Tram1 (translocation associated membrane protein 1) - Rat Genome Database

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Gene: Tram1 (translocation associated membrane protein 1) Rattus norvegicus
Analyze
Symbol: Tram1
Name: translocation associated membrane protein 1
RGD ID: 1359100
Description: Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation; protein insertion into ER membrane; and response to unfolded protein. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TRAM1 (translocation associated membrane protein 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC95042; translocating chain-associated membrane protein 1; translocating chain-associating membrane protein; translocating chain-associating membrane protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905800.1 and NW_007905801.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,425,710 - 10,450,669 (+)NCBIGRCr8
mRatBN7.255,642,579 - 5,667,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,642,546 - 5,686,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx57,780,736 - 7,805,759 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,419,625 - 9,444,647 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,110,778 - 9,135,758 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.055,215,196 - 5,297,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl55,215,196 - 5,316,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0510,062,171 - 10,062,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0510,121,579 - 10,138,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.454,844,208 - 4,869,207 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.154,844,207 - 4,869,206 (+)NCBI
Celera55,235,381 - 5,252,006 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A protein of the endoplasmic reticulum involved early in polypeptide translocation. Gorlich D, etal., Nature 1992 May 7;357(6373):47-52.
4. Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex. Knight BC and High S, Biochem J. 1998 Apr 1;331 ( Pt 1):161-7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8698819   PMID:15489334   PMID:18555783   PMID:21237175   PMID:27105999   PMID:30338452  


Genomics

Comparative Map Data
Tram1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,425,710 - 10,450,669 (+)NCBIGRCr8
mRatBN7.255,642,579 - 5,667,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,642,546 - 5,686,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx57,780,736 - 7,805,759 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,419,625 - 9,444,647 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,110,778 - 9,135,758 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.055,215,196 - 5,297,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl55,215,196 - 5,316,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0510,062,171 - 10,062,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0510,121,579 - 10,138,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.454,844,208 - 4,869,207 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.154,844,207 - 4,869,206 (+)NCBI
Celera55,235,381 - 5,252,006 (+)NCBICelera
Cytogenetic Map5q11NCBI
TRAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38870,573,218 - 70,608,416 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl870,573,218 - 70,608,416 (-)EnsemblGRCh38hg38GRCh38
GRCh37871,485,453 - 71,520,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,648,227 - 71,683,158 (-)NCBINCBI36Build 36hg18NCBI36
Build 34871,648,226 - 71,683,158NCBI
Celera867,483,078 - 67,518,322 (-)NCBICelera
Cytogenetic Map8q13.3NCBI
HuRef866,978,304 - 67,013,532 (-)NCBIHuRef
CHM1_1871,541,019 - 71,576,230 (-)NCBICHM1_1
T2T-CHM13v2.0871,003,150 - 71,038,323 (-)NCBIT2T-CHM13v2.0
Tram1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,634,917 - 13,660,134 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,634,922 - 13,660,134 (-)EnsemblGRCm39 Ensembl
GRCm38113,564,693 - 13,589,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,564,698 - 13,589,910 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,554,783 - 13,579,945 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,549,916 - 13,575,078 (-)NCBIMGSCv36mm8
Celera113,514,581 - 13,539,714 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.18NCBI
Tram1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,110,807 - 9,152,125 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,110,533 - 9,153,585 (+)NCBIChiLan1.0ChiLan1.0
TRAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2786,306,766 - 86,342,548 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1861,936,216 - 61,972,011 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0867,098,588 - 67,133,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1868,759,038 - 68,793,750 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,759,040 - 68,794,303 (-)Ensemblpanpan1.1panPan2
TRAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12919,669,622 - 19,703,707 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,669,628 - 19,703,669 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2919,929,189 - 19,963,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02919,766,644 - 19,800,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2919,766,644 - 19,800,983 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12919,804,740 - 19,838,512 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02919,871,008 - 19,905,124 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02920,151,950 - 20,186,017 (-)NCBIUU_Cfam_GSD_1.0
Tram1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530359,528,340 - 59,551,780 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649615,233,631 - 15,257,140 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649615,233,692 - 15,257,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl464,768,698 - 64,800,508 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1464,768,600 - 64,800,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,399,155 - 70,431,001 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1866,312,103 - 66,344,738 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl866,311,614 - 66,344,840 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603975,081,633 - 75,114,264 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tram1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474420,619,043 - 20,653,438 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474420,618,963 - 20,653,285 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tram1
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:801
Count of miRNA genes:312
Interacting mature miRNAs:401
Transcripts:ENSRNOT00000010481, ENSRNOT00000045373
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)522822265904428Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat

Markers in Region
RH134162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,654,064 - 5,654,247 (+)MAPPERmRatBN7.2
Rnor_6.055,283,820 - 5,284,002NCBIRnor6.0
Rnor_5.0510,124,693 - 10,124,875UniSTSRnor5.0
RGSC_v3.454,855,690 - 4,855,872UniSTSRGSC3.4
Celera55,238,495 - 5,238,677UniSTS
RH 3.4 Map50.0UniSTS
Cytogenetic Map5q11UniSTS
RH136958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,667,272 - 5,667,490 (+)MAPPERmRatBN7.2
Rnor_6.055,297,027 - 5,297,244NCBIRnor6.0
Rnor_5.0510,137,900 - 10,138,117UniSTSRnor5.0
RGSC_v3.454,868,897 - 4,869,114UniSTSRGSC3.4
Celera55,251,696 - 5,251,913UniSTS
Cytogenetic Map5q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 141 227 147 69 147 30 36 250 115 145 57 18
Low 6 9 6
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000010481   ⟹   ENSRNOP00000010481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,642,627 - 5,667,665 (+)Ensembl
Rnor_6.0 Ensembl55,215,196 - 5,297,336 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045373   ⟹   ENSRNOP00000045166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,649,541 - 5,686,971 (+)Ensembl
Rnor_6.0 Ensembl55,279,296 - 5,316,685 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106837   ⟹   ENSRNOP00000096261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,642,546 - 5,667,665 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116001   ⟹   ENSRNOP00000084150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,649,541 - 5,686,971 (+)Ensembl
RefSeq Acc Id: NM_001007701   ⟹   NP_001007702
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,425,710 - 10,450,669 (+)NCBI
mRatBN7.255,642,624 - 5,667,583 (+)NCBI
Rnor_6.055,215,196 - 5,297,337 (+)NCBI
Rnor_5.0510,062,171 - 10,062,451 (+)NCBI
Rnor_5.0510,121,579 - 10,138,210 (+)NCBI
RGSC_v3.454,844,208 - 4,869,207 (+)RGD
Celera55,235,381 - 5,252,006 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001007702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83851 (Get FASTA)   NCBI Sequence Viewer  
  AAQ91025 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010481.4
  ENSRNOP00000045166.1
  ENSRNOP00000084150.1
  ENSRNOP00000096261.1
GenBank Protein Q5XI41 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007702   ⟸   NM_001007701
- UniProtKB: Q5XI41 (UniProtKB/Swiss-Prot),   A0A8L2Q4R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045166   ⟸   ENSRNOT00000045373
Ensembl Acc Id: ENSRNOP00000010481   ⟸   ENSRNOT00000010481
Ensembl Acc Id: ENSRNOP00000084150   ⟸   ENSRNOT00000116001
Ensembl Acc Id: ENSRNOP00000096261   ⟸   ENSRNOT00000106837
Protein Domains
TLC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI41-F1-model_v2 AlphaFold Q5XI41 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693531
Promoter ID:EPDNEW_R4055
Type:initiation region
Name:Tram1_1
Description:translocation associated membrane protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.055,215,246 - 5,215,306EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359100 AgrOrtholog
BioCyc Gene G2FUF-42257 BioCyc
Ensembl Genes ENSRNOG00000007892 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010481.7 UniProtKB/TrEMBL
  ENSRNOT00000045373.2 UniProtKB/TrEMBL
  ENSRNOT00000106837.1 UniProtKB/TrEMBL
  ENSRNOT00000116001.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123274 IMAGE-MGC_LOAD
InterPro TLC-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translocation_assoc_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:312903 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95042 IMAGE-MGC_LOAD
NCBI Gene 312903 ENTREZGENE
PANTHER PTHR12371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TRAM_LAG1_CLN8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tram1 PhenoGen
PIRSF Translocation_assoc_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007892 RatGTEx
SMART TLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZXE6_RAT UniProtKB/TrEMBL
  A0A8I6GLI6_RAT UniProtKB/TrEMBL
  A0A8L2Q4R9 ENTREZGENE, UniProtKB/TrEMBL
  A6JFD3_RAT UniProtKB/TrEMBL
  Q5XI41 ENTREZGENE
  Q6TUH5_RAT UniProtKB/TrEMBL
  TRAM1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tram1  translocation associated membrane protein 1  Tram1  translocating chain-associating membrane protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tram1  translocating chain-associating membrane protein 1  Tram1  translocation associated membrane protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Tram1  translocation associated membrane protein 1    translocating chain-associating membrane protein  Name updated 1299863 APPROVED
2005-07-29 Tram1  translocating chain-associating membrane protein      Symbol and Name status set to provisional 70820 PROVISIONAL