Zfp36l1 (zinc finger protein 36, C3H type-like 1) - Rat Genome Database

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Gene: Zfp36l1 (zinc finger protein 36, C3H type-like 1) Rattus norvegicus
Analyze
Symbol: Zfp36l1
Name: zinc finger protein 36, C3H type-like 1
RGD ID: 62009
Description: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Acts upstream of or within mRNA catabolic process. Located in cytosol. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Berg36; Brf1; butyrate response factor 1; cMG1; EGF-inducible protein CMG1; ERF1; mRNA decay activator protein ZFP36L1; TIS11b; TPA-induced sequence 11b; ZFP36-like 1; zinc finger protein 36, C3H1 type-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,663,396 - 104,669,815 (-)NCBIGRCr8
mRatBN7.2698,930,705 - 98,935,748 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,353,158 - 99,358,199 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,652,241 - 99,657,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,039,210 - 99,044,249 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,308,032 - 103,313,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06115,987,360 - 115,992,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,119,555 - 103,124,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,123,010 - 103,128,032 (-)NCBI
Celera697,294,425 - 97,299,423 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carboplatin  (EXP)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
promegestone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
Shikonin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (ISO,ISS)
apoptotic process  (ISO)
cell population proliferation  (ISO)
cellular response to cAMP  (ISO)
cellular response to epidermal growth factor stimulus  (ISO,ISS)
cellular response to fibroblast growth factor stimulus  (ISO,ISS)
cellular response to glucocorticoid stimulus  (ISO,ISS)
cellular response to hypoxia  (ISO,ISS)
cellular response to insulin stimulus  (ISO,ISS)
cellular response to peptide hormone stimulus  (ISO,ISS)
cellular response to raffinose  (ISO,ISS)
cellular response to salt stress  (ISO,ISS)
cellular response to transforming growth factor beta stimulus  (ISO,ISS)
cellular response to tumor necrosis factor  (ISO,ISS)
chorio-allantoic fusion  (ISO)
embryonic organ development  (ISO)
ERK1 and ERK2 cascade  (ISO,ISS)
heart development  (ISO)
MAPK cascade  (ISO,ISS)
mesendoderm development  (ISO,ISS)
mRNA catabolic process  (IDA)
mRNA processing  (IEA)
mRNA transport  (ISO,ISS)
multicellular organism growth  (ISO)
negative regulation of erythrocyte differentiation  (ISO,ISS)
negative regulation of mitotic cell cycle phase transition  (ISO,ISS)
neural tube development  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISO)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (IDA)
p38MAPK cascade  (ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of intracellular mRNA localization  (ISO,ISS)
positive regulation of monocyte differentiation  (ISO,ISS)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IDA)
proepicardium development  (ISO)
regulation of B cell differentiation  (ISO,ISS)
regulation of gene expression  (ISO,ISS)
regulation of keratinocyte apoptotic process  (ISO,ISS)
regulation of keratinocyte differentiation  (ISO,ISS)
regulation of keratinocyte proliferation  (ISO,ISS)
regulation of mRNA 3'-end processing  (ISO)
regulation of mRNA stability  (IDA,ISO,ISS)
regulation of myoblast differentiation  (ISO,ISS)
regulation of stem cell proliferation  (ISO,ISS)
regulation of translation  (ISO)
response to wounding  (ISO,ISS)
spongiotrophoblast layer development  (ISO)
T cell differentiation in thymus  (ISO,ISS)
vasculogenesis  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IDA)
nucleus  (ISO,ISS)
P-body  (ISO,ISS)
ribonucleoprotein complex  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes. Gomperts M, etal., Oncogene 1990 Jul;5(7):1081-3.
4. Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. Lai WS and Blackshear PJ, J Biol Chem. 2001 Jun 22;276(25):23144-54. Epub 2001 Mar 28.
5. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. Lai WS, etal., J Biol Chem. 2000 Jun 9;275(23):17827-37.
6. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Lai WS, etal., Mol Cell Biol. 2003 Jun;23(11):3798-812.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. Schmidlin M, etal., EMBO J. 2004 Dec 8;23(24):4760-9. Epub 2004 Nov 11.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7575462   PMID:11796723   PMID:12198173   PMID:15226444   PMID:15467755   PMID:15687258   PMID:15814898   PMID:16396499   PMID:17013884   PMID:17369404   PMID:17889962   PMID:18326031  
PMID:19179481   PMID:20166898   PMID:20622884   PMID:20702587   PMID:21832157   PMID:22658674   PMID:22701344   PMID:24700863   PMID:24733888   PMID:25014217   PMID:25106868   PMID:26542173  
PMID:27102483   PMID:27182009  


Genomics

Comparative Map Data
Zfp36l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,663,396 - 104,669,815 (-)NCBIGRCr8
mRatBN7.2698,930,705 - 98,935,748 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,353,158 - 99,358,199 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,652,241 - 99,657,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,039,210 - 99,044,249 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,308,032 - 103,313,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06115,987,360 - 115,992,381 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,119,555 - 103,124,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,123,010 - 103,128,032 (-)NCBI
Celera697,294,425 - 97,299,423 (-)NCBICelera
Cytogenetic Map6q24NCBI
ZFP36L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,787,655 - 68,796,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,787,660 - 68,796,253 (-)EnsemblGRCh38hg38GRCh38
GRCh371469,254,372 - 69,262,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,324,128 - 68,329,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 341468,324,127 - 68,329,538NCBI
Celera1449,313,123 - 49,318,532 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,422,410 - 49,430,997 (-)NCBIHuRef
CHM1_11469,192,821 - 69,201,405 (-)NCBICHM1_1
T2T-CHM13v2.01462,994,521 - 63,003,244 (-)NCBIT2T-CHM13v2.0
Zfp36l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,154,534 - 80,159,787 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,154,528 - 80,159,787 (-)EnsemblGRCm39 Ensembl
GRCm381280,107,760 - 80,113,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,107,754 - 80,113,013 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,208,747 - 81,214,000 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,026,600 - 81,031,853 (-)NCBIMGSCv36mm8
Celera1281,572,651 - 81,577,898 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.46NCBI
Zfp36l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,541,323 - 1,546,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,541,367 - 1,546,617 (+)NCBIChiLan1.0ChiLan1.0
ZFP36L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,902,452 - 69,911,122 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,118,962 - 69,127,451 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,372,058 - 49,379,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,247,341 - 68,255,805 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,247,347 - 68,255,805 (-)Ensemblpanpan1.1panPan2
ZFP36L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,663,287 - 42,668,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,664,223 - 42,668,514 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,352,777 - 42,358,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0842,893,323 - 42,898,832 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,893,325 - 42,898,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,507,658 - 42,513,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,582,437 - 42,587,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,941,809 - 42,947,345 (-)NCBIUU_Cfam_GSD_1.0
Zfp36l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864062,140,623 - 62,145,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,045,377 - 12,051,536 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,045,679 - 12,050,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,490,017 - 92,495,554 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,490,069 - 92,495,864 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,803,589 - 98,809,023 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,000,222 - 46,005,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2445,999,623 - 46,006,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605334,233,922 - 34,240,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfp36l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,251,114 - 32,257,211 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473432,251,100 - 32,256,458 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp36l1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:51
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000041735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

Markers in Region
AI409945  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,937,381 - 98,937,543 (+)MAPPERmRatBN7.2
Rnor_6.06103,314,708 - 103,314,869NCBIRnor6.0
Rnor_5.06115,994,015 - 115,994,176UniSTSRnor5.0
RGSC_v3.46103,126,210 - 103,126,371UniSTSRGSC3.4
Celera697,301,057 - 97,301,218UniSTS
RH 3.4 Map6703.1UniSTS
Cytogenetic Map6q24UniSTS
G15966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,930,451 - 98,930,655 (+)MAPPERmRatBN7.2
Rnor_6.06103,307,779 - 103,307,982NCBIRnor6.0
Rnor_5.06115,987,107 - 115,987,310UniSTSRnor5.0
RGSC_v3.46103,119,302 - 103,119,505UniSTSRGSC3.4
Celera697,294,172 - 97,294,375UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 66 35 39 11 8
Low 1 8 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000083677   ⟹   ENSRNOP00000075412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl698,930,718 - 98,935,748 (-)Ensembl
Rnor_6.0 Ensembl6103,308,045 - 103,313,074 (-)Ensembl
RefSeq Acc Id: NM_017172   ⟹   NP_058868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,663,648 - 104,668,690 (-)NCBI
mRatBN7.2698,930,705 - 98,935,748 (-)NCBI
Rnor_6.06103,308,032 - 103,313,074 (-)NCBI
Rnor_5.06115,987,360 - 115,992,381 (-)NCBI
RGSC_v3.46103,119,555 - 103,124,576 (-)RGD
Celera697,294,425 - 97,299,423 (-)RGD
Sequence:
RefSeq Acc Id: XM_063261577   ⟹   XP_063117647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86104,663,396 - 104,669,815 (-)NCBI
RefSeq Acc Id: NP_058868   ⟸   NM_017172
- UniProtKB: Q6LAU8 (UniProtKB/Swiss-Prot),   P17431 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075412   ⟸   ENSRNOT00000083677
RefSeq Acc Id: XP_063117647   ⟸   XM_063261577
- Peptide Label: isoform X1
Protein Domains
C3H1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17431-F1-model_v2 AlphaFold P17431 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694697
Promoter ID:EPDNEW_R5220
Type:multiple initiation site
Name:Zfp36l1_1
Description:zinc finger protein 36, C3H type-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06103,313,096 - 103,313,156EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62009 AgrOrtholog
BioCyc Gene G2FUF-36942 BioCyc
Ensembl Genes ENSRNOG00000058646 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055019483 UniProtKB/Swiss-Prot
  ENSRNOG00060022117 UniProtKB/Swiss-Prot
  ENSRNOG00065018784 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083677 ENTREZGENE
  ENSRNOT00000083677.2 UniProtKB/Swiss-Prot
  ENSRNOT00055033244 UniProtKB/Swiss-Prot
  ENSRNOT00060038320 UniProtKB/Swiss-Prot
  ENSRNOT00065031544 UniProtKB/Swiss-Prot
Gene3D-CATH Zinc finger, CCCH-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Tis11B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZFP36-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29344 UniProtKB/Swiss-Prot
NCBI Gene 29344 ENTREZGENE
PANTHER CCCH ZINC FINGER/TIS11-RELATED UniProtKB/TrEMBL
  MRNA DECAY ACTIVATOR PROTEIN ZFP36L1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12547 UniProtKB/Swiss-Prot
Pfam Tis11B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zfp36l1 PhenoGen
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058646 RatGTEx
  ENSRNOG00055019483 RatGTEx
  ENSRNOG00060022117 RatGTEx
  ENSRNOG00065018784 RatGTEx
SMART ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CCCH zinc finger UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC216827
UniProt A6HCI0_RAT UniProtKB/TrEMBL
  P17431 ENTREZGENE
  Q6LAU8 ENTREZGENE
  TISB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6LAU8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Zfp36l1  zinc finger protein 36, C3H type-like 1      Name updated 70584 APPROVED
2002-02-27 Zfp36l1  zinc finger protein 36, C3H type-like 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains zinc-finger domain with a repeating cys-his motif 61544
gene_product member of the TIS11 family of early response genes 61544
gene_protein protein contains 338 aa residues 61544