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Gene: Rock2 (Rho-associated coiled-coil containing protein kinase 2) Mus musculus
Symbol: Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and protein phosphorylation. Localizes to Schaffer collateral - CA1 synapse; glutamatergic synapse; and spindle pole centrosome. Is expressed in several structures, including central nervous system; genitourinary system; heart; musculature; and somite. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; Wnt signaling pathway; INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B230113H15Rik; mKIAA0619; p164 ROCK-2; Rho-associated coiled-coil forming kinage 2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; Rho-kinase; Rock-II; Rock2m; ROKalpha
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1216,894,895 - 16,987,823 (+)EnsemblGRCm38mm10GRCm38
GRCm381216,894,978 - 16,988,274 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371216,901,784 - 16,995,080 (+)NCBIGRCm37mm9NCBIm37
MGSCv361216,920,670 - 17,003,586 (+)NCBImm8
Celera1217,218,328 - 17,311,507 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rock2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11243
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.