIHuRef
CHM1_19139,537,630 - 139,588,846 (-)NCBICHM1_1
T2T-CHM13v2.09148,723,532 - 148,777,907 (-)NCBIT2T-CHM13v2.0
Notch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,676,040 - 29,721,613 (-)NCBIGRCr8
mRatBN7.239,277,955 - 9,323,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,278,086 - 9,323,531 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,332,077 - 12,388,087 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,915,306 - 20,971,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,170,646 - 19,226,660 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,905,562 - 3,951,015 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,905,453 - 3,951,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,266,663 - 9,311,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,631,797 - 4,677,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,632,997 - 4,677,652 (-)NCBI
Celera34,097,915 - 4,143,369 (-)NCBICelera
Cytogenetic Map3p13NCBI
Notch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,225,956 - 4,263,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,225,939 - 4,264,875 (+)NCBIChiLan1.0ChiLan1.0
NOTCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,838,339 - 2,890,794 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,840,674 - 2,893,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,568,670 - 107,621,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,544,639 - 136,595,511 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,544,639 - 136,598,740 (-)Ensemblpanpan1.1panPan2
NOTCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,975,972 - 49,018,985 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,974,757 - 49,017,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,226,361 - 48,269,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,852,205 - 49,895,734 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,851,628 - 49,894,186 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,633,237 - 48,676,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,926,759 - 48,970,231 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,974,423 - 49,017,941 (+)NCBIUU_Cfam_GSD_1.0
Notch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,040,997 - 202,083,042 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,292,088 - 1,332,428 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,292,016 - 1,334,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH1
(Sus scrofa - pig)		 No map positions available.
NOTCH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,656,815 - 1,707,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,656,918 - 1,709,585 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,509,673 - 3,610,304 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,634,702 - 1,676,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,636,331 - 1,676,398 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Notch1
1115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2400
Count of miRNA genes:746
Interacting mature miRNAs:950
Transcripts:ENSMUST00000028288, ENSMUST00000123873, ENSMUST00000126872, ENSMUST00000129506, ENSMUST00000131393, ENSMUST00000132820, ENSMUST00000132941, ENSMUST00000138034, ENSMUST00000140082, ENSMUST00000147481, ENSMUST00000148948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse

Markers in Region
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,458,252 - 26,459,242UniSTSGRCm38
MGSCv37226,313,772 - 26,314,762UniSTSGRCm37
Celera226,176,086 - 26,177,076UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
cM Map215.0UniSTS
D2Mit151  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,494,434 - 26,494,563UniSTSGRCm38
MGSCv37226,349,954 - 26,350,083UniSTSGRCm37
Celera226,212,369 - 26,212,502UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Whitehead Genetic220.8UniSTS
Whitehead/MRC_RH2453.92UniSTS
RH134624  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,459,467 - 26,459,646UniSTSGRCm38
MGSCv37226,314,987 - 26,315,166UniSTSGRCm37
Celera226,177,301 - 26,177,480UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
PMC85812P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,465,065 - 26,465,433UniSTSGRCm38
MGSCv37226,320,585 - 26,320,953UniSTSGRCm37
Celera226,182,899 - 26,183,267UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,468,368 - 26,469,911UniSTSGRCm38
MGSCv37226,323,888 - 26,325,431UniSTSGRCm37
Celera226,186,202 - 26,187,745UniSTS
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,460,921 - 26,462,218UniSTSGRCm38
MGSCv37226,316,441 - 26,317,738UniSTSGRCm37
Celera226,178,755 - 26,180,052UniSTS
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,463,929 - 26,464,896UniSTSGRCm38
MGSCv37226,319,449 - 26,320,416UniSTSGRCm37
Celera226,181,763 - 26,182,730UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,459,283 - 26,459,488UniSTSGRCm38
MGSCv37226,314,803 - 26,315,008UniSTSGRCm37
Celera226,177,117 - 26,177,322UniSTS
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,460,744 - 26,460,935UniSTSGRCm38
MGSCv37226,316,264 - 26,316,455UniSTSGRCm37
Celera226,178,578 - 26,178,769UniSTS
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map215.0UniSTS
Notch1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38226,459,604 - 26,459,850UniSTSGRCm38
MGSCv37226,315,124 - 26,315,370UniSTSGRCm37
Celera226,177,438 - 26,177,684UniSTS
Cytogenetic Map2A3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB100603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB100875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB100878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB100879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB101637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB104459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF508809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF318436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY233933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS419139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L02613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z21925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028288   ⟹   ENSMUSP00000028288
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,347,915 - 26,393,834 (-)Ensembl
GRCm38.p6 Ensembl226,457,903 - 26,503,822 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,358,555 - 26,359,761 (-)Ensembl
GRCm38.p6 Ensembl226,468,543 - 26,469,749 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,666 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,654 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,359,837 - 26,360,510 (-)Ensembl
GRCm38.p6 Ensembl226,469,825 - 26,470,498 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131393
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,388,167 - 26,393,836 (-)Ensembl
GRCm38.p6 Ensembl226,498,155 - 26,503,824 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132820   ⟹   ENSMUSP00000115258
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,361,288 - 26,406,675 (-)Ensembl
GRCm38.p6 Ensembl226,471,276 - 26,516,663 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132941
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,352,230 - 26,352,759 (-)Ensembl
GRCm38.p6 Ensembl226,462,218 - 26,462,747 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,379 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,367 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,806 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,794 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147481
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,357,625 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,467,613 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148948
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,355,483 - 26,356,175 (-)Ensembl
GRCm38.p6 Ensembl226,465,471 - 26,466,163 (-)Ensembl
RefSeq Acc Id: NM_008714   ⟹   NP_032740
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,347,914 - 26,393,834 (-)NCBI
GRCm38226,457,902 - 26,503,822 (-)ENTREZGENE
MGSCv37226,313,422 - 26,359,342 (-)RGD
Celera226,175,736 - 26,221,759 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032740   ⟸   NM_008714
- Peptide Label: precursor
- UniProtKB: Q9QW58 (UniProtKB/Swiss-Prot),   Q99JC2 (UniProtKB/Swiss-Prot),   Q8K428 (UniProtKB/Swiss-Prot),   Q7TQ52 (UniProtKB/Swiss-Prot),   Q7TQ51 (UniProtKB/Swiss-Prot),   Q7TQ50 (UniProtKB/Swiss-Prot),   Q61905 (UniProtKB/Swiss-Prot),   Q3U3Y2 (UniProtKB/Swiss-Prot),   Q3TZW2 (UniProtKB/Swiss-Prot),   Q06007 (UniProtKB/Swiss-Prot),   Q9R0X7 (UniProtKB/Swiss-Prot),   Q01705 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000115258   ⟸   ENSMUST00000132820
RefSeq Acc Id: ENSMUSP00000028288   ⟸   ENSMUST00000028288
Protein Domains
EGF-like   Notch C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01705-F1-model_v2 AlphaFold Q01705 1-2531 view protein structure

Promoters
RGD ID:6831933
Promoter ID:MM_KWN:28281
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000030666
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,317,831 - 26,319,262 (-)MPROMDB
RGD ID:6831930
Promoter ID:MM_KWN:28282
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:OTTMUST00000030662,   OTTMUST00000030663,   UC008IVM.1,   UC008IVN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,322,176 - 26,323,252 (-)MPROMDB
RGD ID:6831931
Promoter ID:MM_KWN:28283
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:OTTMUST00000030659
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,323,336 - 26,324,082 (-)MPROMDB
RGD ID:6831934
Promoter ID:MM_KWN:28284
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:OTTMUST00000030665
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,325,026 - 26,326,142 (-)MPROMDB
RGD ID:6831936
Promoter ID:MM_KWN:28285
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   Spleen
Transcripts:UC008IVO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,325,976 - 26,326,627 (-)MPROMDB
RGD ID:6848752
Promoter ID:MM_TRO:5353
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:MTR000375.2.524.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,333,361 - 26,333,861 (-)MPROMDB
RGD ID:6849116
Promoter ID:MM_XEF:3895
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung
Transcripts:NM_001087605,   NM_001097288,   NM_001135695
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,357,401 - 26,357,977 (-)MPROMDB
RGD ID:6831929
Promoter ID:MM_KWN:28286
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000102908,   NM_008714,   OTTMUST00000030664
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,359,226 - 26,360,242 (-)MPROMDB
RGD ID:6876704
Promoter ID:EPDNEW_M1803
Type:multiple initiation site
Name:Notch1_1
Description:Mus musculus notch 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38226,503,824 - 26,503,884EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97363 AgrOrtholog
Ensembl Genes ENSMUSG00000026923 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028288 ENTREZGENE
  ENSMUST00000028288.5 UniProtKB/Swiss-Prot
  ENSMUST00000132820.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.300.320 UniProtKB/Swiss-Prot
  3.30.70.3310 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  DUF3454_notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Notch UniProtKB/Swiss-Prot
  Notch-like_dom_sf UniProtKB/Swiss-Prot
  Notch_1 UniProtKB/Swiss-Prot
  Notch_dom UniProtKB/Swiss-Prot
  Notch_NOD_dom UniProtKB/Swiss-Prot
  Notch_NODP_dom UniProtKB/Swiss-Prot
KEGG Report mmu:18128 UniProtKB/Swiss-Prot
MGD MGI:97363 ENTREZGENE
NCBI Gene 18128 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/Swiss-Prot
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot
  NODP UniProtKB/Swiss-Prot
  Notch UniProtKB/Swiss-Prot
PhenoGen Notch1 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot
PRINTS LNOTCHREPEAT UniProtKB/Swiss-Prot
  NOTCH UniProtKB/Swiss-Prot
  NOTCH1 UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LNR UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  DUF3454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot
  NODP UniProtKB/Swiss-Prot
  SM00004 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF90193 UniProtKB/Swiss-Prot
UniProt A2AIX5_MOUSE UniProtKB/TrEMBL
  NOTC1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q06007 ENTREZGENE
  Q3TZW2 ENTREZGENE
  Q3U3Y2 ENTREZGENE
  Q61905 ENTREZGENE
  Q7TQ50 ENTREZGENE
  Q7TQ51 ENTREZGENE
  Q7TQ52 ENTREZGENE
  Q8BY39_MOUSE UniProtKB/TrEMBL
  Q8K428 ENTREZGENE
  Q99JC2 ENTREZGENE
  Q9QW58 ENTREZGENE
  Q9R0X7 ENTREZGENE
UniProt Secondary Q06007 UniProtKB/Swiss-Prot
  Q3TZW2 UniProtKB/Swiss-Prot
  Q3U3Y2 UniProtKB/Swiss-Prot
  Q61905 UniProtKB/Swiss-Prot
  Q7TQ50 UniProtKB/Swiss-Prot
  Q7TQ51 UniProtKB/Swiss-Prot
  Q7TQ52 UniProtKB/Swiss-Prot
  Q8K428 UniProtKB/Swiss-Prot
  Q99JC2 UniProtKB/Swiss-Prot
  Q9QW58 UniProtKB/Swiss-Prot
  Q9R0X7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-05 Notch1  notch 1  Notch1  Notch gene homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED