Eya1 (EYA transcriptional coactivator and phosphatase 1) - Rat Genome Database

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Gene: Eya1 (EYA transcriptional coactivator and phosphatase 1) Rattus norvegicus
Analyze
Symbol: Eya1
Name: EYA transcriptional coactivator and phosphatase 1
RGD ID: 1584849
Description: Predicted to enable RNA binding activity; histone H2AXY142 phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of nucleobase-containing compound metabolic process; and protein sumoylation. Predicted to act upstream of or within several processes, including embryonic organ morphogenesis; kidney development; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH acrylamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eyes absent 1; eyes absent 1 homolog; eyes absent 1 homolog (Drosophila); eyes absent homolog 1; eyes absent homolog 1 (Drosophila); LOC108350919; LOC502935; similar to eyes absent 1 isoform a; uncharacterized LOC108350919
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr859,646,599 - 9,884,609 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl59,646,591 - 9,884,614 (+)EnsemblGRCr8
mRatBN7.254,863,501 - 5,101,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl54,955,543 - 5,101,483 (+)EnsemblmRatBN7.2
Rnor_6.054,275,728 - 4,495,525 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,373,626 - 4,513,142 (+)Ensemblrn6Rnor6.0
Rnor_5.054,252,745 - 4,487,853 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.454,132,825 - 4,276,837 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera54,581,829 - 4,692,568 (+)NCBICelera
Celera54,454,356 - 4,554,997 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
5-azacytidine  (ISO)
abacavir  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
dabigatran  (ISO)
diallyl disulfide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethylene glycol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
hydrazine  (ISO)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nilotinib  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
aorta morphogenesis  (ISO)
biological_process  (ND)
branching involved in ureteric bud morphogenesis  (ISO)
cell differentiation  (IBA)
cell fate commitment  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
cochlea morphogenesis  (ISO)
DNA damage response  (IEA)
DNA repair  (IEA)
double-strand break repair  (ISO)
embryonic skeletal system morphogenesis  (ISO)
epithelial cell proliferation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
inner ear morphogenesis  (ISO)
mesodermal cell fate specification  (ISO)
metanephros development  (ISO)
middle ear morphogenesis  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
neuron fate specification  (ISO)
otic vesicle development  (ISO)
otic vesicle morphogenesis  (ISO)
outer ear morphogenesis  (ISO)
outflow tract morphogenesis  (ISO)
pattern specification process  (ISO)
pharyngeal system development  (ISO)
positive regulation of DNA repair  (IBA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of secondary heart field cardioblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein dephosphorylation  (ISO)
protein sumoylation  (ISO)
regulation of neuron differentiation  (ISO)
response to ionizing radiation  (ISO)
semicircular canal morphogenesis  (ISO)
striated muscle tissue development  (ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1. Abdelhak S, etal., Hum Mol Genet. 1997 Dec;6(13):2247-55.
2. Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia. Friedmacher F, etal., J Pediatr Surg. 2014 Feb;49(2):301-4. doi: 10.1016/j.jpedsurg.2013.11.043. Epub 2013 Nov 18.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. Guo C, etal., J Clin Invest. 2011 Apr;121(4):1585-95. doi: 10.1172/JCI44630.
5. EYA1 and SIX1 gene mutations in Japanese patients with branchio-oto-renal (BOR) syndrome and related conditions. Okada M, etal., Pediatr Nephrol. 2006 Apr;21(4):475-81. Epub 2006 Feb 21.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses. Sanggaard KM, etal., Eur J Hum Genet. 2007 Nov;15(11):1121-31. Epub 2007 Jul 18.
13. Muscle-fiber transdifferentiation in an experimental model of respiratory chain myopathy. Venhoff N, etal., Arthritis Res Ther. 2012 Oct 29;14(5):R233.
Additional References at PubMed
PMID:10072433   PMID:10471511   PMID:12070080   PMID:12783782   PMID:14628052   PMID:15496442   PMID:15817220   PMID:16018995   PMID:16024294   PMID:16530750   PMID:16916509   PMID:16990542  
PMID:17098221   PMID:17785448   PMID:19234442   PMID:19497856   PMID:21936910   PMID:22513373  


Genomics

Comparative Map Data
Eya1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr859,646,599 - 9,884,609 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl59,646,591 - 9,884,614 (+)EnsemblGRCr8
mRatBN7.254,863,501 - 5,101,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl54,955,543 - 5,101,483 (+)EnsemblmRatBN7.2
Rnor_6.054,275,728 - 4,495,525 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,373,626 - 4,513,142 (+)Ensemblrn6Rnor6.0
Rnor_5.054,252,745 - 4,487,853 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.454,132,825 - 4,276,837 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera54,581,829 - 4,692,568 (+)NCBICelera
Celera54,454,356 - 4,554,997 (+)NCBICelera
Cytogenetic Map5q11NCBI
EYA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38871,197,433 - 71,548,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl871,197,433 - 71,592,025 (-)Ensemblhg38GRCh38
GRCh37872,109,668 - 72,460,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36872,272,222 - 72,437,021 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34872,272,221 - 72,437,021NCBI
Celera868,106,627 - 68,271,433 (-)NCBICelera
Cytogenetic Map8q13.3NCBI
HuRef867,603,371 - 67,768,504 (-)NCBIHuRef
CHM1_1872,164,260 - 72,329,031 (-)NCBICHM1_1
T2T-CHM13v2.0871,626,530 - 71,983,583 (-)NCBIT2T-CHM13v2.0
Eya1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,239,177 - 14,381,259 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,239,178 - 14,380,459 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38114,168,953 - 14,311,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,168,954 - 14,310,235 (-)Ensemblmm10GRCm38
MGSCv37114,159,039 - 14,300,280 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36114,154,172 - 14,295,413 (-)NCBIMGSCv36mm8
Celera114,109,695 - 14,251,151 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.31NCBI
Eya1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554448,495,530 - 8,655,100 (+)Ensembl
ChiLan1.0NW_0049554448,336,071 - 8,655,041 (+)NCBIChiLan1.0ChiLan1.0
EYA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2786,938,623 - 87,280,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1862,568,011 - 62,730,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0867,728,057 - 68,060,069 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1869,387,769 - 69,551,829 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl869,387,769 - 69,551,829 (-)EnsemblpanPan2panpan1.1
EYA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12920,176,306 - 20,595,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2920,177,014 - 20,525,653 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2920,436,698 - 20,855,121 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02920,275,380 - 20,693,971 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2920,274,650 - 20,771,147 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12920,325,900 - 20,743,158 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02920,378,421 - 20,796,035 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02920,660,077 - 21,078,705 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eya1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530358,739,647 - 59,053,061 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936648395,524 - 546,729 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936648395,526 - 546,705 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EYA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl463,970,807 - 64,328,105 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1463,970,939 - 64,328,107 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2469,915,648 - 69,943,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EYA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1866,902,961 - 67,238,149 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl866,902,972 - 67,060,567 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603974,161,305 - 74,511,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eya1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474419,782,790 - 19,977,335 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474419,782,174 - 19,975,496 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Eya1
2020 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000064946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)519895442Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)5706553510687501Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat

Markers in Region
RH131160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,101,167 - 5,101,387 (+)MAPPERmRatBN7.2
Rnor_6.054,514,798 - 4,515,017NCBIRnor6.0
Rnor_5.054,487,538 - 4,487,757UniSTSRnor5.0
RGSC_v3.454,278,492 - 4,278,711UniSTSRGSC3.4
Celera54,692,253 - 4,692,472UniSTS
Cytogenetic Map5q11UniSTS
BE118841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,087,195 - 5,087,397 (+)MAPPERmRatBN7.2
Rnor_6.054,501,555 - 4,501,756NCBIRnor6.0
Rnor_5.054,474,004 - 4,474,205UniSTSRnor5.0
RGSC_v3.454,261,648 - 4,261,849UniSTSRGSC3.4
Celera54,677,816 - 4,678,017UniSTS
RH 3.4 Map50.0UniSTS
Cytogenetic Map5q11UniSTS
Eya1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,013,761 - 5,014,209 (+)MAPPERmRatBN7.2
Rnor_6.054,424,872 - 4,425,319NCBIRnor6.0
Rnor_5.054,401,233 - 4,401,680UniSTSRnor5.0
Celera54,604,211 - 4,604,658UniSTS
Cytogenetic Map5q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 67 153 62 61 30 41 30 6 272 141 11 131 81 90 31 13 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001843561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001843562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010066461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000064946   ⟹   ENSRNOP00000063439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,738,515 - 9,884,609 (+)Ensembl
mRatBN7.2 Ensembl54,955,543 - 5,101,483 (+)Ensembl
Rnor_6.0 Ensembl54,373,626 - 4,513,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082717   ⟹   ENSRNOP00000070005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,738,745 - 9,884,614 (+)Ensembl
mRatBN7.2 Ensembl54,961,075 - 5,101,483 (+)Ensembl
Rnor_6.0 Ensembl54,393,472 - 4,513,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120692   ⟹   ENSRNOP00000098324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,646,643 - 9,870,209 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120693   ⟹   ENSRNOP00000098325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,646,591 - 9,875,798 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120694   ⟹   ENSRNOP00000098326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,738,774 - 9,884,614 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120695   ⟹   ENSRNOP00000098327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl59,646,614 - 9,870,209 (+)Ensembl
RefSeq Acc Id: NM_001427021   ⟹   NP_001413950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,515 - 9,884,609 (+)NCBI
RefSeq Acc Id: XM_039110905   ⟹   XP_038966833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,501 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110906   ⟹   XP_038966834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,506 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110907   ⟹   XP_038966835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,599 - 9,884,609 (+)NCBI
mRatBN7.254,863,501 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110908   ⟹   XP_038966836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,505 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110909   ⟹   XP_038966837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,504 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110911   ⟹   XP_038966839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,780 - 9,884,609 (+)NCBI
mRatBN7.254,955,650 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110912   ⟹   XP_038966840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,743,980 - 9,884,609 (+)NCBI
mRatBN7.254,960,842 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110913   ⟹   XP_038966841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,737,254 - 9,884,609 (+)NCBI
mRatBN7.254,955,487 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110914   ⟹   XP_038966842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,766,336 - 9,884,609 (+)NCBI
mRatBN7.254,983,203 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110916   ⟹   XP_038966844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,766,336 - 9,884,609 (+)NCBI
mRatBN7.254,983,203 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_063288306   ⟹   XP_063144376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,744,094 - 9,884,609 (+)NCBI
RefSeq Acc Id: XM_063288307   ⟹   XP_063144377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,744,110 - 9,884,609 (+)NCBI
RefSeq Acc Id: XM_063288308   ⟹   XP_063144378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,780 - 9,870,577 (+)NCBI
RefSeq Acc Id: XM_063288309   ⟹   XP_063144379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,780 - 9,884,609 (+)NCBI
RefSeq Acc Id: XR_010066461
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
Ensembl Acc Id: ENSRNOP00000070005   ⟸   ENSRNOT00000082717
Ensembl Acc Id: ENSRNOP00000063439   ⟸   ENSRNOT00000064946
RefSeq Acc Id: XP_038966833   ⟸   XM_039110905
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966835   ⟸   XM_039110907
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966837   ⟸   XM_039110909
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966836   ⟸   XM_039110908
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966834   ⟸   XM_039110906
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966841   ⟸   XM_039110913
- Peptide Label: isoform X6
- UniProtKB: D3ZVI5 (UniProtKB/TrEMBL),   A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966839   ⟸   XM_039110911
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966840   ⟸   XM_039110912
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966842   ⟸   XM_039110914
- Peptide Label: isoform X10
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966844   ⟸   XM_039110916
- Peptide Label: isoform X11
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413950   ⟸   NM_001427021
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144379   ⟸   XM_063288309
- Peptide Label: isoform X9
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144378   ⟸   XM_063288308
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144376   ⟸   XM_063288306
- Peptide Label: isoform X6
- UniProtKB: D3ZVI5 (UniProtKB/TrEMBL),   A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144377   ⟸   XM_063288307
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098327   ⟸   ENSRNOT00000120695
Ensembl Acc Id: ENSRNOP00000098325   ⟸   ENSRNOT00000120693
Ensembl Acc Id: ENSRNOP00000098324   ⟸   ENSRNOT00000120692
Ensembl Acc Id: ENSRNOP00000098326   ⟸   ENSRNOT00000120694

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVI5-F1-model_v2 AlphaFold D3ZVI5 1-592 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584849 AgrOrtholog
BioCyc Gene G2FUF-42274 BioCyc
Ensembl Genes ENSRNOG00000007590 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064946 ENTREZGENE
  ENSRNOT00000064946.4 UniProtKB/TrEMBL
  ENSRNOT00000082717 ENTREZGENE
  ENSRNOT00000082717.2 UniProtKB/TrEMBL
  ENSRNOT00000120692 ENTREZGENE
  ENSRNOT00000120693 ENTREZGENE
  ENSRNOT00000120694 ENTREZGENE
  ENSRNOT00000120695 ENTREZGENE
Gene3D-CATH 3.40.50.12350 UniProtKB/TrEMBL
InterPro EYA_dom UniProtKB/TrEMBL
  EYA_dom_metazoan UniProtKB/TrEMBL
  EYA_dom_sf UniProtKB/TrEMBL
  EYA_fam UniProtKB/TrEMBL
NCBI Gene 502935 ENTREZGENE
PANTHER PTHR10190 UniProtKB/TrEMBL
  PTHR10190:SF11 UniProtKB/TrEMBL
Pfam Hydrolase UniProtKB/TrEMBL
PhenoGen Eya1 PhenoGen
RatGTEx ENSRNOG00000007590 RatGTEx
UniProt A0A0G2JWT3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Eya1  EYA transcriptional coactivator and phosphatase 1  LOC108350919  uncharacterized LOC108350919  Data merged from RGD:11376464 737654 PROVISIONAL
2016-08-02 LOC108350919  uncharacterized LOC108350919      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-06-25 Eya1  EYA transcriptional coactivator and phosphatase 1  Eya1  eyes absent homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-29 Eya1  eyes absent homolog 1 (Drosophila)  Eya1  eyes absent 1 homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Eya1  eyes absent 1 homolog (Drosophila)  LOC502935  similar to eyes absent 1 isoform a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC502935  similar to eyes absent 1 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL