Terf1 (telomeric repeat binding factor 1)

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Gene: Terf1 (telomeric repeat binding factor 1) Rattus norvegicus

Analyze

Symbol:

Terf1

Name:

telomeric repeat binding factor 1

RGD ID:

1311574

Description:

Predicted to enable several functions, including DNA binding activity; ankyrin repeat binding activity; and protein homodimerization activity. Predicted to contribute to telomerase activity. Involved in response to xenobiotic stimulus. Located in nucleus. Orthologous to human TERF1 (telomeric repeat binding factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC297758; MGC109063; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat-binding factor 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	3,443,103 - 3,472,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	3,443,106 - 3,472,340 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	5,560,595 - 5,589,792 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	7,199,479 - 7,228,676 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	6,896,804 - 6,926,212 (-)	NCBI	Rnor_WKY
Rnor_6.0	5	2,853,455 - 2,882,731 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	2,853,459 - 2,882,668 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	2,843,150 - 2,872,418 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	2,556,918 - 2,586,086 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	2,556,917 - 2,586,086 (-)	NCBI
Celera	5	3,039,138 - 3,068,345 (-)	NCBI		Celera
Cytogenetic Map	5	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

genetic disease (ISO)

squamous cell carcinoma (ISO)

stomach cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

ciguatoxin CTX1B (ISO)

cyclosporin A (ISO)

cypermethrin (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dimethyl sulfoxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

geraniol (ISO)

idarubicin (ISO)

indometacin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methamphetamine (EXP)

oxaliplatin (EXP)

phenylmercury acetate (ISO)

phenytoin (EXP)

phorbol 13-acetate 12-myristate (ISO)

phosphoramide mustard (EXP)

pirinixic acid (ISO)

pterostilbene (ISO)

resveratrol (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tebuconazole (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

topotecan (EXP)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

meiotic telomere clustering (ISO)

negative regulation of DNA replication (IBA,ISO)

negative regulation of establishment of protein localization to telomere (ISO)

negative regulation of establishment of RNA localization to telomere (ISO)

negative regulation of exonuclease activity (IBA,ISO)

negative regulation of telomerase activity (ISO)

negative regulation of telomere maintenance via telomerase (ISO)

negative regulation of telomeric D-loop disassembly (IBA,ISO)

positive regulation of shelterin complex assembly (ISO)

response to xenobiotic stimulus (IEP)

telomere capping (ISO)

telomere maintenance (ISO)

telomere maintenance via telomerase (IBA,ISO)

telomeric D-loop disassembly (ISO)

telomeric loop formation (ISO)

Cellular Component

chromosome, telomeric region (ISO)

fibrillar center (IEA,ISO)

nuclear body (IEA,ISO)

nuclear telomere cap complex (ISO)

nucleolus (ISO)

nucleus (IDA)

nucleus (ISO)

shelterin complex (ISO)

spindle (ISO)

Molecular Function

ankyrin repeat binding (IBA,ISO)

DNA binding, bending (IBA,ISO)

double-stranded telomeric DNA binding (IBA,ISO)

G-rich strand telomeric DNA binding (IBA,ISO)

identical protein binding (ISO)

microtubule binding (IBA,ISO)

molecular adaptor activity (ISO)

molecular_function (ND)

obsolete protein C-terminus binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

telomerase activity (IBA,ISO)

telomeric DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.	Hu H, etal., J Cancer Res Clin Oncol. 2010 Feb 2.
4.	Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.	Martinez P, etal., Genes Dev. 2009 Sep 1;23(17):2060-75. Epub 2009 Aug 13.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer.	Poonepalli A, etal., Genes Chromosomes Cancer. 2008 Dec;47(12):1098-109.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.	Spallarossa P, etal., Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2169-81. Epub 2009 Oct 2.
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:1406665	PMID:7502076	PMID:9034193	PMID:9130722	PMID:9391075	PMID:11313893	PMID:11327863	PMID:11701125	PMID:11854288	PMID:11943150	PMID:11971978	PMID:12768206
PMID:12782650	PMID:15109494	PMID:15133513	PMID:15200954	PMID:15380063	PMID:15383534	PMID:15608617	PMID:15968270	PMID:16880378	PMID:17010969	PMID:17053789	PMID:17389648
PMID:17694070	PMID:17982445	PMID:19135898	PMID:19265708	PMID:19487455	PMID:19854130	PMID:21119197	PMID:21852327	PMID:22039056	PMID:23685356	PMID:24120135	PMID:24270157
PMID:24415760	PMID:24589552	PMID:25589350	PMID:26586433

Genomics

Comparative Map Data

Terf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	3,443,103 - 3,472,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	3,443,106 - 3,472,340 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	5,560,595 - 5,589,792 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	7,199,479 - 7,228,676 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	6,896,804 - 6,926,212 (-)	NCBI	Rnor_WKY
Rnor_6.0	5	2,853,455 - 2,882,731 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	2,853,459 - 2,882,668 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	2,843,150 - 2,872,418 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	2,556,918 - 2,586,086 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	2,556,917 - 2,586,086 (-)	NCBI
Celera	5	3,039,138 - 3,068,345 (-)	NCBI		Celera
Cytogenetic Map	5	q11	NCBI

TERF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	73,008,864 - 73,048,123 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	73,008,856 - 73,048,123 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	73,921,099 - 73,960,358 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	74,083,661 - 74,122,281 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	74,083,662 - 74,122,281	NCBI
Celera	8	69,918,262 - 69,957,163 (+)	NCBI		Celera
Cytogenetic Map	8	q21.11	NCBI
HuRef	8	69,411,980 - 69,450,876 (+)	NCBI		HuRef
CHM1_1	8	73,973,943 - 74,012,842 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	73,437,901 - 73,477,172 (+)	NCBI		T2T-CHM13v2.0

Terf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	15,875,634 - 15,914,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	15,875,870 - 15,914,276 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	15,805,546 - 15,844,052 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	15,805,646 - 15,844,052 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	15,795,739 - 15,833,510 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	15,790,872 - 15,828,643 (+)	NCBI		MGSCv36	mm8
Celera	1	15,750,793 - 15,788,563 (+)	NCBI		Celera
Cytogenetic Map	1	A3	NCBI
cM Map	1	4.88	NCBI

Terf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955444	7,103,552 - 7,150,323 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955444	7,103,282 - 7,149,450 (-)	NCBI	ChiLan1.0	ChiLan1.0

TERF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	71,192,716 - 71,231,648 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	8	69,545,115 - 69,583,997 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TERF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	21,664,378 - 21,701,491 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	21,664,186 - 21,700,495 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	21,929,296 - 21,966,341 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	21,773,860 - 21,811,415 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	21,773,883 - 21,811,414 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	21,832,463 - 21,869,553 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	21,868,610 - 21,906,117 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	22,149,876 - 22,187,001 (+)	NCBI		UU_Cfam_GSD_1.0

Terf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	57,612,694 - 57,639,199 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936648	1,809,395 - 1,835,890 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TERF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	62,797,000 - 62,831,454 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	62,797,244 - 62,831,459 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	68,341,702 - 68,375,863 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TERF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	68,608,830 - 68,647,220 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	68,608,844 - 68,648,171 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	72,734,995 - 72,774,562 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Terf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	18,121,687 - 18,156,989 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	18,120,677 - 18,156,920 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Terf1
98 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	71
Count of miRNA genes:	66
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000049741
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	2138965	32656739	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
631551	Vetf1	Vascular elastic tissue fragility QTL 1	5	0.0001	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	5	2282226	5904428	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat

Markers in Region

RH130969

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	3,443,177 - 3,443,366 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	2,853,530 - 2,853,718	NCBI	Rnor6.0
Rnor_5.0	5	2,843,225 - 2,843,413	UniSTS	Rnor5.0
RGSC_v3.4	5	2,556,989 - 2,557,177	UniSTS	RGSC3.4
Celera	5	3,039,209 - 3,039,397	UniSTS
Cytogenetic Map	5	q11	UniSTS

RH138681

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	3,443,706 - 3,443,875 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	2,854,059 - 2,854,227	NCBI	Rnor6.0
Rnor_5.0	5	2,843,754 - 2,843,922	UniSTS	Rnor5.0
RGSC_v3.4	5	2,557,518 - 2,557,686	UniSTS	RGSC3.4
Celera	5	3,039,738 - 3,039,906	UniSTS
Cytogenetic Map	5	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	28	18	19	18	1	1	72	25	37	11	1
Low	1	17	29	23		23	7	10	2	10	4		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000049741 ⟹ ENSRNOP00000043160

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	3,443,106 - 3,472,340 (-)	Ensembl
Rnor_6.0 Ensembl	5	2,853,459 - 2,882,668 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108921 ⟹ ENSRNOP00000077638

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	3,443,106 - 3,472,340 (-)	Ensembl

RefSeq Acc Id:

NM_001012464 ⟹ NP_001012482

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	3,443,107 - 3,472,316 (-)	NCBI
Rnor_6.0	5	2,853,459 - 2,882,668 (-)	NCBI
Rnor_5.0	5	2,843,150 - 2,872,418 (-)	NCBI
RGSC_v3.4	5	2,556,918 - 2,586,086 (-)	RGD
Celera	5	3,039,138 - 3,068,345 (-)	RGD

Sequence:

show sequence

ATGGCGGGGACTGTCACCTCAGCAGCTCCGGGCGCGCGGAGCAATGCGGGCGGGACAAGCGCGG
ATTCTCCAGAGAAGGAGGCGGCGAGAGACGACGCAGAGTTGTTCGACTGCCGGGTGCAGCTGGG
GCCCCCGAGAGAGGAGGAGAACGCGGAGCTTGTGGCCGAGGCGGAGGCCGTGGCTGCGGGCTGG
ATGCTCGACTTCCTCTGCCTGTCTCTGTGCCGAGCCTTTCGCGACGGCCGCTGCGAGGACTTTC
GCCAGACTCGTGACAGCGCCGAGGCTATTATTCATGGACTACCCAGTCTTACAGCTTACCAGTT
GAAAACTGTATATATATGTCAGTTTTTGACAAGAGTTGCAGCAGGAAAGTCTCTTGATGCACAG
TTTGAAGTTGATGAGCGGATTACACCCTTGGAATCAGCCCTGATGATTTGGGACTCAATTGAAA
AAGAACATGACAAACTTCATGAAGAAATACAGAATTTAATTAAAATTCAGGCTGTAGCTGTGTG
TATGGAAATGGGCAGCTTTAAGGAAGCAGAAGAAGTGTTTGAAAGAATATTTGGTGACCCAGAA
TTTTACACGCCTTTAGAAAGAAAATTACTTAAGATAATCTCTCAAAAAGACGTCTTCCACGTCC
TTTTTCAACGCTTCAGTTATAACCTCATGATGGAGAAAATTCAGAGTTATGTGGAGTGTGTGTT
AAATGAGAAATCATCAACTTTCCTAATGAAGGCAGCAACAAAAGTAGTGGAAAATGAAAAAGCA
AGGACAGTAGCTTCGGAGGATAAAGCAAAGGCCACCAACACTGGAACAGAAACGGAAGTTAACT
CGAATAAAGGAGAAAGTGTTAATGGCCAACAGTCTGTAGAAACTGAATCCTTGGTGGATACAGG
ATCCTCAGTAAGGTCTCACAAGAATGCCTTATCTCCGTTGAAAAGCAGACGTCTTCAGCCAGAT
TTCAATAGGAATGAAGCAAGAACAGGAACTCTTCAGTGTGAAATAGCAACAAAACGAAACAGAA
GAACCAGTGGAGGGAATAGATTACGTATTTCAAAGAATCAGCCGGACACTAATGAAAAACATGG
GCGCAGGAAAAAACAGACATGGCTTTGGGAAGAAGACAGAAGTTTGAAGTGTGGTGTAAGGAAA
TATGGAGAGGGAAATTGGGCTAAAATACTATCCCATTATAAGTTCAACAACCGAACAAGTGTCA
TGTTAAAGGATCGGTGGAGAACGATGAGGAGGCTAAGGCTCATTAGCTGAGACTCCGAAGGCTG
CCTGGGTTGGTTTCAGCTCACTACAGGACAGTTAAATACTGGATCACTGTGTTGTTTAAAACTT
CTTGGTCAGTAAAGATGAAGCATTATTGTGTGTGTGTGTGAGAGAGAGAGTGTGTGAAAGAGAG
AGGGAATGTGTGTTTTGTTACAAGAGATTTGTACTGTAAAAGTAAAATTATATGTTATCATTAT
TTTCTATAAGAATCTTTATTTTCATAAGACATAGAACCCTACCAAACTCAAGCCCCATCCCATG
TTGTGTTACTACAGAAGCAAGAGCCTAACAAATAAAGAGTACATGACTGTCACTGCTTGTCTAG
TCCATGACTGTAAACTGACCTTACTGAGTGCCACCTAGAGATGGACCAAGTTGGAAAAATCTTT
CGATGTGAGTTTGCTGCTGGATTAATGACTAGTGTACCACTTACTAAAGAGTTACTACTAGAGG
GGTATGCAAAACGACCCATGAGTTCTAACAAGCCTGGCTTGGCTTCTCAAAGTTTCATTTAAAG
GAAGTTGCATTTTCACTAAATATTTATTCATTGCAATATTTAGTCAAAGACTAATAATTAGCAT
TTGAGTTTTATGTGCCATGCTTAACAAGTAAAAACAAGTCTCAACCTATTGAAATATTAACAGG
AATATTACTCAGCGTTGTGTATTTCCTGCAAAGTGTCATCACTGCTTTCCTGTTCTCTTGAATT
TGCTGTCTGATATATATTAAACAGAATCATTAATAATTAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006237729 ⟹ XP_006237791

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	3,443,103 - 3,472,374 (-)	NCBI
Rnor_6.0	5	2,853,455 - 2,882,731 (-)	NCBI
Rnor_5.0	5	2,843,150 - 2,872,418 (-)	NCBI

Sequence:

show sequence

CATCGTGAGCCAAACTGCGCCAGCTGAGGAACAACGCGCGCTTTCGCACGCTTTCGGTTTAACA
TGGCGGGGACTGTCACCTCAGCAGCTCCGGGCGCGCGGAGCAATGCGGGCGGGACAAGCGCGGA
TTCTCCAGAGAAGGAGGCGGCGAGAGACGACGCAGAGTTGTTCGACTGCCGGGTGCAGCTGGGG
CCCCCGAGAGAGGAGGAGAACGCGGAGCTTGTGGCCGAGGCGGAGGCCGTGGCTGCGGGCTGGA
TGCTCGACTTCCTCTGCCTGTCTCTGTGCCGAGCCTTTCGCGACGGCCGCTGCGAGGACTTTCG
CCAGACTCGTGACAGCGCCGAGGCTATTATTCATGGACTACCCAGTCTTACAGCTTACCAGTTG
AAAACTGTATATATATGTCAGTTTTTGACAAGAGTTGCAGCAGGAAAGTCTCTTGATGCACAGT
TTGAAGTTGATGAGCGGATTACACCCTTGGAATCAGCCCTGATGATTTGGGACTCAATTGAAAA
AGAACATGACAAACTTCATGAAGAAATACAGAATTTAATTAAAATTCAGCCTTTAGAAAGAAAA
TTACTTAAGATAATCTCTCAAAAAGACGTCTTCCACGTCCTTTTTCAACGCTTCAGTTATAACC
TCATGATGGAGAAAATTCAGAGTTATGTGGAGTGTGTGTTAAATGAGAAATCATCAACTTTCCT
AATGAAGGCAGCAACAAAAGTAGTGGAAAATGAAAAAGCAAGGACAGTAGCTTCGGAGGATAAA
GCAAAGGCCACCAACACTGGAACAGAAACGGAAGTTAACTCGAATAAAGGAGAAAGTGTTAATG
GCCAACAGTCTGTAGAAACTGAATCCTTGGTGGATACAGGATCCTCAGTAAGGTCTCACAAGAA
TGCCTTATCTCCGTTGAAAAGCAGACGTCTTCAGCCAGATTTCAATAGGAATGAAGCAAGAACA
GGAACTCTTCAGTGTGAAATAGCAACAAAACGAAACAGAAGAACCAGTGGAGGGAATAGATTAC
GTATTTCAAAGAATCAGCCGGACACTAATGAAAAACATGGGCGCAGGAAAAAACAGACATGGCT
TTGGGAAGAAGACAGAAGTTTGAAGTGTGGTGTAAGGAAATATGGAGAGGGAAATTGGGCTAAA
ATACTATCCCATTATAAGTTCAACAACCGAACAAGTGTCATGTTAAAGGATCGGTGGAGAACGA
TGAGGAGGCTAAGGCTCATTAGCTGAGACTCCGAAGGCTGCCTGGGTTGGTTTCAGCTCACTAC
AGGACAGTTAAATACTGGATCACTGTGTTGTTTAAAACTTCTTGGTCAGTAAAGATGAAGCATT
ATTGTGTGTGTGTGTGAGAGAGAGAGTGTGTGAAAGAGAGAGGGAATGTGTGTTTTGTTACAAG
AGATTTGTACTGTAAAAGTAAAATTATATGTTATCATTATTTTCTATAAGAATCTTTATTTTCA
TAAGACATAGAACCCTACCAAACTCAAGCCCCATCCCATGTTGTGTTACTACAGAAGCAAGAGC
CTAACAAATAAAGAGTACATGACTGTCACTGCTTGTCTAGTCCATGACTGTAAACTGACCTTAC
TGAGTGCCACCTAGAGATGGACCAAGTTGGAAAAATCTTTCGATGTGAGTTTGCTGCTGGATTA
ATGACTAGTGTACCACTTACTAAAGAGTTACTACTAGAGGGGTATGCAAAACGACCCATGAGTT
CTAACAAGCCTGGCTTGGCTTCTCAAAGTTTCATTTAAAGGAAGTTGCATTTTCACTAAATATT
TATTCATTGCAATATTTAGTCAAAGACTAATAATTAGCATTTGAGTTTTATGTGCCATGCTTAA
CAAGTAAAAACAAGTCTCAACCTATTGAAATATTAACAGGAATATTACTCAGCGTTGTGTATTT
CCTGCAAAGTGTCATCACTGCTTTCCTGTTCTCTTGAATTTGCTGTCTGATATATATTAAACAG
AATCATTAATAATTGCTA

hide sequence

RefSeq Acc Id:

XM_039109391 ⟹ XP_038965319

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	3,443,103 - 3,472,377 (-)	NCBI

RefSeq Acc Id:

XM_039109392 ⟹ XP_038965320

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	3,448,742 - 3,472,377 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012482	(Get FASTA)	NCBI Sequence Viewer
	XP_006237791	(Get FASTA)	NCBI Sequence Viewer
	XP_038965319	(Get FASTA)	NCBI Sequence Viewer
	XP_038965320	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89888	(Get FASTA)	NCBI Sequence Viewer
	EDM11517	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012482 ⟸ NM_001012464

- UniProtKB:

Q5EB98 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGTVTSAAPGARSNAGGTSADSPEKEAARDDAELFDCRVQLGPPREEENAELVAEAEAVAAGW
MLDFLCLSLCRAFRDGRCEDFRQTRDSAEAIIHGLPSLTAYQLKTVYICQFLTRVAAGKSLDAQ
FEVDERITPLESALMIWDSIEKEHDKLHEEIQNLIKIQAVAVCMEMGSFKEAEEVFERIFGDPE
FYTPLERKLLKIISQKDVFHVLFQRFSYNLMMEKIQSYVECVLNEKSSTFLMKAATKVVENEKA
RTVASEDKAKATNTGTETEVNSNKGESVNGQQSVETESLVDTGSSVRSHKNALSPLKSRRLQPD
FNRNEARTGTLQCEIATKRNRRTSGGNRLRISKNQPDTNEKHGRRKKQTWLWEEDRSLKCGVRK
YGEGNWAKILSHYKFNNRTSVMLKDRWRTMRRLRLIS

hide sequence

RefSeq Acc Id:	XP_006237791 ⟸ XM_006237729
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y1U3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGTVTSAAPGARSNAGGTSADSPEKEAARDDAELFDCRVQLGPPREEENAELVAEAEAVAAGW MLDFLCLSLCRAFRDGRCEDFRQTRDSAEAIIHGLPSLTAYQLKTVYICQFLTRVAAGKSLDAQ FEVDERITPLESALMIWDSIEKEHDKLHEEIQNLIKIQPLERKLLKIISQKDVFHVLFQRFSYN LMMEKIQSYVECVLNEKSSTFLMKAATKVVENEKARTVASEDKAKATNTGTETEVNSNKGESVN GQQSVETESLVDTGSSVRSHKNALSPLKSRRLQPDFNRNEARTGTLQCEIATKRNRRTSGGNRL RISKNQPDTNEKHGRRKKQTWLWEEDRSLKCGVRKYGEGNWAKILSHYKFNNRTSVMLKDRWRT MRRLRLIS hide sequence

RefSeq Acc Id:

ENSRNOP00000043160 ⟸ ENSRNOT00000049741

RefSeq Acc Id:	XP_038965319 ⟸ XM_039109391
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038965320 ⟸ XM_039109392
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000077638 ⟸ ENSRNOT00000108921

Protein Domains

HTH myb-type Myb-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5EB98-F1-model_v2	AlphaFold	Q5EB98	1-421	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693527

Promoter ID:

EPDNEW_R4052

Type:

multiple initiation site

Name:

Terf1_1

Description:

telomeric repeat binding factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	2,882,682 - 2,882,742	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311574	AgrOrtholog
BioCyc Gene	G2FUF-42296	BioCyc
Ensembl Genes	ENSRNOG00000007291	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000043160	ENTREZGENE
	ENSRNOP00000043160.2	UniProtKB/TrEMBL
	ENSRNOP00000077638	ENTREZGENE
	ENSRNOP00000077638.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000049741	ENTREZGENE
	ENSRNOT00000049741.3	UniProtKB/TrEMBL
	ENSRNOT00000108921	ENTREZGENE
	ENSRNOT00000108921.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.210	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7374057	IMAGE-MGC_LOAD
InterPro	Homeodomain-like	UniProtKB/TrEMBL
	HTH_Myb-type_DNA-bd	UniProtKB/TrEMBL
	SANT_DNA-bd	UniProtKB/TrEMBL
	Telomere_rpt-bd_fac_dimer_dom	UniProtKB/TrEMBL
	Telomere_rpt-bd_fac_dimer_sf	UniProtKB/TrEMBL
	TERF1/2	UniProtKB/TrEMBL
KEGG Report	rno:297758	UniProtKB/TrEMBL
MGC_CLONE	MGC:109063	IMAGE-MGC_LOAD
NCBI Gene	297758	ENTREZGENE
PANTHER	TELOMERIC REPEAT-BINDING FACTOR 1	UniProtKB/TrEMBL
	TELOMERIC REPEAT-BINDING FACTOR 1 TERF1	UniProtKB/TrEMBL
Pfam	Myb_DNA-binding	UniProtKB/TrEMBL
	TRF	UniProtKB/TrEMBL
PharmGKB	TERF1	RGD
PhenoGen	Terf1	PhenoGen
PIRSF	Telomere_bd-1_Pin2	UniProtKB/TrEMBL
PROSITE	HTH_MYB	UniProtKB/TrEMBL
	MYB_LIKE	UniProtKB/TrEMBL
SMART	SANT	UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain_like	UniProtKB/TrEMBL
	Telo_rept_bnd_D	UniProtKB/TrEMBL
UniProt	A0A8I5Y1U3	ENTREZGENE, UniProtKB/TrEMBL
	Q5EB98	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Terf1	telomeric repeat binding factor 1	Terf1	telomeric repeat binding factor (NIMA-interacting) 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Terf1	telomeric repeat binding factor (NIMA-interacting) 1	Terf1	telomeric repeat binding factor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Terf1	telomeric repeat binding factor 1	Terf1_predicted	telomeric repeat binding factor 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Terf1_predicted	telomeric repeat binding factor 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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