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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10998
Species: Mus musculus
RGD Object: Gene
Symbol: Notch1
Name: notch 1
Acc ID: CHEBI:75404
Term: tyrphostin AG 1478
Definition: A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Chemical ID: MESH:C101044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1increases expressionISONOTCH1 (Homo sapiens)6480464CTDRTKI cpd results in increased expression of NOTCH1 protein modified formPMID:18633435
Notch1multiple interactionsISONOTCH1 (Homo sapiens)6480464CTDRTKI cpd inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]PMID:18633435 PMID:25118938
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