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GENE - TERM ANNOTATION REPORT

RGD ID: 10998
Species: Mus musculus
RGD Object: Gene
Symbol: Notch1
Name: notch 1
Acc ID: DOID:9001820
Term: Pulmonary Arterial Hypertension
Definition: A progressive rare pulmonary disease characterized by high blood pressure in the PULMONARY ARTERY.
Definition Source(s): MESH:D000081029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1 ISONOTCH1 (Homo sapiens)155646132RGDprotein:decreased expression:endothelial cell, nucleus: 
Notch1 ISONOTCH1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Pulmonary arterial hypertensionPMID:15472075 PMID:16614245 PMID:18593716 PMID:19245433 PMID:19635999 PMID:20951801 PMID:20981092 PMID:21670202 PMID:22077063 PMID:22210878 PMID:22858860 PMID:23086750 PMID:23734977 PMID:24728327 PMID:24943832 PMID:25741868 PMID:26837699 PMID:28387797 PMID:28492532 PMID:29641532 PMID:30059548 PMID:30582441 PMID:35288444
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