GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Notch1 | decreases expression | ISO | Notch1 (Rattus norvegicus) | 6480464 | CTD | Valproic Acid results in decreased expression of NOTCH1 mRNA | PMID:34779009 | Notch1 | decreases expression | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in decreased expression of NOTCH1 mRNA | PMID:23179753 PMID:23527032 | Notch1 | increases expression | ISO | Notch1 (Rattus norvegicus) | 6480464 | CTD | Valproic Acid results in increased expression of NOTCH1 mRNA | PMID:29968957 | Notch1 | increases methylation | ISO | NOTCH1 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased methylation of NOTCH1 gene | PMID:29154799 | Notch1 | multiple interactions | ISO | Notch1 (Rattus norvegicus) | 6480464 | CTD | caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA] | PMID:29968957 | |
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