Atp5f1b (ATP synthase F1 subunit beta) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Atp5f1b (ATP synthase F1 subunit beta) Rattus norvegicus
Analyze
Symbol: Atp5f1b
Name: ATP synthase F1 subunit beta
RGD ID: 621368
Description: Enables several functions, including adenyl ribonucleotide binding activity; calcium ion binding activity; and proton-transporting ATP synthase activity, rotational mechanism. Contributes to ATP hydrolysis activity. Involved in several processes, including cellular response to peptide; cold acclimation; and response to 3,3',5-triiodo-L-thyronine. Located in cell surface; membrane raft; and mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Used to study obesity. Biomarker of cardiomyopathy; polycystic ovary syndrome; transient cerebral ischemia; and type 2 diabetes mellitus. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP synthase subunit beta, mitochondrial; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; Atp5b; mitochondrial ATP synthase beta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,100,058 - 1,106,461 (+)NCBIGRCr8
mRatBN7.27515,454 - 521,858 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7515,460 - 567,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,274,116 - 3,280,516 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,150,130 - 5,156,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,451,361 - 5,457,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,504,708 - 2,511,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,504,695 - 2,511,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,484,095 - 2,490,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,376,552 - 1,383,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,377,178 - 1,383,228 (+)NCBI
Celera7394,648 - 401,125 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatcardiomyopathy treatmentIEP 13792652mRNA:increased expression:heart (rat)RGD 
Atp5f1bRatCOVID-19  ISOATP5F1B (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Atp5f1bRatDiabetic Nephropathies treatmentIDA 13792578mRNA:decreased expression:renal glomerulus (rat)RGD 
Atp5f1bRatExperimental Diabetes Mellitus  IEP 13703107associated with polycystic ovary syndrome more ...RGD 
Atp5f1bRatFetal Growth Retardation  IEP 13782135protein:decreased expression:liver (rat)RGD 
Atp5f1bRatLiver Injury  IEP 13800895protein:increased expression:liver (rat)RGD 
Atp5f1bRatobesity treatmentIDA 13782133 RGD 
Atp5f1bRatpolycystic ovary syndrome  IEP 13703107mRNA and protein:decreased expression:pancreas (rat)RGD 
Atp5f1bRattransient cerebral ischemia  IEP 13792582protein:increased expression:cerebrum (rat)RGD 
Atp5f1bRattype 2 diabetes mellitus  IEP 13792619protein:decreased expression:islet of Langerhans (rat)RGD 
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatcataract 15 multiple types  ISOATP5F1B (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 15 multiple typesClinVarPMID:28492532
Atp5f1bRatCharcot-Marie-Tooth disease axonal type 2U  ISOATP5F1B (Homo sapiens)8554872ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH DISEASE more ...ClinVarPMID:28492532
Atp5f1bRatHypermetabolism due to Defect in Mitochondria  ISOATP5F1B (Homo sapiens)8554872ClinVar Annotator: match by term: Hypermetabolism due to Defect in Mitochondrial CouplingClinVarPMID:36239646
Atp5f1bRatHYPERMETABOLISM DUE TO UNCOUPLED MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION 2  ISOATP5F1B (Homo sapiens)8554872ClinVar Annotator: match by term: Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2ClinVarPMID:36239646
Atp5f1bRatINTERSTITIAL LUNG AND LIVER DISEASE  ISOATP5F1B (Homo sapiens)8554872ClinVar Annotator: match by term: Interstitial lung and liver diseaseClinVarPMID:28492532
Atp5f1bRatparaplegia  ISOATP5F1B (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatacute kidney failure  ISOATP5F1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25666834
Atp5f1bRatHypoxia  ISOATP5F1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19579223
Atp5f1bRatmetabolic dysfunction-associated steatotic liver disease  ISOATP5F1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25666834
Atp5f1bRatpre-malignant neoplasm  ISOATP5F1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21472284
Atp5f1bRatspinocerebellar ataxia type 17  ISOATP5F1B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24413982
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatHYPERMETABOLISM DUE TO UNCOUPLED MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION 2  ISOATP5F1B (Homo sapiens)7240710 OMIM 

1 to 20 of 200 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRat(+)-dexrazoxane decreases expressionISOAtp5f1b (Mus musculus)6480464Dexrazoxane results in decreased expression of ATP5F1B mRNACTDPMID:26873546
Atp5f1bRat(Z)-3-butylidenephthalide decreases expressionISOATP5F1B (Homo sapiens)6480464butylidenephthalide results in decreased expression of ATP5F1B proteinCTDPMID:23770345
Atp5f1bRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o and p'-DDT results in increased expression of ATP5F1B mRNACTDPMID:24096037
Atp5f1bRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOAtp5f1b (Mus musculus)6480464o and p'-DDT results in increased expression of ATP5F1B mRNACTDPMID:24096037
Atp5f1bRat1,2-dimethylhydrazine increases expressionISOAtp5f1b (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ATP5F1B mRNACTDPMID:22206623
Atp5f1bRat1,3-dinitrobenzene increases metabolic processingEXP 64804643-dinitrobenzene results in increased metabolism of ATP5F1B proteinCTDPMID:21402099
Atp5f1bRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOAtp5f1b (Mus musculus)6480464Levodopa inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:23562983
Atp5f1bRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOAtp5f1b (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:23562983
Atp5f1bRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ATP5F1B mRNACTDPMID:19400957 and PMID:24096037
Atp5f1bRat17alpha-ethynylestradiol affects expressionISOAtp5f1b (Mus musculus)6480464Ethinyl Estradiol affects the expression of ATP5F1B mRNACTDPMID:17555576
Atp5f1bRat17alpha-ethynylestradiol multiple interactionsISOAtp5f1b (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5F1B mRNACTDPMID:17942748
Atp5f1bRat17alpha-ethynylestradiol increases expressionISOAtp5f1b (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ATP5F1B mRNACTDPMID:17942748 more ...
Atp5f1bRat17beta-estradiol increases expressionISOATP5F1B (Homo sapiens)6480464Estradiol results in increased expression of ATP5F1B mRNACTDPMID:20211987
Atp5f1bRat17beta-estradiol decreases expressionISOAtp5f1b (Mus musculus)6480464Estradiol results in decreased expression of ATP5F1B mRNACTDPMID:39298647
Atp5f1bRat2,2,2-tetramine multiple interactionsEXP 6480464Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1B protein]CTDPMID:21136691
Atp5f1bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAtp5f1b (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ATP5F1B proteinCTDPMID:29935226
Atp5f1bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ATP5F1B mRNACTDPMID:33387578 and PMID:34747641
Atp5f1bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOAtp5f1b (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of ATP5F1B mRNACTDPMID:20399798
Atp5f1bRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAtp5f1b (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5F1B mRNACTDPMID:17942748
Atp5f1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAtp5f1b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ATP5F1B mRNACTDPMID:21570461

1 to 20 of 200 rows

Biological Process
1 to 20 of 36 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatangiogenesis involved_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatangiogenesis involved_inISOATP5F1B (Homo sapiens)1624291 PMID:17510399RGDPMID:17510399
Atp5f1bRatATP biosynthetic process involved_inISOATP5F1B (Homo sapiens)1624291 PMID:17510399 and PMID:21106936RGDPMID:17510399 and PMID:21106936
Atp5f1bRatATP biosynthetic process involved_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatATP biosynthetic process involved_inIEAUniProtKB-KW:KW-00661600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatATP biosynthetic process involved_inISSUniProtKB:P25705596936199PMID:9736690UniProt 
Atp5f1bRatATP metabolic process involved_inIEAInterPro:IPR004100 and InterPro:IPR0361211600115GO_REF:0000002InterProGO_REF:0000002
Atp5f1bRatcellular response to interleukin-7 acts_upstream_of_or_withinISOAtp5f1b (Mus musculus)1624291 PMID:29581031RGDPMID:29581031
Atp5f1bRatcellular response to interleukin-7 acts_upstream_of_or_withinIEAUniProtKB:P56480 and ensembl:ENSMUSP000000264591600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatcellular response to peptide  IEP 13800889ceruleinRGD 
Atp5f1bRatcold acclimation  IEP 13799276 RGD 
Atp5f1bRatlipid metabolic process acts_upstream_of_or_withinISOAtp5f1b (Mus musculus)1624291 PMID:17612527RGDPMID:17612527
Atp5f1bRatlipid metabolic process acts_upstream_of_or_withinIEAUniProtKB:P56480 and ensembl:ENSMUSP000000264591600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatliver development  IEP 13792579 RGD 
Atp5f1bRatmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatnegative regulation of cell adhesion involved in substrate-bound cell migration acts_upstream_of_or_withinISOAtp5f1b (Mus musculus)1624291 PMID:17612527RGDPMID:17612527
Atp5f1bRatnegative regulation of cell adhesion involved in substrate-bound cell migration acts_upstream_of_or_withinIEAUniProtKB:P56480 and ensembl:ENSMUSP000000264591600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatpositive regulation of blood vessel endothelial cell migration involved_inISOATP5F1B (Homo sapiens)1624291UniProtKB:P62328 and PMID:21106936RGDPMID:21106936
Atp5f1bRatpositive regulation of blood vessel endothelial cell migration involved_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatproton motive force-driven ATP synthesis involved_inISOATP5F1B (Homo sapiens)1624291 PMID:25168243 more ...RGDPMID:25168243 more ...
1 to 20 of 36 rows

Cellular Component
1 to 20 of 34 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatcell surface  IDA 13800910 RGD 
Atp5f1bRatcell surface located_inISOATP5F1B (Homo sapiens)1624291 PMID:17510399RGDPMID:17510399
Atp5f1bRatcell surface located_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Atp5f1bRatmembrane located_inISOATP5F1B (Homo sapiens)1624291 PMID:21106936RGDPMID:21106936
Atp5f1bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatmembrane located_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Atp5f1bRatmembrane raft located_inIDA 12793007PMID:14499952CAFA 
Atp5f1bRatmitochondrial inner membrane  IDA 629531 RGD 
Atp5f1bRatmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-09991600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-01681600115GO_REF:0000044UniProtGO_REF:0000044
Atp5f1bRatmitochondrial inner membrane  IDA 2292224 RGD 
Atp5f1bRatmitochondrial inner membrane  IDA 2292227 RGD 
Atp5f1bRatmitochondrial membrane located_inISOATP5F1B (Homo sapiens)1624291 PMID:8006588RGDPMID:8006588
Atp5f1bRatmitochondrial membrane located_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatmitochondrial nucleoid located_inIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatmitochondrial nucleoid located_inISOATP5F1B (Homo sapiens)1624291 PMID:18063578RGDPMID:18063578
Atp5f1bRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatmitochondrion located_inIEAUniProtKB:V9HW31 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 34 rows

Molecular Function
1 to 20 of 29 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatADP binding  IDA 2292225TNP-ADPRGD 
Atp5f1bRatangiostatin binding enablesISOATP5F1B (Homo sapiens)1624291UniProtKB:P00747-PRO_0000028057 and PMID:21106936RGDPMID:21106936
Atp5f1bRatangiostatin binding enablesIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatATP binding  IDA 629531 RGD 
Atp5f1bRatATP binding enablesIEAInterPro:IPR000194 and InterPro:IPR0200031600115GO_REF:0000002InterProGO_REF:0000002
Atp5f1bRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatATP binding  IPITNP-ATP2292225 RGD 
Atp5f1bRatATP binding  IDA 2292226 RGD 
Atp5f1bRatATP hydrolysis activity contributes_toIDA 2292224 RGD 
Atp5f1bRatATP hydrolysis activity  IDA 629531 RGD 
Atp5f1bRatATP hydrolysis activity enablesIEAInterPro:IPR0035931600115GO_REF:0000002InterProGO_REF:0000002
Atp5f1bRatcalcium ion binding  IDA 2292227 RGD 
Atp5f1bRatlipoprotein particle receptor activity  IDA 629531 RGD 
Atp5f1bRatMHC class I protein binding enablesIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
Atp5f1bRatMHC class I protein binding enablesISOATP5F1B (Homo sapiens)1624291 PMID:17643490RGDPMID:17643490
Atp5f1bRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Atp5f1bRatprotein binding enablesISOAtp5f1b (Mus musculus)1624291UniProtKB:Q3UMW8 and PMID:19941651RGDPMID:19941651
Atp5f1bRatprotein binding enablesISOATP5F1B (Homo sapiens)1624291UniProtKB:O75947 more ...RGDPMID:10077593 more ...
Atp5f1bRatproton-transporting ATP synthase activity, rotational mechanism contributes_toISOATP5F1B (Homo sapiens)1624291 PMID:12110673RGDPMID:12110673
Atp5f1bRatproton-transporting ATP synthase activity, rotational mechanism contributes_toIEAUniProtKB:P06576 and ensembl:ENSP000002620301600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 29 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatelectron transport chain pathway  ISOATP5F1B (Homo sapiens)10402751 SMPDBSMP:00355

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atp5f1bRatAlzheimer's disease pathway   IEA 6907045 KEGGrno:05010
Atp5f1bRatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Atp5f1bRatoxidative phosphorylation pathway  IEA 6907045 KEGGrno:00190
Atp5f1bRatParkinson's disease pathway   IEA 6907045 KEGGrno:05012

BioCyc Pathways


1 to 20 of 33 rows
#
Reference Title
Reference Citation
1. ATP synthase subunit c expression: physiological regulation of the P1 and P2 genes. Andersson U, etal., Biochem J. 1997 Apr 15;323 ( Pt 2):379-85.
2. Mitochondrial ATP synthase. Quaternary structure of the F1 moiety at 3.6 A determined by x-ray diffraction analysis. Bianchet M, etal., J Biol Chem. 1991 Nov 5;266(31):21197-201.
3. The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis. Bianchet MA, etal., Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11065-70. doi: 10.1073/pnas.95.19.11065.
4. Quantitative neuroproteomics of an in vivo rodent model of focal cerebral ischemia/reperfusion injury reveals a temporal regulation of novel pathophysiological molecular markers. Datta A, etal., J Proteome Res. 2011 Nov 4;10(11):5199-213. doi: 10.1021/pr200673y. Epub 2011 Oct 20.
5. Beta subunit of rat liver mitochondrial ATP synthase: cDNA cloning, amino acid sequence, expression in Escherichia coli, and structural relationship to adenylate kinase. Garboczi DN, etal., Biochemistry 1988 Jan 26;27(2):553-60.
6. Mitochondrial ATP synthase. Overexpression in Escherichia coli of a rat liver beta subunit peptide and its interaction with adenine nucleotides. Garboczi DN, etal., J Biol Chem. 1988 Oct 25;263(30):15694-8.
7. Rat liver mitochondrial ATP synthase. Effects of mutations in the glycine-rich region of a beta subunit peptide on its interaction with adenine nucleotides. Garboczi DN, etal., J Biol Chem. 1990 Aug 25;265(24):14632-7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique. Han D, etal., J Proteome Res. 2011 Feb 4;10(2):564-77. doi: 10.1021/pr100759a. Epub 2010 Dec 20.
10. Mitochondrial ATP synthase F1-beta-subunit is a calcium-binding protein. Hubbard MJ and McHugh NJ, FEBS Lett. 1996 Aug 12;391(3):323-9.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, etal., J Biol Chem. 2000 Oct 20;275(42):32931-9.
13. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
14. ATP synthase ß-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus. Li W, etal., J Huazhong Univ Sci Technolog Med Sci. 2017 Apr;37(2):210-216. doi: 10.1007/s11596-017-1717-9. Epub 2017 Apr 11.
15. [Screening of differentially expressed genes in rats with cardiomyopathy after bone marrow mesenchymal stem cell transplantation]. Li Y, etal., Zhonghua Er Ke Za Zhi. 2006 Oct;44(10):787-91.
16. Translational regulation of mitochondrial differentiation in neonatal rat liver. Specific increase in the translational efficiency of the nuclear-encoded mitochondrial beta-F1-ATPase mRNA. Luis AM, etal., J Biol Chem. 1993 Jan 25;268(3):1868-75.
17. Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Martinez LO, etal., Nature 2003 Jan 2;421(6918):75-9.
18. Identification of two proteins associated with mammalian ATP synthase. Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
19. Pharmacological inhibition of galectin-1 by lactulose alleviates weight gain in diet-induced obese rats. Mukherjee R and Yun JW, Life Sci. 2016 Mar 1;148:112-7. doi: 10.1016/j.lfs.2016.02.018. Epub 2016 Feb 13.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
1 to 20 of 33 rows
PMID:2522775   PMID:2531579   PMID:2870059   PMID:2907347   PMID:8006588   PMID:10077593   PMID:12110673   PMID:12477932   PMID:12865426   PMID:14651853   PMID:14673794   PMID:15489334  
PMID:15572201   PMID:16210410   PMID:16751257   PMID:16854843   PMID:17303654   PMID:17510399   PMID:17612527   PMID:17634366   PMID:17643490   PMID:17675573   PMID:17709438   PMID:18063578  
PMID:18510804   PMID:18614015   PMID:19056867   PMID:19199708   PMID:19808025   PMID:19946888   PMID:20458337   PMID:20833797   PMID:21106936   PMID:21630459   PMID:21926988   PMID:22082260  
PMID:23106098   PMID:23376485   PMID:23533145   PMID:23979707   PMID:24042457   PMID:24625528   PMID:25931508   PMID:26316108   PMID:26767982   PMID:26769832   PMID:29476059   PMID:29581031  
PMID:29867124   PMID:30552345   PMID:32357304   PMID:35352799  



Atp5f1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,100,058 - 1,106,461 (+)NCBIGRCr8
mRatBN7.27515,454 - 521,858 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7515,460 - 567,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,274,116 - 3,280,516 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,150,130 - 5,156,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,451,361 - 5,457,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,504,708 - 2,511,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,504,695 - 2,511,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,484,095 - 2,490,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,376,552 - 1,383,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,377,178 - 1,383,228 (+)NCBI
Celera7394,648 - 401,125 (+)NCBICelera
Cytogenetic Map7q11NCBI
ATP5F1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,638,175 - 56,645,984 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,638,175 - 56,645,984 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,031,959 - 57,039,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,318,226 - 55,326,119 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,318,227 - 55,326,119NCBI
Celera1256,683,671 - 56,691,564 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,071,237 - 54,079,130 (-)NCBIHuRef
CHM1_11256,999,492 - 57,007,379 (-)NCBICHM1_1
T2T-CHM13v2.01256,606,172 - 56,613,970 (-)NCBIT2T-CHM13v2.0
Atp5f1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,919,176 - 127,926,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,919,142 - 127,926,260 (+)EnsemblGRCm39 Ensembl
GRCm3810128,083,307 - 128,090,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,083,273 - 128,090,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,520,363 - 127,527,444 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,486,256 - 127,493,337 (+)NCBIMGSCv36mm8
Celera10130,478,043 - 130,485,124 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
Atp5f1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,186,461 - 4,195,494 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,188,167 - 4,195,575 (-)NCBIChiLan1.0ChiLan1.0
ATP5F1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,680,429 - 37,689,113 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,677,947 - 37,685,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,264,570 - 32,272,419 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,519,749 - 32,527,753 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,519,749 - 32,527,753 (+)Ensemblpanpan1.1panPan2
ATP5F1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110870,405 - 876,937 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10870,392 - 909,161 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10933,592 - 940,127 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010879,724 - 886,261 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10879,724 - 919,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110856,580 - 863,114 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,099,743 - 1,106,277 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,223,513 - 1,230,049 (-)NCBIUU_Cfam_GSD_1.0
Atp5f1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,911,328 - 57,918,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646951,009 - 959,516 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646951,236 - 958,907 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP5F1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,984,580 - 21,992,407 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,984,750 - 21,992,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,659,081 - 23,666,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP5F1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,587,608 - 52,600,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,587,143 - 52,600,756 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,380,244 - 193,389,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp5f1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,399,474 - 11,409,700 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,400,288 - 11,408,785 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Atp5f1b
22 total Variants

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000003965
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

ATP5B  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27516,480 - 516,617 (+)MAPPERmRatBN7.2
mRatBN7.2229,136,039 - 29,136,176 (+)MAPPERmRatBN7.2
Rnor_6.0225,599,724 - 25,599,860NCBIRnor6.0
Rnor_6.072,505,735 - 2,505,871NCBIRnor6.0
Rnor_5.072,485,122 - 2,485,258UniSTSRnor5.0
Rnor_5.0244,754,009 - 44,754,145UniSTSRnor5.0
RGSC_v3.4228,334,600 - 28,334,736UniSTSRGSC3.4
RGSC_v3.471,377,579 - 1,377,715UniSTSRGSC3.4
Celera7395,675 - 395,811UniSTS
Celera225,173,156 - 25,173,292UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map7q11UniSTS
RH127966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27520,984 - 521,753 (+)MAPPERmRatBN7.2
mRatBN7.2229,137,525 - 29,137,741 (+)MAPPERmRatBN7.2
Rnor_6.0225,601,210 - 25,601,425NCBIRnor6.0
Rnor_6.072,510,875 - 2,511,643NCBIRnor6.0
Rnor_5.072,489,465 - 2,490,233UniSTSRnor5.0
Rnor_5.0244,755,495 - 44,755,710UniSTSRnor5.0
RGSC_v3.4228,336,799 - 28,337,015UniSTSRGSC3.4
RGSC_v3.471,382,355 - 1,383,123UniSTSRGSC3.4
Celera7400,252 - 401,020UniSTS
Celera225,174,642 - 25,174,857UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map7q11UniSTS
AW549786  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr871,105,619 - 1,106,258 (+)Marker Load Pipeline
mRatBN7.27521,016 - 521,655 (+)MAPPERmRatBN7.2
Rnor_6.072,510,907 - 2,511,545NCBIRnor6.0
Rnor_5.072,489,497 - 2,490,135UniSTSRnor5.0
RGSC_v3.471,382,387 - 1,383,025UniSTSRGSC3.4
Celera7400,284 - 400,922UniSTS
Cytogenetic Map7q11UniSTS
MARC_26134-26135:1030377217:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr871,101,951 - 1,102,527 (+)Marker Load Pipeline
mRatBN7.27517,347 - 517,923 (+)MAPPERmRatBN7.2
Rnor_6.072,506,602 - 2,507,177NCBIRnor6.0
Rnor_5.072,485,989 - 2,486,564UniSTSRnor5.0
RGSC_v3.471,378,446 - 1,379,021UniSTSRGSC3.4
Celera7396,542 - 397,117UniSTS
Cytogenetic Map7q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000003965   ⟹   ENSRNOP00000003965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7515,460 - 567,273 (+)Ensembl
Rnor_6.0 Ensembl72,504,695 - 2,511,749 (+)Ensembl
RefSeq Acc Id: NM_134364   ⟹   NP_599191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,100,058 - 1,106,461 (+)NCBI
mRatBN7.27515,454 - 521,858 (+)NCBI
Rnor_6.072,504,708 - 2,511,748 (+)NCBI
Rnor_5.072,484,095 - 2,490,338 (+)NCBI
RGSC_v3.471,376,552 - 1,383,228 (+)RGD
Celera7394,648 - 401,125 (+)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_599191 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40778 (Get FASTA)   NCBI Sequence Viewer  
  AAA57154 (Get FASTA)   NCBI Sequence Viewer  
  AAB02288 (Get FASTA)   NCBI Sequence Viewer  
  AAH99743 (Get FASTA)   NCBI Sequence Viewer  
  ABD77234 (Get FASTA)   NCBI Sequence Viewer  
  EDL84889 (Get FASTA)   NCBI Sequence Viewer  
  EDL84890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000099290
GenBank Protein P10719 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_599191   ⟸   NM_134364
- Peptide Label: precursor
- UniProtKB: Q499W0 (UniProtKB/Swiss-Prot),   P10719 (UniProtKB/Swiss-Prot),   A6KSA3 (UniProtKB/TrEMBL),   G3V6D3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003965   ⟸   ENSRNOT00000003965
AAA+ ATPase

Name Modeler Protein Id AA Range Protein Structure
AF-P10719-F1-model_v2 AlphaFold P10719 1-529 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694922
Promoter ID:EPDNEW_R5447
Type:multiple initiation site
Name:Atp5f1b_1
Description:ATP synthase F1 subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,504,709 - 2,504,769EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35397 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
BioCyc Pathway Image PWY-7980 BioCyc
Ensembl Genes ENSRNOG00000002840 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000131550 ENTREZGENE
Gene3D-CATH 2.40.10.170 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7937989 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ATP-synt_VA_C UniProtKB/Swiss-Prot
  ATP_synth_F1_bsu UniProtKB/Swiss-Prot
  ATPase_a/bsu_AS UniProtKB/Swiss-Prot
  ATPase_alpha/beta_chains UniProtKB/Swiss-Prot
  ATPase_F1/V1/A1_a/bsu_N UniProtKB/Swiss-Prot
  ATPase_F1/V1/A1_a/bsu_N_sf UniProtKB/Swiss-Prot
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/Swiss-Prot
  ATPase_F1/V1_b/a_C UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:171374 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124522 IMAGE-MGC_LOAD
NCBI Gene 171374 ENTREZGENE
PANTHER ATP SYNTHASE UniProtKB/Swiss-Prot
  ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam ATP-synt_ab UniProtKB/Swiss-Prot
  ATP-synt_ab_N UniProtKB/Swiss-Prot
  ATP-synt_VA_C UniProtKB/Swiss-Prot
PhenoGen Atp5f1b PhenoGen
PIRSF ATPase_subunit_beta UniProtKB/Swiss-Prot
PROSITE ATPASE_ALPHA_BETA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002840 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP C-terminal domain of alpha and beta subunits of F1 ATP synthase UniProtKB/Swiss-Prot
  SSF50615 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A6KSA3 ENTREZGENE, UniProtKB/TrEMBL
  ATPB_RAT UniProtKB/Swiss-Prot
  G3V6D3 ENTREZGENE, UniProtKB/TrEMBL
  P10719 ENTREZGENE
  Q499W0 ENTREZGENE
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-30 Atp5f1b  ATP synthase F1 subunit beta  Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide  Atp5b  ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Atp5b  ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit  Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL