Sele (selectin E) - Rat Genome Database

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Gene: Sele (selectin E) Rattus norvegicus
Analyze
Symbol: Sele
Name: selectin E
RGD ID: 3654
Description: Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in leukocyte migration and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E); PARTICIPATES IN eicosanoid signaling pathway; malaria pathway; sleeping sickness pathway; INTERACTS WITH (S)-colchicine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD62 antigen-like family member E; E-selectin; ELAM-1; endothelial leukocyte adhesion molecule 1; LECAM2; leukocyte-endothelial cell adhesion molecule 2; selectin, endothelial cell
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp329
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,935,997 - 78,945,905 (+)NCBIGRCr8
mRatBN7.21376,402,841 - 76,412,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,403,304 - 76,412,741 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,021,472 - 79,031,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,325,949 - 80,335,341 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,580,536 - 77,589,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,355,234 - 82,365,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,234,842 - 87,244,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,813,455 - 79,822,845 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,827,642 - 79,837,033 (+)NCBI
Celera1376,136,932 - 76,146,318 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-linalyl acetate  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
1,10-phenanthroline  (ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
asbestos  (ISO)
aspalathin  (ISO)
atorvastatin calcium  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
biotin  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chrysin  (ISO)
clobazam  (ISO)
clopidogrel  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cordycepin  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
D-mannitol  (ISO)
dabrafenib  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
desflurane  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
enalapril  (ISO)
Enterolactone  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluticasone  (ISO)
furan  (EXP)
galangin  (ISO)
gallic acid  (ISO)
gastrin-17  (ISO)
gentamycin  (EXP)
geranylgeraniol  (ISO)
ginkgolide B  (ISO)
ginsenoside C-K  (ISO)
glucose  (ISO)
glutathione  (ISO)
griseofulvin  (ISO)
GW 3965  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketorolac  (EXP)
ketotifen  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
mangiferin  (ISO)
methotrexate  (ISO)
Methylthiouracil  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
MitoTEMPO  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
naproxen  (EXP)
nebivolol  (ISO)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
notoginsenoside R1  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oleuropein  (ISO)
oxytocin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parthenolide  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrene  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
PR-39  (ISO)
probucol  (ISO)
progesterone  (ISO)
pyrene  (ISO)
quercetin  (ISO)
Quinupristin-dalfopristin  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rolipram  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
steviol  (ISO)
stevioside  (ISO)
sulfasalazine  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
tebuconazole  (ISO)
tepoxalin  (ISO)
testosterone  (EXP)
tibolone  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valsartan  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
wedelolactone  (ISO)
xanthohumol  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. Abu-Amero KK, etal., BMC Med Genet. 2007 Jun 20;8:35.
2. Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent. Chapon C, etal., MAGMA. 2009 Jun;22(3):167-74. Epub 2008 Dec 24.
3. [Inhibiting effects of interleuin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats] Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62.
4. Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation. Fries JW, etal., Am J Pathol 1993 Sep;143(3):725-37.
5. P- and E-selectin blockade can control bacterial translocation and modulate systemic inflammatory response. Garcia-Criado FJ, etal., J Invest Surg. 2005 Jul-Aug;18(4):167-76.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Prediction of residual valvular lesions in rheumatic heart disease: role of adhesion molecules. Hafez M, etal., Pediatr Cardiol. 2013 Mar;34(3):583-90. doi: 10.1007/s00246-012-0501-7. Epub 2012 Sep 18.
9. A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. Hattori H, etal., Brain Res. 2006 Sep 7;1108(1):221-3. Epub 2006 Jul 14.
10. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. Hirashiki A, etal., J Am Coll Cardiol. 2003 Oct 15;42(8):1429-37.
11. Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. Ishibashi S, etal., J Cereb Blood Flow Metab. 2009 Mar;29(3):606-20. Epub 2008 Dec 24.
12. Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China. Li Y, etal., Int J Cardiol. 2005 Aug 3;103(1):33-6. Epub 2004 Dec 16.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Nowak M, etal., Clin Exp Med. 2008 Sep;8(3):159-64. Epub 2008 Sep 13.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Accelerated development of arthritis in mice lacking endothelial selectins. Ruth JH, etal., Arthritis Res Ther. 2005;7(5):R959-70. Epub 2005 Jun 15.
24. Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Smadja DM, etal., Angiogenesis. 2020 May 27. pii: 10.1007/s10456-020-09730-0. doi: 10.1007/s10456-020-09730-0.
25. Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1.
26. Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation. Ulich TR, etal., Inflammation. 1994 Aug;18(4):389-98.
27. Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex. Wang X, etal., Stroke. 1995 Sep;26(9):1665-8; discussion 1668-9.
28. Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing. Yamazaki KG, etal., Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1387-93. doi: 10.1152/ajpheart.00496.2011. Epub 2012 Jan 20.
Additional References at PubMed
PMID:7680663   PMID:8609175   PMID:9290466   PMID:9312078   PMID:10894166   PMID:12960351   PMID:17114491   PMID:18029551   PMID:20735828   PMID:21194567   PMID:22664869   PMID:24289084  
PMID:24966906   PMID:25182537   PMID:27033411   PMID:28011641  


Genomics

Comparative Map Data
Sele
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81378,935,997 - 78,945,905 (+)NCBIGRCr8
mRatBN7.21376,402,841 - 76,412,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,403,304 - 76,412,741 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,021,472 - 79,031,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,325,949 - 80,335,341 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,580,536 - 77,589,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,355,234 - 82,365,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,234,842 - 87,244,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,813,455 - 79,822,845 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,827,642 - 79,837,033 (+)NCBI
Celera1376,136,932 - 76,146,318 (+)NCBICelera
Cytogenetic Map13q23NCBI
SELE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,722,640 - 169,734,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,722,640 - 169,764,705 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,691,781 - 169,703,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,958,406 - 167,969,803 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,423,439 - 166,434,837NCBI
Celera1142,801,587 - 142,813,012 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,914,126 - 140,925,551 (-)NCBIHuRef
CHM1_11171,113,936 - 171,125,374 (-)NCBICHM1_1
T2T-CHM13v2.01169,078,428 - 169,089,853 (-)NCBIT2T-CHM13v2.0
Sele
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,867,200 - 163,886,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,875,773 - 163,885,246 (+)EnsemblGRCm39 Ensembl
GRCm381164,039,614 - 164,058,487 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,048,234 - 164,057,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv371165,978,365 - 165,987,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,884,909 - 165,894,352 (+)NCBIMGSCv36mm8
Celera1166,489,844 - 166,499,312 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.35NCBI
Sele
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554627,564,437 - 7,575,297 (+)NCBIChiLan1.0ChiLan1.0
SELE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2180,034,813 - 80,046,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1179,703,217 - 79,714,676 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,205,684 - 145,217,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,927,333 - 148,938,781 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,930,437 - 148,938,313 (-)Ensemblpanpan1.1panPan2
SELE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,888,503 - 28,898,787 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,888,197 - 28,898,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,420,727 - 28,430,555 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,690,348 - 28,700,684 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,690,094 - 28,700,681 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,538,997 - 28,548,824 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,574,705 - 28,584,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,811,713 - 28,821,538 (+)NCBIUU_Cfam_GSD_1.0
Sele
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,067,998 - 99,077,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648116,915,182 - 16,921,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648116,915,203 - 16,921,840 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1481,289,061 - 81,299,657 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,914,255 - 88,924,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,305,610 - 59,333,789 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,322,913 - 59,330,668 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605560,978,152 - 60,989,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sele
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,626,380 - 7,635,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248267,624,852 - 7,635,330 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sele
102 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000030677
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 71 70 39 25 39 6 198 97 93 45 57 31

Sequence


Ensembl Acc Id: ENSRNOT00000030677   ⟹   ENSRNOP00000034797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,403,304 - 76,410,170 (+)Ensembl
Rnor_6.0 Ensembl1382,355,471 - 82,365,341 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076757   ⟹   ENSRNOP00000068171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,403,351 - 76,412,741 (+)Ensembl
Rnor_6.0 Ensembl1382,355,886 - 82,365,323 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098346   ⟹   ENSRNOP00000095247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,403,304 - 76,410,167 (+)Ensembl
RefSeq Acc Id: NM_138879   ⟹   NP_620234
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,936,514 - 78,945,904 (+)NCBI
mRatBN7.21376,403,351 - 76,412,741 (+)NCBI
Rnor_6.01382,355,933 - 82,365,323 (+)NCBI
Rnor_5.01387,234,842 - 87,244,746 (+)NCBI
RGSC_v3.41379,813,455 - 79,822,845 (+)RGD
Celera1376,136,932 - 76,146,318 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769608   ⟹   XP_008767830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,935,997 - 78,945,905 (+)NCBI
mRatBN7.21376,402,841 - 76,412,733 (+)NCBI
Rnor_6.01382,355,234 - 82,365,299 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598678   ⟹   XP_017454167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81378,935,997 - 78,945,905 (+)NCBI
mRatBN7.21376,402,841 - 76,412,741 (+)NCBI
Rnor_6.01382,355,236 - 82,365,323 (+)NCBI
Sequence:
RefSeq Acc Id: NP_620234   ⟸   NM_138879
- Peptide Label: precursor
- UniProtKB: P98105 (UniProtKB/Swiss-Prot),   A0A8L2R0D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767830   ⟸   XM_008769608
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHU5 (UniProtKB/TrEMBL),   A6IDD1 (UniProtKB/TrEMBL),   A0A8I6AP16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454167   ⟸   XM_017598678
- Peptide Label: isoform X1
- UniProtKB: A6IDD2 (UniProtKB/TrEMBL),   A0A8L2R0D5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034797   ⟸   ENSRNOT00000030677
Ensembl Acc Id: ENSRNOP00000068171   ⟸   ENSRNOT00000076757
Ensembl Acc Id: ENSRNOP00000095247   ⟸   ENSRNOT00000098346
Protein Domains
C-type lectin   EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P98105-F1-model_v2 AlphaFold P98105 1-549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3654 AgrOrtholog
BioCyc Gene G2FUF-17605 BioCyc
Ensembl Genes ENSRNOG00000002723 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030677.4 UniProtKB/TrEMBL
  ENSRNOT00000076757 ENTREZGENE
  ENSRNOT00000076757.2 UniProtKB/TrEMBL
  ENSRNOT00000098346.1 UniProtKB/TrEMBL
  ENSRNOT00000154598 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25544 UniProtKB/Swiss-Prot
NCBI Gene 25544 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E-SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sele PhenoGen
PRINTS SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002723 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP16 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R0D5 ENTREZGENE, UniProtKB/TrEMBL
  A6IDD1 ENTREZGENE, UniProtKB/TrEMBL
  A6IDD2 ENTREZGENE, UniProtKB/TrEMBL
  LYAM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Sele  selectin E  Sele  selectin, endothelial cell  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sele  Selectin, endothelial cell      Symbol and Name status set to approved 70586 APPROVED