Sell (selectin L) - Rat Genome Database

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Gene: Sell (selectin L) Rattus norvegicus
Analyze
Symbol: Sell
Name: selectin L
RGD ID: 3655
Description: Enables glycolipid binding activity. Involved in several processes, including positive regulation of neutrophil chemotaxis; response to fatty acid; and response to hyperoxia. Located in cell surface. Used to study colitis and peripheral vascular disease. Biomarker of abdominal aortic aneurysm; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A.11; CD62 antigen-like family member L; L-selectin; LAM-1; LECAM-1; LECAM1; leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 1; ly-22; lymph node homing receptor; lymphocyte antigen 22; lymphocyte surface MEL-14 antigen; selectin, lymphocyte
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,416,969 - 76,436,444 (+)NCBI
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01382,369,820 - 82,387,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01387,249,243 - 87,267,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,827,342 - 79,845,296 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11379,841,529 - 79,859,484 (+)NCBI
Celera1376,150,815 - 76,168,775 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
aceclofenac  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bromobenzene  (EXP)
budesonide  (EXP)
buta-1,3-diene  (ISO)
Calcimycin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chlorogenic acid  (EXP)
chloroprene  (ISO)
chrysene  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
enalapril  (ISO)
erythromycin A  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylenediaminetetraacetic acid  (ISO)
flavonoids  (EXP,ISO)
flufenamic acid  (ISO)
flurbiprofen  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
heparin  (ISO)
iloprost  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoprofen  (ISO)
leukotriene B4  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
meclofenamic acid  (ISO)
mefenamic acid  (ISO)
meloxicam  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nabumetone  (ISO)
naloxone  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paricalcitol  (ISO)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
Quinupristin-dalfopristin  (ISO)
resveratrol  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sumatriptan  (EXP)
tamibarotene  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Batra A, etal., Nephrol Dial Transplant. 2007 Sep;22(9):2540-8. Epub 2007 Apr 23.
2. Benlier E, etal., Burns. 2011 Nov;37(7):1216-21.
3. Bigley NJ, etal., J Interferon Cytokine Res. 2008 Feb;28(2):55-63.
4. Cai Q, etal., Neurobiol Dis. 2012 Feb;45(2):723-32. Epub 2011 Oct 25.
5. Charles N, etal., Nat Med. 2010 Jun;16(6):701-7. Epub 2010 May 30.
6. Corsi MM, etal., Biogerontology. 2011 Oct;12(5):451-4. Epub 2011 Apr 12.
7. Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62.
8. Gerik SM, etal., Am J Respir Cell Mol Biol. 2003 Oct;29(4):506-12. Epub 2003 May 1.
9. GOA data from the GO Consortium
10. Haley M, etal., J Appl Physiol. 2005 Jun;98(6):2155-62. Epub 2005 Jan 27.
11. Hannawa KK, etal., Circulation. 2005 Jul 12;112(2):241-7. Epub 2005 Jul 5.
12. Haworth O, etal., J Immunol. 2011 Jun 1;186(11):6129-35. Epub 2011 Apr 22.
13. Khazen D, etal., Eur J Gastroenterol Hepatol. 2009 Feb;21(2):167-75. doi: 10.1097/MEG.0b013e32830e6fc8.
14. Kirveskari J, etal., J Am Soc Nephrol. 2000 Dec;11(12):2358-65.
15. Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
16. Kuhl AA, etal., Gastroenterology. 2007 Dec;133(6):1882-92. Epub 2007 Sep 5.
17. Li L, etal., Free Radic Biol Med. 2009 Jul 1;47(1):103-13. Epub 2009 Apr 15.
18. Lu SY, etal., Clin Exp Immunol. 2011 Aug;165(2):264-77. doi: 10.1111/j.1365-2249.2011.04418.x. Epub 2011 Jun 2.
19. Man SF, etal., Ther Adv Respir Dis. 2009 Apr;3(2):73-80. Epub 2009 May 22.
20. MGD data from the GO Consortium
21. NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Ogawa A, etal., J Invest Dermatol. 2010 Jun;130(6):1558-70. Epub 2010 Feb 25.
23. OMIM Disease Annotation Pipeline
24. RGD automated data pipeline
25. RGD automated import pipeline for gene-chemical interactions
26. Rodrigues HG, etal., Lipids. 2010 Sep;45(9):809-19. Epub 2010 Aug 22.
27. Royce SG, etal., J Asthma Allergy. 2010 Jun 28;3:9-17.
28. Rozenberg I, etal., PLoS One. 2011;6(7):e21675. Epub 2011 Jul 8.
29. Sackstein R, etal., Immunology 1995 Jun;85(2):198-204.
30. Sergent-Tanguy S, etal., Differentiation. 2006 Dec;74(9-10):530-41.
31. Stavarachi M, etal., Rom J Morphol Embryol. 2011;52(3 Suppl):995-8.
32. Suzuki Y, etal., Biochem Biophys Res Commun. 1993 Jan 29;190(2):426-34.
33. Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1.
34. Tran ED and Schmid-Schonbein GW, Microcirculation. 2007 Nov-Dec;14(8):793-804.
35. Watanabe T, etal., Biochim Biophys Acta 1992 Jul 15;1131(3):321-4.
36. Wei YS, etal., J Thromb Thrombolysis. 2011 Jul;32(1):110-5.
37. Zhao X, etal., Lung. 2005 Mar-Apr;183(2):87-100.
38. Zhao X, etal., Respir Physiol Neurobiol. 2006 May;152(1):16-26. Epub 2005 Oct 7.
39. Zhong M, etal., Antimicrob Agents Chemother. 2012 Mar 5.
Additional References at PubMed
PMID:2663882   PMID:7589135   PMID:8043862   PMID:10072077   PMID:11389866   PMID:14597732   PMID:14609575   PMID:15477346   PMID:15914561   PMID:16203996   PMID:16227984   PMID:16769892  
PMID:16973387   PMID:17525255   PMID:17548643   PMID:18628982   PMID:18836449   PMID:18948084   PMID:19008373   PMID:19240088   PMID:23620790   PMID:28011641  


Genomics

Comparative Map Data
Sell
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,416,969 - 76,436,444 (+)NCBI
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01382,369,820 - 82,387,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01387,249,243 - 87,267,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,827,342 - 79,845,296 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11379,841,529 - 79,859,484 (+)NCBI
Celera1376,150,815 - 76,168,775 (+)NCBICelera
Cytogenetic Map13q23NCBI
SELL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,690,665 - 169,711,702 (-)EnsemblGRCh38hg38GRCh38
GRCh381169,690,667 - 169,711,620 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,659,808 - 169,680,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,926,432 - 167,947,461 (-)NCBINCBI36hg18NCBI36
Build 341166,391,465 - 166,412,385NCBI
Celera1142,769,612 - 142,790,649 (-)NCBI
Cytogenetic Map1q24.2NCBI
HuRef1140,882,225 - 140,903,187 (-)NCBIHuRef
CHM1_11171,081,961 - 171,102,996 (-)NCBICHM1_1
Sell
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,889,556 - 163,908,354 (+)NCBIGRCm39mm39
GRCm39 Ensembl1163,889,551 - 163,911,750 (+)Ensembl
GRCm381164,061,987 - 164,082,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,061,982 - 164,084,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371165,992,207 - 166,010,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv361165,898,779 - 165,917,346 (+)NCBImm8
Celera1166,503,711 - 166,522,465 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.37NCBI
Sell
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554627,591,366 - 7,612,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554627,591,997 - 7,611,408 (+)NCBIChiLan1.0ChiLan1.0
SELL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11148,895,373 - 148,916,393 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,895,373 - 148,916,393 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01145,173,700 - 145,194,927 (-)NCBIMhudiblu_PPA_v0panPan3
SELL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,906,752 - 28,927,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,906,809 - 29,094,008 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,438,413 - 28,459,659 (+)NCBI
ROS_Cfam_1.0728,708,675 - 28,729,947 (+)NCBI
UMICH_Zoey_3.1728,556,811 - 28,578,018 (+)NCBI
UNSW_CanFamBas_1.0728,592,509 - 28,613,744 (+)NCBI
UU_Cfam_GSD_1.0728,829,481 - 28,850,708 (+)NCBI
Sell
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,171,899 - 99,194,147 (+)NCBI
SpeTri2.0NW_00493648117,022,421 - 17,032,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,306,373 - 81,326,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,306,363 - 81,325,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,931,520 - 88,950,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,345,080 - 59,365,684 (+)NCBI
ChlSab1.1 Ensembl2559,345,069 - 59,366,946 (+)Ensembl
Vero_WHO_p1.0NW_02366605561,000,872 - 61,021,571 (+)NCBI
Sell
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248267,590,576 - 7,612,370 (-)NCBI

Position Markers
D13Got57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,415,834 - 76,416,086 (+)MAPPER
Rnor_6.01382,368,417 - 82,368,668NCBIRnor6.0
Rnor_5.01387,247,840 - 87,248,091UniSTSRnor5.0
RGSC_v3.41379,825,938 - 79,826,190RGDRGSC3.4
RGSC_v3.41379,825,939 - 79,826,190UniSTSRGSC3.4
RGSC_v3.11379,840,127 - 79,840,378RGD
Celera1376,149,412 - 76,149,663UniSTS
RH 3.4 Map13484.2UniSTS
RH 3.4 Map13484.2RGD
RH 2.0 Map13571.5RGD
Cytogenetic Map13q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)136450135182995671Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136500824591629354Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)137456837882995671Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137456837892916783Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137456837892916783Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137456837892916783Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137956708186833540Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)138040355991629354Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:117
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000003733
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 11
Low 16 47 39 39 3 3 2 19 17 3
Below cutoff 1 17 2 2 2 5 7 38 16 19 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003733   ⟹   ENSRNOP00000003733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)Ensembl
RefSeq Acc Id: NM_019177   ⟹   NP_062050
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,417,240 - 76,435,195 (+)NCBI
Rnor_6.01382,369,820 - 82,387,774 (+)NCBI
Rnor_5.01387,249,243 - 87,267,197 (+)NCBI
RGSC_v3.41379,827,342 - 79,845,296 (+)RGD
Celera1376,150,815 - 76,168,775 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090616   ⟹   XP_038946544
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,416,969 - 76,436,444 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062050   ⟸   NM_019177
- Peptide Label: precursor
- UniProtKB: Q63762 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003733   ⟸   ENSRNOT00000003733
RefSeq Acc Id: XP_038946544   ⟸   XM_039090616
- Peptide Label: isoform X1
Protein Domains
C-type lectin   EGF-like   Sushi

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3655 AgrOrtholog
Ensembl Genes ENSRNOG00000002776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003733 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003733 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-selectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29259 UniProtKB/TrEMBL
NCBI Gene 29259 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sell PhenoGen
PIRSF L-selectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7EY63_RAT UniProtKB/TrEMBL
  LYAM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63762 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Sell  selectin L  Sell  selectin, lymphocyte  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sell  selectin, lymphocyte      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed on thymocytes, thoracic duct lymphocytes and lymph node lymphocytes 729788
gene_expression expressed in peripheral blood mononuclear cells, spleen and thymus 69989
gene_physical_interaction interacts with PPME 69989
gene_process expression on lymphocytes allows binding of cells to high endothelial venules (HEV) 729788
gene_protein protein is 372 amino acids with a 38 amino acid signal peptide 69989
gene_regulation expression in thymocytes may be regulated post-transcriptionally 729788
gene_regulation expression in peripheral blood mononuclear and splenic T cells is downregulated upon stimulation with mitogen 69989
gene_transcript transcript is 3 kb 69989