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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10998
Species: Mus musculus
RGD Object: Gene
Symbol: Notch1
Name: notch 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1affects expressionISONOTCH1 (Homo sapiens)6480464CTDresveratrol affects the expression of NOTCH1 mRNA; resveratrol affects the expression of NOTCH1 proteinPMID:25896424
Notch1decreases expressionISONOTCH1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of NOTCH1 mRNA; resveratrol results in decreased expression of NOTCH1 proteinPMID:17868649 PMID:25061499
Notch1increases activityISONOTCH1 (Homo sapiens)6480464CTDresveratrol results in increased activity of NOTCH1PMID:21743969
Notch1increases expressionISONOTCH1 (Homo sapiens)6480464CTDresveratrol results in increased expression of NOTCH1 mRNA; resveratrol results in increased expression of NOTCH1 proteinPMID:23594881
Notch1multiple interactionsISONOTCH1 (Homo sapiens)6480464CTDMRK 003 inhibits the reaction [resveratrol results in increased activity of NOTCH1]; NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of NKX2-1 mRNA]; NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of PAX8 mRNA]; NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of SLC5A5 mRNA]PMID:21743969 PMID:23594881
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