RGD Reference Report - A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. - Rat Genome Database

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A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

Authors: Johnston, SH  Rauskolb, C  Wilson, R  Prabhakaran, B  Irvine, KD  Vogt, TF 
Citation: Johnston SH, etal., Development 1997 Jun;124(11):2245-54.
RGD ID: 1302739
Pubmed: PMID:9187150   (View Abstract at PubMed)

The formation of boundaries between groups of cells is a universal feature of metazoan development. Drosophila fringe modulates the activation of the Notch signal transduction pathway at the dorsal-ventral boundary of the wing imaginal disc. Three mammalian fringe-related family members have been cloned and characterized: Manic, Radical and Lunatic Fringe. Expression studies in mouse embryos support a conserved role for mammalian Fringe family members in participation in the Notch signaling pathway leading to boundary determination during segmentation. In mammalian cells, Drosophila fringe and the mouse Fringe proteins are subject to posttranslational regulation at the levels of differential secretion and proteolytic processing. When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Notch signaling pathway   ISS 1302739 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Mfng  (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

Objects referenced in this article
Gene LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Homo sapiens
Gene MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Homo sapiens
Gene RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Homo sapiens
Gene Dll1 delta like canonical Notch ligand 1 Mus musculus
Gene Epha4 Eph receptor A4 Mus musculus
Gene Jag1 jagged 1 Mus musculus
Gene Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Mus musculus
Gene Meox1 mesenchyme homeobox 1 Mus musculus
Gene Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Mus musculus
Gene Notch1 notch 1 Mus musculus
Gene Notch2 notch 2 Mus musculus
Gene Notch3 notch 3 Mus musculus
Gene Notch4 notch 4 Mus musculus

Additional Information