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Strain Registration

Strain: BN/Elh

Symbol: BN/Elh
Strain: BN
Substrain: Elh
RGD ID: 631602
Citation ID: RRID:RGD_631602
Ontology ID: RS:0000137
Type: inbred
Source: Department of Surgery and Biochemistry, University of Otago
Origin: These rats were transferred in 1986, from University of Pittsburgh, at 35 generation to University of Otago, New Zealand and have been continuously inbred in a hysterectomy-derived barrier-sustained colony.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetically Hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Bilusic M, etal., Croat Med J. 2008 Oct;49(5):586-99.
2. Kallikrein binding protein (KBP) maps to rat chromosome 6 but does not cosegregate with blood pressure in a GH x BN cross. Chen A, etal., Mamm Genome 1997 Sep;8(9):701-3.
3. Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross. Harris EL, etal., Clin Exp Pharmacol Physiol 1998 Mar-Apr;25(3-4):204-7.
4. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
5. Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Harris EL, etal., Physiol Genomics 2001 Aug 28;6(3):183-9.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Bp322 Blood pressure QTL 322 arterial blood pressure trait   (VT:2000000)    
Bp323 Blood pressure QTL 323 arterial blood pressure trait   (VT:2000000)    
Bp324 Blood pressure QTL 324 arterial blood pressure trait   (VT:2000000)    
Bp325 Blood pressure QTL 325 arterial blood pressure trait   (VT:2000000)    
Bw81 Body weight QTL 81 body mass   (VT:0001259)    
Cm71 Cardiac mass QTL 71 heart left ventricle mass   (VT:0007031)    
Cm72 Cardiac mass QTL 72 heart left ventricle mass   (VT:0007031)    
Cm73 Cardiac mass QTL 73 heart left ventricle mass   (VT:0007031)    
Vetf1 Vascular elastic tissue fragility QTL 1 aorta elastic tissue integrity trait   (VT:0010556)    
Vetf2 Vascular elastic tissue fragility QTL 2 aorta elastic tissue integrity trait   (VT:0010556)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Ren allele of these rats cosegregates with heart mass in males and not in females. 1357163
strain_phys_biochem Abrupt defects in the elastic laminae of the abdominal aorta characterizes vascular fragility in these animals. 619605