RGD Reference Report - Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors. - Rat Genome Database

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Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors.

Authors: Wang, L  Tankersley, LR  Tang, M  Potter, JJ  Mezey, E 
Citation: Wang L, etal., Arch Biochem Biophys. 2004 Aug 1;428(1):92-8.
RGD ID: 5688233
Pubmed: PMID:15234273   (View Abstract at PubMed)
DOI: DOI:10.1016/j.abb.2004.05.004   (Journal Full-text)

Retinoic acid (RA) suppresses alpha 2(I) collagen expression in hepatic stellate cells through the binding of retinoic acid receptor beta (RAR beta) and retinoid X receptor alpha (RXR alpha) to RA response elements (RAREs) in the alpha 2(I) collagen promoter. This study determined the influence of coactivators and corepressors to RAR beta and RXR alpha on the regulation of the alpha 2(I) collagen promoter. The coactivators, steroid receptor coactivator-1 (SRC-1) and growth hormone receptor interacting protein-1 (GRIP-1), enhanced, while the nuclear receptor corepressor (N-CoR) abolished the inhibitory effect of RAR beta and RXR alpha on the promoter activity. In the presence of RA, the coactivators SRC-1 and GRIP-1 formed complexes with RAR beta and RXR alpha which are bound to an oligonucleotide specifying a RARE site in the promoter. In conclusion, this study shows that in the presence of retinoic acid, the coactivators SRC-1 and GRIP-1 augment, while the corepressor N-CoR abolishes, the suppressive effects of RAR beta and RXR alpha on alpha 2(I) collagen promoter activity.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Col1a2Ratcellular response to retinoic acid  IEP  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ncoa1Ratnuclear retinoic acid receptor binding  IPIRarb (Rattus norvegicus)in presence of retinoic acidRGD 
Ncoa2Ratnuclear retinoic acid receptor binding  IPIRarb (Rattus norvegicus)in presence of retinoic acidRGD 
Ncor1Ratnuclear retinoic acid receptor binding  IPIRarb (Rattus norvegicus)in absence of retinoic acidRGD 
Ncor2Ratnuclear retinoic acid receptor binding  IPIRarb (Rattus norvegicus)in absence of retinoic acidRGD 
RxraRatnuclear retinoic acid receptor binding  IPIRarb (Rattus norvegicus) RGD 
Ncoa1Ratnuclear retinoid X receptor binding  IPIRxra (Rattus norvegicus)in presence of retinoic acidRGD 
Ncoa2Ratnuclear retinoid X receptor binding  IPIRxra (Rattus norvegicus)in presence of retinoic acidRGD 
Ncor1Ratnuclear retinoid X receptor binding  IPIRxra (Rattus norvegicus)in absence of retinoic acidRGD 
Ncor2Ratnuclear retinoid X receptor binding  IPIRxra (Rattus norvegicus)in absence of retinoic acidRGD 
RarbRatnuclear retinoid X receptor binding  IPIRxra (Rattus norvegicus) RGD 
RarbRatprotein binding  IPINcoa1 (Rattus norvegicus)in presence of retinoic acidRGD 
RarbRatprotein binding  IPINcor2 (Rattus norvegicus)in absence of retinoic acidRGD 
RarbRatprotein binding  IPINcor1 (Rattus norvegicus)in absence of retinoic acidRGD 
RarbRatprotein binding  IPINcoa2 (Rattus norvegicus)in presence of retinoic acidRGD 
RxraRatprotein binding  IPINcoa1 (Rattus norvegicus)in presence of retinoic acidRGD 
RxraRatprotein binding  IPINcor2 (Rattus norvegicus)in absence of retinoic acidRGD 
RxraRatprotein binding  IPINcor1 (Rattus norvegicus)in absence of retinoic acidRGD 
RxraRatprotein binding  IPINcoa2 (Rattus norvegicus)in presence of retinoic acidRGD 
Ncoa1Ratprotein-containing complex binding  IPINcoa2 (Rattus norvegicus) more ... RGD 
Ncoa2Ratprotein-containing complex binding  IPINcoa1 (Rattus norvegicus) more ... RGD 
RarbRatprotein-containing complex binding  IPINcoa1 (Rattus norvegicus) more ... RGD 
RxraRatprotein-containing complex binding  IPINcoa1 (Rattus norvegicus) more ... RGD 

Objects Annotated

Genes (Rattus norvegicus)
Col1a2  (collagen type I alpha 2 chain)
Ncoa1  (nuclear receptor coactivator 1)
Ncoa2  (nuclear receptor coactivator 2)
Ncor1  (nuclear receptor co-repressor 1)
Ncor2  (nuclear receptor co-repressor 2)
Rarb  (retinoic acid receptor, beta)
Rxra  (retinoid X receptor alpha)


Additional Information