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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | RGD:1618982 | 6480464 | vinylidene chloride results in decreased expression of SBSPON mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | decreases expression | ISO | RGD:1618982 | 6480464 | ethylene dichloride results in decreased expression of SBSPON mRNA | CTD | PMID:28960355 | 17beta-estradiol | increases expression | ISO | RGD:1602645 | 6480464 | Estradiol results in increased expression of SBSPON mRNA | CTD | PMID:25878060 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:1618982 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:1618982 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1602645 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SBSPON mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SBSPON mRNA | CTD | PMID:21215274, PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,7-dihydropurine-6-thione | decreases expression | EXP | | 6480464 | Mercaptopurine results in decreased expression of SBSPON mRNA | CTD | PMID:23358152 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1602645 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SBSPON mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SBSPON mRNA | CTD | PMID:28628672 | 4-nonylphenol | multiple interactions | ISO | RGD:1602645 | 6480464 | [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SBSPON mRNA | CTD | PMID:23626723 | 4-tert-Octylphenol | multiple interactions | ISO | RGD:1602645 | 6480464 | [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SBSPON mRNA | CTD | PMID:23626723 | 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of SBSPON mRNA | CTD | PMID:19483382 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of SBSPON mRNA | CTD | PMID:19483382 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of SBSPON mRNA | CTD | PMID:24780913 | all-trans-retinoic acid | decreases expression | ISO | RGD:1602645 | 6480464 | Tretinoin results in decreased expression of SBSPON mRNA | CTD | PMID:23724009 | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of SBSPON mRNA | CTD | PMID:19483382 | aristolochic acid | increases expression | ISO | RGD:1602645 | 6480464 | aristolochic acid I results in increased expression of SBSPON mRNA | CTD | PMID:33212167 | bazedoxifene | increases expression | ISO | RGD:1602645 | 6480464 | bazedoxifene results in increased expression of SBSPON mRNA | CTD | PMID:19914376 | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of SBSPON mRNA | CTD | PMID:19483382 | benzo[a]pyrene | increases methylation | ISO | RGD:1602645 | 6480464 | Benzo(a)pyrene results in increased methylation of SBSPON exon, Benzo(a)pyrene results in increased methylation of SBSPON promoter | CTD | PMID:27901495 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SBSPON mRNA | CTD | PMID:26496021 | bisphenol A | affects methylation | ISO | RGD:1602645 | 6480464 | bisphenol A affects the methylation of SBSPON gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | RGD:1602645 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SBSPON gene, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SBSPON mRNA | CTD | PMID:28628672, PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SBSPON mRNA | CTD | PMID:25181051 | bisphenol F | increases expression | ISO | RGD:1618982 | 6480464 | bisphenol F results in increased expression of SBSPON mRNA | CTD | PMID:30951980 | chlordecone | increases expression | ISO | RGD:1618982 | 6480464 | Chlordecone results in increased expression of SBSPON mRNA | CTD | PMID:33711761 | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of SBSPON mRNA | CTD | PMID:19483382 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of SBSPON mRNA | CTD | PMID:21865292 | cyclosporin A | decreases expression | ISO | RGD:1602645 | 6480464 | Cyclosporine results in decreased expression of SBSPON mRNA | CTD | PMID:27989131 | cytarabine | decreases expression | ISO | RGD:1602645 | 6480464 | Cytarabine results in decreased expression of SBSPON mRNA | CTD | PMID:21198554 | dexamethasone | multiple interactions | ISO | RGD:1602645 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SBSPON mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SBSPON mRNA | CTD | PMID:28628672 | entinostat | increases expression | ISO | RGD:1602645 | 6480464 | entinostat results in increased expression of SBSPON mRNA | CTD | PMID:27188386 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of SBSPON mRNA | CTD | PMID:23962444 | fulvestrant | multiple interactions | ISO | RGD:1602645 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SBSPON gene | CTD | PMID:31601247 | genistein | decreases expression | ISO | RGD:1618982 | 6480464 | Genistein results in decreased expression of SBSPON mRNA | CTD | PMID:32186404 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SBSPON mRNA | CTD | PMID:22061828 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of SBSPON mRNA | CTD | PMID:21396975 | indometacin | multiple interactions | ISO | RGD:1602645 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SBSPON mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SBSPON mRNA | CTD | PMID:28628672 | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of SBSPON mRNA | CTD | PMID:19483382 | mercaptopurine | decreases expression | EXP | | 6480464 | Mercaptopurine results in decreased expression of SBSPON mRNA | CTD | PMID:23358152 | methotrexate | increases expression | ISO | RGD:1602645 | 6480464 | Methotrexate results in increased expression of SBSPON mRNA | CTD | PMID:24449571 | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of SBSPON mRNA | CTD | PMID:19483382 | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of SBSPON mRNA | CTD | PMID:23665939 | p-tert-Amylphenol | multiple interactions | ISO | RGD:1602645 | 6480464 | [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SBSPON mRNA | CTD | PMID:23626723 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SBSPON mRNA | CTD | PMID:33387578 | PCB138 | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | PCB138 | multiple interactions | ISO | RGD:1618982 | 6480464 | [2 more ... | CTD | PMID:25510870 | pioglitazone | multiple interactions | ISO | RGD:1618982 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SBSPON mRNA | CTD | PMID:27935865 | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of SBSPON mRNA | CTD | PMID:19483382 | purine-6-thiol | decreases expression | EXP | | 6480464 | Mercaptopurine results in decreased expression of SBSPON mRNA | CTD | PMID:23358152 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | RGD:1602645 | 6480464 | S-(1, 2-dichlorovinyl)cysteine results in decreased expression of SBSPON mRNA | CTD | PMID:33725128 | silicon dioxide | decreases expression | ISO | RGD:1602645 | 6480464 | Silicon Dioxide analog results in decreased expression of SBSPON mRNA | CTD | PMID:25895662 | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SBSPON mRNA | CTD | PMID:26496021 | theophylline | decreases expression | ISO | RGD:1602645 | 6480464 | Theophylline results in decreased expression of SBSPON mRNA | CTD | PMID:18951874 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of SBSPON mRNA | CTD | PMID:19483382 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SBSPON mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | RGD:1618982 | 6480464 | titanium dioxide results in decreased expression of SBSPON mRNA | CTD | PMID:23557971 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SBSPON mRNA | CTD | PMID:33387578 | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of SBSPON mRNA | CTD | PMID:30589522 | triptonide | increases expression | ISO | RGD:1618982 | 6480464 | triptonide results in increased expression of SBSPON mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | RGD:1602645 | 6480464 | Valproic Acid results in increased expression of SBSPON mRNA | CTD | PMID:23179753, PMID:28001369 | valproic acid | decreases expression | ISO | RGD:1602645 | 6480464 | Valproic Acid results in decreased expression of SBSPON mRNA | CTD | PMID:29154799 | valproic acid | affects expression | ISO | RGD:1602645 | 6480464 | Valproic Acid affects the expression of SBSPON mRNA | CTD | PMID:25979313 | |