(+)-schisandrin B multiple interactions ISO RGD:732293 6480464 [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein], [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] CTD PMID:22003191 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CHEK1 mRNA] CTD PMID:31150632 1,1-dichloroethene increases expression ISO RGD:732293 6480464 vinylidene chloride results in increased expression of CHEK1 mRNA CTD PMID:26682919 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of CHEK1 mRNA CTD PMID:22841810 17alpha-ethynylestradiol affects expression ISO RGD:732293 6480464 Ethinyl Estradiol affects the expression of CHEK1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:732293 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:732293 6480464 Ethinyl Estradiol results in increased expression of CHEK1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:732293 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK1 mRNA] CTD PMID:25210133 17beta-estradiol increases expression ISO RGD:732292 6480464 Estradiol results in increased expression of CHEK1 mRNA CTD PMID:16474171 , PMID:19167446 17beta-estradiol affects expression ISO RGD:732293 6480464 Estradiol affects the expression of CHEK1 mRNA CTD PMID:15598610 17beta-estradiol increases expression ISO RGD:732293 6480464 Estradiol results in increased expression of CHEK1 mRNA CTD PMID:25210133 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO RGD:732292 6480464 Metribolone results in increased expression of CHEK1 mRNA CTD PMID:19318562 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases phosphorylation ISO RGD:732292 6480464 Metribolone results in increased phosphorylation of CHEK1 protein CTD PMID:23272087 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732293 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732293 6480464 Tetrachlorodibenzodioxin affects the expression of CHEK1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:732292 6480464 Tetrachlorodibenzodioxin results in decreased expression of CHEK1 mRNA CTD PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732293 6480464 Tetrachlorodibenzodioxin results in increased expression of CHEK1 mRNA CTD PMID:15667827 , PMID:19465110 2,6-di-tert-butyl-4-methylphenol increases expression ISO RGD:732293 6480464 Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 2-methylcholine affects expression ISO RGD:732292 6480464 beta-methylcholine affects the expression of CHEK1 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',5-triiodo-L-thyronine increases phosphorylation ISO RGD:732292 6480464 Triiodothyronine analog results in increased phosphorylation of CHEK1 protein CTD PMID:22383522 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:732293 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CHEK1 mRNA CTD PMID:20188158 3-methyladenine multiple interactions ISO RGD:732292 6480464 3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] CTD PMID:24823293 4-hydroxynon-2-enal decreases expression ISO RGD:732293 6480464 4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA CTD PMID:19191707 5-aza-2'-deoxycytidine affects localization ISO RGD:732292 6480464 Decitabine affects the localization of CHEK1 protein modified form CTD PMID:17991895 5-fluorouracil affects response to substance ISO RGD:732292 6480464 CHEK1 protein affects the susceptibility to Fluorouracil CTD PMID:18698031 5-fluorouracil decreases expression ISO RGD:732293 6480464 Fluorouracil results in decreased expression of CHEK1 mRNA CTD PMID:19272435 5-fluorouracil increases expression ISO RGD:732292 6480464 Fluorouracil results in increased expression of CHEK1 protein CTD PMID:15016801 5-fluorouracil multiple interactions ISO RGD:732292 6480464 [CHEK1 protein co-treated with TP53 protein] affects the susceptibility to Fluorouracil more ... CTD PMID:15016801 more ... 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine multiple interactions ISO RGD:732292 6480464 4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein] CTD PMID:26208482 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CHEK1 mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases expression ISO RGD:732293 6480464 9 more ... CTD PMID:20025956 acrylamide increases expression ISO RGD:732293 6480464 Acrylamide results in increased expression of CHEK1 protein CTD PMID:20025956 aflatoxin B1 affects expression ISO RGD:732292 6480464 Aflatoxin B1 affects the expression of CHEK1 protein CTD PMID:20106945 all-trans-retinoic acid decreases expression ISO RGD:732292 6480464 Tretinoin results in decreased expression of CHEK1 mRNA CTD PMID:21934132 all-trans-retinoic acid affects expression ISO RGD:732292 6480464 Tretinoin affects the expression of CHEK1 mRNA CTD PMID:23724009 all-trans-retinoic acid increases expression ISO RGD:732293 6480464 Tretinoin results in increased expression of CHEK1 protein CTD PMID:20025956 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CHEK1 mRNA CTD PMID:16483693 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of CHEK1 protein CTD PMID:16483693 anthocyanin increases phosphorylation ISO RGD:732292 6480464 Anthocyanins results in increased phosphorylation of CHEK1 protein CTD PMID:27444805 anthracene-1,8,9-triol increases expression ISO RGD:732293 6480464 Anthralin results in increased expression of CHEK1 protein CTD PMID:20025956 aphidicolin multiple interactions ISO RGD:732293 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA], [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] CTD PMID:22003191 arsenous acid multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK1 protein] CTD PMID:23337567 arsenous acid increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:23337567 arsenous acid increases phosphorylation ISO RGD:732292 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 arsenous acid increases phosphorylation ISO RGD:732293 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 artesunate multiple interactions ISO RGD:732292 6480464 APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 artesunate increases phosphorylation ISO RGD:732292 6480464 Artesunate results in increased phosphorylation of CHEK1 protein CTD PMID:31664825 atrazine decreases expression ISO RGD:732292 6480464 Atrazine results in decreased expression of CHEK1 mRNA CTD PMID:22378314 auraptene affects expression ISO RGD:732292 6480464 aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 azathioprine decreases expression ISO RGD:732292 6480464 Azathioprine results in decreased expression of CHEK1 mRNA CTD PMID:22623647 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CHEK1 protein modified form CTD PMID:21604763 benzo[a]pyrene increases expression ISO RGD:732292 6480464 Benzo(a)pyrene results in increased expression of CHEK1 mRNA CTD PMID:32234424 benzo[a]pyrene affects methylation ISO RGD:732292 6480464 Benzo(a)pyrene affects the methylation of CHEK1 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:732292 6480464 CLSPN mRNA affects the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein], cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] CTD PMID:19464357 , PMID:20228066 benzo[a]pyrene decreases expression ISO RGD:732292 6480464 Benzo(a)pyrene results in decreased expression of CHEK1 mRNA CTD PMID:21802500 benzo[a]pyrene increases phosphorylation ISO RGD:732292 6480464 Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein CTD PMID:19464357 more ... benzo[a]pyrene diol epoxide I multiple interactions ISO RGD:732293 6480464 POLH protein affects the reaction [7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I increases expression ISO RGD:732292 6480464 7 more ... CTD PMID:26238291 benzo[a]pyrene diol epoxide I increases phosphorylation ISO RGD:732293 6480464 7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:732292 6480464 7 more ... CTD PMID:20018196 , PMID:20382639 berberine increases expression ISO RGD:732292 6480464 Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 biphenyl-4-amine decreases expression ISO RGD:732292 6480464 4-biphenylamine results in decreased expression of CHEK1 mRNA CTD PMID:24857880 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:732292 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:22119920 , PMID:25448276 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:732292 6480464 Mustard Gas results in increased phosphorylation of CHEK1 protein CTD PMID:22119920 , PMID:25448276 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:732292 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] CTD PMID:30720231 bisphenol A increases expression ISO RGD:732292 6480464 bisphenol A results in increased expression of CHEK1 mRNA CTD PMID:16474171 bisphenol A decreases expression ISO RGD:732292 6480464 bisphenol A results in decreased expression of CHEK1 mRNA CTD PMID:29275510 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CHEK1 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA CTD PMID:26496021 Brevetoxin B increases expression ISO RGD:732292 6480464 brevetoxin 2 results in increased expression of CHEK1 mRNA CTD PMID:20498034 busulfan multiple interactions ISO RGD:732292 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 cadmium atom decreases expression ISO RGD:732292 6480464 Cadmium results in decreased expression of CHEK1 mRNA CTD PMID:21120746 caffeine multiple interactions ISO RGD:732292 6480464 Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] more ... CTD PMID:15975956 more ... caffeine increases phosphorylation ISO RGD:732292 6480464 Caffeine results in increased phosphorylation of CHEK1 protein CTD PMID:29074359 caffeine multiple interactions ISO RGD:732293 6480464 Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA], Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 caffeine decreases expression ISO RGD:732293 6480464 Caffeine results in decreased expression of CHEK1 protein modified form CTD PMID:21505179 caffeine decreases phosphorylation ISO RGD:732292 6480464 Caffeine results in decreased phosphorylation of CHEK1 protein CTD PMID:21561856 camptothecin multiple interactions ISO RGD:732292 6480464 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form], Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] CTD PMID:25269479 , PMID:30720231 camptothecin increases phosphorylation ISO RGD:732292 6480464 Camptothecin results in increased phosphorylation of CHEK1 protein CTD PMID:21646468 , PMID:30555576 camptothecin increases phosphorylation ISO RGD:732293 6480464 Camptothecin results in increased phosphorylation of CHEK1 protein CTD PMID:22403396 camptothecin increases expression ISO RGD:732293 6480464 Camptothecin results in increased expression of CHEK1 mRNA CTD PMID:22403396 camptothecin multiple interactions ISO RGD:732293 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:22403396 camptothecin decreases response to substance ISO RGD:732292 6480464 CHEK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 camptothecin increases expression ISO RGD:732292 6480464 Camptothecin results in increased expression of CHEK1 protein modified form CTD PMID:25269479 , PMID:30720231 carbamazepine affects expression ISO RGD:732292 6480464 Carbamazepine affects the expression of CHEK1 mRNA CTD PMID:24752500 carmustine multiple interactions ISO RGD:732292 6480464 ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] more ... CTD PMID:19261750 catechol increases expression ISO RGD:732293 6480464 catechol results in increased expression of CHEK1 protein CTD PMID:20025956 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of CHEK1 mRNA CTD PMID:18500788 chlorpyrifos decreases expression ISO RGD:732293 6480464 Chlorpyrifos results in decreased expression of CHEK1 mRNA CTD PMID:20350560 cholic acid increases expression ISO RGD:732293 6480464 Cholic Acid results in increased expression of CHEK1 protein CTD PMID:20025956 choline affects expression ISO RGD:732292 6480464 Choline affects the expression of CHEK1 mRNA CTD PMID:17616785 choline multiple interactions ISO RGD:732293 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 ciprofloxacin increases expression EXP 6480464 Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 cisplatin multiple interactions ISO RGD:732292 6480464 BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]] more ... CTD PMID:20623183 more ... cisplatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] CTD PMID:26739623 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CHEK1 protein modified form CTD PMID:26739623 cisplatin increases phosphorylation ISO RGD:732292 6480464 Cisplatin results in increased phosphorylation of CHEK1 protein CTD PMID:20623183 more ... cisplatin increases phosphorylation ISO RGD:732293 6480464 Cisplatin results in increased phosphorylation of CHEK1 protein CTD PMID:21285353 , PMID:22006019 cisplatin multiple interactions ISO RGD:732293 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA] more ... CTD PMID:21324906 , PMID:22003191 cisplatin increases activity ISO RGD:732292 6480464 Cisplatin results in increased activity of CHEK1 protein CTD PMID:21324906 , PMID:21592546 cisplatin decreases expression ISO RGD:732292 6480464 Cisplatin results in decreased expression of CHEK1 protein CTD PMID:12740909 clofarabine multiple interactions ISO RGD:732292 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 clofibrate increases expression ISO RGD:732293 6480464 Clofibrate results in increased expression of CHEK1 protein CTD PMID:20025956 cobalt dichloride multiple interactions ISO RGD:732292 6480464 cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] CTD PMID:20228066 cobalt dichloride decreases expression ISO RGD:732292 6480464 cobaltous chloride results in decreased expression of CHEK1 mRNA CTD PMID:19320972 , PMID:19376846 cobalt dichloride increases phosphorylation ISO RGD:732292 6480464 cobaltous chloride results in increased phosphorylation of CHEK1 protein CTD PMID:20228066 copper atom increases expression EXP 6480464 Copper results in increased expression of CHEK1 mRNA CTD PMID:22465980 copper atom multiple interactions ISO RGD:732292 6480464 [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA CTD PMID:20971185 copper(0) increases expression EXP 6480464 Copper results in increased expression of CHEK1 mRNA CTD PMID:22465980 copper(0) multiple interactions ISO RGD:732292 6480464 [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:732292 6480464 Copper Sulfate results in decreased expression of CHEK1 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:732292 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:732292 6480464 Coumestrol results in increased expression of CHEK1 mRNA CTD PMID:19167446 crocidolite asbestos increases expression ISO RGD:732292 6480464 Asbestos, Crocidolite results in increased expression of CHEK1 protein CTD PMID:21570478 curcumin decreases response to substance ISO RGD:732292 6480464 CHEK1 protein results in decreased susceptibility to Curcumin CTD PMID:18602917 curcumin increases activity ISO RGD:732292 6480464 Curcumin results in increased activity of CHEK1 protein CTD PMID:18602917 curcumin increases phosphorylation ISO RGD:732292 6480464 Curcumin results in increased phosphorylation of CHEK1 protein CTD PMID:19401701 cyclosporin A decreases expression ISO RGD:732293 6480464 Cyclosporine results in decreased expression of CHEK1 mRNA CTD PMID:25270620 cyclosporin A decreases expression ISO RGD:732292 6480464 Cyclosporine results in decreased expression of CHEK1 mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO RGD:732292 6480464 cylindrospermopsin results in increased expression of CHEK1 mRNA CTD PMID:23726867 Diallyl sulfide increases phosphorylation ISO RGD:732292 6480464 allyl sulfide results in increased phosphorylation of CHEK1 protein CTD PMID:24650757 Diallyl sulfide multiple interactions ISO RGD:732292 6480464 CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CCNB1 protein], CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CDC25C protein] CTD PMID:24650757 diarsenic trioxide increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:23337567 diarsenic trioxide increases phosphorylation ISO RGD:732292 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 diarsenic trioxide increases phosphorylation ISO RGD:732293 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 diarsenic trioxide multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK1 protein] CTD PMID:23337567 dibutyl phthalate decreases expression ISO RGD:732293 6480464 Dibutyl Phthalate results in decreased expression of CHEK1 mRNA CTD PMID:21266533 diclofenac affects expression ISO RGD:732292 6480464 Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 dicrotophos decreases expression ISO RGD:732292 6480464 dicrotophos results in decreased expression of CHEK1 mRNA CTD PMID:28302478 diepoxybutane multiple interactions ISO RGD:732293 6480464 7-hydroxystaurosporine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form] more ... CTD PMID:25633853 diepoxybutane increases phosphorylation ISO RGD:732293 6480464 diepoxybutane results in increased phosphorylation of CHEK1 protein CTD PMID:25633853 diepoxybutane increases expression ISO RGD:732293 6480464 diepoxybutane results in increased expression of CHEK1 protein modified form CTD PMID:25633853 diethyl sulfate decreases expression ISO RGD:732292 6480464 diethyl sulfate results in decreased expression of CHEK1 protein modified form CTD PMID:23830811 diethyl sulfate increases expression ISO RGD:732292 6480464 diethyl sulfate results in increased expression of CHEK1 protein modified form CTD PMID:23830811 digitoxin decreases expression ISO RGD:732292 6480464 Digitoxin analog results in decreased expression of CHEK1 protein, Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 doxorubicin multiple interactions ISO RGD:732292 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:15489221 more ... doxorubicin decreases expression ISO RGD:732293 6480464 Doxorubicin results in decreased expression of CHEK1 mRNA CTD PMID:29653124 doxorubicin increases phosphorylation ISO RGD:732292 6480464 Doxorubicin results in increased phosphorylation of CHEK1 protein CTD PMID:17085670 more ... doxorubicin affects response to substance ISO RGD:732292 6480464 CHEK1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 , PMID:18698031 doxorubicin decreases expression ISO RGD:732292 6480464 Doxorubicin results in decreased expression of CHEK1 mRNA, Doxorubicin results in decreased expression of CHEK1 protein CTD PMID:15870702 more ... Enterolactone multiple interactions ISO RGD:732292 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CHEK1 mRNA CTD PMID:19167446 Enterolactone increases expression ISO RGD:732292 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of CHEK1 mRNA CTD PMID:19167446 equol decreases expression ISO RGD:732292 6480464 Equol results in decreased expression of CHEK1 mRNA CTD PMID:16865672 Estragole increases expression EXP 6480464 estragole results in increased expression of CHEK1 protein CTD PMID:29054680 etoposide affects response to substance ISO RGD:732292 6480464 CHEK1 protein affects the susceptibility to Etoposide CTD PMID:18698031 etoposide multiple interactions ISO RGD:732292 6480464 TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide] CTD PMID:18698031 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of CHEK1 mRNA CTD PMID:17264098 fisetin increases expression ISO RGD:732292 6480464 fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of CHEK1 mRNA CTD PMID:18035473 floxuridine multiple interactions ISO RGD:732292 6480464 Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406 , PMID:22194930 flumequine multiple interactions ISO RGD:732293 6480464 [flumequine co-treated with 2-amino-3 more ... CTD PMID:23681119 folic acid affects expression ISO RGD:732292 6480464 Folic Acid affects the expression of CHEK1 mRNA CTD PMID:16361273 folic acid multiple interactions ISO RGD:732293 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 furan increases expression ISO RGD:732293 6480464 furan results in increased expression of CHEK1 mRNA CTD PMID:20194422 furan increases expression EXP 6480464 furan results in increased expression of CHEK1 mRNA CTD PMID:20562052 more ... furosemide affects expression EXP 6480464 Furosemide affects the expression of CHEK1 mRNA CTD PMID:17497460 genistein increases expression ISO RGD:732292 6480464 Genistein results in increased expression of CHEK1 mRNA CTD PMID:16474171 geraniol decreases expression ISO RGD:732292 6480464 geraniol results in decreased expression of CHEK1 mRNA CTD PMID:27683099 Goe 6976 decreases activity ISO RGD:732292 6480464 Go 6976 results in decreased activity of CHEK1 protein CTD PMID:10998351 , PMID:20619533 Goe 6976 multiple interactions ISO RGD:732292 6480464 xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein] CTD PMID:29074359 Goe 6976 increases phosphorylation ISO RGD:732292 6480464 Go 6976 results in increased phosphorylation of CHEK1 protein CTD PMID:29074359 gold atom multiple interactions ISO RGD:732292 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA CTD PMID:28433809 gold(0) multiple interactions ISO RGD:732292 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA CTD PMID:28433809 GW 4064 increases expression ISO RGD:732292 6480464 GW 4064 results in increased expression of CHEK1 mRNA CTD PMID:31437187 hydrogen peroxide decreases expression ISO RGD:732292 6480464 Hydrogen Peroxide results in decreased expression of CHEK1 mRNA CTD PMID:12414654 hydrogen peroxide increases phosphorylation ISO RGD:732292 6480464 Hydrogen Peroxide results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 , PMID:29074359 hydrogen peroxide multiple interactions ISO RGD:732292 6480464 MIRLET7G mRNA inhibits the reaction [Hydrogen Peroxide results in increased expression of CHEK1 protein] CTD PMID:25972194 hydrogen peroxide increases expression ISO RGD:732292 6480464 Hydrogen Peroxide results in increased expression of CHEK1 mRNA, Hydrogen Peroxide results in increased expression of CHEK1 protein CTD PMID:25972194 hydroxyurea multiple interactions ISO RGD:732292 6480464 Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334 hydroxyurea increases expression ISO RGD:732292 6480464 Hydroxyurea results in increased expression of CHK1 protein modified form CTD PMID:21840268 hydroxyurea decreases expression ISO RGD:732293 6480464 Hydroxyurea results in decreased expression of CHEK1 mRNA CTD PMID:12929121 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of CHEK1 mRNA CTD PMID:21396975 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA CTD PMID:22129741 irinotecan increases phosphorylation ISO RGD:732292 6480464 Irinotecan results in increased phosphorylation of CHEK1 protein CTD PMID:22111927 , PMID:22898888 irinotecan multiple interactions ISO RGD:732292 6480464 Irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein, SAR 020106 inhibits the reaction [Irinotecan results in increased phosphorylation of CHEK1 protein] CTD PMID:22111927 , PMID:22510560 iron dichloride increases expression ISO RGD:732293 6480464 ferrous chloride results in increased expression of CHEK1 protein CTD PMID:20025956 iron trichloride increases expression ISO RGD:732293 6480464 ferric chloride results in increased expression of CHEK1 protein CTD PMID:20025956 isoflurane decreases expression EXP 6480464 Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 kaempferol increases phosphorylation ISO RGD:732293 6480464 kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 L-methionine multiple interactions ISO RGD:732293 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 lead diacetate increases expression ISO RGD:732293 6480464 lead acetate results in increased expression of CHEK1 mRNA CTD PMID:22609695 lead(0) affects expression ISO RGD:732292 6480464 Lead affects the expression of CHEK1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:732292 6480464 Lead affects the expression of CHEK1 mRNA CTD PMID:28903495 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of CHEK1 mRNA CTD PMID:24136188 leptomycin B decreases expression ISO RGD:732292 6480464 leptomycin B results in decreased expression of CHEK1 mRNA CTD PMID:20803015 lovastatin multiple interactions ISO RGD:732292 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein], Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] CTD PMID:17088865 , PMID:21356574 lovastatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] CTD PMID:26739623 MeIQx multiple interactions ISO RGD:732293 6480464 [flumequine co-treated with 2-amino-3 more ... CTD PMID:23681119 melphalan increases phosphorylation ISO RGD:732292 6480464 Melphalan results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 menadione decreases expression ISO RGD:732292 6480464 Vitamin K 3 results in decreased expression of CHEK1 mRNA CTD PMID:12414654 metformin multiple interactions ISO RGD:732292 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of CHEK1 mRNA CTD PMID:26558467 methotrexate increases expression ISO RGD:732292 6480464 Methotrexate results in increased expression of CHEK1 mRNA CTD PMID:22484375 methotrexate increases expression ISO RGD:732293 6480464 Methotrexate results in increased expression of CHEK1 protein modified form CTD PMID:22484375 methotrexate multiple interactions ISO RGD:732292 6480464 Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter], Methotrexate results in increased expression of and results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:22484375 methotrexate decreases response to substance ISO RGD:732292 6480464 CHEK1 protein results in decreased susceptibility to Methotrexate CTD PMID:22484375 methotrexate multiple interactions ISO RGD:732293 6480464 Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] CTD PMID:22484375 methyl isocyanate increases expression ISO RGD:732293 6480464 methyl isocyanate results in increased expression of CHEK1 mRNA CTD PMID:22223508 methylmercury chloride decreases expression ISO RGD:732293 6480464 methylmercuric chloride results in decreased expression of CHEK1 mRNA CTD PMID:20061341 Mezerein increases expression ISO RGD:732293 6480464 mezerein results in increased expression of CHEK1 mRNA CTD PMID:19000923 mifepristone multiple interactions ISO RGD:732293 6480464 Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 mitomycin C increases phosphorylation ISO RGD:732292 6480464 Mitomycin results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 N-acetyl-L-cysteine multiple interactions ISO RGD:732292 6480464 Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]] CTD PMID:15489221 N-acetyl-L-cysteine multiple interactions ISO RGD:732293 6480464 Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form] CTD PMID:25633853 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:732293 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHEK1 mRNA CTD PMID:20061341 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:732292 6480464 CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein] more ... CTD PMID:26921499 N-nitrosodiethylamine multiple interactions ISO RGD:732293 6480464 ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA] more ... CTD PMID:17854601 , PMID:19919837 N-nitrosodiethylamine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA CTD PMID:22129741 N-nitrosodiethylamine increases expression ISO RGD:732293 6480464 Diethylnitrosamine results in increased expression of CHEK1 mRNA, Diethylnitrosamine results in increased expression of CHEK1 protein CTD PMID:17854601 , PMID:19919837 nickel atom decreases expression ISO RGD:732292 6480464 Nickel results in decreased expression of CHEK1 mRNA CTD PMID:24768652 nickel atom increases expression ISO RGD:732292 6480464 Nickel results in increased expression of CHEK1 mRNA CTD PMID:25583101 nimustine increases phosphorylation ISO RGD:732292 6480464 Nimustine results in increased phosphorylation of CHEK1 protein CTD PMID:22609303 nimustine multiple interactions ISO RGD:732292 6480464 FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] CTD PMID:22609303 nocodazole decreases expression ISO RGD:732292 6480464 Nocodazole results in decreased expression of CHEK1 protein CTD PMID:26914363 O-methyleugenol affects expression EXP 6480464 methyleugenol affects the expression of CHEK1 mRNA CTD PMID:26011634 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of CHEK1 mRNA CTD PMID:19237604 more ... ochratoxin A decreases acetylation ISO RGD:732292 6480464 ochratoxin A results in decreased acetylation of CHEK1 promoter CTD PMID:29098329 octamethylcyclotetrasiloxane decreases expression ISO RGD:732292 6480464 octamethylcyclotetrasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 olaparib increases phosphorylation ISO RGD:732292 6480464 olaparib results in increased phosphorylation of CHEK1 protein CTD PMID:25531448 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of CHEK1 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA CTD PMID:25729387 oxfendazole affects expression EXP 6480464 oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 ozone increases expression ISO RGD:732293 6480464 Ozone results in increased expression of CHEK1 mRNA CTD PMID:19555225 p-anisidine decreases expression ISO RGD:732293 6480464 4-anisidine results in decreased expression of CHEK1 mRNA CTD PMID:12929121 paclitaxel decreases expression ISO RGD:732293 6480464 Paclitaxel results in decreased expression of CHEK1 mRNA CTD PMID:12929121 paclitaxel multiple interactions ISO RGD:732292 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 paracetamol increases expression ISO RGD:732293 6480464 Acetaminophen results in increased expression of CHEK1 protein CTD PMID:20025956 paraquat multiple interactions ISO RGD:732293 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CHEK1 mRNA CTD PMID:28012437 PF-00477736 decreases activity ISO RGD:732292 6480464 PF 00477736 results in decreased activity of CHEK1 protein CTD PMID:21707865 PF-00477736 multiple interactions ISO RGD:732292 6480464 PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] CTD PMID:25448276 phenobarbital affects expression ISO RGD:732293 6480464 Phenobarbital affects the expression of CHEK1 mRNA CTD PMID:23091169 phorbol 13-acetate 12-myristate increases expression ISO RGD:732293 6480464 Tetradecanoylphorbol Acetate results in increased expression of CHEK1 mRNA CTD PMID:19000923 pirinixic acid increases expression ISO RGD:732293 6480464 pirinixic acid results in increased expression of CHEK1 mRNA CTD PMID:20813756 pirinixic acid multiple interactions ISO RGD:732293 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of CHEK1 mRNA CTD PMID:20813756 platinum multiple interactions ISO RGD:732292 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21107699 platinum(0) multiple interactions ISO RGD:732292 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21107699 pregnenolone 16alpha-carbonitrile multiple interactions ISO RGD:732293 6480464 [1 more ... CTD PMID:23626729 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of CHEK1 mRNA CTD PMID:20726854 progesterone increases phosphorylation ISO RGD:732293 6480464 Progesterone results in increased phosphorylation of CHEK1 protein CTD PMID:22403396 progesterone multiple interactions ISO RGD:732293 6480464 Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 promethazine increases expression EXP 6480464 Promethazine results in increased expression of CHEK1 mRNA CTD PMID:26558467 promethazine decreases expression EXP 6480464 Promethazine results in decreased expression of CHEK1 mRNA CTD PMID:26011634 propiconazole increases expression ISO RGD:732293 6480464 propiconazole results in increased expression of CHEK1 mRNA CTD PMID:21278054 Ptaquiloside increases phosphorylation ISO RGD:732292 6480464 ptaquiloside results in increased phosphorylation of CHEK1 protein CTD PMID:22143989 quercetin decreases expression ISO RGD:732292 6480464 Quercetin results in decreased expression of CHEK1 mRNA CTD PMID:23727915 quercetin decreases expression ISO RGD:732293 6480464 Quercetin results in decreased expression of CHEK1 mRNA CTD PMID:25862958 quercetin increases phosphorylation ISO RGD:732293 6480464 Quercetin results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 resveratrol increases expression ISO RGD:732292 6480464 resveratrol results in increased expression of CHEK1 mRNA CTD PMID:19167446 resveratrol decreases expression ISO RGD:732292 6480464 resveratrol results in decreased expression of CHEK1 mRNA CTD PMID:18089832 resveratrol affects expression ISO RGD:732292 6480464 resveratrol affects the expression of CHEK1 protein CTD PMID:18089832 resveratrol multiple interactions ISO RGD:732292 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CHEK1 mRNA more ... CTD PMID:15975956 , PMID:19167446 rotenone increases expression ISO RGD:732292 6480464 Rotenone results in increased expression of CHEK1 mRNA CTD PMID:18191903 saccharin increases expression ISO RGD:732293 6480464 Saccharin results in increased expression of CHEK1 mRNA CTD PMID:19000923 silver(1+) nitrate increases expression ISO RGD:732292 6480464 Silver Nitrate analog results in increased expression of CHEK1 mRNA CTD PMID:22831968 sodium arsenite increases phosphorylation ISO RGD:732292 6480464 sodium arsenite results in increased phosphorylation of CHEK1 protein CTD PMID:29039521 sodium nitrite increases expression ISO RGD:732293 6480464 Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 stavudine increases phosphorylation ISO RGD:732293 6480464 Stavudine results in increased phosphorylation of CHEK1 protein CTD PMID:32278789 sterigmatocystin multiple interactions ISO RGD:732292 6480464 ATR protein promotes the reaction [Sterigmatocystin results in increased phosphorylation of CHEK1 protein], Sterigmatocystin results in increased expression of and results in increased phosphorylation of CHEK1 protein CTD PMID:26914363 sterigmatocystin increases expression ISO RGD:732292 6480464 Sterigmatocystin results in increased expression of CHEK1 protein modified form CTD PMID:26914363 styrene oxide increases expression ISO RGD:732293 6480464 styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 succimer multiple interactions ISO RGD:732293 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CHEK1 mRNA CTD PMID:21641980 sunitinib decreases expression ISO RGD:732292 6480464 Sunitinib results in decreased expression of CHEK1 mRNA CTD PMID:31533062 tamoxifen affects expression ISO RGD:732293 6480464 Tamoxifen affects the expression of CHEK1 mRNA CTD PMID:17555576 temozolomide increases phosphorylation ISO RGD:732292 6480464 temozolomide results in increased phosphorylation of CHEK1 protein, temozolomide results in increased phosphorylation of CHK1 protein CTD PMID:15930307 , PMID:28122345 temozolomide multiple interactions ISO RGD:732292 6480464 XAF1 protein promotes the reaction [temozolomide results in increased phosphorylation of CHK1 protein] CTD PMID:28122345 tert-butyl hydroperoxide decreases expression ISO RGD:732292 6480464 tert-Butylhydroperoxide results in decreased expression of CHEK1 mRNA CTD PMID:12414654 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA CTD PMID:26496021 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CHEK1 mRNA CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:732293 6480464 Carbon Tetrachloride results in increased expression of CHEK1 mRNA CTD PMID:31919559 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CHEK1 mRNA] CTD PMID:31150632 thapsigargin decreases expression ISO RGD:732292 6480464 Thapsigargin results in decreased expression of CHEK1 mRNA CTD PMID:22378314 thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of CHEK1 protein CTD PMID:22659510 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of CHEK1 mRNA CTD PMID:22659510 more ... topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA CTD PMID:25729387 trichostatin A decreases expression ISO RGD:732292 6480464 trichostatin A results in decreased expression of CHEK1 mRNA CTD PMID:23770000 trimellitic anhydride increases expression ISO RGD:732293 6480464 trimellitic anhydride results in increased expression of CHEK1 mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:732292 6480464 troglitazone results in decreased expression of CHEK1 mRNA CTD PMID:19140230 tungsten increases expression ISO RGD:732293 6480464 Tungsten results in increased expression of CHEK1 mRNA CTD PMID:30912803 usnic acid increases expression ISO RGD:732292 6480464 usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 valproic acid affects expression ISO RGD:732292 6480464 Valproic Acid affects the expression of CHEK1 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:732292 6480464 Valproic Acid results in decreased expression of CHEK1 mRNA CTD PMID:20585447 more ... vemurafenib multiple interactions ISO RGD:732292 6480464 [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CHEK1 mRNA CTD PMID:27169980 wortmannin multiple interactions ISO RGD:732292 6480464 wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein], wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] CTD PMID:19261750 , PMID:22119920 wortmannin decreases expression ISO RGD:732292 6480464 wortmannin results in decreased expression of CHEK1 protein CTD PMID:22409540 Xanthatin multiple interactions ISO RGD:732292 6480464 TP53 protein promotes the reaction [xanthatin results in decreased phosphorylation of CHEK1 protein] more ... CTD PMID:29074359 Xanthatin affects phosphorylation ISO RGD:732292 6480464 xanthatin affects the phosphorylation of CHEK1 protein CTD PMID:29074359 zidovudine increases phosphorylation ISO RGD:732292 6480464 Zidovudine results in increased phosphorylation of CHEK1 protein CTD PMID:19541796 zidovudine decreases expression ISO RGD:732292 6480464 Zidovudine results in decreased expression of CHEK1 protein CTD PMID:19541796 zinc dichloride increases expression ISO RGD:732293 6480464 zinc chloride results in increased expression of CHEK1 mRNA CTD PMID:19000923
Gene-Chemical Interaction Annotations
