GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ncoa2 | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of NCOA2 mRNA | PMID:32145629 | Ncoa2 | affects binding | ISO | NCOA2 (Homo sapiens) | 6480464 | CTD | [Estradiol binds to ESR1 protein] which binds to NCOA2 protein; [Estradiol binds to ESR2 protein] which binds to NCOA2 protein | PMID:15123288 | Ncoa2 | affects localization | ISO | Ncoa2 (Mus musculus) | 6480464 | CTD | Estradiol affects the localization of NCOA2 protein | PMID:17556502 | Ncoa2 | increases expression | ISO | NCOA2 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of NCOA2 mRNA; Estradiol results in increased expression of NCOA2 protein | PMID:16739346 PMID:31646340 | Ncoa2 | multiple interactions | ISO | NCOA2 (Homo sapiens) | 6480464 | CTD | [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to CST5 promoter]; [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to HAVCR2 promoter]; [Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein; afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to H19 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to KLRC1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to LLGL2 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]]; ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]]; ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]]; Estradiol promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Estradiol promotes the reaction [ESR1 protein binds to NCOA2 protein]; Estradiol promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Estradiol promotes the reaction [ESR2 protein binds to NCOA2 protein]; Estradiol promotes the reaction [NCOA2 protein binds to ESR1 protein]; Estradiol promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA2 protein binds to KLRC3 gene]; Estradiol promotes the reaction [NCOA2 protein binds to PTGS2 promoter]; Estradiol promotes the reaction [NCOA2 protein binds to TFF1 promoter]; Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B promoter]; Estradiol promotes the reaction [TNF protein promotes the reaction [NCOA2 protein binds to IL6 promoter]]; fluorene-9-bisphenol inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]; NCOA2 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; NCOA2 mutant form inhibits the reaction [Estradiol results in increased expression of KRT19 mRNA]; NCOA2 mutant form inhibits the reaction [Estradiol results in increased expression of TMEM121B mRNA]; NCOA2 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein] | PMID:10964929 PMID:15084758 PMID:16328721 PMID:17395694 PMID:17872375 PMID:17962382 PMID:19838210 PMID:20160136 PMID:20404318 PMID:23665804 PMID:24771768 PMID:28248286 PMID:28807876 PMID:29389661 PMID:32088792 | Ncoa2 | multiple interactions | ISO | Ncoa2 (Mus musculus) | 6480464 | CTD | NCOA2 protein inhibits the reaction [ESR2 protein alternative form inhibits the reaction [Estradiol results in increased expression of ESR2 protein]]; NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]; NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein] | PMID:27634370 | | ||||||||||||||||||||||
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