Lactb2 (lactamase, beta 2) - Rat Genome Database

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Pathways
Gene: Lactb2 (lactamase, beta 2) Rattus norvegicus
Analyze
Symbol: Lactb2
Name: lactamase, beta 2
RGD ID: 1307876
Description: Predicted to enable RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human LACTB2 (lactamase beta 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-lactamase-like protein 2; endoribonuclease LACTB2; LOC297768; MGC112672
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,352,165 - 10,374,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl510,352,154 - 10,379,255 (+)EnsemblGRCr8
mRatBN7.255,569,080 - 5,591,843 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,569,067 - 5,596,429 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx57,706,604 - 7,729,324 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,345,494 - 9,368,214 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,036,663 - 9,059,389 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.054,982,348 - 5,005,111 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,982,348 - 5,005,109 (+)Ensemblrn6Rnor6.0
Rnor_5.054,950,859 - 4,973,622 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.454,770,321 - 4,793,420 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera55,153,652 - 5,176,439 (+)NCBICelera
RGSC_v3.154,770,320 - 4,793,418 (+)NCBI
Cytogenetic Map5q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phorone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrial matrix  (IBA,IEA,ISO,ISS)
mitochondrion  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:18614015   PMID:26826708   PMID:34800366  


Genomics

Comparative Map Data
Lactb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,352,165 - 10,374,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl510,352,154 - 10,379,255 (+)EnsemblGRCr8
mRatBN7.255,569,080 - 5,591,843 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,569,067 - 5,596,429 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx57,706,604 - 7,729,324 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,345,494 - 9,368,214 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,036,663 - 9,059,389 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.054,982,348 - 5,005,111 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,982,348 - 5,005,109 (+)Ensemblrn6Rnor6.0
Rnor_5.054,950,859 - 4,973,622 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.454,770,321 - 4,793,420 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera55,153,652 - 5,176,439 (+)NCBICelera
RGSC_v3.154,770,320 - 4,793,418 (+)NCBI
Cytogenetic Map5q11NCBI
LACTB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38870,637,266 - 70,669,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl870,635,318 - 70,669,185 (-)Ensemblhg38GRCh38
GRCh37871,549,501 - 71,581,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,712,045 - 71,743,946 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34871,712,044 - 71,743,946NCBI
Celera867,547,128 - 67,579,082 (-)NCBICelera
Cytogenetic Map8q13.3ENTREZGENE
HuRef867,042,341 - 67,074,194 (-)NCBIHuRef
CHM1_1871,605,012 - 71,636,965 (-)NCBICHM1_1
T2T-CHM13v2.0871,067,173 - 71,099,092 (-)NCBIT2T-CHM13v2.0
Lactb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,695,069 - 13,730,749 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,693,554 - 13,730,770 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38113,625,893 - 13,660,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,623,330 - 13,660,546 (-)Ensemblmm10GRCm38
MGSCv37113,615,979 - 13,650,590 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36113,611,112 - 13,645,723 (-)NCBIMGSCv36mm8
Celera113,576,714 - 13,611,343 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.29NCBI
Lactb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,059,572 - 9,088,705 (+)Ensembl
ChiLan1.0NW_0049554449,059,999 - 9,088,705 (+)NCBIChiLan1.0ChiLan1.0
LACTB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2786,371,145 - 86,402,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1862,000,310 - 62,032,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0867,162,667 - 67,194,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1868,823,061 - 68,854,992 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,824,302 - 68,854,833 (-)EnsemblpanPan2panpan1.1
LACTB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12919,723,155 - 19,749,147 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,720,144 - 19,749,387 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2919,982,569 - 20,008,565 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02919,820,428 - 19,846,653 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2919,820,990 - 19,846,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12919,857,861 - 19,883,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02919,924,490 - 19,950,473 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02920,205,437 - 20,231,448 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lactb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530359,465,676 - 59,492,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649615,292,216 - 15,319,786 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649615,292,216 - 15,319,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LACTB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl464,710,771 - 64,748,936 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1464,710,777 - 64,748,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,341,257 - 70,379,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LACTB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1866,375,284 - 66,406,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl866,370,596 - 66,406,406 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603975,020,323 - 75,051,298 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lactb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474420,577,545 - 20,605,149 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Lactb2
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000010369
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)5706553510687501Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010369   ⟹   ENSRNOP00000010369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl510,352,165 - 10,379,255 (+)Ensembl
mRatBN7.2 Ensembl55,569,067 - 5,596,429 (+)Ensembl
Rnor_6.0 Ensembl54,982,348 - 5,005,109 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112393   ⟹   ENSRNOP00000084220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl510,352,154 - 10,375,630 (+)Ensembl
mRatBN7.2 Ensembl55,569,067 - 5,592,527 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164040   ⟹   ENSRNOP00000111862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl510,352,165 - 10,378,853 (+)Ensembl
RefSeq Acc Id: NM_001024247   ⟹   NP_001019418
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,352,165 - 10,374,928 (+)NCBI
mRatBN7.255,569,080 - 5,591,843 (+)NCBI
Rnor_6.054,982,348 - 5,005,111 (+)NCBI
Rnor_5.054,950,859 - 4,973,622 (+)NCBI
RGSC_v3.454,770,321 - 4,793,420 (+)RGD
Celera55,153,652 - 5,176,439 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019418 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH93378 (Get FASTA)   NCBI Sequence Viewer  
  EDM11526 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084220.1
  ENSRNOP00000111862
GenBank Protein Q561R9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019418   ⟸   NM_001024247
- UniProtKB: Q561R9 (UniProtKB/Swiss-Prot),   A0A8L2UIE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010369   ⟸   ENSRNOT00000010369
Ensembl Acc Id: ENSRNOP00000084220   ⟸   ENSRNOT00000112393
Ensembl Acc Id: ENSRNOP00000111862   ⟸   ENSRNOT00000164040
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q561R9-F1-model_v2 AlphaFold Q561R9 1-288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693529
Promoter ID:EPDNEW_R4054
Type:initiation region
Name:Lactb2_1
Description:lactamase, beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.054,982,333 - 4,982,393EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307876 AgrOrtholog
BioCyc Gene G2FUF-42262 BioCyc
Ensembl Genes ENSRNOG00000007829 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000112393.1 UniProtKB/Swiss-Prot
  ENSRNOT00000164040 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  3.60.15.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7388096 IMAGE-MGC_LOAD
InterPro LACTB2-like_MBL-fold UniProtKB/Swiss-Prot
  LACTB2_WH UniProtKB/Swiss-Prot
  Metallo-B-lactamas UniProtKB/Swiss-Prot
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot
  Sec-metab_biosynth-thioest UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:297768 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112672 IMAGE-MGC_LOAD
NCBI Gene 297768 ENTREZGENE
PANTHER ENDORIBONUCLEASE LACTB2 UniProtKB/Swiss-Prot
  ENDORIBONUCLEASE LACTB2 UniProtKB/Swiss-Prot
Pfam BLACT_WH UniProtKB/Swiss-Prot
  Lactamase_B UniProtKB/Swiss-Prot
PhenoGen Lactb2 PhenoGen
RatGTEx ENSRNOG00000007829 RatGTEx
SMART Lactamase_B UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot
UniProt A0A8L2UIE1 ENTREZGENE, UniProtKB/TrEMBL
  A6JFD0_RAT UniProtKB/TrEMBL
  LACB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Lactb2  lactamase, beta 2  Lactb2_predicted  lactamase, beta 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lactb2_predicted  lactamase, beta 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED