(+)-schisandrin B multiple interactions ISO Chek1 (Mus musculus) 6480464 [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] and [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] CTD PMID:22003191 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CHEK1 mRNA] CTD PMID:31150632 (S)-naringenin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of CHEK1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK1 mRNA CTD PMID:36235125 1,1-dichloroethene increases expression ISO Chek1 (Mus musculus) 6480464 vinylidene chloride results in increased expression of CHEK1 mRNA CTD PMID:26682919 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of CHEK1 mRNA CTD PMID:22841810 17alpha-ethynylestradiol affects expression ISO Chek1 (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of CHEK1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO Chek1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO Chek1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of CHEK1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO Chek1 (Mus musculus) 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK1 mRNA] CTD PMID:25210133 17beta-estradiol increases expression ISO CHEK1 (Homo sapiens) 6480464 Estradiol results in increased expression of CHEK1 mRNA CTD PMID:16474171 and PMID:19167446 17beta-estradiol affects expression ISO Chek1 (Mus musculus) 6480464 Estradiol affects the expression of CHEK1 mRNA CTD PMID:15598610 17beta-estradiol increases expression ISO Chek1 (Mus musculus) 6480464 Estradiol results in increased expression of CHEK1 mRNA CTD PMID:25210133 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO CHEK1 (Homo sapiens) 6480464 Metribolone results in increased expression of CHEK1 mRNA CTD PMID:19318562 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Metribolone results in increased phosphorylation of CHEK1 protein CTD PMID:23272087 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Chek1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Chek1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of CHEK1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO CHEK1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of CHEK1 mRNA CTD PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Chek1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of CHEK1 mRNA CTD PMID:15667827 and PMID:19465110 2,6-di-tert-butyl-4-methylphenol increases expression ISO Chek1 (Mus musculus) 6480464 Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 2-methylcholine affects expression ISO CHEK1 (Homo sapiens) 6480464 beta-methylcholine affects the expression of CHEK1 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',5-triiodo-L-thyronine increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Triiodothyronine analog results in increased phosphorylation of CHEK1 protein CTD PMID:22383522 3,4-methylenedioxymethamphetamine decreases expression ISO Chek1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CHEK1 mRNA CTD PMID:20188158 3-methyladenine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] CTD PMID:24823293 4-hydroxynon-2-enal decreases expression ISO Chek1 (Mus musculus) 6480464 4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA CTD PMID:19191707 4-methoxy-TEMPO increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 4-methoxy-2 more ... CTD PMID:28993908 4-nitrophenol decreases expression ISO Chek1 (Mus musculus) 6480464 4-nitrophenol results in decreased expression of CHEK1 mRNA CTD PMID:34673133 4-nonylphenol increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 4-nonylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 4-tert-Octylphenol increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 4-tert-octylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 5,7-dihydroxy-4'-methoxyflavone increases expression ISO CHEK1 (Homo sapiens) 6480464 acacetin results in increased expression of CHK1 protein CTD PMID:36740148 5-aza-2'-deoxycytidine affects localization ISO CHEK1 (Homo sapiens) 6480464 Decitabine affects the localization of CHEK1 protein modified form CTD PMID:17991895 5-fluorouracil affects response to substance ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein affects the susceptibility to Fluorouracil CTD PMID:18698031 5-fluorouracil decreases expression ISO Chek1 (Mus musculus) 6480464 Fluorouracil results in decreased expression of CHEK1 mRNA CTD PMID:19272435 5-fluorouracil increases expression ISO CHEK1 (Homo sapiens) 6480464 Fluorouracil results in increased expression of CHEK1 protein CTD PMID:15016801 5-fluorouracil multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [CHEK1 protein co-treated with TP53 protein] affects the susceptibility to Fluorouracil more ... CTD PMID:15016801 more ... 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 4-cyclohexylmethoxy-5-nitrosopyrimidine-2 and 6-diamine inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein] CTD PMID:26208482 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CHEK1 mRNA CTD PMID:24780913 and PMID:30047161 7,12-dimethyltetraphene increases expression ISO Chek1 (Mus musculus) 6480464 9 more ... CTD PMID:20025956 acrolein increases expression ISO CHEK1 (Homo sapiens) 6480464 Acrolein results in increased expression of CHEK1 protein CTD PMID:34958888 acrylamide increases expression ISO Chek1 (Mus musculus) 6480464 Acrylamide results in increased expression of CHEK1 protein CTD PMID:20025956 aflatoxin B1 affects expression ISO CHEK1 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of CHEK1 protein CTD PMID:20106945 aflatoxin B1 increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased phosphorylation of CHEK1 protein CTD PMID:32106047 all-trans-retinoic acid decreases expression ISO CHEK1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of CHEK1 mRNA CTD PMID:21934132 and PMID:33167477 all-trans-retinoic acid affects expression ISO CHEK1 (Homo sapiens) 6480464 Tretinoin affects the expression of CHEK1 mRNA CTD PMID:23724009 all-trans-retinoic acid increases expression ISO Chek1 (Mus musculus) 6480464 Tretinoin results in increased expression of CHEK1 protein CTD PMID:20025956 amitrole increases expression EXP 6480464 Amitrole results in increased expression of CHEK1 mRNA CTD PMID:30047161 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CHEK1 mRNA CTD PMID:16483693 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of CHEK1 protein CTD PMID:16483693 anthocyanin increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Anthocyanins results in increased phosphorylation of CHEK1 protein CTD PMID:27444805 anthracene-1,8,9-triol increases expression ISO Chek1 (Mus musculus) 6480464 Anthralin results in increased expression of CHEK1 protein CTD PMID:20025956 antimycin A increases expression ISO CHEK1 (Homo sapiens) 6480464 Antimycin A results in increased expression of CHEK1 mRNA CTD PMID:33512557 aphidicolin multiple interactions ISO Chek1 (Mus musculus) 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA] and [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] CTD PMID:22003191 aristolochic acid A decreases expression ISO CHEK1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of CHEK1 mRNA and aristolochic acid I results in decreased expression of CHEK1 protein CTD PMID:33212167 arsenite(3-) multiple interactions ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein affects the reaction [arsenite promotes the reaction [TP53 protein binds to EP300 protein modified form binds to CREBBP protein modified form]] and CHEK1 protein affects the reaction [arsenite results in increased acetylation of TP53 protein] CTD PMID:33097607 arsenite(3-) increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 arsenite results in increased phosphorylation of CHEK1 protein CTD PMID:33097607 arsenous acid multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK1 protein] CTD PMID:23337567 arsenous acid increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:23337567 arsenous acid increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 arsenous acid increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 artesunate multiple interactions ISO CHEK1 (Homo sapiens) 6480464 APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 artesunate increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Artesunate results in increased phosphorylation of CHEK1 protein CTD PMID:31664825 atrazine decreases expression ISO CHEK1 (Homo sapiens) 6480464 Atrazine results in decreased expression of CHEK1 mRNA CTD PMID:22378314 auraptene affects expression ISO CHEK1 (Homo sapiens) 6480464 aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 azathioprine decreases expression ISO CHEK1 (Homo sapiens) 6480464 Azathioprine results in decreased expression of CHEK1 mRNA CTD PMID:22623647 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CHEK1 protein modified form CTD PMID:21604763 benzo[a]pyrene increases expression ISO CHEK1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of CHEK1 mRNA CTD PMID:32234424 benzo[a]pyrene affects methylation ISO CHEK1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of CHEK1 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO CHEK1 (Homo sapiens) 6480464 CLSPN mRNA affects the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] and cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] CTD PMID:19464357 and PMID:20228066 benzo[a]pyrene decreases expression ISO CHEK1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of CHEK1 mRNA CTD PMID:21802500 and PMID:32244372 benzo[a]pyrene increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein CTD PMID:19464357 more ... benzo[a]pyrene diol epoxide I multiple interactions ISO Chek1 (Mus musculus) 6480464 POLH protein affects the reaction [7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I increases expression ISO CHEK1 (Homo sapiens) 6480464 7 more ... CTD PMID:26238291 benzo[a]pyrene diol epoxide I increases phosphorylation ISO Chek1 (Mus musculus) 6480464 7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I decreases expression ISO CHEK1 (Homo sapiens) 6480464 7 more ... CTD PMID:20018196 and PMID:20382639 berberine increases expression ISO CHEK1 (Homo sapiens) 6480464 Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 biphenyl-4-amine decreases expression ISO CHEK1 (Homo sapiens) 6480464 4-biphenylamine results in decreased expression of CHEK1 mRNA CTD PMID:24857880 bis(2-chloroethyl) sulfide multiple interactions ISO CHEK1 (Homo sapiens) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:22119920 and PMID:25448276 bis(2-chloroethyl) sulfide decreases expression ISO CHEK1 (Homo sapiens) 6480464 Mustard Gas results in decreased expression of CHEK1 mRNA CTD PMID:33491125 bis(2-chloroethyl) sulfide increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Mustard Gas results in increased phosphorylation of CHEK1 protein CTD PMID:22119920 and PMID:25448276 bis(2-ethylhexyl) phthalate multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] CTD PMID:30720231 bisphenol A increases expression ISO CHEK1 (Homo sapiens) 6480464 bisphenol A results in increased expression of CHEK1 mRNA CTD PMID:16474171 bisphenol A multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [bisphenol A co-treated with cylindrospermopsin] results in decreased expression of CHEK1 mRNA more ... CTD PMID:32244372 and PMID:36235125 bisphenol A increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 bisphenol A results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 bisphenol A decreases expression ISO CHEK1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of CHEK1 mRNA CTD PMID:29275510 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CHEK1 mRNA CTD PMID:25181051 more ... bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA CTD PMID:26496021 Brevetoxin B increases expression ISO CHEK1 (Homo sapiens) 6480464 brevetoxin 2 results in increased expression of CHEK1 mRNA CTD PMID:20498034 busulfan multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 cadmium atom decreases expression ISO CHEK1 (Homo sapiens) 6480464 Cadmium results in decreased expression of CHEK1 mRNA CTD PMID:21120746 caffeine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] more ... CTD PMID:15975956 more ... caffeine increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of CHEK1 protein CTD PMID:29074359 caffeine multiple interactions ISO Chek1 (Mus musculus) 6480464 Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA] and Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 caffeine decreases expression ISO Chek1 (Mus musculus) 6480464 Caffeine results in decreased expression of CHEK1 protein modified form CTD PMID:21505179 caffeine decreases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Caffeine results in decreased phosphorylation of CHEK1 protein CTD PMID:21561856 and PMID:35688186 camptothecin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] and Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] CTD PMID:25269479 and PMID:30720231 camptothecin increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Camptothecin results in increased phosphorylation of CHEK1 protein CTD PMID:21646468 and PMID:30555576 camptothecin increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Camptothecin results in increased phosphorylation of CHEK1 protein CTD PMID:22403396 camptothecin increases expression ISO Chek1 (Mus musculus) 6480464 Camptothecin results in increased expression of CHEK1 mRNA CTD PMID:22403396 camptothecin multiple interactions ISO Chek1 (Mus musculus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:22403396 camptothecin decreases response to substance ISO CHEK1 (Homo sapiens) 6480464 CHEK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 camptothecin increases expression ISO CHEK1 (Homo sapiens) 6480464 Camptothecin results in increased expression of CHEK1 protein modified form CTD PMID:25269479 and PMID:30720231 cannabidiol decreases expression ISO CHEK1 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of CHEK1 mRNA CTD PMID:36519830 carbamazepine affects expression ISO CHEK1 (Homo sapiens) 6480464 Carbamazepine affects the expression of CHEK1 mRNA CTD PMID:24752500 carmustine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] more ... CTD PMID:19261750 catechol increases expression ISO Chek1 (Mus musculus) 6480464 catechol results in increased expression of CHEK1 protein CTD PMID:20025956 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of CHEK1 mRNA CTD PMID:18500788 chlorpyrifos decreases expression ISO Chek1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of CHEK1 mRNA CTD PMID:20350560 and PMID:37019170 cholic acid increases expression ISO Chek1 (Mus musculus) 6480464 Cholic Acid results in increased expression of CHEK1 protein CTD PMID:20025956 choline affects expression ISO CHEK1 (Homo sapiens) 6480464 Choline affects the expression of CHEK1 mRNA CTD PMID:17616785 choline multiple interactions ISO Chek1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 ciprofloxacin increases expression EXP 6480464 Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 cisplatin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]] more ... CTD PMID:20623183 more ... cisplatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] CTD PMID:26739623 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CHEK1 protein modified form CTD PMID:26739623 cisplatin increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Cisplatin results in increased phosphorylation of CHEK1 protein CTD PMID:20623183 more ... cisplatin increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of CHEK1 protein CTD PMID:21285353 and PMID:22006019 cisplatin multiple interactions ISO Chek1 (Mus musculus) 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA] more ... CTD PMID:21324906 and PMID:22003191 cisplatin increases activity ISO CHEK1 (Homo sapiens) 6480464 Cisplatin results in increased activity of CHEK1 protein CTD PMID:21324906 and PMID:21592546 cisplatin decreases expression ISO CHEK1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of CHEK1 protein CTD PMID:12740909 clofarabine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 clofibrate increases expression ISO Chek1 (Mus musculus) 6480464 Clofibrate results in increased expression of CHEK1 protein CTD PMID:20025956 cobalt dichloride multiple interactions ISO CHEK1 (Homo sapiens) 6480464 cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] CTD PMID:20228066 cobalt dichloride decreases expression ISO CHEK1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of CHEK1 mRNA CTD PMID:19320972 and PMID:19376846 cobalt dichloride increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 cobaltous chloride results in increased phosphorylation of CHEK1 protein CTD PMID:20228066 copper atom increases expression EXP 6480464 Copper results in increased expression of CHEK1 mRNA CTD PMID:22465980 copper atom multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of CHEK1 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA CTD PMID:20971185 and PMID:30911355 copper(0) increases expression EXP 6480464 Copper results in increased expression of CHEK1 mRNA CTD PMID:22465980 copper(0) multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of CHEK1 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA CTD PMID:20971185 and PMID:30911355 copper(II) sulfate decreases expression ISO CHEK1 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of CHEK1 mRNA CTD PMID:19549813 coumarin decreases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 coumarin results in decreased phosphorylation of CHEK1 protein CTD PMID:35688186 coumestrol multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO CHEK1 (Homo sapiens) 6480464 Coumestrol results in increased expression of CHEK1 mRNA CTD PMID:19167446 crocidolite asbestos increases expression ISO CHEK1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of CHEK1 protein CTD PMID:21570478 curcumin decreases response to substance ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein results in decreased susceptibility to Curcumin CTD PMID:18602917 curcumin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] CTD PMID:27996348 curcumin increases activity ISO CHEK1 (Homo sapiens) 6480464 Curcumin results in increased activity of CHEK1 protein CTD PMID:18602917 curcumin increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Curcumin results in increased phosphorylation of CHEK1 protein CTD PMID:19401701 CX-5461 increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 CX 5461 results in increased phosphorylation of CHEK1 protein CTD PMID:28211448 cyclosporin A decreases expression ISO Chek1 (Mus musculus) 6480464 Cyclosporine results in decreased expression of CHEK1 mRNA CTD PMID:25270620 cyclosporin A decreases expression ISO CHEK1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of CHEK1 mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO CHEK1 (Homo sapiens) 6480464 cylindrospermopsin results in increased expression of CHEK1 mRNA CTD PMID:23726867 cylindrospermopsin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [bisphenol A co-treated with cylindrospermopsin] results in decreased expression of CHEK1 mRNA CTD PMID:32244372 Decamethylcyclopentasiloxane decreases expression ISO CHEK1 (Homo sapiens) 6480464 decamethylcyclopentasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 deguelin increases expression ISO CHEK1 (Homo sapiens) 6480464 deguelin results in increased expression of CHEK1 mRNA CTD PMID:33512557 Diallyl sulfide increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 allyl sulfide results in increased phosphorylation of CHEK1 protein CTD PMID:24650757 Diallyl sulfide multiple interactions ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CCNB1 protein] and CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CDC25C protein] CTD PMID:24650757 diarsenic trioxide increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:23337567 diarsenic trioxide increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 diarsenic trioxide increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 diarsenic trioxide multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK1 protein] CTD PMID:23337567 dibutyl phthalate decreases expression ISO Chek1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of CHEK1 mRNA CTD PMID:21266533 diclofenac affects expression ISO CHEK1 (Homo sapiens) 6480464 Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 dicrotophos decreases expression ISO CHEK1 (Homo sapiens) 6480464 dicrotophos results in decreased expression of CHEK1 mRNA CTD PMID:28302478 diepoxybutane multiple interactions ISO Chek1 (Mus musculus) 6480464 7-hydroxystaurosporine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form] more ... CTD PMID:25633853 diepoxybutane increases phosphorylation ISO Chek1 (Mus musculus) 6480464 diepoxybutane results in increased phosphorylation of CHEK1 protein CTD PMID:25633853 diepoxybutane increases expression ISO Chek1 (Mus musculus) 6480464 diepoxybutane results in increased expression of CHEK1 protein modified form CTD PMID:25633853 diethyl sulfate decreases expression ISO CHEK1 (Homo sapiens) 6480464 diethyl sulfate results in decreased expression of CHEK1 protein modified form CTD PMID:23830811 diethyl sulfate increases expression ISO CHEK1 (Homo sapiens) 6480464 diethyl sulfate results in increased expression of CHEK1 protein modified form CTD PMID:23830811 digitoxin decreases expression ISO CHEK1 (Homo sapiens) 6480464 Digitoxin analog results in decreased expression of CHEK1 protein and Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 dioscin decreases expression ISO CHEK1 (Homo sapiens) 6480464 dioscin results in decreased expression of CHEK1 mRNA and dioscin results in decreased expression of CHEK1 protein CTD PMID:33359023 doxorubicin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:15489221 more ... doxorubicin decreases expression ISO Chek1 (Mus musculus) 6480464 Doxorubicin results in decreased expression of CHEK1 mRNA CTD PMID:29653124 doxorubicin increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Doxorubicin results in increased phosphorylation of CHEK1 protein CTD PMID:17085670 more ... doxorubicin affects response to substance ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 and PMID:18698031 doxorubicin decreases expression ISO CHEK1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of CHEK1 mRNA and Doxorubicin results in decreased expression of CHEK1 protein CTD PMID:15870702 more ... Echimidine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 Enterolactone multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CHEK1 mRNA CTD PMID:19167446 Enterolactone increases expression ISO CHEK1 (Homo sapiens) 6480464 2 and 3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of CHEK1 mRNA CTD PMID:19167446 entinostat decreases expression ISO CHEK1 (Homo sapiens) 6480464 entinostat results in decreased expression of CHEK1 protein CTD PMID:34665271 epoxiconazole increases expression ISO Chek1 (Mus musculus) 6480464 epoxiconazole results in increased expression of CHEK1 mRNA CTD PMID:35436446 equol decreases expression ISO CHEK1 (Homo sapiens) 6480464 Equol results in decreased expression of CHEK1 mRNA CTD PMID:16865672 estragole increases expression EXP 6480464 estragole results in increased expression of CHEK1 protein CTD PMID:29054680 etoposide affects response to substance ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein affects the susceptibility to Etoposide CTD PMID:18698031 etoposide multiple interactions ISO CHEK1 (Homo sapiens) 6480464 TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide] CTD PMID:18698031 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of CHEK1 mRNA CTD PMID:17264098 fenpyroximate increases expression ISO CHEK1 (Homo sapiens) 6480464 fenpyroximate results in increased expression of CHEK1 mRNA CTD PMID:33512557 fisetin increases expression ISO CHEK1 (Homo sapiens) 6480464 fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of CHEK1 mRNA CTD PMID:18035473 floxuridine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406 and PMID:22194930 flumequine multiple interactions ISO Chek1 (Mus musculus) 6480464 [flumequine co-treated with 2-amino-3 more ... CTD PMID:23681119 folic acid affects expression ISO CHEK1 (Homo sapiens) 6480464 Folic Acid affects the expression of CHEK1 mRNA CTD PMID:16361273 folic acid multiple interactions ISO Chek1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 furan increases expression ISO Chek1 (Mus musculus) 6480464 furan results in increased expression of CHEK1 mRNA CTD PMID:20194422 furan increases expression EXP 6480464 furan results in increased expression of CHEK1 mRNA CTD PMID:20562052 more ... furazolidone multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] CTD PMID:27996348 furazolidone increases expression ISO CHEK1 (Homo sapiens) 6480464 Furazolidone results in increased expression of CHEK1 protein CTD PMID:27996348 furosemide affects expression EXP 6480464 Furosemide affects the expression of CHEK1 mRNA CTD PMID:17497460 genistein increases expression ISO CHEK1 (Homo sapiens) 6480464 Genistein results in increased expression of CHEK1 mRNA CTD PMID:16474171 geraniol decreases expression ISO CHEK1 (Homo sapiens) 6480464 geraniol results in decreased expression of CHEK1 mRNA CTD PMID:27683099 glyphosate decreases expression ISO CHEK1 (Homo sapiens) 6480464 glyphosate results in decreased expression of CHEK1 mRNA CTD PMID:31295307 Goe 6976 decreases activity ISO CHEK1 (Homo sapiens) 6480464 Go 6976 results in decreased activity of CHEK1 protein CTD PMID:10998351 and PMID:20619533 Goe 6976 multiple interactions ISO CHEK1 (Homo sapiens) 6480464 xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein] CTD PMID:29074359 Goe 6976 increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Go 6976 results in increased phosphorylation of CHEK1 protein CTD PMID:29074359 gold atom multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA CTD PMID:28433809 gold atom decreases expression ISO CHEK1 (Homo sapiens) 6480464 Gold analog results in decreased expression of CHEK1 mRNA CTD PMID:36057382 gold(0) multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA CTD PMID:28433809 gold(0) decreases expression ISO CHEK1 (Homo sapiens) 6480464 Gold analog results in decreased expression of CHEK1 mRNA CTD PMID:36057382 GW 4064 increases expression ISO CHEK1 (Homo sapiens) 6480464 GW 4064 results in increased expression of CHEK1 mRNA CTD PMID:31437187 hexamethylcyclotrisiloxane decreases expression ISO CHEK1 (Homo sapiens) 6480464 hexamethylcyclotrisiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 hydrogen peroxide decreases expression ISO CHEK1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of CHEK1 mRNA CTD PMID:12414654 hydrogen peroxide increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 and PMID:29074359 hydrogen peroxide multiple interactions ISO CHEK1 (Homo sapiens) 6480464 MIRLET7G mRNA inhibits the reaction [Hydrogen Peroxide results in increased expression of CHEK1 protein] CTD PMID:25972194 hydrogen peroxide increases expression ISO CHEK1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of CHEK1 mRNA and Hydrogen Peroxide results in increased expression of CHEK1 protein CTD PMID:25972194 hydroxyurea multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334 hydroxyurea increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Hydroxyurea results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 hydroxyurea increases expression ISO CHEK1 (Homo sapiens) 6480464 Hydroxyurea results in increased expression of CHK1 protein modified form CTD PMID:21840268 hydroxyurea decreases expression ISO Chek1 (Mus musculus) 6480464 Hydroxyurea results in decreased expression of CHEK1 mRNA CTD PMID:12929121 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of CHEK1 mRNA CTD PMID:21396975 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA CTD PMID:22129741 irinotecan increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Irinotecan results in increased phosphorylation of CHEK1 protein CTD PMID:22111927 and PMID:22898888 irinotecan multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein and SAR 020106 inhibits the reaction [Irinotecan results in increased phosphorylation of CHEK1 protein] CTD PMID:22111927 and PMID:22510560 iron dichloride increases expression ISO Chek1 (Mus musculus) 6480464 ferrous chloride results in increased expression of CHEK1 protein CTD PMID:20025956 iron trichloride increases expression ISO Chek1 (Mus musculus) 6480464 ferric chloride results in increased expression of CHEK1 protein CTD PMID:20025956 isoflurane decreases expression EXP 6480464 Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 kaempferol increases phosphorylation ISO Chek1 (Mus musculus) 6480464 kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 L-methionine multiple interactions ISO Chek1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 Lasiocarpine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 lead diacetate increases expression ISO Chek1 (Mus musculus) 6480464 lead acetate results in increased expression of CHEK1 mRNA CTD PMID:22609695 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of CHEK1 mRNA CTD PMID:33862172 lead(0) affects expression ISO CHEK1 (Homo sapiens) 6480464 Lead affects the expression of CHEK1 mRNA CTD PMID:28903495 lead(0) affects methylation ISO CHEK1 (Homo sapiens) 6480464 Lead affects the methylation of CHEK1 gene CTD PMID:31636367 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of CHEK1 mRNA CTD PMID:24136188 leptomycin B decreases expression ISO CHEK1 (Homo sapiens) 6480464 leptomycin B results in decreased expression of CHEK1 mRNA CTD PMID:20803015 lovastatin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] and Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] CTD PMID:17088865 and PMID:21356574 lovastatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] CTD PMID:26739623 MeIQx multiple interactions ISO Chek1 (Mus musculus) 6480464 [flumequine co-treated with 2-amino-3 more ... CTD PMID:23681119 melphalan increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Melphalan results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 menadione decreases expression ISO CHEK1 (Homo sapiens) 6480464 Vitamin K 3 results in decreased expression of CHEK1 mRNA CTD PMID:12414654 metformin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of CHEK1 mRNA CTD PMID:26558467 methimazole increases expression EXP 6480464 Methimazole results in increased expression of CHEK1 mRNA CTD PMID:30047161 methotrexate increases expression ISO CHEK1 (Homo sapiens) 6480464 Methotrexate results in increased expression of CHEK1 mRNA CTD PMID:22484375 methotrexate increases expression ISO Chek1 (Mus musculus) 6480464 Methotrexate results in increased expression of CHEK1 protein modified form CTD PMID:22484375 methotrexate multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] and Methotrexate results in increased expression of and results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:22484375 methotrexate decreases response to substance ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein results in decreased susceptibility to Methotrexate CTD PMID:22484375 methotrexate multiple interactions ISO Chek1 (Mus musculus) 6480464 Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] CTD PMID:22484375 methyl isocyanate increases expression ISO Chek1 (Mus musculus) 6480464 methyl isocyanate results in increased expression of CHEK1 mRNA CTD PMID:22223508 methylmercury chloride decreases expression ISO Chek1 (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of CHEK1 mRNA CTD PMID:20061341 Mezerein increases expression ISO Chek1 (Mus musculus) 6480464 mezerein results in increased expression of CHEK1 mRNA CTD PMID:19000923 mifepristone multiple interactions ISO Chek1 (Mus musculus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 mitomycin C increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Mitomycin results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 monocrotaline multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA and [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 N-acetyl-L-cysteine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CHEK1 mRNA] and Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]] CTD PMID:15489221 and PMID:33971260 N-acetyl-L-cysteine multiple interactions ISO Chek1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form] CTD PMID:25633853 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO Chek1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHEK1 mRNA CTD PMID:20061341 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein] more ... CTD PMID:26921499 N-nitrosodiethylamine multiple interactions ISO Chek1 (Mus musculus) 6480464 ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA] more ... CTD PMID:17854601 and PMID:19919837 N-nitrosodiethylamine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA CTD PMID:22129741 N-nitrosodiethylamine increases expression ISO Chek1 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of CHEK1 mRNA and Diethylnitrosamine results in increased expression of CHEK1 protein CTD PMID:17854601 and PMID:19919837 nickel atom decreases expression ISO CHEK1 (Homo sapiens) 6480464 Nickel results in decreased expression of CHEK1 mRNA CTD PMID:24768652 nickel atom increases expression ISO CHEK1 (Homo sapiens) 6480464 Nickel results in increased expression of CHEK1 mRNA CTD PMID:25583101 nimustine increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Nimustine results in increased phosphorylation of CHEK1 protein CTD PMID:22609303 nimustine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] CTD PMID:22609303 nocodazole decreases expression ISO CHEK1 (Homo sapiens) 6480464 Nocodazole results in decreased expression of CHEK1 protein CTD PMID:26914363 NORCANTHARIDIN increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 norcantharidin results in increased phosphorylation of CHEK1 protein CTD PMID:21266192 O-methyleugenol affects expression EXP 6480464 methyleugenol affects the expression of CHEK1 mRNA CTD PMID:26011634 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of CHEK1 mRNA CTD PMID:19237604 more ... ochratoxin A decreases acetylation ISO CHEK1 (Homo sapiens) 6480464 ochratoxin A results in decreased acetylation of CHEK1 promoter CTD PMID:29098329 octamethylcyclotetrasiloxane decreases expression ISO CHEK1 (Homo sapiens) 6480464 octamethylcyclotetrasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 olaparib increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 olaparib results in increased phosphorylation of CHEK1 protein CTD PMID:25531448 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of CHEK1 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA CTD PMID:25729387 oxfendazole affects expression EXP 6480464 oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 ozone increases expression ISO Chek1 (Mus musculus) 6480464 Ozone results in increased expression of CHEK1 mRNA CTD PMID:19555225 ozone multiple interactions ISO Chek1 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of CHEK1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CHEK1 mRNA CTD PMID:27106289 and PMID:34911549 p-anisidine decreases expression ISO Chek1 (Mus musculus) 6480464 4-anisidine results in decreased expression of CHEK1 mRNA CTD PMID:12929121 p-tert-Amylphenol increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 4-tert-octylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 paclitaxel decreases expression ISO Chek1 (Mus musculus) 6480464 Paclitaxel results in decreased expression of CHEK1 mRNA CTD PMID:12929121 paclitaxel multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 paracetamol increases expression ISO Chek1 (Mus musculus) 6480464 Acetaminophen results in increased expression of CHEK1 protein CTD PMID:20025956 paracetamol increases expression ISO CHEK1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of CHEK1 mRNA CTD PMID:33971260 paracetamol multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CHEK1 mRNA] CTD PMID:33971260 paraquat multiple interactions ISO Chek1 (Mus musculus) 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CHEK1 mRNA CTD PMID:28012437 perfluorooctane-1-sulfonic acid multiple interactions ISO Chek1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of CHEK1 mRNA CTD PMID:36331819 PF-00477736 decreases activity ISO CHEK1 (Homo sapiens) 6480464 PF 00477736 results in decreased activity of CHEK1 protein CTD PMID:21707865 PF-00477736 multiple interactions ISO CHEK1 (Homo sapiens) 6480464 PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] CTD PMID:25448276 phenobarbital affects expression ISO Chek1 (Mus musculus) 6480464 Phenobarbital affects the expression of CHEK1 mRNA CTD PMID:23091169 PhIP increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 phorbol 13-acetate 12-myristate increases expression ISO Chek1 (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of CHEK1 mRNA CTD PMID:19000923 pirinixic acid increases expression ISO Chek1 (Mus musculus) 6480464 pirinixic acid results in increased expression of CHEK1 mRNA CTD PMID:20813756 pirinixic acid multiple interactions ISO Chek1 (Mus musculus) 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of CHEK1 mRNA CTD PMID:20813756 platinum multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21107699 platinum(0) multiple interactions ISO CHEK1 (Homo sapiens) 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21107699 pregnenolone 16alpha-carbonitrile multiple interactions ISO Chek1 (Mus musculus) 6480464 [1 more ... CTD PMID:23626729 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of CHEK1 mRNA CTD PMID:20726854 progesterone increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Progesterone results in increased phosphorylation of CHEK1 protein CTD PMID:22403396 progesterone multiple interactions ISO Chek1 (Mus musculus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 promethazine increases expression EXP 6480464 Promethazine results in increased expression of CHEK1 mRNA CTD PMID:26558467 promethazine decreases expression EXP 6480464 Promethazine results in decreased expression of CHEK1 mRNA CTD PMID:26011634 propiconazole increases expression ISO Chek1 (Mus musculus) 6480464 propiconazole results in increased expression of CHEK1 mRNA CTD PMID:21278054 Ptaquiloside increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 ptaquiloside results in increased phosphorylation of CHEK1 protein CTD PMID:22143989 pyrimidifen increases expression ISO CHEK1 (Homo sapiens) 6480464 pyrimidifen results in increased expression of CHEK1 mRNA CTD PMID:33512557 quercetin decreases expression ISO CHEK1 (Homo sapiens) 6480464 Quercetin results in decreased expression of CHEK1 mRNA CTD PMID:23727915 quercetin decreases expression ISO Chek1 (Mus musculus) 6480464 Quercetin results in decreased expression of CHEK1 mRNA CTD PMID:25862958 quercetin increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Quercetin results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 quizartinib multiple interactions ISO CHEK1 (Homo sapiens) 6480464 quizartinib promotes the reaction [RGFP966 results in decreased expression of CHEK1 protein] more ... CTD PMID:34665271 quizartinib decreases expression ISO CHEK1 (Homo sapiens) 6480464 quizartinib results in decreased expression of CHEK1 protein CTD PMID:34665271 resveratrol increases expression ISO CHEK1 (Homo sapiens) 6480464 resveratrol results in increased expression of CHEK1 mRNA CTD PMID:19167446 resveratrol decreases expression EXP 6480464 Resveratrol results in decreased expression of CHEK1 mRNA CTD PMID:33775663 resveratrol decreases expression ISO CHEK1 (Homo sapiens) 6480464 resveratrol results in decreased expression of CHEK1 mRNA CTD PMID:18089832 resveratrol affects expression ISO CHEK1 (Homo sapiens) 6480464 resveratrol affects the expression of CHEK1 protein CTD PMID:18089832 resveratrol multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CHEK1 mRNA more ... CTD PMID:15975956 and PMID:19167446 riddelliine multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 rimonabant decreases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Rimonabant results in decreased phosphorylation of CHEK1 protein CTD PMID:19479993 romidepsin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 romidepsin promotes the reaction [quizartinib results in decreased expression of and results in increased phosphorylation of CHEK1 protein] CTD PMID:34665271 rotenone increases expression ISO CHEK1 (Homo sapiens) 6480464 Rotenone results in increased expression of CHEK1 mRNA CTD PMID:18191903 and PMID:33512557 saccharin increases expression ISO Chek1 (Mus musculus) 6480464 Saccharin results in increased expression of CHEK1 mRNA CTD PMID:19000923 silver(1+) nitrate increases expression ISO CHEK1 (Homo sapiens) 6480464 Silver Nitrate analog results in increased expression of CHEK1 mRNA CTD PMID:22831968 sodium arsenite increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 sodium arsenite results in increased phosphorylation of CHEK1 protein CTD PMID:29039521 sodium nitrite increases expression ISO Chek1 (Mus musculus) 6480464 Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 stavudine increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Stavudine results in increased phosphorylation of CHEK1 protein CTD PMID:32278789 sterigmatocystin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 ATR protein promotes the reaction [Sterigmatocystin results in increased phosphorylation of CHEK1 protein] and Sterigmatocystin results in increased expression of and results in increased phosphorylation of CHEK1 protein CTD PMID:26914363 sterigmatocystin increases expression ISO CHEK1 (Homo sapiens) 6480464 Sterigmatocystin results in increased expression of CHEK1 protein modified form CTD PMID:26914363 styrene oxide increases expression ISO Chek1 (Mus musculus) 6480464 styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 succimer multiple interactions ISO Chek1 (Mus musculus) 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CHEK1 mRNA CTD PMID:21641980 sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of CHEK1 mRNA CTD PMID:30047161 sunitinib decreases expression ISO CHEK1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of CHEK1 mRNA CTD PMID:31533062 tamoxifen affects expression ISO Chek1 (Mus musculus) 6480464 Tamoxifen affects the expression of CHEK1 mRNA CTD PMID:17555576 temozolomide increases expression ISO CHEK1 (Homo sapiens) 6480464 Temozolomide results in increased expression of CHEK1 mRNA CTD PMID:31758290 temozolomide multiple interactions ISO CHEK1 (Homo sapiens) 6480464 XAF1 protein promotes the reaction [temozolomide results in increased phosphorylation of CHK1 protein] CTD PMID:28122345 temozolomide increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 temozolomide results in increased phosphorylation of CHEK1 protein and temozolomide results in increased phosphorylation of CHK1 protein CTD PMID:15930307 and PMID:28122345 tert-butyl hydroperoxide decreases expression ISO CHEK1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of CHEK1 mRNA CTD PMID:12414654 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA CTD PMID:26496021 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CHEK1 mRNA CTD PMID:31150632 tetrachloromethane increases expression ISO Chek1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of CHEK1 mRNA CTD PMID:31919559 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CHEK1 mRNA] CTD PMID:31150632 thapsigargin decreases expression ISO CHEK1 (Homo sapiens) 6480464 Thapsigargin results in decreased expression of CHEK1 mRNA CTD PMID:22378314 thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of CHEK1 protein CTD PMID:22659510 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of CHEK1 mRNA CTD PMID:22659510 more ... topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA CTD PMID:25729387 trichostatin A decreases expression ISO CHEK1 (Homo sapiens) 6480464 trichostatin A results in decreased expression of CHEK1 mRNA CTD PMID:23770000 trimellitic anhydride increases expression ISO Chek1 (Mus musculus) 6480464 trimellitic anhydride results in increased expression of CHEK1 mRNA CTD PMID:19042947 troglitazone decreases expression ISO CHEK1 (Homo sapiens) 6480464 troglitazone results in decreased expression of CHEK1 mRNA CTD PMID:19140230 tungsten increases expression ISO Chek1 (Mus musculus) 6480464 Tungsten results in increased expression of CHEK1 mRNA CTD PMID:30912803 usnic acid increases expression ISO CHEK1 (Homo sapiens) 6480464 usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 valproic acid affects expression ISO CHEK1 (Homo sapiens) 6480464 Valproic Acid affects the expression of CHEK1 mRNA CTD PMID:25979313 valproic acid decreases expression ISO CHEK1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of CHEK1 mRNA CTD PMID:20585447 more ... vemurafenib multiple interactions ISO CHEK1 (Homo sapiens) 6480464 [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CHEK1 mRNA CTD PMID:27169980 versicolorin A increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 versicolorin A results in increased phosphorylation of CHEK1 protein CTD PMID:32106047 wortmannin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] and wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] CTD PMID:19261750 and PMID:22119920 wortmannin decreases expression ISO CHEK1 (Homo sapiens) 6480464 wortmannin results in decreased expression of CHEK1 protein CTD PMID:22409540 Xanthatin multiple interactions ISO CHEK1 (Homo sapiens) 6480464 TP53 protein promotes the reaction [xanthatin results in decreased phosphorylation of CHEK1 protein] more ... CTD PMID:29074359 Xanthatin affects phosphorylation ISO CHEK1 (Homo sapiens) 6480464 xanthatin affects the phosphorylation of CHEK1 protein CTD PMID:29074359 zearalenone decreases phosphorylation ISO Chek1 (Mus musculus) 6480464 Zearalenone results in decreased phosphorylation of CHK1 protein CTD PMID:34716709 zearalenone increases expression ISO Chek1 (Mus musculus) 6480464 Zearalenone results in increased expression of CHEK1 protein CTD PMID:35504548 zidovudine increases phosphorylation ISO CHEK1 (Homo sapiens) 6480464 Zidovudine results in increased phosphorylation of CHEK1 protein CTD PMID:19541796 zidovudine decreases expression ISO CHEK1 (Homo sapiens) 6480464 Zidovudine results in decreased expression of CHEK1 protein CTD PMID:19541796 zinc dichloride increases expression ISO Chek1 (Mus musculus) 6480464 zinc chloride results in increased expression of CHEK1 mRNA CTD PMID:19000923