Selp (selectin P) - Rat Genome Database

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Gene: Selp (selectin P) Rattus norvegicus
Analyze
Symbol: Selp
Name: selectin P
RGD ID: 3656
Description: Predicted to enable several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including leukocyte migration; regulation of cellular extravasation; and response to lipopolysaccharide. Located in external side of plasma membrane and extracellular space. Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P); PARTICIPATES IN interleukin-4 signaling pathway; malaria pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD62 antigen-like family member P; GMP-140; granule membrane protein 140; LECAM3; leukocyte-endothelial cell adhesion molecule 3; MGC124632; P-selectin; PADGEM; platelet activation dependent granule-external membrane protein; PSELECT; Selectin platelet; selectin, platelet
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   F344.ACI-Lmx1aqc/Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81379,009,379 - 79,044,994 (+)NCBIGRCr8
mRatBN7.21376,476,229 - 76,511,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,476,295 - 76,511,845 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,094,917 - 79,130,437 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,398,945 - 80,434,427 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,653,541 - 77,689,020 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,428,914 - 82,464,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,429,063 - 82,464,628 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,308,435 - 87,344,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,886,614 - 79,922,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,910,278 - 79,936,368 (+)NCBI
Celera1376,209,805 - 76,244,685 (+)NCBICelera
RH 3.4 Map13482.6RGD
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-linalyl acetate  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
biotin  (ISO)
bisphenol A  (EXP,ISO)
bivalirudin  (ISO)
budesonide  (EXP)
Calcimycin  (ISO)
cangrelor  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carrageenan  (EXP)
catechol  (ISO)
CGP 52608  (ISO)
chloramine T  (ISO)
choline  (ISO)
cimetidine  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
curcumin  (EXP,ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP)
estrone  (EXP)
ethanol  (EXP)
fenvalerate  (EXP)
genistein  (EXP,ISO)
glucose  (ISO)
glyphosate  (EXP)
heparin  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
losartan  (EXP)
manganese(II) chloride  (EXP)
metformin  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
obeticholic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
pravastatin  (ISO)
progesterone  (EXP)
quercetin  (ISO)
resolvin D1  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (EXP)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP,ISO)
triphenyl phosphate  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectin molecules protects rat steatotic liver grafts from ischemia/reperfusion injury. Amersi F, etal., Am J Transplant 2002 Aug;2(7):600-8.
2. Cloning, sequence comparison and in vivo expression of the gene encoding rat P-selectin. Auchampach JA, etal., Gene 1994 Aug 5;145(2):251-5.
3. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. Barbaux SC, etal., Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):1668-73.
4. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Bourgain C, etal., Am J Hum Genet. 2003 Sep;73(3):612-26. Epub 2003 Aug 15.
5. Dysregulated selectin expression and monocyte recruitment during ischemia-related vascular remodeling in diabetes mellitus. Carr CL, etal., Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2526-33.
6. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Corsi MM, etal., Biogerontology. 2011 Oct;12(5):451-4. Epub 2011 Apr 12.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. P-selectin inhibition reduces severity of acute experimental pancreatitis. Hackert T, etal., Pancreatology. 2009;9(4):369-74. Epub 2009 May 19.
10. Hypothermia-induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model. Horioka K, etal., J Thromb Haemost. 2019 Oct;17(10):1762-1771. doi: 10.1111/jth.14555. Epub 2019 Jul 17.
11. Intestinal ischemia-reperfusion injury leads to inflammatory changes in the brain. Hsieh YH, etal., Shock. 2011 Oct;36(4):424-30.
12. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Impellizzeri D, etal., Biochem Pharmacol. 2011 Mar 1;81(5):636-48. Epub 2010 Dec 11.
13. Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke. Jin AY, etal., BMC Neurosci. 2010 Feb 2;11:12.
14. Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of disease. Kaufmann BA, etal., Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):54-9. Epub 2009 Oct 15.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes] Li Q, etal., Wei Sheng Yan Jiu. 2007 Sep;36(5):581-3, 595.
17. Urine Peptidomic and Targeted Plasma Protein Analyses in the Diagnosis and Monitoring of Systemic Juvenile Idiopathic Arthritis. Ling XB, etal., Clin Proteomics. 2010 Dec;6(4):175-193. Epub 2010 Sep 30.
18. Levels of soluble adhesion molecules in patients with various clinical presentations of coronary atherosclerosis. Lu HH, etal., Chin Med J (Engl). 2010 Nov;123(21):3123-6.
19. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection. Lu XY, etal., Lupus. 2010 May;19(6):689-95. Epub 2010 Feb 23.
20. Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression. Mayne E, etal., J Acquir Immune Defic Syndr. 2011 Dec 9.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Markers of endothelial dysfunction, coagulation and tissue fibrosis independently predict venous thromboembolism in HIV. Musselwhite LW, etal., AIDS. 2011 Mar 27;25(6):787-95.
23. Investigation of Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in type 2 diabetes mellitus. Nagy B Jr, etal., Thromb Haemost. 2007 Jul;98(1):186-91.
24. P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. Naruse T, etal., Kidney Int. 2002 Jul;62(1):94-105.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Activation of platelets and cellular coagulation in cerebral small-vessel disease. Oberheiden T, etal., Blood Coagul Fibrinolysis. 2010 Dec;21(8):729-35.
27. Preventive effect of sulphated colominic acid on P-selectin-dependent infiltration of macrophages in experimentally induced crescentic glomerulonephritis. Ogawa D, etal., Clin Exp Immunol 2002 Jul;129(1):43-53.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. [Integrin-associated proteins in blood plasma of patients with acute exacerbation of chronic obstructive pulmonary disease]. Pan L, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2010 Apr;33(4):265-7.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease. Polanowska-Grabowska R, etal., Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2392-9. Epub 2010 Nov 11.
33. Assessment of the influence of the inflammatory process on the activation of blood platelets and morphological parameters in patients with ulcerative colitis (colitis ulcerosa). Polinska B, etal., Folia Histochem Cytobiol. 2011;49(1):119-24.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
38. Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer. Schafer A, etal., Eur J Heart Fail. 2009 Apr;11(4):336-41. Epub 2009 Feb 3.
39. Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy. Schneider DJ, etal., Diabetes Care. 2009 May;32(5):944-9. Epub 2009 Feb 19.
40. Lactobacillus reuteri prevents colitis by reducing P-selectin-associated leukocyte- and platelet-endothelial cell interactions. Schreiber O, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G534-42. Epub 2009 Jan 15.
41. Increased levels of circulating microparticles in primary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity. Sellam J, etal., Arthritis Res Ther. 2009;11(5):R156. Epub 2009 Oct 15.
42. P-selectin mediates the microvascular dysfunction associated with persistent cytomegalovirus infection in normocholesterolemic and hypercholesterolemic mice. Senchenkov E, etal., Microcirculation. 2011 Aug;18(6):452-62. doi: 10.1111/j.1549-8719.2011.00106.x.
43. Oxidative stress and defective platelet apoptosis in naive patients with Kawasaki disease. Straface E, etal., Biochem Biophys Res Commun. 2010 Feb 12;392(3):426-30. Epub 2010 Jan 15.
44. [Volatile oil of Magnolia biondii inhibits expressions of P-selectin protein in serum and renal tissue of rats with diabetic nephropathy] Sun XP, etal., Zhong Xi Yi Jie He Xue Bao. 2008 May;6(5):524-9.
45. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Tregouet DA, etal., Hum Mol Genet. 2002 Aug 15;11(17):2015-23.
47. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Vachharajani V, etal., Microcirculation. 2010 Aug;17(6):407-16.
48. Platelet reactivity and response to aspirin in subjects with the metabolic syndrome. Vaduganathan M, etal., Am Heart J. 2008 Nov;156(5):1002.e1-1002.e7.
49. Prognostic value of plasma soluble P-selectin and von Willebrand factor as indices of platelet activation and endothelial damage/dysfunction in high-risk patients with hypertension: a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial. Varughese GI, etal., J Intern Med. 2007 Apr;261(4):384-91.
50. Aberrant expression of soluble co-stimulatory molecules and adhesion molecules in type 2 diabetic patients with nephropathy. Wong CK, etal., J Clin Immunol. 2008 Jan;28(1):36-43. Epub 2007 Nov 17.
51. Protective effect of glutathione against liver warm ischemia-reperfusion injury in rats is associated with regulation of P-selectin and neutrophil infiltration. Xue F, etal., Anat Rec (Hoboken). 2008 Aug;291(8):1016-22.
52. Dynamic expression of the main related indicators of thrombosis, inflammatory reaction and tissue damage in a rat model of myocardial infarction. Xue M, etal., Mol Med Report. 2011 Jul-Aug;4(4):693-6. doi: 10.3892/mmr.2011.485. Epub 2011 May 5.
53. Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model. Yang W, etal., Life Sci. 2011 Feb 14;88(7-8):302-6. Epub 2010 Dec 10.
54. Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines. Zeiffer U, etal., Circ Res. 2004 Apr 2;94(6):776-84. Epub 2004 Feb 12.
55. Alterations of Bone Marrow Sinusoidal Endothelium in Rat and Patients with Liver Cirrhosis. Zhao S, etal., Dig Dis Sci. 2009 Apr 1.
56. L-Selectin and P-Selectin Are Novel Biomarkers of Cervicovaginal Inflammation for Preclinical Mucosal Safety Assessment of Anti-HIV-1 Microbicide. Zhong M, etal., Antimicrob Agents Chemother. 2012 Mar 5.
57. Fibrinogen and P-selectin expression in atherosclerosis model of Sprague Dawley rat. Zhou BR, etal., Chin Med J (Engl). 2011 Nov;124(22):3768-72.
58. Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model. Zhou Z, etal., Arterioscler Thromb Vasc Biol 2002 Oct 1;22(10):1598-603.
Additional References at PubMed
PMID:7524641   PMID:7680663   PMID:7688665   PMID:8557754   PMID:8562500   PMID:9290466   PMID:10894166   PMID:11081633   PMID:12477932   PMID:15201548   PMID:15297306   PMID:15484189  
PMID:15742404   PMID:15879141   PMID:15888973   PMID:15956287   PMID:16514062   PMID:17114491   PMID:17488661   PMID:17632516   PMID:17690033   PMID:19349303   PMID:19780886   PMID:21180132  
PMID:21961520   PMID:22575043   PMID:23583643   PMID:28011641   PMID:29378361  


Genomics

Comparative Map Data
Selp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81379,009,379 - 79,044,994 (+)NCBIGRCr8
mRatBN7.21376,476,229 - 76,511,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,476,295 - 76,511,845 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,094,917 - 79,130,437 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,398,945 - 80,434,427 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,653,541 - 77,689,020 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,428,914 - 82,464,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,429,063 - 82,464,628 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,308,435 - 87,344,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,886,614 - 79,922,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11379,910,278 - 79,936,368 (+)NCBI
Celera1376,209,805 - 76,244,685 (+)NCBICelera
RH 3.4 Map13482.6RGD
Cytogenetic Map13q23NCBI
SELP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,588,849 - 169,630,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,588,849 - 169,630,193 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,558,087 - 169,599,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,824,711 - 167,866,001 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,289,747 - 166,331,065NCBI
Celera1142,667,866 - 142,709,161 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,780,771 - 140,822,069 (-)NCBIHuRef
CHM1_11170,980,248 - 171,021,531 (-)NCBICHM1_1
T2T-CHM13v2.01168,944,736 - 168,986,000 (-)NCBIT2T-CHM13v2.0
Selp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,942,833 - 163,977,595 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,942,833 - 163,977,595 (+)EnsemblGRCm39 Ensembl
GRCm381164,115,264 - 164,150,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,115,264 - 164,150,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,045,509 - 166,079,876 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,952,053 - 165,986,420 (+)NCBIMGSCv36mm8
MGSCv361165,306,067 - 165,340,774 (+)NCBIMGSCv36mm8
Celera1166,568,384 - 166,587,846 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.42NCBI
Selp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554627,652,437 - 7,693,994 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554627,658,371 - 7,692,870 (+)NCBIChiLan1.0ChiLan1.0
SELP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2180,139,053 - 80,179,968 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1179,807,454 - 79,848,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,071,094 - 145,112,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,793,677 - 148,834,701 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,793,677 - 148,834,701 (-)Ensemblpanpan1.1panPan2
SELP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,956,428 - 28,997,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,490,155 - 28,527,988 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,758,392 - 28,799,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,760,327 - 28,798,333 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,608,516 - 28,646,330 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,644,251 - 28,682,064 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,881,019 - 28,918,852 (+)NCBIUU_Cfam_GSD_1.0
Selp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,229,898 - 99,265,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648117,076,536 - 17,107,963 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648117,076,660 - 17,112,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,365,740 - 81,399,955 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,376,804 - 81,401,240 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,001,468 - 89,025,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SELP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,420,910 - 59,465,140 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,433,333 - 59,462,598 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605561,082,227 - 61,140,767 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Selp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,511,646 - 7,537,924 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248267,510,039 - 7,544,332 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Selp
330 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:79
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000003759
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
D13Got55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,478,359 - 76,478,532 (+)MAPPERmRatBN7.2
Rnor_6.01382,431,060 - 82,431,236NCBIRnor6.0
Rnor_5.01387,310,475 - 87,310,651UniSTSRnor5.0
RGSC_v3.41379,888,615 - 79,888,788RGDRGSC3.4
RGSC_v3.41379,888,616 - 79,888,788UniSTSRGSC3.4
RGSC_v3.11379,902,804 - 79,902,976RGD
Celera1376,211,815 - 76,211,987UniSTS
RH 3.4 Map13481.1UniSTS
RH 3.4 Map13481.1RGD
RH 2.0 Map13496.1RGD
Cytogenetic Map13q22UniSTS
RH132595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,511,507 - 76,511,724 (+)MAPPERmRatBN7.2
Rnor_6.01382,464,291 - 82,464,507NCBIRnor6.0
Rnor_5.01387,343,826 - 87,344,042UniSTSRnor5.0
RGSC_v3.41379,921,843 - 79,922,059UniSTSRGSC3.4
Celera1376,244,348 - 76,244,564UniSTS
Cytogenetic Map13q22UniSTS
RH94491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,511,709 - 76,511,799 (+)MAPPERmRatBN7.2
Rnor_6.01382,464,493 - 82,464,582NCBIRnor6.0
Rnor_5.01387,344,028 - 87,344,117UniSTSRnor5.0
RGSC_v3.41379,922,045 - 79,922,134UniSTSRGSC3.4
Celera1376,244,550 - 76,244,639UniSTS
RH 3.4 Map13482.6UniSTS
Cytogenetic Map13q22UniSTS


Related Rat Strains
The following Strains have been annotated to Selp
F344.ACI-Lmx1aqc/Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 65 90 90 59 25 59 6 212 96 46 40 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000003759   ⟹   ENSRNOP00000003759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,476,295 - 76,511,845 (+)Ensembl
Rnor_6.0 Ensembl1382,438,697 - 82,464,628 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076879   ⟹   ENSRNOP00000068338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,485,700 - 76,507,195 (+)Ensembl
Rnor_6.0 Ensembl1382,429,063 - 82,464,628 (+)Ensembl
RefSeq Acc Id: NM_013114   ⟹   NP_037246
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81379,009,511 - 79,044,993 (+)NCBI
mRatBN7.21376,476,358 - 76,511,845 (+)NCBI
Rnor_6.01382,429,058 - 82,464,628 (+)NCBI
Rnor_5.01387,308,435 - 87,344,164 (+)NCBI
RGSC_v3.41379,886,614 - 79,922,180 (+)RGD
Celera1376,209,805 - 76,244,685 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250150   ⟹   XP_006250212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81379,009,379 - 79,044,994 (+)NCBI
mRatBN7.21376,476,229 - 76,511,846 (+)NCBI
Rnor_6.01382,428,914 - 82,464,629 (+)NCBI
Rnor_5.01387,308,435 - 87,344,164 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037246 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250212 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA60325 (Get FASTA)   NCBI Sequence Viewer  
  AAI01920 (Get FASTA)   NCBI Sequence Viewer  
  EDM09362 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003759.4
  ENSRNOP00000068338.2
GenBank Protein P98106 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037246   ⟸   NM_013114
- Peptide Label: precursor
- UniProtKB: F1LNV1 (UniProtKB/TrEMBL),   Q3MID1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250212   ⟸   XM_006250150
- Peptide Label: isoform X1
- UniProtKB: Q3MID1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068338   ⟸   ENSRNOT00000076879
Ensembl Acc Id: ENSRNOP00000003759   ⟸   ENSRNOT00000003759
Protein Domains
C-type lectin   EGF-like   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P98106-F1-model_v2 AlphaFold P98106 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698953
Promoter ID:EPDNEW_R9478
Type:single initiation site
Name:Selp_1
Description:selectin P
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01382,429,051 - 82,429,111EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3656 AgrOrtholog
BioCyc Gene G2FUF-17602 BioCyc
Ensembl Genes ENSRNOG00000002794 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003759.5 UniProtKB/TrEMBL
  ENSRNOT00000076879.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7935390 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Selectin_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25651 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124632 IMAGE-MGC_LOAD
NCBI Gene 25651 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Selp PhenoGen
PRINTS SELECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002794 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC236522
UniProt A0A096MK10_RAT UniProtKB/TrEMBL
  A6IDD5_RAT UniProtKB/TrEMBL
  F1LNV1 ENTREZGENE, UniProtKB/TrEMBL
  LYAM3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3MID1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Selp  selectin P  Selp  selectin, platelet  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Selp  selectin, platelet    Selectin, platelet  Name updated 629478 APPROVED
2002-06-10 Selp  Selectin, platelet      Symbol and Name status set to approved 70586 APPROVED