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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sele
Name: selectin E
Acc ID: CHEBI:75045
Term: dabrafenib
Definition: An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Chemical ID: MESH:C561627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Selemultiple interactionsISOSELE (Homo sapiens)6480464CTDdabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE mRNA]; dabrafenib inhibits the reaction [Polyphosphates results in increased expression of SELE protein]; dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein]PMID:27458080 PMID:29042256
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