ESR2 (estrogen receptor 2) - Rat Genome Database

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Gene: ESR2 (estrogen receptor 2) Homo sapiens
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Symbol: ESR2
Name: estrogen receptor 2
RGD ID: 69213
HGNC Page HGNC:3468
Description: Enables several functions, including estrogen response element binding activity; nuclear estrogen receptor activity; and nuclear receptor activity. Involved in cellular response to lipid and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleoplasm. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Biomarker of several diseases, including Alzheimer's disease; Crohn's disease; aortic valve stenosis; autoimmune disease (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ER beta; ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; estrogen receptor 2 (ER beta); estrogen receptor beta; estrogen receptor beta 2; estrogen receptor beta 4; estrogen receptor beta splice variant, ERbeta2delta7; estrogen receptor beta splice variant, ERbeta4delta7; estrogen receptor beta splice variant, ERbeta6; estrogen receptor beta splice variant, ERbeta6delta7; estrogen receptor beta splice variant, ERbeta7; estrogen receptor beta splice variant, ERbeta7delta7; estrogen receptor beta splice variant, ERbetaEx. 4L; estrogen receptor beta splice variant, ERbetaEx. 6L; NR3A2; nuclear receptor subfamily 3 group A member 2; ODG8; oestrogen receptor beta
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,226,707 - 64,338,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,084,232 - 64,338,112 (-)EnsemblGRCh38hg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBINCBI36Build 36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBICelera
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (EXP)
adenoma  (IEP)
alopecia  (IAGP)
Alzheimer's disease  (IAGP,IEP,ISO)
Animal Mammary Neoplasms  (EXP)
anxiety disorder  (ISO)
aortic valve stenosis  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (EXP)
Blast Crisis  (ISO)
brain ischemia  (ISO)
breast cancer  (IAGP,ISO)
Breast Neoplasms  (EXP,IEP)
carcinoma  (EXP)
Cardiac Arrhythmias  (EXP)
Cocaine-Related Disorders  (EXP)
Cognitive Dysfunction  (IAGP)
colitis  (ISO)
colon cancer  (ISO)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
contact dermatitis  (ISO)
coronary artery disease  (EXP,IAGP)
Coronary Disease  (EXP)
COVID-19  (HEP)
Crohn's disease  (IEP)
cystitis  (ISO)
Deafness  (ISO)
depressive disorder  (ISO)
Endometrial Neoplasms  (EXP)
endometriosis  (EXP,ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Mammary Neoplasms  (EXP,ISO)
Experimental Melanoma  (ISO)
Female Infertility  (EXP,ISO)
genetic disease  (IAGP)
glomerulosclerosis  (ISO)
Graves' disease  (IAGP)
Hand Osteoarthritis  (IAGP)
Hashimoto Disease  (IAGP)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
Hot Flashes  (ISO)
Hyperalgesia  (ISO)
hypertension  (IAGP,ISO)
hypospadias  (IAGP)
in situ carcinoma  (IEP)
inflammatory bowel disease  (ISO)
interstitial cystitis  (ISO)
Knee Osteoarthritis  (IAGP)
Left Ventricular Hypertrophy  (IAGP)
Lithiasis  (EXP)
Lung Injury  (ISO)
malignant astrocytoma  (EXP)
medulloblastoma  (EXP)
melanoma  (IEP)
myasthenia gravis  (IEP)
myeloid leukemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (EXP)
obesity  (ISO)
osteoarthritis  (IAGP)
osteoporosis  (IAGP,ISO)
Osteoporotic Fractures  (IAGP,ISO)
ovarian dysgenesis 8  (IAGP)
Parkinson's disease  (IAGP)
peritonitis  (ISO)
Pituitary Neoplasms  (IEP)
Postmenopausal Osteoporosis  (IAGP)
pre-eclampsia  (IAGP)
primary open angle glaucoma  (IAGP)
prostate cancer  (IAGP)
prostate carcinoma in situ  (EXP,ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (EXP,IEP)
pulmonary hypertension  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (IAGP)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (IAGP,IEP,ISO)
systemic scleroderma  (IAGP)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (EXP)
ulcerative colitis  (IEP)
urinary bladder cancer  (EXP,IEP)
Urination Disorders  (ISO)
Varicose Ulcer  (IAGP)
Vulvar Lichen Sclerosus  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(3-phenoxyphenyl)methanol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (ISO)
1-Hydroxypyrene  (EXP)
1-naphthol  (EXP)
10H-phenothiazine  (EXP)
16-Ketoestrone  (EXP)
17alpha-estradiol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2'-Bisphenol F  (EXP)
2,2'-Dihydroxy-4-methoxybenzophenone  (EXP)
2,2,2-trichloroethanol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (EXP)
2,4,6-Trimethylbenzaldehyde  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (EXP)
2,4-Dihydroxybenzophenone  (EXP)
2,6-diisopropylnaphthalene  (EXP)
2,6-dimethylnaphthalene  (EXP)
2-benzyl-4-chlorophenol  (EXP)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-hydroxyestrone  (EXP)
2-tert-butylhydroquinone  (EXP)
2-tert-Butylphenol  (EXP)
22-Hydroxycholesterol  (EXP)
25-hydroxycholesterol  (EXP)
26-hydroxycholesterol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
3,3'-Dimethylbenzidine  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (EXP)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (EXP)
4-Androstenediol  (ISO)
4-chloro-3,5-dimethylphenol  (EXP)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (EXP,ISO)
4-Hydroxybenzophenone  (EXP)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nitrotoluene  (EXP)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-Propylphenol  (ISO)
4-tert-butylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5alpha-androstane-3alpha,17beta-diol  (ISO)
5alpha-androstane-3beta,17beta-diol  (ISO)
6-oxocampestanol  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
9-phenanthrol  (EXP)
acetochlor  (EXP)
acetophenone  (EXP)
acrylamide  (EXP)
adenosine  (EXP,ISO)
afimoxifene  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldrin  (EXP)
all-trans-phytoene  (EXP)
all-trans-phytofluene  (EXP)
all-trans-retinoic acid  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
androst-4-ene-3,17-dione  (EXP)
androst-5-ene-3beta,17beta-diol  (ISO)
androstane-3,17-diol  (EXP,ISO)
anilines  (EXP)
apigenin  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (EXP,ISO)
azadirachtin A  (EXP,ISO)
bazedoxifene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzophenone  (EXP)
benzyl benzoate  (EXP)
Benzyl parahydroxybenzoate  (EXP)
Benzyl salicylate  (EXP)
beta-carotene  (EXP)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (ISO)
beta-tocopherol  (ISO)
beta-Zearalanol  (ISO)
bexarotene  (EXP,ISO)
bicalutamide  (EXP)
bifenthrin  (EXP)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (EXP)
biphenyl-4-ol  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (EXP)
brassinolide  (EXP)
Bromofos  (EXP)
Bromophos-ethyl  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (EXP)
butylbenzene  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
camptothecin  (EXP)
captan  (ISO)
carbaryl  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP)
cedrol  (EXP)
CGP 52608  (EXP)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chloropropylate  (EXP)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP)
citral  (EXP)
clomiphene  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumaphos  (EXP)
coumestrol  (EXP,ISO)
Cuprizon  (ISO)
cyanazine  (EXP)
Cyanofenphos  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproterone acetate  (EXP)
D-aspartic acid  (ISO)
D-glucose  (EXP)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDD  (EXP)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
Decamethylcyclopentasiloxane  (EXP)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (EXP)
delta-tocopherol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (EXP)
diarylheptanoid  (EXP)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (EXP)
dicofol  (EXP)
Dicyclohexyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dienestrol  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
diniconazole  (EXP)
dioscin  (EXP,ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diphenylmethanol  (EXP)
dipropyl phthalate  (EXP)
disodium selenite  (EXP)
diuron  (EXP)
dodecylamine  (EXP)
doxorubicin  (EXP)
dronedarone  (EXP)
emetine  (EXP)
emodin  (EXP)
endosulfan  (EXP,ISO)
endrin  (EXP)
enilconazole  (EXP,ISO)
enzacamene  (EXP,ISO)
EPN  (EXP)
equilin  (EXP)
equol  (EXP)
estradiol  (ISO)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (ISO)
ethanol  (ISO)
ethion  (EXP)
Ethyl cinnamate  (EXP)
ethyl myristate  (EXP)
ethylparaben  (EXP,ISO)
etoposide  (EXP)
eugenol  (EXP)
fenamiphos  (EXP)
fenarimol  (EXP,ISO)
fenbuconazole  (EXP)
fenhexamid  (EXP)
fenitrothion  (EXP)
fenpyroximate  (EXP)
fenthion  (EXP)
fentin chloride  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (EXP)
fipronil  (EXP)
flavone  (EXP)
flavonoids  (ISO)
fludioxonil  (EXP)
flumethrin  (EXP)
fluoranthene  (EXP)
fluoxastrobin  (EXP)
flutamide  (EXP,ISO)
formononetin  (EXP)
fulvestrant  (EXP,ISO)
galaxolide  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geranial  (EXP)
geraniol  (EXP)
glucose  (EXP)
glycitein  (EXP,ISO)
glycitin  (ISO)
glyphosate  (EXP,ISO)
heptachlor  (EXP)
Heptachlor epoxide  (EXP)
herbicide  (EXP)
hexachlorobenzene  (EXP,ISO)
hexestrol  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
ibuprofen  (ISO)
Icaritin  (EXP)
ICI-164384  (ISO)
imidacloprid  (EXP)
indinavir  (ISO)
indoles  (ISO)
ipriflavone  (EXP)
iprodione  (EXP)
irilone  (EXP)
Isobutylparaben  (EXP,ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (EXP)
isorhamnetin  (EXP)
isotretinoin  (ISO)
kaempferol  (EXP,ISO)
kresoxim-methyl  (EXP)
L-ascorbic acid  (ISO)
lamivudine  (ISO)
lasofoxifene  (ISO)
leptophos  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
luteolin  (EXP)
luteolin 7-O-beta-D-glucoside  (EXP)
lycopene  (EXP)
M1  (EXP)
mancozeb  (EXP)
melatonin  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
mestranol  (EXP,ISO)
metconazole  (EXP)
metformin  (ISO)
methimazole  (ISO)
methiocarb  (EXP)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (EXP)
Methyl palmitate  (EXP)
methylparaben  (EXP)
methylseleninic acid  (EXP)
methyltestosterone  (EXP)
metolachlor  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (EXP)
MK 571  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP,ISO)
monoethyl phthalate  (ISO)
Moxestrol  (ISO)
mycophenolic acid  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-butylbenzenesulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
n-propyl gallate  (EXP)
Nafoxidine  (ISO)
nandrolone  (ISO)
Nandrolone decanoate  (ISO)
napropamide  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Nonylphenol  (EXP,ISO)
norethisterone  (EXP)
Norethynodrel  (ISO)
notoginsenoside R1  (ISO)
nuarimol  (EXP)
O-Desmethylangolensin  (EXP)
octocrylene  (EXP)
ormeloxifene  (ISO)
oryzalin  (EXP)
Osajin  (EXP)
Oxadiazon  (EXP)
oxybenzone  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
p-tolualdehyde  (EXP)
paclitaxel  (EXP)
parathion-methyl  (EXP)
pendimethalin  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenanthrene  (EXP)
phenothrin  (EXP)
PhIP  (ISO)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phthalic acid  (EXP)
phytoestrogen  (EXP)
picoxystrobin  (EXP)
Pomiferin  (EXP)
potassium dichromate  (ISO)
prallethrin  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propamocarb  (EXP)
propargite  (EXP)
propiconazole  (EXP)
propylparaben  (EXP,ISO)
propyzamide  (EXP)
prothiofos  (EXP)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrazoles  (EXP)
pyrene  (EXP)
pyridaben  (EXP)
quercetin  (EXP)
quinalphos  (EXP)
raloxifene  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Rhapontigenin  (EXP)
rifapentine  (EXP)
Rosavin  (EXP)
rotenone  (EXP)
royal jelly  (EXP)
rubitecan  (EXP)
rutin  (ISO)
salicylates  (EXP)
saquinavir  (ISO)
SB 203580  (EXP)
serpentine asbestos  (EXP)
silibinin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium hypochlorite  (EXP)
sophoraflavanone B  (EXP,ISO)
staurosporine  (EXP)
streptozocin  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (EXP)
testosterone  (EXP,ISO)
Testosterone propionate  (EXP)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (ISO)
tetrachlorvinphos  (EXP)
tetradifon  (EXP)
tetralin  (EXP)
tetramethrin  (ISO)
tibolone  (EXP)
tolclofos-methyl  (EXP)
topotecan  (EXP)
toremifene  (EXP,ISO)
toxaphene  (EXP,ISO)
trans-piceid  (ISO)
Tri-2-ethylhexyl trimellitate  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP,ISO)
trifloxystrobin  (EXP)
trifluralin  (EXP)
trifluridine  (EXP)
trilostane  (ISO)
triphenyl phosphate  (EXP)
Triphenylethylene  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
undecan-2-one  (EXP)
Urolithin A  (EXP)
valinomycin  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP,ISO)
vincristine  (EXP)
vinyl carbamate  (ISO)
vitamin D  (EXP)
zearalenone  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (ISO)
androgen receptor signaling pathway  (ISO)
behavioral fear response  (ISO)
brain development  (ISO)
cell population proliferation  (ISO)
cell-cell signaling  (TAS)
cellular response to estradiol stimulus  (IDA,IEA,ISO)
cellular response to estrogen stimulus  (IBA,IEA)
cellular response to lipopolysaccharide  (ISO)
cellular response to magnetism  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebellum development  (ISO)
epithelial cell maturation involved in prostate gland development  (ISO)
epithelial cell proliferation  (ISO)
estrous cycle  (ISO)
female gonad development  (ISO)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (ISO)
intracellular estrogen receptor signaling pathway  (IBA,IDA,IEA,ISO,TAS)
intracellular receptor signaling pathway  (IEA)
intracellular steroid hormone receptor signaling pathway  (ISO)
learning or memory  (ISO)
male gonad development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of behavior  (ISO)
negative regulation of cell growth  (NAS)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
neuron migration  (ISO)
ovarian follicle development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
prostate gland development  (ISO)
prostate gland epithelium morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA,TAS)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (ISO)
response to bisphenol A  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to genistein  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to insecticide  (ISO)
response to lipid  (IEA)
response to nutrient levels  (ISO)
response to organic cyclic compound  (IEA,ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
signal transduction  (TAS)
steroid hormone mediated signaling pathway  (IEA)
uterus development  (ISO)
vagina development  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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93. Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. Rivadeneira F, etal., J Bone Miner Res. 2006 Sep;21(9):1443-56.
94. Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers. Rosa FE, etal., Hum Pathol. 2008 Jan 29;.
95. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.
96. An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, etal., Cell. 2011 May 13;145(4):584-95.
97. Association of Rsa polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis. Sato H, etal., Rheumatol Int. 2011 Apr 27.
98. Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. Sharawy N, etal., Microvasc Res. 2013 Jan;85:118-27. doi: 10.1016/j.mvr.2012.10.002. Epub 2012 Oct 11.
99. Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Shim GJ, etal., Proc Natl Acad Sci U S A 2003 May 27;100(11):6694-9. Epub 2003 May 9.
100. Inner ear pathology and loss of hearing in estrogen receptor-beta deficient mice. Simonoska R, etal., J Endocrinol. 2009 Jun;201(3):397-406. doi: 10.1677/JOE-09-0060. Epub 2009 Mar 17.
101. The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes. Sonestedt E, etal., J Nutr. 2009 May;139(5):993-1001. doi: 10.3945/jn.108.101691. Epub 2009 Mar 25.
102. Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8beta-VE2. Sun J, etal., J Cardiovasc Pharmacol. 2011 Oct;58(4):399-405.
103. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Taylor AH, etal., Br J Dermatol. 2008 Feb;158(2):319-28. Epub 2007 Dec 11.
104. Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. Treeck O, etal., J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):207-11. doi: 10.1016/j.jsbmb.2009.02.012. Epub 2009 Mar 3.
105. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. Tsezou A, etal., Breast. 2008 Apr;17(2):159-66. Epub 2007 Sep 29.
106. Estrogen Rescues Pre-existing Severe Pulmonary Hypertension in Rats. Umar S, etal., Am J Respir Crit Care Med. 2011 Jun 23.
107. Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Wang J, etal., Lupus. 2010 May;19(6):734-40. Epub 2010 Mar 19.
108. Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Wang L, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):703-8. Epub 2003 Jan 6.
109. Estrogen receptor beta mediates acute myocardial protection following ischemia. Wang M, etal., Surgery. 2008 Aug;144(2):233-8. Epub 2008 May 9.
110. Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. Weigt C, etal., Mol Cell Endocrinol. 2012 Apr 4;351(2):227-38. doi: 10.1016/j.mce.2011.12.013. Epub 2011 Dec 30.
111. Association between the estrogen receptor beta gene and age of onset of Parkinson's disease. Westberg L, etal., Psychoneuroendocrinology. 2004 Sep;29(8):993-8.
112. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. Wise BL, etal., J Rheumatol. 2009 Dec;36(12):2772-9. doi: 10.3899/jrheum.081208. Epub 2009 Nov 2.
113. Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: structural comparison with estrogen receptor alpha. Witkowska HE, etal., Steroids. 1997 Aug-Sep;62(8-9):621-31.
114. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
115. Estrogen receptor-beta in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. Xue B, etal., Hypertension. 2013 Jun;61(6):1255-62. doi: 10.1161/HYPERTENSIONAHA.111.00903. Epub 2013 Apr 22.
116. Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Yaffe K, etal., Neurobiol Aging. 2009 Apr;30(4):607-14. Epub 2007 Sep 21.
117. Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. Yang F, etal., Neuroreport. 2014 Jan 22;25(2):100-4. doi: 10.1097/WNR.0000000000000052.
118. Expression of oestrogen receptor-alpha and oestrogen receptor-beta in prostate cancer. Yang GS, etal., Chin Med J (Engl). 2007 Sep 20;120(18):1611-5.
119. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Yip L, etal., Br J Dermatol. 2012 May;166(5):1131-4. doi: 10.1111/j.1365-2133.2011.10702.x. Epub 2012 Mar 5.
120. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. Zhai G, etal., PLoS One. 2013 May 21;8(5):e64445. doi: 10.1371/journal.pone.0064445. Print 2013.
121. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Zheng SL, etal., Cancer Res. 2003 Nov 15;63(22):7624-9.
122. Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. Zheng Y, etal., PLoS One. 2012;7(7):e40494. doi: 10.1371/journal.pone.0040494. Epub 2012 Jul 11.
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124. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Zhu Y, etal., Science 2002 Jan 18;295(5554):505-8.
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PMID:9671811   PMID:9685228   PMID:9765300   PMID:9773978   PMID:9892018   PMID:10352100   PMID:10554010   PMID:10579320   PMID:10598587   PMID:10601611   PMID:10648597   PMID:10667568  
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PMID:29655286   PMID:29661831   PMID:29666032   PMID:29680290   PMID:29684419   PMID:29961922   PMID:30018006   PMID:30022688   PMID:30036658   PMID:30046904   PMID:30049354   PMID:30113650  
PMID:30156935   PMID:30250297   PMID:30257941   PMID:30277666   PMID:30300610   PMID:30389909   PMID:30396310   PMID:30488195   PMID:30550979   PMID:30556843   PMID:30591454   PMID:30660702  
PMID:30669416   PMID:30705367   PMID:30721582   PMID:30737644   PMID:30742303   PMID:30838396   PMID:30864727   PMID:30873822   PMID:30953748   PMID:30971527   PMID:30974833   PMID:30992459  
PMID:30995525   PMID:31163192   PMID:31173821   PMID:31178964   PMID:31200086   PMID:31288527   PMID:31297844   PMID:31322012   PMID:31332160   PMID:31357971   PMID:31412908   PMID:31433456  
PMID:31504401   PMID:31511014   PMID:31595422   PMID:31646926   PMID:31811898   PMID:31847265   PMID:31882419   PMID:31908053   PMID:31928047   PMID:31945389   PMID:32007580   PMID:32054506  
PMID:32108623   PMID:32124842   PMID:32132580   PMID:32144339   PMID:32159700   PMID:32169631   PMID:32218412   PMID:32296183   PMID:32316608   PMID:32333795   PMID:32335869   PMID:32359133  
PMID:32444257   PMID:32448371   PMID:32472323   PMID:32487333   PMID:32544536   PMID:32593802   PMID:32658928   PMID:32853964   PMID:32854465   PMID:32926922   PMID:32985343   PMID:32992652  
PMID:33022573   PMID:33037185   PMID:33092894   PMID:33153202   PMID:33159119   PMID:33176961   PMID:33189448   PMID:33189851   PMID:33278557   PMID:33311801   PMID:33332474   PMID:33339862  
PMID:33348207   PMID:33422777   PMID:33430254   PMID:33456993   PMID:33462142   PMID:33470499   PMID:33514514   PMID:33562134   PMID:33592140   PMID:33660790   PMID:33788729   PMID:33825969  
PMID:33859619   PMID:33952462   PMID:33987175   PMID:34068748   PMID:34077003   PMID:34088265   PMID:34115005   PMID:34147032   PMID:34190995   PMID:34370841   PMID:34461182   PMID:34499926  
PMID:34638689   PMID:34657250   PMID:34671317   PMID:34690921   PMID:34757767   PMID:34860807   PMID:35011656   PMID:35019014   PMID:35033667   PMID:35064116   PMID:35064304   PMID:35162942  
PMID:35285722   PMID:35304506   PMID:35305523   PMID:35573183   PMID:35599350   PMID:35627124   PMID:35792284   PMID:35830136   PMID:35856485   PMID:35872983   PMID:35886868   PMID:36109631  
PMID:36175246   PMID:36223738   PMID:36261089   PMID:36476832   PMID:36577884   PMID:36608623   PMID:36690079   PMID:36769338   PMID:36835157   PMID:36901930   PMID:37075218   PMID:37193881  
PMID:37306500   PMID:37329151   PMID:37335680   PMID:37748565   PMID:37832086   PMID:37862941   PMID:37996888   PMID:38097136   PMID:38281964  


Genomics

Comparative Map Data
ESR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,226,707 - 64,338,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,084,232 - 64,338,112 (-)EnsemblGRCh38hg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBINCBI36Build 36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBICelera
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBIT2T-CHM13v2.0
Esr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)EnsemblGRCm39 Ensembl
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBIMGSCv36mm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
Esr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,589,553 - 100,645,240 (-)NCBIGRCr8
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,252,364 - 95,302,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,550,861 - 95,600,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,979,673 - 95,029,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
Esr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,575,088 - 5,638,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,587,003 - 5,644,765 (+)NCBIChiLan1.0ChiLan1.0
ESR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,338,719 - 65,450,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,555,234 - 64,666,706 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01444,807,875 - 44,919,780 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,064,397 - 63,175,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,064,402 - 63,131,303 (-)Ensemblpanpan1.1panPan2
ESR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,645,917 - 38,715,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,645,430 - 38,702,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,338,303 - 38,407,225 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0838,869,013 - 38,937,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,868,526 - 38,925,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,489,186 - 38,557,866 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,561,325 - 38,629,870 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,921,461 - 38,990,144 (-)NCBIUU_Cfam_GSD_1.0
Esr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,173,041 - 66,235,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364957,956,766 - 8,004,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364957,956,168 - 8,018,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,829,560 - 193,906,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,823,666 - 193,907,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,715,909 - 215,788,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,426,333 - 41,513,802 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,447,224 - 41,512,486 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605329,619,854 - 29,688,619 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Esr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,759,104 - 36,825,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473436,742,913 - 36,862,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ESR2
97 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q23.1-23.3(chr14:59917051-66750803)x1 copy number loss See cases [RCV000050892] Chr14:59917051..66750803 [GRCh38]
Chr14:60383769..67217521 [GRCh37]
Chr14:59453522..66287274 [NCBI36]
Chr14:14q23.1-23.3
pathogenic
GRCh38/hg38 14q22.3-23.3(chr14:57041036-67208231)x1 copy number loss See cases [RCV000051521] Chr14:57041036..67208231 [GRCh38]
Chr14:57507754..67674948 [GRCh37]
Chr14:56577507..66744701 [NCBI36]
Chr14:14q22.3-23.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q23.2-23.3(chr14:62252700-65753416)x1 copy number loss See cases [RCV000138250] Chr14:62252700..65753416 [GRCh38]
Chr14:62719418..66220134 [GRCh37]
Chr14:61789171..65289887 [NCBI36]
Chr14:14q23.2-23.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
NM_182914.2(SYNE2):c.17446G>A (p.Glu5816Lys) single nucleotide variant Malignant melanoma [RCV000070570] Chr14:64177373 [GRCh38]
Chr14:64644091 [GRCh37]
Chr14:63713844 [NCBI36]
Chr14:14q23.2
not provided
NM_001437.3(ESR2):c.1508G>A (p.Cys503Tyr) single nucleotide variant Inborn genetic diseases [RCV003245486] Chr14:64233222 [GRCh38]
Chr14:64699940 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.400G>A (p.Ala134Thr) single nucleotide variant Inborn genetic diseases [RCV003244285] Chr14:64280116 [GRCh38]
Chr14:64746834 [GRCh37]
Chr14:14q23.2
likely benign
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2(chr14:64527206-64782659)x3 copy number gain See cases [RCV000511764] Chr14:64527206..64782659 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.211C>T (p.Arg71Trp) single nucleotide variant Inborn genetic diseases [RCV003258649] Chr14:64282775 [GRCh38]
Chr14:64749493 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1277T>G (p.Leu426Arg) single nucleotide variant not provided [RCV000721934] Chr14:64235099 [GRCh38]
Chr14:64701817 [GRCh37]
Chr14:14q23.2
uncertain significance
GRCh37/hg19 14q23.2(chr14:64709416-64785421)x1 copy number loss not provided [RCV000683581] Chr14:64709416..64785421 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.941A>G (p.Lys314Arg) single nucleotide variant Ovarian dysgenesis 8 [RCV000721932] Chr14:64260460 [GRCh38]
Chr14:64727178 [GRCh37]
Chr14:14q23.2
pathogenic
NM_001437.3(ESR2):c.541_543del (p.Asn181del) deletion not provided [RCV000721933] Chr14:64268904..64268906 [GRCh38]
Chr14:64735622..64735624 [GRCh37]
Chr14:14q23.2
conflicting interpretations of pathogenicity|uncertain significance
NR_073505.1(ESR2):n.2324A>G single nucleotide variant not provided [RCV001609148] Chr14:64227440 [GRCh38]
Chr14:64694158 [GRCh37]
Chr14:14q23.2
benign
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
NM_001437.3(ESR2):c.363-299T>C single nucleotide variant not provided [RCV001679938] Chr14:64280452 [GRCh38]
Chr14:64747170 [GRCh37]
Chr14:14q23.2
benign
NM_001040275.1(ESR2):c.1407-662A>C single nucleotide variant not provided [RCV001647939] Chr14:64228276 [GRCh38]
Chr14:64694994 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1406+258G>C single nucleotide variant not provided [RCV001692955] Chr14:64234712 [GRCh38]
Chr14:64701430 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1176C>G (p.Leu392=) single nucleotide variant not provided [RCV000885234] Chr14:64249595 [GRCh38]
Chr14:64716313 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.633A>G (p.Glu211=) single nucleotide variant not provided [RCV000969368] Chr14:64268814 [GRCh38]
Chr14:64735532 [GRCh37]
Chr14:14q23.2
benign|likely benign
NM_001437.3(ESR2):c.1332C>T (p.Ser444=) single nucleotide variant not provided [RCV000915355] Chr14:64235044 [GRCh38]
Chr14:64701762 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.395G>A (p.Arg132His) single nucleotide variant not provided [RCV000884743] Chr14:64280121 [GRCh38]
Chr14:64746839 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.468A>T (p.Ala156=) single nucleotide variant not provided [RCV000903245] Chr14:64280048 [GRCh38]
Chr14:64746766 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.7A>G (p.Ile3Val) single nucleotide variant not provided [RCV000903246] Chr14:64282979 [GRCh38]
Chr14:64749697 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1101G>A (p.Gly367=) single nucleotide variant not provided [RCV000967868] Chr14:64249670 [GRCh38]
Chr14:64716388 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1237C>G (p.Leu413Val) single nucleotide variant not provided [RCV000895667] Chr14:64235139 [GRCh38]
Chr14:64701857 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.81C>T (p.His27=) single nucleotide variant not provided [RCV000886501] Chr14:64282905 [GRCh38]
Chr14:64749623 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.705C>T (p.Ala235=) single nucleotide variant not provided [RCV000920121] Chr14:64260696 [GRCh38]
Chr14:64727414 [GRCh37]
Chr14:14q23.2
likely benign
NM_001040275.1(ESR2):c.1407-417A>C single nucleotide variant not provided [RCV001659489] Chr14:64228031 [GRCh38]
Chr14:64694749 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1092-296T>G single nucleotide variant not provided [RCV001673957] Chr14:64249975 [GRCh38]
Chr14:64716693 [GRCh37]
Chr14:14q23.2
benign
NM_001291712.2(ESR2):c.-91+2334T>G single nucleotide variant not provided [RCV001619667] Chr14:64295199 [GRCh38]
Chr14:64761917 [GRCh37]
Chr14:14q23.2
benign
NR_073505.1(ESR2):n.2287G>A single nucleotide variant not provided [RCV001710028] Chr14:64227477 [GRCh38]
Chr14:64694195 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.363-71dup duplication not provided [RCV001689021] Chr14:64280215..64280216 [GRCh38]
Chr14:64746933..64746934 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1092-232T>G single nucleotide variant not provided [RCV001676801] Chr14:64249911 [GRCh38]
Chr14:64716629 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.984G>A (p.Val328=) single nucleotide variant not provided [RCV001616556] Chr14:64257333 [GRCh38]
Chr14:64724051 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.653-6C>T single nucleotide variant not provided [RCV000932406] Chr14:64260754 [GRCh38]
Chr14:64727472 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.335C>T (p.Ser112Leu) single nucleotide variant not provided [RCV000929733] Chr14:64282651 [GRCh38]
Chr14:64749369 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.45C>T (p.Ser15=) single nucleotide variant not provided [RCV000972504] Chr14:64282941 [GRCh38]
Chr14:64749659 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1323T>C (p.Ile441=) single nucleotide variant not provided [RCV000959131] Chr14:64235053 [GRCh38]
Chr14:64701771 [GRCh37]
Chr14:14q23.2
benign|likely benign
NM_001437.3(ESR2):c.808C>T (p.Leu270Phe) single nucleotide variant not provided [RCV000910912] Chr14:64260593 [GRCh38]
Chr14:64727311 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1542G>A (p.Pro514=) single nucleotide variant not provided [RCV000933443] Chr14:64233188 [GRCh38]
Chr14:64699906 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.748G>A (p.Gly250Ser) single nucleotide variant not provided [RCV000933799] Chr14:64260653 [GRCh38]
Chr14:64727371 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.661A>G (p.Arg221Gly) single nucleotide variant not provided [RCV000890454] Chr14:64260740 [GRCh38]
Chr14:64727458 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1011G>A (p.Glu337=) single nucleotide variant not provided [RCV000889727] Chr14:64257306 [GRCh38]
Chr14:64724024 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.630C>T (p.Tyr210=) single nucleotide variant not provided [RCV000889728] Chr14:64268817 [GRCh38]
Chr14:64735535 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.369A>C (p.Thr123=) single nucleotide variant not provided [RCV000911553] Chr14:64280147 [GRCh38]
Chr14:64746865 [GRCh37]
Chr14:14q23.2
likely benign
NR_073505.1(ESR2):n.2400A>G single nucleotide variant not provided [RCV001637137] Chr14:64227364 [GRCh38]
Chr14:64694082 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.363-71_363-70dup duplication not provided [RCV001688858] Chr14:64280215..64280216 [GRCh38]
Chr14:64746933..64746934 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1407-258C>T single nucleotide variant not provided [RCV001608596] Chr14:64233581 [GRCh38]
Chr14:64700299 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.*39G>A single nucleotide variant not provided [RCV001675307] Chr14:64233098 [GRCh38]
Chr14:64699816 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1407-4A>G single nucleotide variant not provided [RCV001678343] Chr14:64233327 [GRCh38]
Chr14:64700045 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1406+242A>G single nucleotide variant not provided [RCV001645748] Chr14:64234728 [GRCh38]
Chr14:64701446 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.652+17C>T single nucleotide variant not provided [RCV001612282] Chr14:64268778 [GRCh38]
Chr14:64735496 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1406+232G>C single nucleotide variant not provided [RCV001695926] Chr14:64234738 [GRCh38]
Chr14:64701456 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.*4768T>C single nucleotide variant not provided [RCV001666635] Chr14:64228369 [GRCh38]
Chr14:64695087 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.653-237_653-236del deletion not provided [RCV001693979] Chr14:64260984..64260985 [GRCh38]
Chr14:64727702..64727703 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.1406+44T>C single nucleotide variant not provided [RCV001684722] Chr14:64234926 [GRCh38]
Chr14:64701644 [GRCh37]
Chr14:14q23.2
benign
GRCh37/hg19 14q23.1-23.3(chr14:61409856-65742610)x3 copy number gain not provided [RCV001259780] Chr14:61409856..65742610 [GRCh37]
Chr14:14q23.1-23.3
likely pathogenic
GRCh37/hg19 14q23.2(chr14:64399555-64748326)x3 copy number gain not provided [RCV001259782] Chr14:64399555..64748326 [GRCh37]
Chr14:14q23.2
uncertain significance
GRCh37/hg19 14q23.2-23.3(chr14:64016496-65834490)x3 copy number gain See cases [RCV002285053] Chr14:64016496..65834490 [GRCh37]
Chr14:14q23.2-23.3
uncertain significance
NM_001437.3(ESR2):c.1407-251G>A single nucleotide variant not provided [RCV001674611] Chr14:64233574 [GRCh38]
Chr14:64700292 [GRCh37]
Chr14:14q23.2
benign
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3
likely pathogenic
NM_001437.3(ESR2):c.60A>G (p.Gln20=) single nucleotide variant not provided [RCV001726915] Chr14:64282926 [GRCh38]
Chr14:64749644 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1504G>A (p.Gly502Arg) single nucleotide variant Inborn genetic diseases [RCV003252252] Chr14:64233226 [GRCh38]
Chr14:64699944 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.693A>G (p.Arg231=) single nucleotide variant not provided [RCV001815761] Chr14:64260708 [GRCh38]
Chr14:64727426 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.298G>A (p.Ala100Thr) single nucleotide variant not provided [RCV001896787] Chr14:64282688 [GRCh38]
Chr14:64749406 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1185dup (p.Glu396fs) duplication not provided [RCV001891415] Chr14:64249585..64249586 [GRCh38]
Chr14:64716303..64716304 [GRCh37]
Chr14:14q23.2
uncertain significance
NC_000014.8:g.(?_64746679)_(66975329_?)del deletion Sulfite oxidase deficiency due to molybdenum cofactor deficiency type C [RCV002007295] Chr14:64746679..66975329 [GRCh37]
Chr14:14q23.2-23.3
pathogenic
NM_001437.3(ESR2):c.757C>A (p.Pro253Thr) single nucleotide variant not provided [RCV001989705] Chr14:64260644 [GRCh38]
Chr14:64727362 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.64A>G (p.Ile22Val) single nucleotide variant Inborn genetic diseases [RCV002555807]|not provided [RCV001920432] Chr14:64282922 [GRCh38]
Chr14:64749640 [GRCh37]
Chr14:14q23.2
likely benign|uncertain significance
NM_001437.3(ESR2):c.1525G>T (p.Gly509Trp) single nucleotide variant not provided [RCV001936968] Chr14:64233205 [GRCh38]
Chr14:64699923 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.728G>A (p.Gly243Asp) single nucleotide variant not provided [RCV001925797] Chr14:64260673 [GRCh38]
Chr14:64727391 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1260T>A (p.Ala420=) single nucleotide variant not provided [RCV002190664] Chr14:64235116 [GRCh38]
Chr14:64701834 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.846C>T (p.Ile282=) single nucleotide variant not provided [RCV002189650] Chr14:64260555 [GRCh38]
Chr14:64727273 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.535+14G>A single nucleotide variant not provided [RCV002114668] Chr14:64279967 [GRCh38]
Chr14:64746685 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.783C>T (p.Asp261=) single nucleotide variant not provided [RCV002133006] Chr14:64260618 [GRCh38]
Chr14:64727336 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.801G>T (p.Gln267His) single nucleotide variant not provided [RCV002171444] Chr14:64260600 [GRCh38]
Chr14:64727318 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.362+19C>A single nucleotide variant not provided [RCV002146608] Chr14:64282605 [GRCh38]
Chr14:64749323 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.953-19C>T single nucleotide variant not provided [RCV002156868] Chr14:64257383 [GRCh38]
Chr14:64724101 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.300G>A (p.Ala100=) single nucleotide variant not provided [RCV003110888] Chr14:64282686 [GRCh38]
Chr14:64749404 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1036C>T (p.Arg346Cys) single nucleotide variant not provided [RCV003115851] Chr14:64257281 [GRCh38]
Chr14:64723999 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.82G>A (p.Gly28Ser) single nucleotide variant Inborn genetic diseases [RCV003252647] Chr14:64282904 [GRCh38]
Chr14:64749622 [GRCh37]
Chr14:14q23.2
uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33
pathogenic
NM_001437.3(ESR2):c.844A>G (p.Ile282Val) single nucleotide variant not provided [RCV002511780] Chr14:64260557 [GRCh38]
Chr14:64727275 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.904G>T (p.Ala302Ser) single nucleotide variant Inborn genetic diseases [RCV002778192] Chr14:64260497 [GRCh38]
Chr14:64727215 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1526G>T (p.Gly509Val) single nucleotide variant not provided [RCV002971415] Chr14:64233204 [GRCh38]
Chr14:64699922 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.853C>T (p.Pro285Ser) single nucleotide variant Inborn genetic diseases [RCV002992877] Chr14:64260548 [GRCh38]
Chr14:64727266 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.199G>A (p.Gly67Ser) single nucleotide variant not provided [RCV002947560] Chr14:64282787 [GRCh38]
Chr14:64749505 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.460G>A (p.Asp154Asn) single nucleotide variant Inborn genetic diseases [RCV003357986]|not provided [RCV002706659] Chr14:64280056 [GRCh38]
Chr14:64746774 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1229T>C (p.Met410Thr) single nucleotide variant Inborn genetic diseases [RCV002870630] Chr14:64235147 [GRCh38]
Chr14:64701865 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.475T>C (p.Tyr159His) single nucleotide variant not provided [RCV002820339] Chr14:64280041 [GRCh38]
Chr14:64746759 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1280C>T (p.Ala427Val) single nucleotide variant not provided [RCV002948651] Chr14:64235096 [GRCh38]
Chr14:64701814 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1317G>T (p.Trp439Cys) single nucleotide variant Inborn genetic diseases [RCV002822748] Chr14:64235059 [GRCh38]
Chr14:64701777 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.105C>T (p.Ser35=) single nucleotide variant not provided [RCV002885362] Chr14:64282881 [GRCh38]
Chr14:64749599 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.506G>T (p.Cys169Phe) single nucleotide variant not provided [RCV003054427] Chr14:64280010 [GRCh38]
Chr14:64746728 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.619C>T (p.Arg207Trp) single nucleotide variant not provided [RCV002790524] Chr14:64268828 [GRCh38]
Chr14:64735546 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1102A>G (p.Lys368Glu) single nucleotide variant Inborn genetic diseases [RCV002804982] Chr14:64249669 [GRCh38]
Chr14:64716387 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1331G>A (p.Ser444Asn) single nucleotide variant not provided [RCV002932582] Chr14:64235045 [GRCh38]
Chr14:64701763 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.536-16T>C single nucleotide variant not provided [RCV003059461] Chr14:64268927 [GRCh38]
Chr14:64735645 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1584G>A (p.Gln528=) single nucleotide variant not provided [RCV002573978] Chr14:64233146 [GRCh38]
Chr14:64699864 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1163G>A (p.Arg388Gln) single nucleotide variant Inborn genetic diseases [RCV002803778] Chr14:64249608 [GRCh38]
Chr14:64716326 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1582_1583del (p.Gln528fs) microsatellite not provided [RCV002581934] Chr14:64233147..64233148 [GRCh38]
Chr14:64699865..64699866 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.495G>A (p.Ser165=) single nucleotide variant not provided [RCV002961991] Chr14:64280021 [GRCh38]
Chr14:64746739 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.761G>C (p.Arg254Pro) single nucleotide variant Inborn genetic diseases [RCV002714020] Chr14:64260640 [GRCh38]
Chr14:64727358 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1151C>T (p.Thr384Ile) single nucleotide variant Inborn genetic diseases [RCV002812515] Chr14:64249620 [GRCh38]
Chr14:64716338 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1545A>G (p.Ala515=) single nucleotide variant not provided [RCV002942180] Chr14:64233185 [GRCh38]
Chr14:64699903 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.394C>G (p.Arg132Gly) single nucleotide variant not provided [RCV002582485] Chr14:64280122 [GRCh38]
Chr14:64746840 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1385T>C (p.Leu462Pro) single nucleotide variant not provided [RCV002588621] Chr14:64234991 [GRCh38]
Chr14:64701709 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.953-10C>T single nucleotide variant not provided [RCV002942132] Chr14:64257374 [GRCh38]
Chr14:64724092 [GRCh37]
Chr14:14q23.2
benign
NM_001437.3(ESR2):c.871G>A (p.Glu291Lys) single nucleotide variant Inborn genetic diseases [RCV003202137] Chr14:64260530 [GRCh38]
Chr14:64727248 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.755C>T (p.Ala252Val) single nucleotide variant Inborn genetic diseases [RCV003178628] Chr14:64260646 [GRCh38]
Chr14:64727364 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.1058A>T (p.Lys353Met) single nucleotide variant Inborn genetic diseases [RCV003378893] Chr14:64257259 [GRCh38]
Chr14:64723977 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.736A>G (p.Lys246Glu) single nucleotide variant Inborn genetic diseases [RCV003355088] Chr14:64260665 [GRCh38]
Chr14:64727383 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1216C>G (p.Leu406Val) single nucleotide variant Inborn genetic diseases [RCV003366469] Chr14:64249555 [GRCh38]
Chr14:64716273 [GRCh37]
Chr14:14q23.2
uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33
pathogenic
GRCh37/hg19 14q22.3-24.1(chr14:57588965-68334517)x3 copy number gain not provided [RCV003485034] Chr14:57588965..68334517 [GRCh37]
Chr14:14q22.3-24.1
likely pathogenic
NM_001437.3(ESR2):c.712_732del (p.Gln238_Lys244del) deletion not provided [RCV003695638] Chr14:64260669..64260689 [GRCh38]
Chr14:64727387..64727407 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.504A>T (p.Gly168=) single nucleotide variant not provided [RCV003661175] Chr14:64280012 [GRCh38]
Chr14:64746730 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.689G>A (p.Arg230Gln) single nucleotide variant not provided [RCV003739775] Chr14:64260712 [GRCh38]
Chr14:64727430 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.666G>A (p.Glu222=) single nucleotide variant not provided [RCV003713752] Chr14:64260735 [GRCh38]
Chr14:64727453 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.428A>G (p.Lys143Arg) single nucleotide variant not provided [RCV003580166] Chr14:64280088 [GRCh38]
Chr14:64746806 [GRCh37]
Chr14:14q23.2
uncertain significance
NM_001437.3(ESR2):c.1092-13C>T single nucleotide variant not provided [RCV003810869] Chr14:64249692 [GRCh38]
Chr14:64716410 [GRCh37]
Chr14:14q23.2
likely benign
NM_001437.3(ESR2):c.232G>T (p.Val78Leu) single nucleotide variant not provided [RCV003699644] Chr14:64282754 [GRCh38]
Chr14:64749472 [GRCh37]
Chr14:14q23.2
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR92A2hsa-miR-92a-3pMirtarbaseexternal_infoGFP reporter assayFunctional MTI20484043
MIR92A2hsa-miR-92a-3pOncomiRDBexternal_infoNANA20484043
MIR92Bhsa-miR-92b-3pOncomiRDBexternal_infoNANA20484043

Predicted Target Of
Summary Value
Count of predictions:4781
Count of miRNA genes:1297
Interacting mature miRNAs:1694
Transcripts:ENST00000267525, ENST00000341099, ENST00000344288, ENST00000353772, ENST00000357782, ENST00000358599, ENST00000542956, ENST00000553796, ENST00000554520, ENST00000554572, ENST00000555278, ENST00000555483, ENST00000555783, ENST00000556275, ENST00000557772
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D14S1026  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,720,245 - 64,720,388UniSTSGRCh37
Build 361463,789,998 - 63,790,141RGDNCBI36
Celera1444,777,952 - 44,778,097RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,892,780 - 44,892,927UniSTS
Marshfield Genetic Map1469.18RGD
Marshfield Genetic Map1469.18UniSTS
Genethon Genetic Map1458.5UniSTS
deCODE Assembly Map1463.85UniSTS
Whitehead-YAC Contig Map14 UniSTS
RH71305  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,699,811 - 64,699,988UniSTSGRCh37
Build 361463,769,564 - 63,769,741RGDNCBI36
Celera1444,757,520 - 44,757,697RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,872,393 - 44,872,570UniSTS
GeneMap99-GB4 RH Map14153.14UniSTS
NCBI RH Map14647.8UniSTS
G35720  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,737,517 - 64,737,859UniSTSGRCh37
Build 361463,807,270 - 63,807,612RGDNCBI36
Celera1444,795,227 - 44,795,569RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,910,057 - 44,910,399UniSTS
PMC29094P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,720,235 - 64,720,395UniSTSGRCh37
Build 361463,789,988 - 63,790,148RGDNCBI36
Celera1444,777,942 - 44,778,104RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,892,770 - 44,892,934UniSTS
G35928  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,551,036 - 64,551,162UniSTSGRCh37
Build 361463,620,789 - 63,620,915RGDNCBI36
Celera1444,608,740 - 44,608,866RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,724,024 - 44,724,150UniSTS
G36178  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,707,900 - 64,708,054UniSTSGRCh37
Build 361463,777,653 - 63,777,807RGDNCBI36
Celera1444,765,609 - 44,765,763RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,880,482 - 44,880,636UniSTS
G36177  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,712,622 - 64,712,730UniSTSGRCh37
Build 361463,782,375 - 63,782,483RGDNCBI36
Celera1444,770,330 - 44,770,438RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,885,204 - 44,885,312UniSTS
G35938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,774,592 - 64,774,809UniSTSGRCh37
Build 361463,844,345 - 63,844,562RGDNCBI36
Celera1444,832,302 - 44,832,519RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,947,131 - 44,947,348UniSTS
G36170  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371464,712,293 - 64,712,400UniSTSGRCh37
Build 361463,782,046 - 63,782,153RGDNCBI36
Celera1444,770,001 - 44,770,108RGD
Cytogenetic Map14q23.2UniSTS
HuRef1444,884,875 - 44,884,982UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 18 1 12
Low 416 233 1093 157 1105 50 2023 396 997 129 1091 1015 109 880 1041 1
Below cutoff 1985 2741 564 403 776 350 2305 1781 2678 261 324 564 61 324 1747 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001040275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001214902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047431076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047431077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047431078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001750187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB006590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF014796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF060555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF124790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF191544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF215937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL161756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY438022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY640407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY785359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX094834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX247957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN366005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ777076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ777077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ838582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ838583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ692820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ692821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC604512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC777388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC122972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC515463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC515464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OK188992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000267525   ⟹   ENSP00000267525
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,233,029 - 64,283,075 (-)Ensembl
RefSeq Acc Id: ENST00000341099   ⟹   ENSP00000343925
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,228,317 - 64,294,371 (-)Ensembl
RefSeq Acc Id: ENST00000344288   ⟹   ENSP00000345616
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,227,506 - 64,283,036 (-)Ensembl
RefSeq Acc Id: ENST00000353772   ⟹   ENSP00000335551
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,227,035 - 64,294,410 (-)Ensembl
RefSeq Acc Id: ENST00000358599   ⟹   ENSP00000351412
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,227,427 - 64,338,112 (-)Ensembl
RefSeq Acc Id: ENST00000553796   ⟹   ENSP00000452426
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,227,818 - 64,282,985 (-)Ensembl
RefSeq Acc Id: ENST00000554520
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,233,070 - 64,282,813 (-)Ensembl
RefSeq Acc Id: ENST00000554572   ⟹   ENSP00000450699
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,226,707 - 64,338,096 (-)Ensembl
RefSeq Acc Id: ENST00000555278   ⟹   ENSP00000450488
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,227,453 - 64,282,985 (-)Ensembl
RefSeq Acc Id: ENST00000555483
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,233,029 - 64,282,842 (-)Ensembl
RefSeq Acc Id: ENST00000555783
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,235,063 - 64,260,527 (-)Ensembl
RefSeq Acc Id: ENST00000556275   ⟹   ENSP00000452485
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,084,232 - 64,294,410 (-)Ensembl
RefSeq Acc Id: ENST00000557772   ⟹   ENSP00000451582
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,230,918 - 64,282,985 (-)Ensembl
RefSeq Acc Id: NM_001040275   ⟹   NP_001035365
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,227,033 - 64,294,410 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)ENTREZGENE
Build 361463,763,504 - 63,830,881 (-)NCBI Archive
HuRef1444,866,333 - 44,977,880 (-)ENTREZGENE
CHM1_11464,633,573 - 64,700,955 (-)NCBI
T2T-CHM13v2.01458,434,748 - 58,502,125 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001214902   ⟹   NP_001201831
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,227,033 - 64,283,075 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)ENTREZGENE
HuRef1444,866,333 - 44,977,880 (-)ENTREZGENE
CHM1_11464,633,573 - 64,689,620 (-)NCBI
T2T-CHM13v2.01458,434,748 - 58,490,790 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271876   ⟹   NP_001258805
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,227,818 - 64,283,075 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBI
CHM1_11464,634,358 - 64,689,620 (-)NCBI
T2T-CHM13v2.01458,435,533 - 58,490,790 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271877   ⟹   NP_001258806
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,233,029 - 64,283,075 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBI
CHM1_11464,639,564 - 64,689,620 (-)NCBI
T2T-CHM13v2.01458,440,744 - 58,490,790 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291712   ⟹   NP_001278641
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,226,707 - 64,338,613 (-)NCBI
CHM1_11464,633,252 - 64,745,077 (-)NCBI
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291723   ⟹   NP_001278652
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,227,033 - 64,338,550 (-)NCBI
CHM1_11464,633,573 - 64,745,077 (-)NCBI
T2T-CHM13v2.01458,434,748 - 58,546,254 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001437   ⟹   NP_001428
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,228,317 - 64,294,371 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)ENTREZGENE
Build 361463,769,500 - 63,830,881 (-)NCBI Archive
HuRef1444,866,333 - 44,977,880 (-)ENTREZGENE
CHM1_11464,639,564 - 64,700,955 (-)NCBI
T2T-CHM13v2.01458,436,032 - 58,502,086 (-)NCBI
Sequence:
RefSeq Acc Id: NR_073496
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,226,707 - 64,338,613 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBI
CHM1_11464,633,573 - 64,745,077 (-)NCBI
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBI
Sequence:
RefSeq Acc Id: NR_073497
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,233,029 - 64,283,075 (-)NCBI
GRCh371464,693,751 - 64,805,268 (-)NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBI
CHM1_11464,639,564 - 64,689,620 (-)NCBI
T2T-CHM13v2.01458,440,744 - 58,490,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047431076   ⟹   XP_047287032
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,227,033 - 64,338,613 (-)NCBI
RefSeq Acc Id: XM_047431077   ⟹   XP_047287033
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,227,818 - 64,338,613 (-)NCBI
RefSeq Acc Id: XM_047431078   ⟹   XP_047287034
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,249,568 - 64,338,613 (-)NCBI
RefSeq Acc Id: XM_054375559   ⟹   XP_054231534
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBI
RefSeq Acc Id: XM_054375560   ⟹   XP_054231535
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01458,434,748 - 58,546,317 (-)NCBI
RefSeq Acc Id: XM_054375561   ⟹   XP_054231536
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01458,435,533 - 58,546,317 (-)NCBI
RefSeq Acc Id: XM_054375562   ⟹   XP_054231537
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01458,457,280 - 58,546,317 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001035365 (Get FASTA)   NCBI Sequence Viewer  
  NP_001201831 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258805 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258806 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278641 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278652 (Get FASTA)   NCBI Sequence Viewer  
  NP_001428 (Get FASTA)   NCBI Sequence Viewer  
  XP_047287032 (Get FASTA)   NCBI Sequence Viewer  
  XP_047287033 (Get FASTA)   NCBI Sequence Viewer  
  XP_047287034 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231534 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231535 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231536 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231537 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC05751 (Get FASTA)   NCBI Sequence Viewer  
  AAC05985 (Get FASTA)   NCBI Sequence Viewer  
  AAC15234 (Get FASTA)   NCBI Sequence Viewer  
  AAC25602 (Get FASTA)   NCBI Sequence Viewer  
  AAC25603 (Get FASTA)   NCBI Sequence Viewer  
  AAC39784 (Get FASTA)   NCBI Sequence Viewer  
  AAC39785 (Get FASTA)   NCBI Sequence Viewer  
  AAD32580 (Get FASTA)   NCBI Sequence Viewer  
  AAG29940 (Get FASTA)   NCBI Sequence Viewer  
  AAH24181 (Get FASTA)   NCBI Sequence Viewer  
  AAV31779 (Get FASTA)   NCBI Sequence Viewer  
  ABG88022 (Get FASTA)   NCBI Sequence Viewer  
  ABH09189 (Get FASTA)   NCBI Sequence Viewer  
  ABH09190 (Get FASTA)   NCBI Sequence Viewer  
  ADZ17331 (Get FASTA)   NCBI Sequence Viewer  
  ADZ17332 (Get FASTA)   NCBI Sequence Viewer  
  AHW56473 (Get FASTA)   NCBI Sequence Viewer  
  BAA24953 (Get FASTA)   NCBI Sequence Viewer  
  BAA31966 (Get FASTA)   NCBI Sequence Viewer  
  BAD92857 (Get FASTA)   NCBI Sequence Viewer  
  BAF85059 (Get FASTA)   NCBI Sequence Viewer  
  BBF89161 (Get FASTA)   NCBI Sequence Viewer  
  BBF89162 (Get FASTA)   NCBI Sequence Viewer  
  BBF89163 (Get FASTA)   NCBI Sequence Viewer  
  BBF89164 (Get FASTA)   NCBI Sequence Viewer  
  BBF89165 (Get FASTA)   NCBI Sequence Viewer  
  BBF89166 (Get FASTA)   NCBI Sequence Viewer  
  BBF89167 (Get FASTA)   NCBI Sequence Viewer  
  BBF89168 (Get FASTA)   NCBI Sequence Viewer  
  BBQ09561 (Get FASTA)   NCBI Sequence Viewer  
  BBQ09562 (Get FASTA)   NCBI Sequence Viewer  
  CAA67555 (Get FASTA)   NCBI Sequence Viewer  
  CAD62297 (Get FASTA)   NCBI Sequence Viewer  
  CEF39419 (Get FASTA)   NCBI Sequence Viewer  
  EAW80845 (Get FASTA)   NCBI Sequence Viewer  
  EAW80846 (Get FASTA)   NCBI Sequence Viewer  
  EAW80847 (Get FASTA)   NCBI Sequence Viewer  
  EAW80848 (Get FASTA)   NCBI Sequence Viewer  
  EAW80849 (Get FASTA)   NCBI Sequence Viewer  
  EAW80850 (Get FASTA)   NCBI Sequence Viewer  
  EAW80851 (Get FASTA)   NCBI Sequence Viewer  
  EAW80852 (Get FASTA)   NCBI Sequence Viewer  
  EAW80853 (Get FASTA)   NCBI Sequence Viewer  
  EAW80854 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000267525
  ENSP00000267525.6
  ENSP00000335551
  ENSP00000335551.4
  ENSP00000343925
  ENSP00000343925.4
  ENSP00000345616
  ENSP00000345616.6
  ENSP00000351412
  ENSP00000351412.5
  ENSP00000450488
  ENSP00000450488.1
  ENSP00000450699
  ENSP00000450699.1
  ENSP00000451582.1
  ENSP00000452426
  ENSP00000452426.1
  ENSP00000452485.2
GenBank Protein Q92731 (Get FASTA)   NCBI Sequence Viewer  
  UDL18776 (Get FASTA)   NCBI Sequence Viewer  
  UDL18777 (Get FASTA)   NCBI Sequence Viewer  
  UDL18778 (Get FASTA)   NCBI Sequence Viewer  
  UDL18779 (Get FASTA)   NCBI Sequence Viewer  
  UDL18780 (Get FASTA)   NCBI Sequence Viewer  
  UDL18781 (Get FASTA)   NCBI Sequence Viewer  
  UDL18782 (Get FASTA)   NCBI Sequence Viewer  
  UDL18783 (Get FASTA)   NCBI Sequence Viewer  
  UDL18784 (Get FASTA)   NCBI Sequence Viewer  
  UDL18785 (Get FASTA)   NCBI Sequence Viewer  
  UDL18786 (Get FASTA)   NCBI Sequence Viewer  
  UDL18787 (Get FASTA)   NCBI Sequence Viewer  
  UDL18788 (Get FASTA)   NCBI Sequence Viewer  
  UDL18789 (Get FASTA)   NCBI Sequence Viewer  
  UDL18790 (Get FASTA)   NCBI Sequence Viewer  
  UDL18791 (Get FASTA)   NCBI Sequence Viewer  
  UDL18792 (Get FASTA)   NCBI Sequence Viewer  
  UDL18793 (Get FASTA)   NCBI Sequence Viewer  
  UDL18794 (Get FASTA)   NCBI Sequence Viewer  
  UDL18795 (Get FASTA)   NCBI Sequence Viewer  
  UDL18796 (Get FASTA)   NCBI Sequence Viewer  
  UDL18797 (Get FASTA)   NCBI Sequence Viewer  
  UDL18798 (Get FASTA)   NCBI Sequence Viewer  
  UDL18799 (Get FASTA)   NCBI Sequence Viewer  
  UDL18800 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001035365   ⟸   NM_001040275
- Peptide Label: isoform 2
- UniProtKB: F1D8N3 (UniProtKB/TrEMBL),   A0A348FV95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001201831   ⟸   NM_001214902
- Peptide Label: isoform 3
- UniProtKB: A0A348FV95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001428   ⟸   NM_001437
- Peptide Label: isoform 1
- UniProtKB: Q9UHD3 (UniProtKB/Swiss-Prot),   Q9UEV6 (UniProtKB/Swiss-Prot),   Q86Z31 (UniProtKB/Swiss-Prot),   Q0MWT6 (UniProtKB/Swiss-Prot),   Q0MWT5 (UniProtKB/Swiss-Prot),   O75584 (UniProtKB/Swiss-Prot),   O75583 (UniProtKB/Swiss-Prot),   O60703 (UniProtKB/Swiss-Prot),   O60702 (UniProtKB/Swiss-Prot),   O60685 (UniProtKB/Swiss-Prot),   O60608 (UniProtKB/Swiss-Prot),   G3V5M5 (UniProtKB/Swiss-Prot),   A8K8K5 (UniProtKB/Swiss-Prot),   Q9UQK9 (UniProtKB/Swiss-Prot),   Q92731 (UniProtKB/Swiss-Prot),   Q7LCB3 (UniProtKB/TrEMBL),   A0A348FV95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258805   ⟸   NM_001271876
- Peptide Label: isoform 5
- UniProtKB: Q0PTK2 (UniProtKB/TrEMBL),   A0A348FV93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258806   ⟸   NM_001271877
- Peptide Label: isoform 6
- UniProtKB: Q92731 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278641   ⟸   NM_001291712
- Peptide Label: isoform 2
- UniProtKB: F1D8N3 (UniProtKB/TrEMBL),   A0A348FV95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278652   ⟸   NM_001291723
- Peptide Label: isoform 2
- UniProtKB: F1D8N3 (UniProtKB/TrEMBL),   A0A348FV95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000450488   ⟸   ENST00000555278
RefSeq Acc Id: ENSP00000452485   ⟸   ENST00000556275
RefSeq Acc Id: ENSP00000267525   ⟸   ENST00000267525
RefSeq Acc Id: ENSP00000451582   ⟸   ENST00000557772
RefSeq Acc Id: ENSP00000335551   ⟸   ENST00000353772
RefSeq Acc Id: ENSP00000343925   ⟸   ENST00000341099
RefSeq Acc Id: ENSP00000452426   ⟸   ENST00000553796
RefSeq Acc Id: ENSP00000450699   ⟸   ENST00000554572
RefSeq Acc Id: ENSP00000351412   ⟸   ENST00000358599
RefSeq Acc Id: ENSP00000345616   ⟸   ENST00000344288
RefSeq Acc Id: XP_047287032   ⟸   XM_047431076
- Peptide Label: isoform X1
- UniProtKB: A0A348FV95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047287033   ⟸   XM_047431077
- Peptide Label: isoform X2
- UniProtKB: A0A348FV93 (UniProtKB/TrEMBL),   Q0PTK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047287034   ⟸   XM_047431078
- Peptide Label: isoform X3
- UniProtKB: A0A348FV97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054231534   ⟸   XM_054375559
- Peptide Label: isoform X4
- UniProtKB: F1D8N3 (UniProtKB/TrEMBL),   A0A348FV95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054231535   ⟸   XM_054375560
- Peptide Label: isoform X1
- UniProtKB: A0A348FV95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054231536   ⟸   XM_054375561
- Peptide Label: isoform X2
- UniProtKB: A0A348FV93 (UniProtKB/TrEMBL),   Q0PTK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054231537   ⟸   XM_054375562
- Peptide Label: isoform X3
- UniProtKB: A0A348FV97 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q92731-F1-model_v2 AlphaFold Q92731 1-530 view protein structure

Promoters
RGD ID:6814585
Promoter ID:HG_XEF:2440
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001040012,   NM_001104702,   NM_001123577,   NM_001124570,   NM_001124753,   NM_001128512,   NM_001129985,   NM_001130954,   NM_174862
Position:
Human AssemblyChrPosition (strand)Source
Build 361463,816,656 - 63,817,156 (-)MPROMDB
RGD ID:6791563
Promoter ID:HG_KWN:19571
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:ENST00000267525,   ENST00000344288,   ENST00000357782,   NM_001040275,   NM_001437
Position:
Human AssemblyChrPosition (strand)Source
Build 361463,830,571 - 63,831,497 (-)MPROMDB
RGD ID:6791564
Promoter ID:HG_KWN:19572
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001040276,   UC001XGW.1,   UC001XGX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361463,874,421 - 63,875,607 (-)MPROMDB
RGD ID:7227841
Promoter ID:EPDNEW_H19666
Type:initiation region
Name:ESR2_1
Description:estrogen receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19667  EPDNEW_H19668  EPDNEW_H19669  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,294,371 - 64,294,431EPDNEW
RGD ID:7227843
Promoter ID:EPDNEW_H19667
Type:initiation region
Name:ESR2_3
Description:estrogen receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19666  EPDNEW_H19668  EPDNEW_H19669  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,338,074 - 64,338,134EPDNEW
RGD ID:7227845
Promoter ID:EPDNEW_H19668
Type:initiation region
Name:ESR2_4
Description:estrogen receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19666  EPDNEW_H19667  EPDNEW_H19669  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,338,415 - 64,338,475EPDNEW
RGD ID:7227847
Promoter ID:EPDNEW_H19669
Type:initiation region
Name:ESR2_2
Description:estrogen receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19666  EPDNEW_H19667  EPDNEW_H19668  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,338,614 - 64,338,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3468 AgrOrtholog
COSMIC ESR2 COSMIC
Ensembl Genes ENSG00000140009 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000267525 ENTREZGENE
  ENST00000267525.10 UniProtKB/Swiss-Prot
  ENST00000341099 ENTREZGENE
  ENST00000341099.6 UniProtKB/Swiss-Prot
  ENST00000344288 ENTREZGENE
  ENST00000344288.10 UniProtKB/Swiss-Prot
  ENST00000353772 ENTREZGENE
  ENST00000353772.7 UniProtKB/Swiss-Prot
  ENST00000358599 ENTREZGENE
  ENST00000358599.9 UniProtKB/Swiss-Prot
  ENST00000553796 ENTREZGENE
  ENST00000553796.5 UniProtKB/Swiss-Prot
  ENST00000554572 ENTREZGENE
  ENST00000554572.5 UniProtKB/Swiss-Prot
  ENST00000555278 ENTREZGENE
  ENST00000555278.5 UniProtKB/Swiss-Prot
  ENST00000555483 ENTREZGENE
  ENST00000556275.5 UniProtKB/TrEMBL
  ENST00000557772.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000140009 GTEx
HGNC ID HGNC:3468 ENTREZGENE
Human Proteome Map ESR2 Human Proteome Map
InterPro ER-beta/gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Estrogen_rcpt_beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oest_rcpt/oest-rel_rcp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2100 ENTREZGENE
OMIM 601663 OMIM
PANTHER ESTROGEN RECEPTOR BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERbeta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ESR2 RGD, PharmGKB
PIRSF ER-b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ER-like_NR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A348FV91_HUMAN UniProtKB/TrEMBL
  A0A348FV92_HUMAN UniProtKB/TrEMBL
  A0A348FV93 ENTREZGENE, UniProtKB/TrEMBL
  A0A348FV94_HUMAN UniProtKB/TrEMBL
  A0A348FV95 ENTREZGENE, UniProtKB/TrEMBL
  A0A348FV96_HUMAN UniProtKB/TrEMBL
  A0A348FV97 ENTREZGENE, UniProtKB/TrEMBL
  A0A348FV98_HUMAN UniProtKB/TrEMBL
  A0A679EN27_HUMAN UniProtKB/TrEMBL
  A8K8K5 ENTREZGENE
  ESR2_HUMAN UniProtKB/Swiss-Prot
  F1D8N3 ENTREZGENE, UniProtKB/TrEMBL
  G3V5M5 ENTREZGENE
  G3V5S2_HUMAN UniProtKB/TrEMBL
  O60608 ENTREZGENE
  O60685 ENTREZGENE
  O60702 ENTREZGENE
  O60703 ENTREZGENE
  O75583 ENTREZGENE
  O75584 ENTREZGENE
  Q0MWT5 ENTREZGENE
  Q0MWT6 ENTREZGENE
  Q0PTK2 ENTREZGENE, UniProtKB/TrEMBL
  Q7LCB3 ENTREZGENE, UniProtKB/TrEMBL
  Q86Z31 ENTREZGENE
  Q92731 ENTREZGENE
  Q9UEV6 ENTREZGENE
  Q9UHD3 ENTREZGENE
  Q9UQK9 ENTREZGENE
UniProt Secondary A8K8K5 UniProtKB/Swiss-Prot
  G3V5M5 UniProtKB/Swiss-Prot
  O60608 UniProtKB/Swiss-Prot
  O60685 UniProtKB/Swiss-Prot
  O60702 UniProtKB/Swiss-Prot
  O60703 UniProtKB/Swiss-Prot
  O75583 UniProtKB/Swiss-Prot
  O75584 UniProtKB/Swiss-Prot
  Q0MWT5 UniProtKB/Swiss-Prot
  Q0MWT6 UniProtKB/Swiss-Prot
  Q86Z31 UniProtKB/Swiss-Prot
  Q9UEV6 UniProtKB/Swiss-Prot
  Q9UHD3 UniProtKB/Swiss-Prot
  Q9UQK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 ESR2  estrogen receptor 2  ESR2  estrogen receptor 2 (ER beta)  Symbol and/or name change 5135510 APPROVED