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Gene: Gjb2 (gap junction protein, beta 2) Rattus norvegicus
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Symbol: Gjb2
Name: gap junction protein, beta 2
Description: Exhibits gap junction channel activity. Involved in several processes, including reproductive structure development; response to ischemia; and response to steroid hormone. Localizes to several cellular components, including astrocyte projection; gap junction; and lateral plasma membrane. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of autoimmune thyroiditis; extrahepatic cholestasis; ischemia; sensorineural hearing loss; and urethral obstruction. Human ortholog(s) of this gene implicated in Bart-Pumphrey syndrome; Vohwinkel syndrome; autosomal dominant keratitis-ichthyosis-deafness syndrome; nonsyndromic deafness (multiple); and palmoplantar keratoderma-deafness syndrome. Orthologous to human GJB2 (gap junction protein beta 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: connexin 26; connexin e; connexin-26; Cx26; CXN-26; Cxne; gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; MGC93804
Orthologs:
Homo sapiens (human) : GJB2 (gap junction protein beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Gjb2 (gap junction protein, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gjb2 (gap junction protein beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GJB2 (gap junction protein beta 2)
Canis lupus familiaris (dog) : GJB2 (gap junction protein beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gjb2 (gap junction protein beta 2)
Sus scrofa (pig) : GJB2 (gap junction protein beta 2)
Chlorocebus sabaeus (African green monkey) : GJB2 (gap junction protein beta 2)
Heterocephalus glaber (naked mole-rat) : Gjb2 (gap junction protein beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01537,377,313 - 37,394,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,377,316 - 37,383,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,224,497 - 41,236,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,153,526 - 36,159,490 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11536,169,226 - 36,175,190 (-)NCBI
Celera1530,972,813 - 30,978,777 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gjb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 728891
Created: 2003-11-21
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.