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Strain Registration

Strain: GH/Omr

Symbol: GH/Omr
Strain: GH
Substrain: Omr
Full Name: Genetically Hypertensive
RGD ID: 10016
Citation ID: RRID:RGD_10016
Ontology ID: RS:0000374
Also Known As: 619605
Type: inbred
Available Source: Not Available
Origination: University of Otago Wellcome Med. Res. Inst, New Zealand.
Description: This colony was established from rats of Wistar origin. This is an hysterectomy-derived colony at the University of Otago, which was established from the Wellcome Institute colony at generation 79. These have been inbred for over 90 generations.
Coat Color: Albino
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetically Hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Bilusic M, etal., Croat Med J. 2008 Oct;49(5):586-99.
2. Kallikrein binding protein (KBP) maps to rat chromosome 6 but does not cosegregate with blood pressure in a GH x BN cross. Chen A, etal., Mamm Genome 1997 Sep;8(9):701-3.
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross. Harris EL, etal., Clin Exp Pharmacol Physiol 1998 Mar-Apr;25(3-4):204-7.
6. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
7. Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Harris EL, etal., Physiol Genomics 2001 Aug 28;6(3):183-9.
8. PhysGen Strains PhysGen strains
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Bp322 Blood pressure QTL 322 arterial blood pressure trait   (VT:2000000)    
Bp323 Blood pressure QTL 323 arterial blood pressure trait   (VT:2000000)    
Bp324 Blood pressure QTL 324 arterial blood pressure trait   (VT:2000000)    
Bp325 Blood pressure QTL 325 arterial blood pressure trait   (VT:2000000)    
Bw81 Body weight QTL 81 body mass   (VT:0001259)    
Cm71 Cardiac mass QTL 71 heart left ventricle mass   (VT:0007031)    
Cm72 Cardiac mass QTL 72 heart left ventricle mass   (VT:0007031)    
Cm73 Cardiac mass QTL 73 heart left ventricle mass   (VT:0007031)    
Vetf1 Vascular elastic tissue fragility QTL 1 aorta elastic tissue integrity trait   (VT:0010556)    
Vetf2 Vascular elastic tissue fragility QTL 2 aorta elastic tissue integrity trait   (VT:0010556)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease They have full-blown hypertension but are not proned to internal elastic lamina lesions. 619605
strain_life_disease GH allele of Ace cosegregates with larger heart in males and females. 1357231
strain_life_disease GH allele of Ace cosegregates with increased blood pressure in females 1357231
strain_life_disease GH allele of Npr1 cosegregates with blood pressure in male rats whereas Tnf cosegregates with increased body mass in females. 1357163
strain_life_disease The development of blood pressure is not effected by salt intake. 1357231
strain_life_disease The blood pressure of females is 158 mmHg and of males is 171 mmHg. 629526
strain_other The average weight of females is 182g and of males 251g. 629526
strain_phys_biochem These have some genetic component which interacts with severity of the elastic lesion phenotype. 619605
strain_reproduction The average litter size is 8.1 pups and the average generation time is 47 days. 629526