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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3187
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch1
Name: notch receptor 1
Acc ID: CHEBI:4021
Term: Cyclopamine
Definition: A piperidine that has formula C27H41NO2.
Chemical ID: MESH:C000541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1decreases cleavageISONOTCH1 (Homo sapiens)6480464CTDcyclopamine results in decreased cleavage of NOTCH1 proteinPMID:21498710
Notch1multiple interactionsISONOTCH1 (Homo sapiens)6480464CTD[2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with cyclopamine] results in decreased expression of and results in decreased cleavage of NOTCH1 protein; [cyclopamine co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein; cyclopamine results in decreased expression of and results in decreased cleavage of NOTCH1 proteinPMID:21498710
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