RETINOIC ACID SIGNALING PATHWAY (PW:0001014)

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Description

Vitamin A or retinol and its metabolites are essential for life processes. Retinal is well known for its role in vision while retinoic acid, through the many genes whose expression it regulates, is important for growth and development, cellular proliferation and differentiation, tissue homeostasis, immune and nervous systems function. Retinol itself could be involved in mitochondrial signaling where it may serve as a co-factor in redox sensing and energy homeostasis. All-trans retinoic acid (atR

Pathway Diagram:

Ariadne Genomics Inc. RAR corepressors ---- RAR_noLig RAR corepressors RXR-lig direct and indirect target gene expression RAR_noLig RXR_noLig released RAR corepressors retinoic acid metabolic pathway all-trans retinoic acid RAR uncoventional coregulators RAR coactivators RAR-lig RAR target genes RAR-lig ---> RAR target genes RXR-lig ---> RAR target genes RAR_noLig ---- RXR_noLig RAR-lig ---- RXR-lig RAR coactivators ---- RAR-lig RAR uncoventional coregulators ---- RAR-lig RAR coactivators ---- RXR-lig all-trans retinoic acid ---- RAR-lig RXR_noLig ---| RAR target genes RAR_noLig ---| RAR target genes RAR uncoventional coregulators ---> RAR target genes
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Genes in Pathway:

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retinoic acid signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6484676
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:6484676
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:6484676
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:6484676
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:6484676
G Nrip1 nuclear receptor interacting protein 1 JBrowse link 11 14,658,225 14,742,478 RGD:6484676
G Psmc5 proteasome 26S subunit, ATPase 5 JBrowse link 10 94,445,877 94,451,811 RGD:6484676
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6484674
RGD:6484731
RGD:6484676
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6484674
RGD:6484731
RGD:6484676
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6484674
RGD:6484676
RGD:6484731
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6484675
RGD:6484731
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6484675
RGD:6484731
G Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6484675
RGD:6484731

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassRAR coactivators
Functional ClassRAR unconventional coregulators
Functional ClassRAR corepressors
Gene GroupRAR target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinoic acid signaling pathway
Disease TermsGene Symbols
acute myeloid leukemiaNcoa2
acute promyelocytic leukemiaRara
Acute-Phase ReactionNcor1
adenocarcinomaNcoa3 , Rarb
alcoholic cardiomyopathyRxra
Alzheimer's diseaseNrip1
amyotrophic lateral sclerosisRara
amyotrophic lateral sclerosis type 1Rxra
ANTERIOR SEGMENT DYSGENESIS 6Rarg
anxiety disorderNcor1
asbestos-related lung carcinomaRarb
astrocytomaNcoa3
Bone NeoplasmsNcoa3
Breast Cancer, FamilialNcor1
Breast NeoplasmsNcoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Nrip1 , Rara , Rarb , Rxrb
CAKUTNrip1
CardiotoxicityRarg
cleft palateRarg
congenital heart diseaseRxra
congestive heart failureNrip1
Developmental DisabilitiesNcor1
Diaphragmatic HerniaRxra
dilated cardiomyopathyRxra
Disease ProgressionRxrb
Endometrial NeoplasmsNcoa1 , Ncor2 , Nrip1
endometriosisNcoa1 , Ncor1 , Rarb
Experimental Liver CirrhosisNcor2 , Rxra
Experimental Liver NeoplasmsRxra
FibroadenomaRara
genetic diseaseRarb
glioblastoma multiformeNcor1
Head and Neck NeoplasmsRarb
heart diseaseRarg
hepatocellular carcinomaRara , Rxra
human immunodeficiency virus infectious diseasePsmc5
Huntington's diseaseNcor1
hypothyroidismNcoa1 , Ncor1
leukemiaNcoa3
liver benign neoplasmNcor1
long QT syndromeNrip1
lung adenocarcinomaRarb
Lung NeoplasmsRarb
lung small cell carcinomaRarb
malignant mesotheliomaRxra
Mammary Neoplasms, ExperimentalNcoa1 , Rxra
Microphthalmia, Syndromic 12Rarb
mood disorderRara
Musculoskeletal AbnormalitiesRarg
myelofibrosisNcor2
myocardial infarctionNrip1
Myocardial IschemiaRxrg
Neonatal HyperbilirubinemiaNcor1
Neoplasm MetastasisNcoa1 , Rxra
Neoplasms, Second PrimaryRara
Neurogenic InflammationRxra
non-small cell lung carcinomaNcoa3 , Rarb , Rxrg
obesityNcoa1 , Ncoa3 , Rxra
osteoarthritisNcor2
osteoporosisNrip1
pancreatic adenocarcinomaRxra
pancreatic cancerRxra
pancreatic ductal carcinomaRxra
papillary thyroid carcinomaRxrg
Peters anomalyRarg
Phyllodes TumorRara
polycystic ovary syndromeNcor1
Postmenopausal OsteoporosisNrip1
Pregnancy ComplicationsNcoa2
prostate carcinoma in situRxra
Prostatic NeoplasmsNcoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Rxra
schizophreniaNrip1
sciatic neuropathyRara , Rarb , Rxra
SepsisRxra
Smith-Magenis syndromePsmc5 , Rara
Spinal Cord InjuriesRara
squamous cell carcinomaNcoa3 , Rarb
Stevens-Johnson syndromePsmc5
Stomach NeoplasmsRarb , Rxrb
systemic lupus erythematosusRxra
thyroid hormone resistance syndromeNcoa1
Thyroid NeoplasmsRxra
transitional cell carcinomaNcor1 , Rxra
urinary bladder cancerNcor1
Uterine Cervical NeoplasmsRarb
Wallerian DegenerationRxra
Pathway Annotations Associated with Genes in the retinoic acid signaling pathway

References Associated with the retinoic acid signaling pathway:

Ontology Path Diagram:

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