Ncoa2 (nuclear receptor coactivator 2) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ncoa2 (nuclear receptor coactivator 2) Rattus norvegicus
Analyze
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
RGD ID: 620108
Description: Exhibits DNA polymerase binding activity; PDZ domain binding activity; and nuclear hormone receptor binding activity. Involved in several processes, including male gonad development; positive regulation of female receptivity; and positive regulation of glucocorticoid receptor signaling pathway. Localizes to several cellular components, including dendritic spine; postsynaptic density; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2); PARTICIPATES IN aldosterone signaling pathway; altered androgen signaling pathway; androgen signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC102549300; NCoA-2; Tif2; transcriptional intermediary factor 2; uncharacterized LOC102549300
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.055,466,544 - 5,696,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0510,306,581 - 10,538,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,197,891 - 5,275,776 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.155,197,890 - 5,273,000 (+)NCBI
Celera55,570,901 - 5,648,759 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-linalyl acetate  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (EXP)
2-hydroxypropanoic acid  (ISO)
22,23-dihydroavermectin B1a  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3beta-hydroxycholest-5-en-26-oic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-terpineol  (ISO)
4-tert-Octylphenol  (ISO)
9,9-bis(4-hydroxyphenyl)fluorene  (ISO)
[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-terpineol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androst-4-ene-3,17-dione  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butamben  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
chenodeoxycholic acid  (ISO)
cholesterol  (ISO)
cilnidipine  (ISO)
clevidipine  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
coumestrol  (ISO)
cyproterone acetate  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
Doramectin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emamectin  (ISO)
emodin  (ISO)
entinostat  (ISO)
eprinomectin  (ISO)
ethanol  (ISO)
Ethyl salicylate  (ISO)
ethylparaben  (ISO)
Falecalcitriol  (ISO)
felodipine  (ISO)
flavonol  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
guggulsterone  (ISO)
GW 1929  (ISO)
hexadecanoic acid  (ISO)
Isradipine  (ISO)
ivermectin  (ISO)
lacidipine  (ISO)
lead diacetate  (EXP,ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl salicylate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
milbemycin  (ISO)
N-benzoyl-L-alanine  (ISO)
Nicardipine  (ISO)
nimodipine  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
toxaphene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Apostolakis EM, etal., Mol Endocrinol. 2002 Jul;16(7):1511-23.
2. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
3. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
4. Chung HJ, etal., J Neurosci. 2000 Oct 1;20(19):7258-67.
5. Deguchi K, etal., Cancer Cell. 2003 Mar;3(3):259-71.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
9. Heemers HV, etal., Prostate. 2010 Jun 15;70(9):959-70.
10. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
11. Igarashi-Migitaka J, etal., Eur J Endocrinol. 2005 Oct;153(4):595-604.
12. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
13. Jonason AS, etal., Chromosoma. 2001 Nov;110(6):402-10. Epub 2001 Sep 12.
14. Konno T, etal., Endocrinology. 2010 Sep;151(9):4537-50. Epub 2010 Jul 21.
15. Leers J, etal., Mol Cell Biol 1998 Oct;18(10):6001-13.
16. Li RW, etal., J Comp Neurol. 2005 Jul 18;488(1):11-27.
17. Martinez de Arrieta C, etal., Endocrinology. 2000 May;141(5):1693-8.
18. MGD data from the GO Consortium
19. NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Nicolaides NC, etal., Steroids. 2010 Jan;75(1):1-12. Epub 2009 Oct 7.
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. RGD automated data pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Rochette-Egly C and Germain P, Nucl Recept Signal. 2009 May 8;7:e005.
26. Trousson A, etal., J Steroid Biochem Mol Biol. 2007 May;104(3-5):305-11. Epub 2007 Mar 23.
27. Wang L, etal., Arch Biochem Biophys. 2004 Aug 1;428(1):92-8.
28. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
29. Yore MA, etal., Neuroscience. 2010 Sep 1;169(3):1017-28. Epub 2010 Jun 2.
Additional References at PubMed
PMID:8643509   PMID:10478845   PMID:11583620   PMID:11675124   PMID:12130539   PMID:12709428   PMID:15001550   PMID:15072553   PMID:15383530   PMID:15539428   PMID:15641800   PMID:16109736  
PMID:16148126   PMID:17363140   PMID:18798693   PMID:19039140   PMID:23132854   PMID:24529706   PMID:24550004   PMID:24571987   PMID:31272713  


Genomics

Comparative Map Data
Ncoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.055,466,544 - 5,696,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0510,306,581 - 10,538,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,197,891 - 5,275,776 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.155,197,890 - 5,273,000 (+)NCBI
Celera55,570,901 - 5,648,759 (+)NCBICelera
Cytogenetic Map5q11NCBI
NCOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl870,109,782 - 70,403,808 (-)EnsemblGRCh38hg38GRCh38
GRCh38870,109,770 - 70,405,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37871,022,017 - 71,316,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,186,821 - 71,478,574 (-)NCBINCBI36hg18NCBI36
Build 34871,186,820 - 71,478,574NCBI
Celera867,021,935 - 67,313,703 (-)NCBI
Cytogenetic Map8q13.3NCBI
HuRef866,517,566 - 66,809,329 (-)NCBIHuRef
CHM1_1871,077,538 - 71,372,108 (-)NCBICHM1_1
Ncoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,209,329 - 13,444,451 (-)NCBIGRCm39mm39
GRCm39 Ensembl113,209,329 - 13,444,307 (-)Ensembl
GRCm38113,139,105 - 13,374,227 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,139,105 - 13,374,083 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,129,240 - 13,364,164 (-)NCBIGRCm37mm9NCBIm37
MGSCv36113,127,689 - 13,359,278 (-)NCBImm8
Celera113,103,226 - 13,334,430 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.12NCBI
Ncoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,313,447 - 9,584,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,313,748 - 9,587,109 (+)NCBIChiLan1.0ChiLan1.0
NCOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1868,293,012 - 68,480,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,293,018 - 68,400,479 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0866,632,139 - 66,929,526 (-)NCBIMhudiblu_PPA_v0panPan3
NCOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12919,253,849 - 19,471,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,222,842 - 19,545,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2919,511,986 - 19,805,562 (-)NCBI
ROS_Cfam_1.02919,347,144 - 19,643,120 (-)NCBI
UMICH_Zoey_3.12919,386,646 - 19,682,493 (-)NCBI
UNSW_CanFamBas_1.02919,452,837 - 19,748,399 (-)NCBI
UU_Cfam_GSD_1.02919,733,575 - 20,029,399 (-)NCBI
Ncoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530359,680,707 - 59,940,562 (+)NCBI
SpeTri2.0NW_00493649614,844,923 - 15,102,922 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl464,954,120 - 65,246,572 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1464,888,029 - 65,245,757 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,584,741 - 70,791,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1865,855,232 - 66,151,733 (-)NCBI
ChlSab1.1 Ensembl865,855,235 - 66,040,947 (-)Ensembl
Ncoa2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474420,795,385 - 21,078,706 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5152509833001026Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)516665875533324Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5166658771552720Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5325132926252076Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5325132948722188Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5452573847978104Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:94
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000011026
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 36 43 27 18 27 1 1 74 35 40 11 1
Low 2 7 14 14 1 14 7 10 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011026   ⟹   ENSRNOP00000011026
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)Ensembl
RefSeq Acc Id: NM_031822   ⟹   NP_114010
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,987,973 - 6,065,865 (+)NCBI
Rnor_6.055,616,483 - 5,694,598 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
RGSC_v3.455,197,891 - 5,275,776 (+)RGD
Celera55,570,901 - 5,648,759 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237744   ⟹   XP_006237806
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Rnor_6.055,466,544 - 5,696,540 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237745   ⟹   XP_006237807
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,919,185 - 6,069,693 (+)NCBI
Rnor_6.055,548,089 - 5,696,540 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237747   ⟹   XP_006237809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,985,136 - 6,069,693 (+)NCBI
Rnor_6.055,613,995 - 5,696,540 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593660   ⟹   XP_017449149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,836,034 - 6,069,693 (+)NCBI
Rnor_6.055,466,892 - 5,696,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593661   ⟹   XP_017449150
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.055,525,287 - 5,696,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593662   ⟹   XP_017449151
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.055,548,089 - 5,696,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110852   ⟹   XP_038966780
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,835,654 - 6,069,693 (+)NCBI
RefSeq Acc Id: XM_039110853   ⟹   XP_038966781
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_114010   ⟸   NM_031822
- UniProtKB: Q9WUI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006237806   ⟸   XM_006237744
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237807   ⟸   XM_006237745
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237809   ⟸   XM_006237747
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449149   ⟸   XM_017593660
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449150   ⟸   XM_017593661
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017449151   ⟸   XM_017593662
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000011026   ⟸   ENSRNOT00000011026
RefSeq Acc Id: XP_038966781   ⟸   XM_039110853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038966780   ⟸   XM_039110852
- Peptide Label: isoform X1
Protein Domains
bHLH   PAS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620108 AgrOrtholog
Ensembl Genes ENSRNOG00000007975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011026 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011026 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa_int_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_rcpt_coactivator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC/p160_LXXLL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83724 UniProtKB/Swiss-Prot
NCBI Gene 83724 ENTREZGENE
PANTHER PTHR10684 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10684:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rec_co-act UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ncoa2 PhenoGen
PIRSF Nuclear_receptor_coactivator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1MA61 ENTREZGENE, UniProtKB/TrEMBL
  NCOA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ncoa2  nuclear receptor coactivator 2  LOC102549300  uncharacterized LOC102549300  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102549300  uncharacterized LOC102549300      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Ncoa2  nuclear receptor coactivator 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ncoa2  nuclear receptor coactivator 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains three short conserved NR box motifs 633360