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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620108
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa2affects methylationISONCOA2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NCOA2 3' UTR; Benzo(a)pyrene affects the methylation of NCOA2 5' UTR; Benzo(a)pyrene affects the methylation of NCOA2 intronPMID:27901495 PMID:30157460
Ncoa2decreases expressionISONCOA2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NCOA2 mRNA; Benzo(a)pyrene results in decreased expression of NCOA2 proteinPMID:20106945 PMID:21632981 PMID:26350169 PMID:32234424
Ncoa2decreases expressionISONcoa2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of NCOA2 mRNAPMID:19770486
Ncoa2decreases methylationISONCOA2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of NCOA2 promoterPMID:27901495
Ncoa2multiple interactionsISONCOA2 (Homo sapiens)6480464CTDBenzo(a)pyrene inhibits the reaction [cobaltous chloride affects the localization of NCOA2 protein]PMID:26350169
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