RGD Reference Report - Mitochondrial ATP synthase F1-beta-subunit is a calcium-binding protein. - Rat Genome Database

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Mitochondrial ATP synthase F1-beta-subunit is a calcium-binding protein.

Authors: Hubbard, MJ  McHugh, NJ 
Citation: Hubbard MJ and McHugh NJ, FEBS Lett. 1996 Aug 12;391(3):323-9.
RGD ID: 2292227
Pubmed: PMID:8764999   (View Abstract at PubMed)

Mitochondrial ATP synthase is responsive to changes in cytosolic calcium concentration, but the regulatory mechanisms are unclear. Here we identified a major 52 kDa calcium-binding protein in rat enamel cells as the mitochondrial ATP synthase F1-beta-subunit. The F1-beta-subunit behaved as a low affinity and moderate capacity calcium-binding protein during comparative 45Ca overlay analyses. Equivalent behavior was shown by the F1-beta-subunit from rat liver mitochondria, but not by the homologous F1-alpha-subunit, supporting the specificity of calcium binding. Evidence that the catalytic F1-beta-subunit binds calcium specifically introduces new mechanistic possibilities for regulating ATP synthase, and thereby coordinating ATP production with demand for ATP-fuelled calcium pump activity.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mitochondrial inner membrane  IDA 2292227 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
calcium ion binding  IDA 2292227 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp5f1b  (ATP synthase F1 subunit beta)


Additional Information