View Ontology Report


Vitamin A or retinol and its metabolites are essential for life processes. Retinal is well known for its role in vision while retinoic acid, through the many genes whose expression it regulates, is important for growth and development, cellular proliferation and differentiation, tissue homeostasis, immune and nervous systems function. Retinol itself could be involved in mitochondrial signaling where it may serve as a co-factor in redox sensing and energy homeostasis. All-trans retinoic acid (atR

Pathway Diagram:

Ariadne Genomics Inc. RAR corepressors ---- RAR_noLig RAR corepressors RXR-lig direct and indirect target gene expression RAR_noLig RXR_noLig released RAR corepressors retinoic acid metabolic pathway all-trans retinoic acid RAR uncoventional coregulators RAR coactivators RAR-lig RAR target genes RAR-lig ---> RAR target genes RXR-lig ---> RAR target genes RAR_noLig ---- RXR_noLig RAR-lig ---- RXR-lig RAR coactivators ---- RAR-lig RAR uncoventional coregulators ---- RAR-lig RAR coactivators ---- RXR-lig all-trans retinoic acid ---- RAR-lig RXR_noLig ---| RAR target genes RAR_noLig ---| RAR target genes RAR uncoventional coregulators ---> RAR target genes

Genes in Pathway:

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retinoic acid signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6484676
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:6484676
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:6484676
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:6484676
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:6484676
G Nrip1 nuclear receptor interacting protein 1 JBrowse link 11 14,658,225 14,742,478 RGD:6484676
G Psmc5 proteasome 26S subunit, ATPase 5 JBrowse link 10 94,445,877 94,451,811 RGD:6484676
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6484674
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6484674
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6484674
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6484675
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6484675
G Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6484675

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassRAR corepressors
Functional ClassRAR coactivators
Functional ClassRAR uncoventional coregulators
Gene GroupRAR target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinoic acid signaling pathway
Disease TermsGene Symbols
Acute-Phase ReactionNcor1
adenocarcinomaNcoa3 , Rarb
Alzheimer's DiseaseNrip1
amyotrophic lateral sclerosisRara
amyotrophic lateral sclerosis type 1Rxra
Anterior Segment Dysgenesis 5Rarg
Anxiety DisordersNcor1
asbestos-related lung carcinomaRarb
Bone NeoplasmsNcoa3
breast cancer, familialNcor1
Breast NeoplasmsNcoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Nrip1 , Rara , Rarb , Rxrb
Carcinoma, HepatocellularRara , Rxra
Carcinoma, Squamous CellNcoa3 , Rarb
Carcinoma, Transitional CellNcor1 , Rxra
Cardiomyopathy, AlcoholicRxra
cleft palateRarg
Developmental DisabilitiesNcor1
Disease ProgressionRxrb
Endometrial NeoplasmsNcoa1 , Ncor2 , Nrip1
EndometriosisNcoa1 , Ncor1 , Rarb
head and neck neoplasmsRarb
Heart DiseasesRarg
Heart FailureNrip1
Hernia, DiaphragmaticRxra
HIV InfectionsPsmc5
Huntington's DiseaseNcor1
Hyperbilirubinemia, NeonatalNcor1
HypothyroidismNcoa1 , Ncor1
Leukemia, Myeloid, AcuteNcoa2
Leukemia, Promyelocytic, AcuteRara
Liver Cirrhosis, ExperimentalNcor2 , Rxra
Liver NeoplasmsNcor1
Liver Neoplasms, ExperimentalRxra
Long QT SyndromeNrip1
lung adenocarcinomaRarb
Lung NeoplasmsRarb
Mammary Neoplasms, ExperimentalNcoa1 , Rxra
Mesothelioma, MalignantRxra
Microphthalmia, Syndromic 12Rarb
Mood DisordersRara
Musculoskeletal AbnormalitiesRarg
Myocardial InfarctionNrip1
Myocardial IschemiaRxrg
Neoplasm MetastasisNcoa1 , Rxra
Neoplasms, Second PrimaryRara
Neurogenic InflammationRxra
non-small cell lung carcinomaNcoa3 , Rarb , Rxrg
obesityNcoa3 , Rxra
Osteoporosis, PostmenopausalNrip1
pancreatic adenocarcinomaRxra
pancreatic ductal carcinomaRxra
Pancreatic NeoplasmsRxra
Phyllodes TumorRara
Polycystic Ovary SyndromeNcor1
Pregnancy ComplicationsNcoa2
prostate carcinoma in situRxra
prostatic neoplasmsNcoa1 , Ncoa2 , Ncoa3 , Ncor2 , Rxra
Sciatic NeuropathyRara , Rarb , Rxra
Smith-Magenis syndromePsmc5 , Rara
Spinal Cord InjuriesRara
Stevens-Johnson SyndromePsmc5
Stomach NeoplasmsRarb , Rxrb
Thyroid NeoplasmsRxra
urinary bladder cancerNcor1
uterine cervical neoplasmsRarb
Wallerian DegenerationRxra
Pathway Annotations Associated with Genes in the retinoic acid signaling pathway

References Associated with the retinoic acid signaling pathway:

Ontology Path Diagram:

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Import into Pathway Studio: