Rock2 (Rho-associated coiled-coil containing protein kinase 2) - Rat Genome Database

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Gene: Rock2 (Rho-associated coiled-coil containing protein kinase 2) Rattus norvegicus
Symbol: Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
RGD ID: 3590
Description: Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Acts upstream of or within Rho protein signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and spindle pole centrosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; centrosome; and glutamatergic synapse. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2); PARTICIPATES IN chemokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; Wnt signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p150 ROK-alpha; p164 ROCK-2; Rho-associated coiled-coil forming kinase 2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); rhoA-binding kinase 2; ROCK-II; ROK; ROKalpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8645,407,823 - 45,502,773 (+)NCBIGRCr8
mRatBN7.2639,679,116 - 39,774,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,679,082 - 39,774,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,012,204 - 40,106,584 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,326,914 - 40,421,294 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,760,198 - 39,854,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,180,864 - 42,289,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,900,048 - 52,009,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,581,247 - 40,672,854 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1640,584,199 - 40,675,807 (+)NCBI
Celera638,987,591 - 39,082,080 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Alkannin  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
BQ 123  (EXP)
Brodifacoum  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
emodin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fasudil  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
methylmercury(1+)  (ISO)
miconazole  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
ochratoxin A  (ISO)
oleic acid  (ISO)
oroxylin A  (EXP)
ouabain  (ISO)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
Sanggenon C  (EXP)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
Thrombin  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
Y-27632  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actomyosin structure organization  (IBA,IEA)
aortic valve morphogenesis  (ISO)
blood vessel diameter maintenance  (ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cellular response to acetylcholine  (ISO)
cellular response to testosterone stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
centrosome duplication  (IEA,ISO)
chromosome condensation  (TAS)
cortical actin cytoskeleton organization  (IBA,IEA,ISO)
dendrite morphogenesis  (ISO)
embryonic morphogenesis  (IBA,IEA)
epithelial to mesenchymal transition  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
mitotic cytokinesis  (IBA,IEA)
modulation by host of viral process  (IEA)
mRNA destabilization  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of bicellular tight junction assembly  (IEA,ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO)
negative regulation of protein localization to lysosome  (IEA,ISO)
neural tube closure  (ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IMP,ISO)
positive regulation of cell migration  (ISO)
positive regulation of centrosome duplication  (IEA,ISO)
positive regulation of connective tissue growth factor production  (IMP)
positive regulation of connective tissue replacement  (IMP,ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of fibroblast growth factor production  (IMP)
positive regulation of gene expression  (IEA,IMP,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of protein localization to early endosome  (IEA,ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
postsynaptic actin cytoskeleton organization  (ISO)
protein localization to plasma membrane  (IEA,ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of angiotensin-activated signaling pathway  (ISO)
regulation of cell junction assembly  (IBA,IEA)
regulation of cellular response to hypoxia  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of establishment of endothelial barrier  (IEA,ISO)
regulation of keratinocyte differentiation  (IEA,ISO)
regulation of nervous system process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of synapse maturation  (ISO)
response to angiotensin  (ISO)
response to ischemia  (ISO)
response to transforming growth factor beta  (IGI,ISO)
Rho protein signal transduction  (IBA,IEA,IMP)
rhythmic process  (IEA)
smooth muscle contraction  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Ahuja P, etal., Exp Cell Res. 2007 Apr 1;313(6):1270-83. Epub 2007 Jan 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. Jeon S, etal., J Biol Chem 2002 May 10;277(19):16576-84.
5. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. Leung T, etal., J Biol Chem 1995 Dec 8;270(49):29051-4.
6. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Leung T, etal., Mol Cell Biol 1996 Oct;16(10):5313-27.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Ogata T, etal., Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. Shimizu T, etal., JCI Insight. 2017 Jul 6;2(13). pii: 93187. doi: 10.1172/jci.insight.93187.
15. ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. Song Y, etal., Exp Cell Res 2002 Aug 1;278(1):45-52.
16. Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. Tan I, etal., FEBS Lett. 2011 May 6;585(9):1260-8. doi: 10.1016/j.febslet.2011.03.054. Epub 2011 Mar 30.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:9353125   PMID:11739394   PMID:12506136   PMID:12902637   PMID:15121898   PMID:15310556   PMID:16141308   PMID:16249236   PMID:16365167   PMID:16396994   PMID:16574662  
PMID:17015463   PMID:17065553   PMID:17220176   PMID:17229766   PMID:17379756   PMID:17468135   PMID:17720771   PMID:18167063   PMID:18524939   PMID:18555800   PMID:18559669   PMID:18621909  
PMID:18640982   PMID:18718479   PMID:19131646   PMID:19181962   PMID:19222995   PMID:19376974   PMID:19391109   PMID:19746421   PMID:19997641   PMID:20232393   PMID:20889845   PMID:20970835  
PMID:21147781   PMID:21411727   PMID:21545816   PMID:22031832   PMID:22136148   PMID:22479572   PMID:22681889   PMID:22727353   PMID:23172836   PMID:23258382   PMID:23365224   PMID:23402758  
PMID:23530857   PMID:23641788   PMID:23826343   PMID:23891689   PMID:24036111   PMID:24065547   PMID:24305806   PMID:24466133   PMID:24699328   PMID:24792035   PMID:24832597   PMID:25243430  
PMID:25260465   PMID:25761652   PMID:25816133   PMID:25959411   PMID:26169356   PMID:26191148   PMID:26194354   PMID:26391686   PMID:26634652   PMID:27288754   PMID:27333569   PMID:28469189  
PMID:28657365   PMID:28820400   PMID:29219181   PMID:29353861   PMID:29791873   PMID:30053369   PMID:30363018   PMID:30747210   PMID:31825931   PMID:32308124   PMID:32386193   PMID:32485129  
PMID:32813542   PMID:37096660  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8645,407,823 - 45,502,773 (+)NCBIGRCr8
mRatBN7.2639,679,116 - 39,774,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,679,082 - 39,774,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,012,204 - 40,106,584 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,326,914 - 40,421,294 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,760,198 - 39,854,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,180,864 - 42,289,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,900,048 - 52,009,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,581,247 - 40,672,854 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1640,584,199 - 40,675,807 (+)NCBI
Celera638,987,591 - 39,082,080 (+)NCBICelera
Cytogenetic Map6q16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38211,179,759 - 11,345,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl211,179,759 - 11,348,330 (-)EnsemblGRCh38hg38GRCh38
GRCh37211,319,885 - 11,485,563 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36211,239,229 - 11,402,162 (-)NCBINCBI36Build 36hg18NCBI36
Build 34211,272,375 - 11,435,309NCBI
Celera211,237,615 - 11,400,586 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef211,171,519 - 11,335,102 (-)NCBIHuRef
CHM1_1211,251,294 - 11,414,170 (-)NCBICHM1_1
T2T-CHM13v2.0211,212,159 - 11,378,745 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391216,944,808 - 17,038,275 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1216,944,896 - 17,037,824 (+)EnsemblGRCm39 Ensembl
GRCm381216,894,978 - 16,988,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1216,894,895 - 16,987,823 (+)EnsemblGRCm38mm10GRCm38
MGSCv371216,901,784 - 16,995,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361216,920,670 - 17,003,586 (+)NCBIMGSCv36mm8
Celera1217,218,328 - 17,311,507 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.04NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554875,859,204 - 5,972,401 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,856,190 - 5,972,408 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v212115,184,603 - 115,347,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,188,575 - 115,351,748 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A11,167,353 - 11,331,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A11,316,755 - 11,478,986 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A11,318,370 - 11,478,986 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1177,931,786 - 8,012,484 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,934,739 - 8,178,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,863,769 - 8,005,135 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0178,035,035 - 8,176,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl178,037,253 - 8,177,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,920,092 - 8,061,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,923,254 - 8,065,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,943,547 - 8,085,045 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629252,387,532 - 52,529,676 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365327,145,882 - 7,286,244 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365327,142,580 - 7,284,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl3125,352,920 - 125,493,362 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,353,063 - 125,493,368 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,221,182 - 134,297,878 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11496,275,889 - 96,443,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,276,023 - 96,432,790 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604515,835,723 - 16,002,638 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248654,461,215 - 4,588,836 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,461,200 - 4,591,309 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Rock2
347 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:103
Interacting mature miRNAs:106
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,714,550 - 39,714,722 (+)MAPPERmRatBN7.2
Rnor_6.0642,230,436 - 42,230,607NCBIRnor6.0
Rnor_5.0651,949,590 - 51,949,761UniSTSRnor5.0
RGSC_v3.4640,616,049 - 40,616,221RGDRGSC3.4
RGSC_v3.4640,616,050 - 40,616,221UniSTSRGSC3.4
RGSC_v3.1640,619,003 - 40,619,174RGD
Celera639,022,855 - 39,023,026UniSTS
RH 3.4 Map6179.0RGD
RH 3.4 Map6179.0UniSTS
RH 2.0 Map6341.7RGD
SHRSP x BN Map633.0298RGD
Cytogenetic Map6q15-q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,773,701 - 39,773,833 (+)MAPPERmRatBN7.2
Rnor_6.0642,289,579 - 42,289,710NCBIRnor6.0
Rnor_5.0652,008,903 - 52,009,034UniSTSRnor5.0
RGSC_v3.4640,675,463 - 40,675,594UniSTSRGSC3.4
Celera639,081,749 - 39,081,880UniSTS
Cytogenetic Map6q15-q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,766,688 - 39,766,898 (+)MAPPERmRatBN7.2
Rnor_6.0642,282,566 - 42,282,775NCBIRnor6.0
Rnor_5.0652,001,890 - 52,002,099UniSTSRnor5.0
RGSC_v3.4640,668,450 - 40,668,659UniSTSRGSC3.4
Celera639,074,736 - 39,074,945UniSTS
RH 3.4 Map6181.0UniSTS
Cytogenetic Map6q15-q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,733,600 - 39,733,864 (+)MAPPERmRatBN7.2
Rnor_6.0642,249,477 - 42,249,740NCBIRnor6.0
Rnor_5.0651,968,801 - 51,969,064UniSTSRnor5.0
RGSC_v3.4640,635,361 - 40,635,624UniSTSRGSC3.4
Celera639,041,920 - 39,042,183UniSTS
RH 3.4 Map6178.9UniSTS
Cytogenetic Map6q15-q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,773,561 - 39,773,775 (+)MAPPERmRatBN7.2
Rnor_6.0642,289,439 - 42,289,652NCBIRnor6.0
Rnor_5.0652,008,763 - 52,008,976UniSTSRnor5.0
RGSC_v3.4640,675,323 - 40,675,536UniSTSRGSC3.4
Celera639,081,609 - 39,081,822UniSTS
RH 3.4 Map6181.1UniSTS
Cytogenetic Map6q15-q16UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 42 26 19 26 8 10 74 35 37 11 8
Low 15 15 15 1 4
Below cutoff


RefSeq Acc Id: ENSRNOT00000006403   ⟹   ENSRNOP00000006403
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,679,371 - 39,766,576 (+)Ensembl
Rnor_6.0 Ensembl642,180,894 - 42,286,970 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090816   ⟹   ENSRNOP00000073496
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,679,371 - 39,774,031 (+)Ensembl
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109820   ⟹   ENSRNOP00000091227
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,679,082 - 39,774,031 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119147   ⟹   ENSRNOP00000088194
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,679,371 - 39,772,743 (+)Ensembl
RefSeq Acc Id: NM_013022   ⟹   NP_037154
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8645,408,116 - 45,502,773 (+)NCBI
mRatBN7.2639,679,371 - 39,774,033 (+)NCBI
Rnor_6.0642,180,894 - 42,289,910 (+)NCBI
Rnor_5.0651,900,048 - 52,009,234 (+)NCBI
RGSC_v3.4640,581,247 - 40,672,854 (+)RGD
Celera638,987,591 - 39,082,080 (+)NCBI
RefSeq Acc Id: XM_006239909   ⟹   XP_006239971
Rat AssemblyChrPosition (strand)Source
GRCr8645,407,823 - 45,502,755 (+)NCBI
mRatBN7.2639,679,419 - 39,774,020 (+)NCBI
Rnor_6.0642,180,942 - 42,289,896 (+)NCBI
Rnor_5.0651,900,048 - 52,009,234 (+)NCBI
RefSeq Acc Id: XM_039111810   ⟹   XP_038967738
Rat AssemblyChrPosition (strand)Source
GRCr8645,473,437 - 45,502,755 (+)NCBI
mRatBN7.2639,715,390 - 39,774,020 (+)NCBI
RefSeq Acc Id: NP_037154   ⟸   NM_013022
- UniProtKB: Q62868 (UniProtKB/Swiss-Prot),   A0A0G2K5N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239971   ⟸   XM_006239909
- Peptide Label: isoform X2
- UniProtKB: F1LQT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006403   ⟸   ENSRNOT00000006403
RefSeq Acc Id: ENSRNOP00000073496   ⟸   ENSRNOT00000090816
RefSeq Acc Id: XP_038967738   ⟸   XM_039111810
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000091227   ⟸   ENSRNOT00000109820
RefSeq Acc Id: ENSRNOP00000088194   ⟸   ENSRNOT00000119147
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62868-F1-model_v2 AlphaFold Q62868 1-1388 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694504
Promoter ID:EPDNEW_R5029
Type:single initiation site
Description:Rho-associated coiled-coil containing protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0642,180,876 - 42,180,936EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3590 AgrOrtholog
BioCyc Gene G2FUF-38062 BioCyc
Ensembl Genes ENSRNOG00000004496 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006403.8 UniProtKB/TrEMBL
  ENSRNOT00000090816.2 UniProtKB/TrEMBL
  ENSRNOT00000109820.1 UniProtKB/TrEMBL
  ENSRNOT00000119147.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HR1_rho-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROCK1/ROCK2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROCK2_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROCK2_HR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_Binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rock2 PhenoGen
PIRSF Rho_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004496 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP G protein-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205230
  Q62868 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Rock2  Rho-associated coiled-coil containing protein kinase 2  Rock2  Rho-associated coiled-coil forming kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rock2  RhoA - binding serine/threosine kinase alpha (ROK - alpha)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds RhoA, RhoB, and RhoC but not Rac1 and Cdc42 633784