Advanced Search (OLGA)

Gene: ROCK2 (Rho associated coiled-coil containing protein kinase 2) Pan paniscus

Analyze

Symbol:

ROCK2

Name:

Rho associated coiled-coil containing protein kinase 2

RGD ID:

11737043

Description:

ENCODES a protein that exhibits ATP binding (inferred); diacylglycerol binding (inferred); endopeptidase activator activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); aortic valve morphogenesis (ortholog); blood vessel diameter maintenance (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); Breast Cancer, Familial (ortholog); Cardiomegaly (ortholog); FOUND IN glutamatergic synapse (ortholog); neuromuscular junction (ortholog); postsynaptic density (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

rho-associated protein kinase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	115,184,603 - 115,347,775 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	115,188,575 - 115,351,748 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	11,167,353 - 11,331,339 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	11,316,755 - 11,478,986 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	11,318,370 - 11,478,986 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Breast Cancer, Familial (ISO)

Cardiomegaly (ISO)

cervical cancer (ISO)

colorectal cancer (ISO)

congestive heart failure (ISO)

dextrocardia (ISO)

esophageal cancer (ISO)

Familial Pancreatic Carcinoma (ISO)

Hydrops Fetalis (ISO)

Left Ventricular Hypertrophy (ISO)

lung cancer (ISO)

lung squamous cell carcinoma (ISO)

melanoma (ISO)

nonpapillary renal cell carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

patent ductus arteriosus (ISO)

Prenatal Injuries (ISO)

primary biliary cholangitis (ISO)

sarcoma (ISO)

stomach cancer (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

urinary bladder cancer (ISO)

uterine corpus endometrial carcinoma (ISO)

Ventricular Remodeling (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

actomyosin structure organization (IEA)

aortic valve morphogenesis (ISO)

blood vessel diameter maintenance (ISO)

cellular response to acetylcholine (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

centrosome duplication (IEA)

cortical actin cytoskeleton organization (IEA)

dendrite morphogenesis (ISO)

embryonic morphogenesis (IEA)

epithelial to mesenchymal transition (ISO)

extrinsic apoptotic signaling pathway via death domain receptors (ISO)

host-mediated perturbation of viral process (IEA)

mitotic cytokinesis (IEA)

mRNA destabilization (ISO)

negative regulation of angiogenesis (IEA)

negative regulation of bicellular tight junction assembly (IEA)

negative regulation of biomineral tissue development (ISO)

negative regulation of gene expression (ISO)

negative regulation of nitric oxide biosynthetic process (IEA)

negative regulation of protein localization to lysosome (IEA)

neural tube closure (ISO)

positive regulation of amyloid precursor protein catabolic process (IEA)

positive regulation of amyloid-beta formation (IEA)

positive regulation of cardiac muscle hypertrophy (ISO)

positive regulation of cell migration (IEA)

positive regulation of centrosome duplication (IEA,ISO)

positive regulation of connective tissue growth factor production (ISO)

positive regulation of connective tissue replacement (ISO)

positive regulation of fibroblast growth factor production (ISO)

positive regulation of gene expression (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of protein localization to early endosome (IEA)

positive regulation of protein localization to nucleus (ISO)

positive regulation of stress fiber assembly (IEA)

postsynaptic actin cytoskeleton organization (ISO)

protein localization to plasma membrane (IEA)

protein phosphorylation (ISO)

regulation of actin cytoskeleton organization (IEA)

regulation of amyloid-beta formation (IEA)

regulation of angiotensin-activated signaling pathway (ISO)

regulation of cell junction assembly (IEA)

regulation of cellular response to hypoxia (ISO)

regulation of circadian rhythm (ISO)

regulation of establishment of cell polarity (IEA)

regulation of establishment of endothelial barrier (IEA)

regulation of focal adhesion assembly (IEA)

regulation of keratinocyte differentiation (IEA)

regulation of nervous system process (ISO)

regulation of stress fiber assembly (IEA)

regulation of synapse maturation (ISO)

response to angiotensin (ISO)

response to ischemia (ISO)

response to transforming growth factor beta (ISO)

Rho protein signal transduction (IEA,ISO)

signal transduction (IEA)

smooth muscle contraction (IEA)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

cytoplasmic ribonucleoprotein granule (IEA)

cytoskeleton (IEA)

cytosol (IEA)

glutamatergic synapse (ISO)

neuromuscular junction (ISO)

nucleus (IEA)

plasma membrane (IEA)

postsynaptic density (ISO)

presynaptic active zone (ISO)

Schaffer collateral - CA1 synapse (ISO)

spindle pole centrosome (ISO)

Molecular Function

ATP binding (IEA)

diacylglycerol binding (IEA)

endopeptidase activator activity (IEA)

kinase activity (IEA)

nucleotide binding (IEA)

protease binding (IEA)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

Rho-dependent protein serine/threonine kinase activity (IEA)

small GTPase binding (IEA)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ROCK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	115,184,603 - 115,347,775 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	115,188,575 - 115,351,748 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	11,167,353 - 11,331,339 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	11,316,755 - 11,478,986 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	11,318,370 - 11,478,986 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

ROCK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	11,179,759 - 11,345,437 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	11,179,759 - 11,348,330 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	2	11,319,885 - 11,485,563 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	11,239,229 - 11,402,162 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	11,272,375 - 11,435,309	NCBI
Celera	2	11,237,615 - 11,400,586 (-)	NCBI		Celera
Cytogenetic Map	2	p25.1	NCBI
HuRef	2	11,171,519 - 11,335,102 (-)	NCBI		HuRef
CHM1_1	2	11,251,294 - 11,414,170 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	11,212,159 - 11,378,745 (-)	NCBI		T2T-CHM13v2.0

Rock2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	16,944,808 - 17,038,275 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	16,944,797 - 17,037,834 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	16,894,978 - 16,988,274 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	16,894,895 - 16,987,823 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	12	16,901,784 - 16,995,080 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	16,920,670 - 17,003,586 (+)	NCBI		MGSCv36	mm8
Celera	12	17,218,328 - 17,311,507 (+)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	8.04	NCBI

Rock2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	45,407,823 - 45,502,773 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	45,407,965 - 45,502,771 (+)	Ensembl				GRCr8
mRatBN7.2	6	39,679,116 - 39,774,033 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	39,679,082 - 39,774,031 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	40,012,204 - 40,106,584 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	40,326,914 - 40,421,294 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	39,760,198 - 39,854,585 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	6	46,872,364 - 46,966,737 (+)	NCBI
Lyon_Normotensive	6	46,302,770 - 46,397,153 (+)	NCBI
Lyon_Hypertensive	6	44,098,703 - 44,193,086 (+)	NCBI
F344_StmMcwi	6	43,315,442 - 43,409,833 (+)	NCBI
Rnor_6.0	6	42,180,864 - 42,289,910 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	42,180,894 - 42,289,908 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	6	51,900,048 - 52,009,234 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	40,581,247 - 40,672,854 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	38,987,591 - 39,082,080 (+)	NCBI		Celera
RGSC_v3.1	6	40,584,199 - 40,675,807 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

Rock2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	5,859,204 - 5,972,401 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955487	5,856,190 - 5,972,408 (-)	NCBI	ChiLan1.0	ChiLan1.0

ROCK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	7,931,786 - 8,012,484 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	7,934,739 - 8,178,707 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	7,863,769 - 8,005,135 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	8,035,035 - 8,176,737 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	8,037,253 - 8,177,067 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	7,920,092 - 8,061,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	7,923,254 - 8,065,610 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	7,943,547 - 8,085,045 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rock2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	12	113,296,176 - 113,431,201 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024406292	52,387,532 - 52,529,676 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	7,145,882 - 7,286,244 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936532	7,142,580 - 7,284,722 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ROCK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	125,352,920 - 125,493,362 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	3	125,353,063 - 125,493,368 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	134,221,182 - 134,297,878 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ROCK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	14	11,089,605 - 11,253,821 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666045	15,835,723 - 16,002,638 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	14	96,275,889 - 96,443,048 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	96,276,023 - 96,432,790 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Rock2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624865	4,461,200 - 4,591,309 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624865	4,461,215 - 4,588,836 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	27	465,153 - 639,827 (-)	Ensembl

Rock2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	36,704,377 - 36,798,321 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003826972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008952314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034952617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000054779 ⟹ ENSPPAP00000031913

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	11,318,370 - 11,478,986 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000054799 ⟹ ENSPPAP00000031933

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	11,318,370 - 11,478,986 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000054816 ⟹ ENSPPAP00000031950

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	11,329,111 - 11,478,796 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000054825 ⟹ ENSPPAP00000031959

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	11,329,111 - 11,478,796 (-)	Ensembl

RefSeq Acc Id:

XM_003826972 ⟹ XP_003827020

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	12	115,184,603 - 115,347,775 (+)	NCBI
NHGRI_mPanPan1	2A	115,188,575 - 115,351,748 (+)	NCBI
Mhudiblu_PPA_v0	2A	11,167,353 - 11,330,491 (-)	NCBI
PanPan1.1	2A	11,316,755 - 11,478,986 (-)	NCBI

Sequence:

show sequence

TGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGG
AGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGAAGCTGGTGGTTCGGGGGCGGTGC
TAGGCCCCGAGGCTGCCGAACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCAT
GAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCA
GGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGG
AGAGCTTGCTGGATGGCTTAAATTCCTTGGTCCTTGATTTAGATTTTCCTGCTTTGAGGAAAAA
CAAGAACATAGATAATTTCTTAAATAGATATGAGAAAATTGTGAAAAAAATCAGAGGTCTACAG
ATGAAGGCAGAAGACTATGATGTTGTAAAAGTTATTGGAAGAGGTGCTTTTGGTGAAGTGCAGT
TGGTTCGTCACAAGGCATCGCAGAAGGTTTATGCTATGAAGCTTCTTAGTAAGTTTGAAATGAT
AAAAAGATCAGATTCTGCCTTTTTTTGGGAAGAAAGAGATATTATGGCCTTTGCCAATAGCCCC
TGGGTGGTTCAGCTTTTTTATGCCTTTCAAGATGATAGGTATCTGTACATGGTAATGGAGTACA
TGCCTGGTGGAGACCTTGTAAACCTTATGAGTAATTACGATGTGCCTGAAAAATGGGCCAAATT
TTACACTGCTGAAGTTGTTCTTGCTCTGGATGCAATACACTCCATGGGTTTAATACACAGAGAT
GTGAAGCCTGACAACATGCTCTTGGATAAACATGGACATCTAAAATTAGCAGATTTTGGCACGT
GTATGAAGATGGATGAAACAGGCATGGTACATTGTGATACAGCAGTTGGAACACCGGATTATAT
ATCACCTGAGGTTCTGAAATCACAAGGGGGTGATGGTTACTATGGGCGAGAATGTGATTGGTGG
TCTGTAGGTGTTTTCCTTTATGAGATGCTAGTGGGGGATACTCCATTTTATGCGGATTCACTTG
TAGGAACATATAGCAAAATTATGGATCATAAGAATTCACTGTGTTTCCCTGAAGATGCAGAAAT
TTCCAAACATGCAAAGAATCTCATCTGTGCTTTCTTAACAGATAGGGAGGTACGACTTGGGAGA
AATGGGGTGGAAGAAATCAGACAGCATCCTTTCTTTAAGAATGATCAGTGGCATTGGGATAACA
TAAGAGAAACGGCAGCTCCTGTAGTACCTGAACTCAGCAGTGACATAGACAGCAGCAATTTCGA
TGACATTGAAGATGACAAAGGAGATGTAGAAACCTTCCCAATTCCTAAAGCTTTTGTTGGAAAT
CAGCTGCCTTTCATCGGATTTACCTACTATAGAGAAAATTTATTATTAAGTGACTCTCCATCTT
GTAGAGAAAATGATTCAATACAATCAAGGAAAAATGAAGAAAGTCAAGAGATTCAGAAAAAACT
GTATACATTAGAAGAACATCTTAGCAATGAGATGCAAGCCAAAGAGGAACTGGAACAGAAGTGC
AAATCTGTTAATACTCGCCTAGAAAAGACAGCAAAGGAGCTAGAAGAGGAGATTACCTTACGGA
AAAGTGTGGAATCAGCATTAAGACAGTTAGAAAGAGAAAAGGCGCTTCTTCAGCACAAAAATGC
AGAATATCAGAGGAAAGCTGATCATGAAGCAGACAAAAAACGAAATTTGGAAAATGATGTTAAC
AGCTTAAAAGATCAACTTGAAGATTTGAAAAAAAGAAATCAAAACTCTCAAATATCCACTGAGA
AAGTGAATCAACTCCAGAGACAACTGGATGAAACCAATGCTTTACTGCGAACAGAGTCTGATAC
TGCAGCCCGGTTAAGGAAAACCCAGGCAGAAAGTTCAAAACAGATTCAGCAGCTGGAATCTAAC
AATAGAGATCTACAAGATAAAAACTGCCTGCTGGAGACTGCCAAGTTAAAACTTGAAAAGGAAT
TTATCAATCTTCAGTCAGCTCTAGAATCTGAAAGGAGGGATCGAACCCATGGATCAGAGATAAT
TAATGATTTACAAGGTAGAATATGTGGCCTAGAAGAAGATTTAAAGAACGGCAAAATCTTATTA
GCGAAAGTAGAACTGGAGAAGAGACAACTTCAGGAGAGATTTACTGATTTGGAAAAGGAAAAAA
GCAACATGGAAATAGATATGACATACCAACTAAAAGTTATACAGCAGAGCCTAGAACAAGAAGA
AGCTGAACATAAGGCCACAAAGGCACGACTAGCAGATAAAAATAAGATCTATGAGTCCATCGAA
GAAGCCAAATCAGAAGCCATGAAAGAAATGGAGAAGAAGCTCTTGGAGGAAAGAACTTTAAAAC
AGAAAGTGGAGAACCTATTGCTAGAAGCTGAGAAAAGATGTTCTCTATTAGACTGTGACCTCAA
ACAGTCACAGCAGAAAATAAATGAGCTCCTTAAACAGAAAGATGTGCTAAATGAGGATGTTAGA
AACCTGACATTAAAAATAGAGCAAGAAACTCAGAAGCGCTGCCTTACACAAAATGACCTGAAGA
TGCAAACACAACAGGTTAACACACTAAAAATGTCAGAAAAGCAGTTAAAGCAAGAAAATAACCA
TCTCATGGAAATGAAAATGAACTTGGAAAAACAAAATGCTGAACTTCGAAAAGAACGTCAGGAT
GCAGATGGGCAAATGAAAGAGCTCCAGGATCAGCTCGAAGCAGAACAGTATTTCTCAACCCTTT
ATAAAACACAAGTTAGGGAGCTTAAAGAAGAATGTGAAGAAAAGACCAAACTTGGTAAAGAATT
GCAGCAGAAGAAACAGGAATTACAGGATGAACGGGACTCTTTGGCTGCCCAACTGGAGATCACC
TTGACCAAAGCAGATTCTGAGCAACTGGCTCGTTCAATTGCTGAAGAACAATATTCTGATTTGG
AAAAAGAGAAGATCATGAAAGAGCTGGAGATCAAAGAGATGATGGCTAGACACAAACAGGAACT
TACTGAAAAAGATGCTACAATTGCTTCTCTTGAGGAAACTAATAGGACACTAACTAGTGATGTT
GCCAATCTTGCAAATGAGAAAGAAGAATTAAATAACAAATTGAAAGATGTTCAAGAGCAACTGT
CAAGATTGAAAGATGAAGAAATAAGCGCAGCAGCTATTAAAGCACAGTTTGAGAAGCAGCTATT
AACAGAAAGAACACTCAAAACTCAAGCTGTGAATAAGTTGGCTGAGATCATGAATCGAAAAGAA
CCTGTCAAGCGTGGTAATGACACAGATGTGCGGAGAAAAGAGAAGGAGAATAGAAAGCTACATA
TGGAGCTTAAATCTGAACGTGAGAAATTGACCCAGCAGATGATCAAGTATCAGAAAGAACTGAA
TGAAATGCAGGCACAAATAGCTGAAGAGAGCCAGATTCGAATTGAACTGCAGATGACATTGGAC
AGTAAAGACAGTGACATTGAGCAGCTGCGGTCACAACTCCAAGCCTTGCATATTGGTCTGGATA
GTTCCAGTATAGGCAGTGGACCAGGGGATGCTGAGGCAGATGATGGGTTTCCAGAATCAAGATT
AGAAGGATGGCTTTCATTGCCTGTACGAAACAACACTAAGAAATTTGGATGGGTTAAAAAGTAT
GTGATTGTAAGCAGTAAGAAGATTCTTTTCTATGACAGTGAACAAGATAAAGAACAATCCAATC
CTTACATGGTTTTAGATATAGACAAGTTATTTCATGTCCGACCAGTTACACAGACAGATGTGTA
TAGAGCAGATGCTAAAGAAATTCCAAGGATATTCCAGATTCTGTATGCCAATGAAGGAGAAAGT
AAGAAGGAACAAGAATTTCCAGTGGAGCCAGTTGGAGAAAAATCTAATTATATTTGCCACAAGG
GACATGAGTTTATTCCTACTCTTTATCATTTCCCAACCAACTGTGAGGCTTGTATGAAGCCCCT
GTGGCACATGTTTAAGCCTCCTCCTGCTTTGGAGTGCCGCCGTTGCCATATTAAGTGTCATAAA
GATCATATGGACAAAAAGGAGGAGATTATAGCACCTTGCAAAGTATATTATGATATTTCAACGG
CAAAGAATCTGTTATTACTAGCAAATTCTACAGAAGAGCAGCAGAAGTGGGTTAGTCGGTTGGT
GAAAAAGATACCTAAAAAGCCCCCAGCTCCAGACCCTTTTGCCCGATCATCTCCTAGAACTTCA
ATGAAGATACAGCAAAACCAGTCTATTAGACGGCCAAGTCGACAGCTTGCCCCAAACAAACCTA
GCTAACTGCCTTCTATGAAAGCAGTCATTATTCAAGGTGATCGTATTCTTCCAGTGAAAACAAG
ACTGAAATATGATGGCCCAAAATTTATTAAAAAGCTATATTTTCCTGAGAGACTGATACATACA
CTCATACATATATGTGTTCCCCTTTTCCCTGTAATATAAATTACAAATCTGGGCTCCTTTGAAG
CAACAGGTTGAACCAACAATGATTGGTTGATAGACTAAGGATATATGCAACTCTTCCAGACTTT
TCCATAAAGCTCTCTCGGCAGTCGCTCACACTACAATGCACACAAGGATTGAGAAGAGTTAAAG
GCTAAAGAAAACATCTTTTCTAGCTTCAACAGAGAGGTTTCACCAGCACATTTACCAGAAGAAT
CTGGGAATGGATTCCACTACAGTGATATTGACTGCATCTTTAAGAAGTGACCATTATACTGTGT
ATATATATATAAACACACACACATATATATATATATATAGTACTCTAATACTGCAAGAAGGTTT
TTTAAACTTCCCACTTTATTTTTTATACACATTAATCAGATATCATTACTTGCTGCAGTTGCAA
CTATGCACTTGTATAAAGCCATAATGTTGGAGTTTATATCACTCATTCCTGTGTACCTGATGGA
AGTTGCATGTTCATGTTTAAGCAGTTACTGTAACAAGAAGTTTAAAGTTAATTATCAGTTTCCT
AATGCTTCATGATAGGCAACTTTACCCATTTTGAATGCCTTAATTTAATTTTTTTCGAAGTCTC
AGCCCTGTCTGTATTAAAAAACAAAAAAAGCGTTTACCAGCTCTTAGGATGTAAACTAGCTTTG
TGGAAGATAAATCGTGCACTATTTTTACACATAAATAGTTATATCAGTGTCAGCCTATTTTGAT
TAACAAATGTTTTTAAAGTATTATTGGTTATAGAAACAATAATGGATGGTGTTGGAACTAATAT
ATCCTTGATGTCTGTCTATTATGCATTCAACTCTTTCTACAGACCTCAGTATTAGTCTGTGACT
ACAAAATATTTTCTTTGCTTTAAATTTGCTGGCTACCCTAGATGTGTTTTTATTCCTGGTAAAG
ACATTTGTGATTACATTTTCACACTTAAGATTCAAAATTTTTCCCAAATATAAAGAAAACTAAG
ACAGACTGTAGATGCATTTTAAATATTTAAATATGATCCTCAGACATGCAGCTGTGTGTGGCAG
TATTTTAGTACCGGGTTAAGAAAACTGGTAACTGGGAAGAAGTGGCCTCAAAGGCACTTAATTT
GATTTTTATTTTTTAAATGCTGTCAAAAGTTACAGTTTACGCAGGACATTCTTGCCGTATTCTC
ATGATCCCAGATAAGTGTGTGTTTTATACTGCAACAATATGCAGCAATGGTAAGCGTAAAGTTT
TTTTTTGTTTTGTTTTGTTTTTTTTAAATTATGAAGTCTTTTAACAGTCTCTCTTTATATAAAT
ACACAGAGTTTGGTATGATATTTAAATACATCATCTGGCCGGGCATGGTGGCTTACGCCTGTAA
TCCTAGCACTTTGGGAGGCCAAGACGGGCGGATCACCTGAGGTGAGGAGTTCAAGACCAGCCTG
ACCAACATGGTGAAACTCCGTCTCTACCAATATACAAAAATTAGCCGGGCATGATGGTGGTGGC
CTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGGAGACGGTGGTT
GCAGTGAGCGAAGATCGAGCCACTGCACTCCAGCCTGGGCGGCTGAACAAGACTCCGTCTACAA
AAAAAAAAAAAAAAAGTAAGTCATCTAATATTTCGATGAAGGAAATAGACATTTTTCATTGATT
CCCTCTGATGTCAGTTAGAGATGTTTAAAAAGTTAGATCCCCATAATAGATACTATTGTGGAAA
CTGAAGAGTAGCTACTGGCCTACTGATAGACTGAAACTGATTTCGTTATTCTTACGTTCTCCAG
TCTGCACTCTGCTGTGCTGTCTGTGCTCAGACTAGACGTGCATGCCGTTTCCTTTGCAGGTGTG
TTCTGCAGCTCTGGTTTTGGGGGATAGCTCTTTTTTAAGTAAGATTAAAAAATGAAAAATATAT
AAATTTATATAGAATAAATATTTCCATTCATTAGAGTTGTTAAAAGGAGACTGAATTAATATTT
TATATAAAGATTTTGTTACATTATGGGAGGTTCTATCCTATTCTGAATTGGAGAGTATATATAT
ATATATATTTTTAATAAACTTTATTAAGGTGAAATAATTTCAAGTTTACATATGAGTGAAATAT
TTGAGTAAAAGCAAAAGTTTAAATTTGGAATGCTGTATATATTAGAGAATATGGGGAATCATGG
TGTGACCAACTGTACAAGGAAGATTCATATGAAGGTCTTAGGGGAAAAAGATAATTCTGAAGGG
TGAAAAAAAAATCTCTCCCATGGAGATTCTTCACATTATATGGTTTGACATAAGGGTTTATAAG
GTTGTTTGTCCAACTAATGAAAATGCGCTTAATAAAAAAATTCTGACCTTGGGTAAGAATTTGC
TTTTTACCGCATTGCCGCTTTCATGTACATACATGAGTGCATGCACCTATCAATGTGTTTTCTT
CCCAACACTTATTAAATATAAAACAACCTGATTTTGTGCTCGTTTCTCGTTTTTCTTGAGGCCC
TAAAGCTTCCAAGATAAATATTTATAAGACTAAAATTTGCTTGTTCCTTCACACCTGATTTCTC
CTAGAACCATAAATACCTCCTGTGGGGAACTAAGAAATCATGAATACTGGGATTTTCTTATTGG
ATTTTTTACTTTTGTTTTGTGGGGATAACGAGACAGAAGTGAAAGGAAAACTGGTGCCGGTATT
ACTGTTGAAATTAATGTACAGTGAATGTTTTTAAAGTATTAATTTTAAAAAACCATGTTCTCTA
GAAACAAGTTTTAAAAATCTATATGAAAGTTTTAAAATGTTCCAGCTAACTAATGGATAAGCAT
ACCAGTAAAGCCAAAGTAAAGGTTAGTGCCTTTAAAACTAACCTGTGTTAGAGTTACATGAATC
TGGCTCTAAAGTATCTATTTTGCATCCATTTATATATAGATCTTAAACAGAAATACTCTAGGTT
GCCACACCACAGTTTTAAGAAGTTATGCTGCTGCTGTTATTCTCTTCTAGGATTCTGGTGGTAA
AGTAGAGAAACTTGGACACTATATTAACCTTACTGAAACATGCTTTAAATCGTGTCTAAAATCT
GATTTGAGCAAGTCACTGCCGAGCTTCTGAGTCTGCATTGACACTGCTACTGACTCACCTCTCC
TTCCCTGGAATAAGGCTTCAGCTTCCCTATGCTGTGAAGACACCATTTGTAAGCACTTTGAACA
TAAGCACTGTGTGACAGCGCTGGATATCATGCTTGGGGGGGCCTCTCCCTGACTCCCATCCCCA
TAATAATGAGTTTTGTTTGGAATTGTAATAAGTAATGAACTGCATGGTTTAGAAAATTATAAAT
ATTTGATCAGCTGTCCCCTCTGAAAAAAATTGCACCCCTTTTTCTTTTTTAAAATTTTGTTGCA
TCTTCGTAGTAATGTAATTGTATTTTATGCCTGCTTTTTTATTAAAAAAAATAAAATAAATGGA
GACATAAGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003827020	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000031913.1
	ENSPPAP00000031933.1
	ENSPPAP00000031950.1
	ENSPPAP00000031959.1
	ENSPPAP00050020450

RefSeq Acc Id:

XP_003827020 ⟸ XM_003826972

- UniProtKB:

A0A2R9BR94 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRK
NKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEM
IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAK
FYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAE
ISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNF
DDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRENDSIQSRKNEESQEIQKK
LYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKN
AEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESD
TAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEI
INDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQE
EAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDL
KQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENN
HLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKE
LQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQL
LTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKEL
NEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESR
LEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDV
YRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKP
LWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRL
VKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS

hide sequence

Ensembl Acc Id:

ENSPPAP00000031913 ⟸ ENSPPAT00000054779

Ensembl Acc Id:

ENSPPAP00000031933 ⟸ ENSPPAT00000054799

Ensembl Acc Id:

ENSPPAP00000031959 ⟸ ENSPPAT00000054825

Ensembl Acc Id:

ENSPPAP00000031950 ⟸ ENSPPAT00000054816

Protein Domains

AGC-kinase C-terminal PH Phorbol-ester/DAG-type Protein kinase REM-1 RhoBD

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038618	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050015374	ENTREZGENE
Ensembl Transcript	ENSPPAT00000054779.1	UniProtKB/TrEMBL
	ENSPPAT00000054799.1	UniProtKB/TrEMBL
	ENSPPAT00000054816.1	UniProtKB/TrEMBL
	ENSPPAT00000054825.1	UniProtKB/TrEMBL
	ENSPPAT00050032484	ENTREZGENE
Gene3D-CATH	1.20.5.340	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	3.30.60.20	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Single helix bin	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	AGC-kinase_C	UniProtKB/TrEMBL
	C1-like_sf	UniProtKB/TrEMBL
	HR1_rho-bd	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	MRCK/ROCK_PH	UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Rho-assoc_Ser/Thr_Kinase	UniProtKB/TrEMBL
	ROCK1/ROCK2	UniProtKB/TrEMBL
	ROCK2_cat	UniProtKB/TrEMBL
	ROCK2_HR1	UniProtKB/TrEMBL
	ROCK_Rho-bd_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	ROCK2	ENTREZGENE
PANTHER	MYOTONIC DYSTROPHY S/T KINASE-RELATED	UniProtKB/TrEMBL
	RHO-ASSOCIATED PROTEIN KINASE 2	UniProtKB/TrEMBL
Pfam	PH_MRCK	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
	Rho_Binding	UniProtKB/TrEMBL
PIRSF	Rho_kinase	UniProtKB/TrEMBL
PROSITE	AGC_KINASE_CTER	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	REM_1	UniProtKB/TrEMBL
	RHO_BD	UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/TrEMBL
SMART	S_TK_X	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
	SM00109	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	G protein-binding domain	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
	SSF57889	UniProtKB/TrEMBL
UniProt	A0A2R9BR94	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BU42_PANPA	UniProtKB/TrEMBL
	A0A2R9BZI7_PANPA	UniProtKB/TrEMBL
	A0A2R9BZK9_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD