Atp5f1b (ATP synthase F1 subunit beta) - Rat Genome Database

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Gene: Atp5f1b (ATP synthase F1 subunit beta) Rattus norvegicus
Symbol: Atp5f1b
Name: ATP synthase F1 subunit beta
RGD ID: 621368
Description: Enables adenyl ribonucleotide binding activity; calcium ion binding activity; and lipoprotein particle receptor activity. Contributes to ATP hydrolysis activity. Involved in several processes, including cold acclimation; response to 3,3',5-triiodo-L-thyronine; and response to curcumin. Located in cell surface; membrane raft; and mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Used to study obesity. Biomarker of cardiomyopathy; polycystic ovary syndrome; transient cerebral ischemia; and type 2 diabetes mellitus. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP synthase subunit beta, mitochondrial; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; Atp5b; mitochondrial ATP synthase beta subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27515,454 - 521,858 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7515,460 - 567,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,274,116 - 3,280,516 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,150,130 - 5,156,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,451,361 - 5,457,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,504,708 - 2,511,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,504,695 - 2,511,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,484,095 - 2,490,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,376,552 - 1,383,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,377,178 - 1,383,228 (+)NCBI
Celera7394,648 - 401,125 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atrazine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium trinitrate  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diclofenac  (EXP)
diethyl maleate  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
isoflavones  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
mitoxantrone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nafenopin  (EXP)
naphthalene  (ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oxybenzone  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
progesterone  (EXP)
promethazine  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. ATP synthase subunit c expression: physiological regulation of the P1 and P2 genes. Andersson U, etal., Biochem J. 1997 Apr 15;323 ( Pt 2):379-85.
2. Mitochondrial ATP synthase. Quaternary structure of the F1 moiety at 3.6 A determined by x-ray diffraction analysis. Bianchet M, etal., J Biol Chem. 1991 Nov 5;266(31):21197-201.
3. Quantitative neuroproteomics of an in vivo rodent model of focal cerebral ischemia/reperfusion injury reveals a temporal regulation of novel pathophysiological molecular markers. Datta A, etal., J Proteome Res. 2011 Nov 4;10(11):5199-213. doi: 10.1021/pr200673y. Epub 2011 Oct 20.
4. Beta subunit of rat liver mitochondrial ATP synthase: cDNA cloning, amino acid sequence, expression in Escherichia coli, and structural relationship to adenylate kinase. Garboczi DN, etal., Biochemistry 1988 Jan 26;27(2):553-60.
5. Mitochondrial ATP synthase. Overexpression in Escherichia coli of a rat liver beta subunit peptide and its interaction with adenine nucleotides. Garboczi DN, etal., J Biol Chem. 1988 Oct 25;263(30):15694-8.
6. Rat liver mitochondrial ATP synthase. Effects of mutations in the glycine-rich region of a beta subunit peptide on its interaction with adenine nucleotides. Garboczi DN, etal., J Biol Chem. 1990 Aug 25;265(24):14632-7.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique. Han D, etal., J Proteome Res. 2011 Feb 4;10(2):564-77. doi: 10.1021/pr100759a. Epub 2010 Dec 20.
9. Mitochondrial ATP synthase F1-beta-subunit is a calcium-binding protein. Hubbard MJ and McHugh NJ, FEBS Lett. 1996 Aug 12;391(3):323-9.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, etal., J Biol Chem. 2000 Oct 20;275(42):32931-9.
12. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
13. ATP synthase ß-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus. Li W, etal., J Huazhong Univ Sci Technolog Med Sci. 2017 Apr;37(2):210-216. doi: 10.1007/s11596-017-1717-9. Epub 2017 Apr 11.
14. [Screening of differentially expressed genes in rats with cardiomyopathy after bone marrow mesenchymal stem cell transplantation]. Li Y, etal., Zhonghua Er Ke Za Zhi. 2006 Oct;44(10):787-91.
15. Translational regulation of mitochondrial differentiation in neonatal rat liver. Specific increase in the translational efficiency of the nuclear-encoded mitochondrial beta-F1-ATPase mRNA. Luis AM, etal., J Biol Chem. 1993 Jan 25;268(3):1868-75.
16. Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Martinez LO, etal., Nature 2003 Jan 2;421(6918):75-9.
17. Identification of two proteins associated with mammalian ATP synthase. Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
18. Pharmacological inhibition of galectin-1 by lactulose alleviates weight gain in diet-induced obese rats. Mukherjee R and Yun JW, Life Sci. 2016 Mar 1;148:112-7. doi: 10.1016/j.lfs.2016.02.018. Epub 2016 Feb 13.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells. Osanai T, etal., Cardiovasc Res. 2009 Mar 1;81(4):780-7. doi: 10.1093/cvr/cvn356. Epub 2008 Dec 22.
21. Mitochondrial ATP synthase: dramatic Mg2+-induced alterations in the structure and function of the F1-ATPase moiety. Pedersen PL, etal., Biochemistry. 1987 Dec 29;26(26):8631-7.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Overdose Intake of Curcumin Initiates the Unbalanced State of Bodies. Qiu P, etal., J Agric Food Chem. 2016 Apr 6;64(13):2765-71. doi: 10.1021/acs.jafc.6b00053. Epub 2016 Mar 25.
25. Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration. Ramm S, etal., Toxicology. 2015 May 4;331:100-11. doi: 10.1016/j.tox.2015.03.004. Epub 2015 Mar 13.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Proteomic characterization of early changes induced by triiodothyronine in rat liver. Severino V, etal., J Proteome Res. 2011 Jul 1;10(7):3212-24. Epub 2011 Jun 1.
29. Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring. You YA, etal., Mol Cell Proteomics. 2015 Nov;14(11):2901-9. doi: 10.1074/mcp.M114.046888. Epub 2015 Sep 4.
30. Proteome analysis of rat pancreatic acinar cells: implication for cerulein-induced acute pancreatitis. Yu JH, etal., Proteomics. 2003 Dec;3(12):2446-53. doi: 10.1002/pmic.200300545.
31. Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats. Zhang Q, etal., J Mol Endocrinol. 2012 Jun 26;49(1):35-46. doi: 10.1530/JME-12-0020. Print 2012 Aug.
32. Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chloride. Zhang S, etal., Toxicol Appl Pharmacol. 2005 Jan 1;202(1):13-7.
Additional References at PubMed
PMID:2522775   PMID:2531579   PMID:2870059   PMID:2907347   PMID:8006588   PMID:9736690   PMID:10077593   PMID:12110673   PMID:12477932   PMID:12865426   PMID:14651853   PMID:14673794  
PMID:15489334   PMID:15572201   PMID:16210410   PMID:16751257   PMID:16854843   PMID:17303654   PMID:17510399   PMID:17612527   PMID:17634366   PMID:17643490   PMID:17675573   PMID:17709438  
PMID:18063578   PMID:18510804   PMID:18614015   PMID:19056867   PMID:19199708   PMID:19808025   PMID:19946888   PMID:20458337   PMID:20833797   PMID:21106936   PMID:21630459   PMID:21926988  
PMID:22082260   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23979707   PMID:24042457   PMID:24625528   PMID:25931508   PMID:26316108   PMID:26767982   PMID:26769832   PMID:29476059  
PMID:29581031   PMID:29867124   PMID:30552345   PMID:32357304  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27515,454 - 521,858 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7515,460 - 567,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,274,116 - 3,280,516 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,150,130 - 5,156,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,451,361 - 5,457,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,504,708 - 2,511,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,504,695 - 2,511,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,484,095 - 2,490,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,376,552 - 1,383,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,377,178 - 1,383,228 (+)NCBI
Celera7394,648 - 401,125 (+)NCBICelera
Cytogenetic Map7q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381256,638,175 - 56,645,984 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,638,175 - 56,645,984 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,031,959 - 57,039,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,318,226 - 55,326,119 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,318,227 - 55,326,119NCBI
Celera1256,683,671 - 56,691,564 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,071,237 - 54,079,130 (-)NCBIHuRef
CHM1_11256,999,492 - 57,007,379 (-)NCBICHM1_1
T2T-CHM13v2.01256,606,172 - 56,613,970 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910127,919,176 - 127,926,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,919,142 - 127,926,260 (+)EnsemblGRCm39 Ensembl
GRCm3810128,083,307 - 128,090,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,083,273 - 128,090,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,520,363 - 127,527,444 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,486,256 - 127,493,337 (+)NCBIMGSCv36mm8
Celera10130,478,043 - 130,485,124 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554584,186,461 - 4,195,494 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,188,167 - 4,195,575 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11237,677,947 - 37,685,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,264,570 - 32,272,419 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,519,749 - 32,527,753 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,519,749 - 32,527,753 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.110870,405 - 876,937 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10870,392 - 909,161 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10933,592 - 940,127 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010879,724 - 886,261 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10879,724 - 919,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110856,580 - 863,114 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,099,743 - 1,106,277 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,223,513 - 1,230,049 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494557,911,328 - 57,918,999 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936646951,236 - 958,907 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl521,984,580 - 21,992,407 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,984,750 - 21,992,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,659,081 - 23,666,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11152,587,608 - 52,600,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,587,143 - 52,600,756 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,380,244 - 193,389,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480211,399,474 - 11,409,700 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,400,288 - 11,408,785 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Atp5f1b
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:37
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27516,480 - 516,617 (+)MAPPERmRatBN7.2
mRatBN7.2229,136,039 - 29,136,176 (+)MAPPERmRatBN7.2
Rnor_6.0225,599,724 - 25,599,860NCBIRnor6.0
Rnor_6.072,505,735 - 2,505,871NCBIRnor6.0
Rnor_5.072,485,122 - 2,485,258UniSTSRnor5.0
Rnor_5.0244,754,009 - 44,754,145UniSTSRnor5.0
RGSC_v3.4228,334,600 - 28,334,736UniSTSRGSC3.4
RGSC_v3.471,377,579 - 1,377,715UniSTSRGSC3.4
Celera7395,675 - 395,811UniSTS
Celera225,173,156 - 25,173,292UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map7q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27520,984 - 521,753 (+)MAPPERmRatBN7.2
mRatBN7.2229,137,525 - 29,137,741 (+)MAPPERmRatBN7.2
Rnor_6.0225,601,210 - 25,601,425NCBIRnor6.0
Rnor_6.072,510,875 - 2,511,643NCBIRnor6.0
Rnor_5.072,489,465 - 2,490,233UniSTSRnor5.0
Rnor_5.0244,755,495 - 44,755,710UniSTSRnor5.0
RGSC_v3.4228,336,799 - 28,337,015UniSTSRGSC3.4
RGSC_v3.471,382,355 - 1,383,123UniSTSRGSC3.4
Celera7400,252 - 401,020UniSTS
Celera225,174,642 - 25,174,857UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map7q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27521,016 - 521,655 (+)MAPPERmRatBN7.2
Rnor_6.072,510,907 - 2,511,545NCBIRnor6.0
Rnor_5.072,489,497 - 2,490,135UniSTSRnor5.0
RGSC_v3.471,382,387 - 1,383,025UniSTSRGSC3.4
Celera7400,284 - 400,922UniSTS
Cytogenetic Map7q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27517,347 - 517,923 (+)MAPPERmRatBN7.2
Rnor_6.072,506,602 - 2,507,177NCBIRnor6.0
Rnor_5.072,485,989 - 2,486,564UniSTSRnor5.0
RGSC_v3.471,378,446 - 1,379,021UniSTSRGSC3.4
Celera7396,542 - 397,117UniSTS
Cytogenetic Map7q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 43 53 41 4 41 8 11 70 35 27 8
Medium 4 15 4 14 11
Below cutoff


RefSeq Acc Id: ENSRNOT00000003965   ⟹   ENSRNOP00000003965
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7515,460 - 567,273 (+)Ensembl
Rnor_6.0 Ensembl72,504,695 - 2,511,749 (+)Ensembl
RefSeq Acc Id: NM_134364   ⟹   NP_599191
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.27515,454 - 521,858 (+)NCBI
Rnor_6.072,504,708 - 2,511,748 (+)NCBI
Rnor_5.072,484,095 - 2,490,338 (+)NCBI
RGSC_v3.471,376,552 - 1,383,228 (+)RGD
Celera7394,648 - 401,125 (+)RGD
RefSeq Acc Id: NP_599191   ⟸   NM_134364
- Peptide Label: precursor
- UniProtKB: Q499W0 (UniProtKB/Swiss-Prot),   P10719 (UniProtKB/Swiss-Prot),   A6KSA3 (UniProtKB/TrEMBL),   G3V6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003965   ⟸   ENSRNOT00000003965
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10719-F1-model_v2 AlphaFold P10719 1-529 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694922
Promoter ID:EPDNEW_R5447
Type:multiple initiation site
Description:ATP synthase F1 subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,504,709 - 2,504,769EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621368 AgrOrtholog
BioCyc Gene G2FUF-35397 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
BioCyc Pathway Image PWY-7980 BioCyc
Ensembl Genes ENSRNOG00000002840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065013279 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003965 ENTREZGENE
  ENSRNOT00000003965.5 UniProtKB/TrEMBL
  ENSRNOT00065021804 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F1_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_a/bsu_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1_b/a_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171374 UniProtKB/Swiss-Prot
Pfam ATP-synt_ab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_ab_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp5f1b PhenoGen
PIRSF ATPase_subunit_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002840 RatGTEx
  ENSRNOG00065013279 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C-terminal domain of alpha and beta subunits of F1 ATP synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50615 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q499W0 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-30 Atp5f1b  ATP synthase F1 subunit beta  Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide  Atp5b  ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Atp5b  ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit  Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Atp5b  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL