Vetf1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Vetf1 (Vascular elastic tissue fragility QTL 1) Rattus norvegicus

Symbol: Vetf1
Name: Vascular elastic tissue fragility QTL 1
RGD ID: 631551
Trait: aorta elastic tissue integrity trait   (VT:0010556)    
Measurement Type: artery internal elastic lamina non-tumorous lesion count   (CMO:0001913)    
LOD Score: 5.0
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.252,282,226 - 5,904,428RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.051,666,587 - 5,533,324RGD_MAPPER_PIPELINERnor6.0
Rnor_5.051,662,934 - 10,373,154RGDRnor5.0
RGSC_v3.451,368,223 - 5,112,800RGDRGSC3.4
RGSC_v3.151,368,224 - 5,112,800RGD
Cross Type: Not Available
Strains Crossed: GH/Omr BN/Elh 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Lyn is a candidate Gene for Vetf1

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method
necropsy  (IDA)

Vertebrate Trait

Rat Strain
BN/Elh  (IEA)
GH/Omr  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Harris EL, etal., Physiol Genomics 2001 Aug 28;6(3):183-9.
2. Quantitative genetic basis of arterial phenotypes in the Brown Norway rat. Kota L, etal., Physiol Genomics. 2007 Jun 19;30(1):17-25. Epub 2007 Mar 13.
Related QTLs

Related QTL Description Reference
Vetf3 maps to same region RGD:8662443


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2322123Tmem251-ps1Transmembrane protein 251, pseudogene 1523423672342941Rat
1563586Rps4x-ps8ribosomal protein S4, X-linked, pseudogene 8523498632350756Rat
1585970Acbd5-ps2acyl-CoA binding domain containing 5, pseudogene 2523507182462194Rat
1302993Ly96lymphocyte antigen 96525822332612357Rat
1566224Tmem70transmembrane protein 70526371022654729Rat
2320348Idi1-ps1isopentenyl-diphosphate delta isomerase 1, pseudogene 1526561612657460Rat
620658Elocelongin C526615272677893Rat
6503620Ube2wubiquitin-conjugating enzyme E2W526907422754491Rat
621479Stau2staufen double-stranded RNA binding protein 2528407413084935Rat
7641998LOC102555040uncharacterized LOC102555040531205153149122Rat
727793Rdh10retinol dehydrogenase 10531866713215572Rat
735169Rpl7ribosomal protein L7532171843220192Rat
6487565C5h8orf89similar to human chromosome 8 open reading frame 89532255863247575Rat
1359575LOC297756ribosomal protein S8-like533928463393523Rat
1559717Sbsponsomatomedin B and thrombospondin, type 1 domain containing534027633433338Rat
1311574Terf1telomeric repeat binding factor 1534431033472377Rat
2320313Ergic2-ps2ERGIC and golgi 2, pseudogene 2534774413478415Rat
41244691LOC120103307small nucleolar RNA SNORA17535408223540951Rat
621349Kcnb2potassium voltage-gated channel subfamily B member 2535670124028564Rat
40956976LOC120103364U2 spliceosomal RNA536612473661373Rat
7567361LOC102555640uncharacterized LOC102555640542246724238926Rat
1564405Nufip2-ps1nuclear FMR1 interacting protein 2, pseudogene 1542710524273239Rat
41271882LOC120103310small nucleolar RNA SNORA17542817024281825Rat
1303284Trpa1transient receptor potential cation channel, subfamily A, member 1543798624434133Rat
7696412LOC102555885uncharacterized LOC102555885545287604547276Rat
1305496Mscmusculin545473354553206Rat
1584850Ndufb4-ps8NADH:ubiquinone oxidoreductase subunit B4, pseudogene 8547967974797193Rat
1584849Eya1EYA transcriptional coactivator and phosphatase 1548635015101483Rat
41204020LOC120102805uncharacterized LOC120102805550600945159282Rat
41046558LOC120102806uncharacterized LOC120102806553188005323393Rat
1584867Phb1-ps14prohibitin 1, pseudogene 14553298535331546Rat
40928183LOC120102807uncharacterized LOC120102807554355395438349Rat
1310557Rbpjl2recombination signal binding protein for immunoglobulin kappa J region-like 2554649695466367Rat
1359260Xkr9XK related 9555303845562168Rat
1307876Lactb2lactamase, beta 2555690805591843Rat
41087792LOC120102808uncharacterized LOC120102808555815695621082Rat
1359100Tram1translocation associated membrane protein 1556425795667666Rat
7520808LOC102548182uncharacterized LOC102548182556719475680129Rat
41205794Trnaa-agc87transfer RNA alanine (anticodon AGC) 87556893565689436Rat
41377667Ptmal6prothymosin alpha like 6557646715765429Rat
41210398LOC120103350small nucleolar RNA SNORA40558334695833590Rat
620108Ncoa2nuclear receptor coactivator 2558356426069693Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
37596D5Rat118157559042635904428Ratregion
37784D5Rat59221522822262282446Ratregion
39686D5Rat119235538440183844247Ratregion
42730D5Rat214229556227075622920Ratregion
43868D5Got3212543281744328386Ratregion
43869D5Got4296531498213150117Ratregion
43870D5Wox8163551121595112316Ratregion
60478D5Got2199546582474658448Ratregion
69540D5Uwm6195551428455143044Ratregion
69568D5Uwm56116539579533958063Ratregion
1631759D5Got295154546582754658431Ratregion
1640077D5Uia15976553859995386975Ratregion
1635992D5Got200132531499723150104Ratregion
7206004Eya1448550137615014209Ratregion
5039278RH127614219531874953187714Ratregion
5032453Rbpsuh-rs3624554652285465852Ratregion
5059578BE097333150558995015899651Ratregion
5050620RH134162183556540645654247Ratregion
5045074RH130969189534431773443366Ratregion
5045406RH131160220551011675101387Ratregion
5040672RH128417209531867913187000Ratregion
5075876RH138848152530803383080490Ratregion
5072626RH136958217556672725667490Ratregion
5075588RH138681171534437063443875Ratregion
5077374RH139719185527516552751840Ratregion
5070658RH134630193526378162638009Ratregion
5073130RH137255187534395613439748Ratregion
5070944RH134796186538029063803092Ratregion
5071440RH135083180529892932989473Ratregion
5071758RH135267211526776542677865Ratregion
5074230RH137896174529576272957801Ratregion
5066854AU048111176554120905412266Ratregion
5088191AU048421205540036454003852Ratregion
5090585AU049839277531705763170853Ratregion
5081947BE118841202550871955087397Ratregion
5503654Rbpj499554656335466132Ratregion
5506473AFM342xc10545921134592784Ratregion
Position Markers

Flank 1: (D5Rat59)
Rat AssemblyChrPosition (strand)Source
mRatBN7.252,282,226 - 2,282,446 (+)MAPPER
Rnor_6.051,666,587 - 1,666,805NCBI
Rnor_5.051,662,934 - 1,663,152UniSTS
RGSC_v3.451,368,224 - 1,368,442UniSTS
RGSC_v3.451,368,223 - 1,368,442RGD
RGSC_v3.151,368,224 - 1,368,442RGD
Celera51,917,196 - 1,917,414UniSTS
RH 3.4 Map50.0RGD
RH 3.4 Map50.0UniSTS
RH 2.0 Map50.0RGD
SHRSP x BN Map50.0RGD
Peak: (D5Rat119)
Rat AssemblyChrPosition (strand)Source
mRatBN7.253,844,018 - 3,844,247 (+)MAPPER
Rnor_6.053,251,329 - 3,251,557NCBI
Rnor_5.053,239,567 - 3,239,795UniSTS
RGSC_v3.452,965,857 - 2,966,086RGD
RGSC_v3.452,965,858 - 2,966,086UniSTS
RGSC_v3.152,965,812 - 2,966,107RGD
Celera53,437,394 - 3,437,622UniSTS
RH 2.0 Map50.0RGD
SHRSP x BN Map51.1599RGD
Cytogenetic Map5q11UniSTS
Flank 2: (D5Rat118)
Rat AssemblyChrPosition (strand)Source
mRatBN7.255,904,263 - 5,904,428 (+)MAPPER
Rnor_6.055,533,160 - 5,533,324NCBI
Rnor_5.0510,372,990 - 10,373,154UniSTS
RGSC_v3.455,112,635 - 5,112,799UniSTS
RGSC_v3.455,112,634 - 5,112,800RGD
RGSC_v3.155,112,634 - 5,112,800RGD
Celera55,487,313 - 5,487,477UniSTS
RH 3.4 Map50.0RGD
RH 3.4 Map50.0UniSTS
RH 2.0 Map50.0RGD
SHRSP x BN Map52.3599RGD
Cytogenetic Map5q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)522822265904428Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Vetf1

RGD Curation Notes
Note Type Note Reference
qtl_disease vascular fragility of the internal elastic lamina is associated with atherosclerosis and other vascular diseases 619605