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Gene: Rock2 (Rho-associated coiled-coil containing protein kinase 2) Rattus norvegicus
Symbol: Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
RGD ID: 3590
Description: Predicted to have GTP-Rho binding activity and Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including Rho protein signal transduction; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Predicted to localize to several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and spindle pole centrosome. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2); PARTICIPATES IN chemokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; Wnt signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,4-dinitrotoluene; 5-(1,4-diazepane-1-sulfonyl)isoquinoline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: p150 ROK-alpha; p164 ROCK-2; Rho-associated coiled-coil forming kinase 2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); rhoA-binding kinase 2; ROCK-II; ROK; ROKalpha
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0642,180,864 - 42,289,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,900,048 - 52,009,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,581,247 - 40,672,854 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1640,584,199 - 40,675,807 (+)NCBI
Celera638,987,591 - 39,082,080 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Rock2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3590
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.