Sell (selectin L) - Rat Genome Database

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Gene: Sell (selectin L) Rattus norvegicus
Symbol: Sell
Name: selectin L
RGD ID: 3655
Description: Enables glycolipid binding activity. Involved in several processes, including positive regulation of neutrophil chemotaxis; response to fatty acid; and response to hyperoxia. Located in cell surface. Used to study colitis and peripheral vascular disease. Biomarker of abdominal aortic aneurysm; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn's disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
Previously known as: A.11; CD62 antigen-like family member L; L-selectin; LAM-1; LECAM-1; LECAM1; leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 1; ly-22; lymph node homing receptor; lymphocyte antigen 22; lymphocyte surface MEL-14 antigen; selectin, lymphocyte
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21376,416,969 - 76,436,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,416,915 - 76,436,456 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,035,789 - 79,053,737 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,339,838 - 80,357,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,594,427 - 77,612,381 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,369,820 - 82,387,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,249,243 - 87,267,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,827,342 - 79,845,296 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,841,529 - 79,859,484 (+)NCBI
Celera1376,150,815 - 76,168,775 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
aceclofenac  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
budesonide  (EXP)
buta-1,3-diene  (ISO)
Calcimycin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (EXP)
chloroprene  (ISO)
chrysene  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
erythromycin A  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylenediaminetetraacetic acid  (ISO)
flavonoids  (EXP,ISO)
flufenamic acid  (ISO)
flurbiprofen  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
heparin  (ISO)
iloprost  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoprofen  (ISO)
leukotriene B4  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
meclofenamic acid  (ISO)
mefenamic acid  (ISO)
meloxicam  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
morphine  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nabumetone  (ISO)
naloxone  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
Quinupristin-dalfopristin  (ISO)
resveratrol  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sumatriptan  (EXP)
tamibarotene  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. T-cell homing receptor expression in IgA nephropathy. Batra A, etal., Nephrol Dial Transplant. 2007 Sep;22(9):2540-8. Epub 2007 Apr 23.
2. Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model. Benlier E, etal., Burns. 2011 Nov;37(7):1216-21.
3. Inflammatory cytokines and cell adhesion molecules in a rat model of decompression sickness. Bigley NJ, etal., J Interferon Cytokine Res. 2008 Feb;28(2):55-63.
4. Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis. Cai Q, etal., Neurobiol Dis. 2012 Feb;45(2):723-32. Epub 2011 Oct 25.
5. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Charles N, etal., Nat Med. 2010 Jun;16(6):701-7. Epub 2010 May 30.
6. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Corsi MM, etal., Biogerontology. 2011 Oct;12(5):451-4. Epub 2011 Apr 12.
7. [Inhibiting effects of interleuin-10 on expression of E-selectin and L-selectin in cerebral ischemia-reperfusion: experiment with rats] Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Neutrophil adhesion molecule expression in the developing neonatal rat exposed to hyperoxia. Gerik SM, etal., Am J Respir Cell Mol Biol. 2003 Oct;29(4):506-12. Epub 2003 May 1.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model. Haley M, etal., J Appl Physiol. 2005 Jun;98(6):2155-62. Epub 2005 Jan 27.
12. L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation. Hannawa KK, etal., Circulation. 2005 Jul 12;112(2):241-7. Epub 2005 Jul 5.
13. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. Haworth O, etal., J Immunol. 2011 Jun 1;186(11):6129-35. Epub 2011 Apr 22.
14. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. Khazen D, etal., Eur J Gastroenterol Hepatol. 2009 Feb;21(2):167-75. doi: 10.1097/MEG.0b013e32830e6fc8.
15. De novo induction of endothelial L-selectin ligands during kidney allograft rejection. Kirveskari J, etal., J Am Soc Nephrol. 2000 Dec;11(12):2358-65.
16. Gene expression profiling of the rat endometriosis model. Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
17. Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils. Kuhl AA, etal., Gastroenterology. 2007 Dec;133(6):1882-92. Epub 2007 Sep 5.
18. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Li L, etal., Free Radic Biol Med. 2009 Jul 1;47(1):103-13. Epub 2009 Apr 15.
19. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
20. High frequencies of CD62L naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation. Lu SY, etal., Clin Exp Immunol. 2011 Aug;165(2):264-77. doi: 10.1111/j.1365-2249.2011.04418.x. Epub 2011 Jun 2.
21. The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory study. Man SF, etal., Ther Adv Respir Dis. 2009 Apr;3(2):73-80. Epub 2009 May 22.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. Ogawa A, etal., J Invest Dermatol. 2010 Jun;130(6):1558-70. Epub 2010 Feb 25.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats. Rodrigues HG, etal., Lipids. 2010 Sep;45(9):809-19. Epub 2010 Aug 22.
29. The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease. Royce SG, etal., J Asthma Allergy. 2010 Jun 28;3:9-17.
30. Deletion of L-selectin increases atherosclerosis development in ApoE-/- mice. Rozenberg I, etal., PLoS One. 2011;6(7):e21675. Epub 2011 Jul 8.
31. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Sackstein R, etal., Immunology 1995 Jun;85(2):198-204.
32. Cell surface antigens on rat neural progenitors and characterization of the CD3 (+)/CD3 (-) cell populations. Sergent-Tanguy S, etal., Differentiation. 2006 Dec;74(9-10):530-41.
33. Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study. Stavarachi M, etal., Rom J Morphol Embryol. 2011;52(3 Suppl):995-8.
34. Sulfated glycolipids are ligands for a lymphocyte homing receptor, L-selectin (LECAM-1), Binding epitope in sulfated sugar chain. Suzuki Y, etal., Biochem Biophys Res Commun. 1993 Jan 29;190(2):426-34.
35. Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1.
36. An in-vivo analysis of capillary stasis and endothelial apoptosis in a model of hypertension. Tran ED and Schmid-Schonbein GW, Microcirculation. 2007 Nov-Dec;14(8):793-804.
37. Sequence and expression of a rat cDNA for LECAM-1. Watanabe T, etal., Biochim Biophys Acta 1992 Jul 15;1131(3):321-4.
38. The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke. Wei YS, etal., J Thromb Thrombolysis. 2011 Jul;32(1):110-5.
39. Alterations of adhesion molecule expression and inflammatory mediators in acute lung injury induced by septic and non-septic challenges. Zhao X, etal., Lung. 2005 Mar-Apr;183(2):87-100.
40. Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis. Zhao X, etal., Respir Physiol Neurobiol. 2006 May;152(1):16-26. Epub 2005 Oct 7.
41. L-Selectin and P-Selectin Are Novel Biomarkers of Cervicovaginal Inflammation for Preclinical Mucosal Safety Assessment of Anti-HIV-1 Microbicide. Zhong M, etal., Antimicrob Agents Chemother. 2012 Mar 5.
Additional References at PubMed
PMID:2663882   PMID:7589135   PMID:8043862   PMID:10072077   PMID:11389866   PMID:14597732   PMID:14609575   PMID:15477346   PMID:15914561   PMID:16203996   PMID:16227984   PMID:16769892  
PMID:16973387   PMID:17525255   PMID:17548643   PMID:18628982   PMID:18836449   PMID:18948084   PMID:19008373   PMID:19240088   PMID:23620790   PMID:28011641  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21376,416,969 - 76,436,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,416,915 - 76,436,456 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,035,789 - 79,053,737 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,339,838 - 80,357,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,594,427 - 77,612,381 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,369,820 - 82,387,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,249,243 - 87,267,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,827,342 - 79,845,296 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,841,529 - 79,859,484 (+)NCBI
Celera1376,150,815 - 76,168,775 (+)NCBICelera
Cytogenetic Map13q23NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381169,690,667 - 169,711,620 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,690,665 - 169,711,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,659,808 - 169,680,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,926,432 - 167,947,461 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,391,465 - 166,412,385NCBI
Celera1142,769,612 - 142,790,649 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,882,225 - 140,903,187 (-)NCBIHuRef
CHM1_11171,081,961 - 171,102,996 (-)NCBICHM1_1
T2T-CHM13v2.01169,046,455 - 169,067,407 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391163,889,556 - 163,908,354 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,889,551 - 163,911,750 (+)EnsemblGRCm39 Ensembl
GRCm381164,061,987 - 164,082,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,061,982 - 164,084,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371165,992,207 - 166,010,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,898,779 - 165,917,346 (+)NCBIMGSCv36mm8
Celera1166,503,711 - 166,522,465 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.37NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554627,591,366 - 7,612,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554627,591,997 - 7,611,408 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1179,725,636 - 79,746,670 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,173,700 - 145,194,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,895,373 - 148,916,393 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,895,373 - 148,916,393 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1728,906,752 - 28,927,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,906,809 - 29,094,008 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,438,413 - 28,459,659 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,708,675 - 28,729,947 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,708,712 - 28,731,608 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,556,811 - 28,578,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,592,509 - 28,613,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,829,481 - 28,850,708 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934499,171,899 - 99,194,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648117,022,580 - 17,032,124 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648117,022,421 - 17,032,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl481,306,353 - 81,326,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,306,363 - 81,325,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2488,931,520 - 88,950,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12559,345,080 - 59,365,684 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,345,069 - 59,366,946 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605561,000,872 - 61,021,571 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248267,587,970 - 7,610,163 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248267,590,576 - 7,612,370 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sell
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:117
Interacting mature miRNAs:132
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,415,834 - 76,416,086 (+)MAPPERmRatBN7.2
Rnor_6.01382,368,417 - 82,368,668NCBIRnor6.0
Rnor_5.01387,247,840 - 87,248,091UniSTSRnor5.0
RGSC_v3.41379,825,938 - 79,826,190RGDRGSC3.4
RGSC_v3.41379,825,939 - 79,826,190UniSTSRGSC3.4
RGSC_v3.11379,840,127 - 79,840,378RGD
Celera1376,149,412 - 76,149,663UniSTS
RH 3.4 Map13484.2UniSTS
RH 3.4 Map13484.2RGD
RH 2.0 Map13571.5RGD
Cytogenetic Map13q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 8 19 11
Low 16 47 39 39 3 3 2 19 17 3
Below cutoff 1 17 2 2 2 5 7 38 16 19 5


RefSeq Acc Id: ENSRNOT00000003733   ⟹   ENSRNOP00000003733
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,416,915 - 76,432,377 (+)Ensembl
Rnor_6.0 Ensembl1382,369,493 - 82,387,631 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106952   ⟹   ENSRNOP00000089128
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,416,915 - 76,436,456 (+)Ensembl
RefSeq Acc Id: NM_019177   ⟹   NP_062050
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,417,240 - 76,435,195 (+)NCBI
Rnor_6.01382,369,820 - 82,387,774 (+)NCBI
Rnor_5.01387,249,243 - 87,267,197 (+)NCBI
RGSC_v3.41379,827,342 - 79,845,296 (+)RGD
Celera1376,150,815 - 76,168,775 (+)RGD
RefSeq Acc Id: XM_039090616   ⟹   XP_038946544
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,416,969 - 76,436,444 (+)NCBI
RefSeq Acc Id: NP_062050   ⟸   NM_019177
- Peptide Label: precursor
- UniProtKB: P30836 (UniProtKB/Swiss-Prot),   Q63762 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003733   ⟸   ENSRNOT00000003733
RefSeq Acc Id: XP_038946544   ⟸   XM_039090616
- Peptide Label: isoform X1
- UniProtKB: F7EY63 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089128   ⟸   ENSRNOT00000106952
Protein Domains
C-type lectin   EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30836-F1-model_v2 AlphaFold P30836 1-372 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3655 AgrOrtholog
BioCyc Gene G2FUF-17603 BioCyc
Ensembl Genes ENSRNOG00000002776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003733 ENTREZGENE
  ENSRNOP00000003733.6 UniProtKB/TrEMBL
  ENSRNOP00000089128.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003733 ENTREZGENE
  ENSRNOT00000003733.7 UniProtKB/TrEMBL
  ENSRNOT00000106952.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-selectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29259 UniProtKB/TrEMBL
  L-SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sell PhenoGen
PIRSF L-selectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7Z4_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Sell  selectin L  Sell  selectin, lymphocyte  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sell  selectin, lymphocyte      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed on thymocytes, thoracic duct lymphocytes and lymph node lymphocytes 729788
gene_expression expressed in peripheral blood mononuclear cells, spleen and thymus 69989
gene_physical_interaction interacts with PPME 69989
gene_process expression on lymphocytes allows binding of cells to high endothelial venules (HEV) 729788
gene_protein protein is 372 amino acids with a 38 amino acid signal peptide 69989
gene_regulation expression in thymocytes may be regulated post-transcriptionally 729788
gene_regulation expression in peripheral blood mononuclear and splenic T cells is downregulated upon stimulation with mitogen 69989
gene_transcript transcript is 3 kb 69989