Ikbkb (inhibitor of nuclear factor kappa B kinase subunit beta) - Rat Genome Database

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Gene: Ikbkb (inhibitor of nuclear factor kappa B kinase subunit beta) Rattus norvegicus
Analyze
Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
RGD ID: 621375
Description: Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AIM-1; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,319,487 - 69,373,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,593,277 - 74,646,961 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01678,025,765 - 78,078,546 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01673,274,913 - 73,327,717 (+)NCBIRnor_WKY
Rnor_6.01674,177,233 - 74,230,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,809,854 - 73,863,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,804,730 - 73,858,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,805,346 - 73,858,348 (+)NCBI
Celera1667,214,025 - 67,266,348 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-dithiothreitol  (ISO)
15-oxo-ETE  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-tert-butylhydroquinone  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anethole  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP,ISO)
aristolochic acid  (ISO)
arjunolic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
Atractylodin  (ISO)
azadirachtin A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (EXP)
cannabidiol  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
Carnosol  (ISO)
carvedilol  (EXP)
cerium trichloride  (ISO)
chloroquine  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-ribofuranose  (ISO)
deferiprone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dimercaprol  (ISO)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
eugenol  (EXP)
Evodiamine  (ISO)
febuxostat  (EXP)
filipin III  (EXP)
flavonoids  (EXP)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
Fusaric acid  (ISO)
gallic acid  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
homoeriodictyol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibrutinib  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
Isorhapontigenin  (EXP)
L-1,4-dithiothreitol  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP,ISO)
melittin  (ISO)
metformin  (ISO)
methapyrilene  (EXP,ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
miquelianin  (ISO)
Monobutylphthalate  (EXP,ISO)
monosodium L-glutamate  (ISO)
monotropein  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
neratinib  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nitroprusside  (ISO)
Nonylphenol  (EXP)
notoginsenoside R1  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (ISO)
parthenolide  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
rocaglamide  (ISO)
SB 203580  (EXP,ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
Sodium salicylate  (ISO)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
taurine  (EXP)
testosterone  (ISO)
titanium dioxide  (ISO)
trans-anethole  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
umbelliferone  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
2. Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. Azoitei N, etal., J Neurochem. 2005 Jun;93(6):1487-501.
3. Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. Baumann B, etal., J Clin Invest. 2007 Jun;117(6):1502-13. Epub 2007 May 24.
4. Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. Bruno ME, etal., Arch Biochem Biophys. 2002 Oct 15;406(2):153-64.
5. IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia. Bu DX, etal., FASEB J. 2005 Aug;19(10):1293-5. Epub 2005 Jun 6.
6. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Cai D, etal., Nat Med. 2005 Feb;11(2):183-90. Epub 2005 Jan 30.
7. The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. Chang NS J Biol Chem 2002 Mar 22;277(12):10323-31.
8. Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. Chen X, etal., Am J Nephrol. 2009;30(3):287-94. doi: 10.1159/000225928. Epub 2009 Jun 16.
9. 20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. Cheng J, etal., J Pharmacol Exp Ther. 2010 Jan;332(1):57-65. doi: 10.1124/jpet.109.159863. Epub 2009 Oct 19.
10. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. Daniluk J, etal., J Clin Invest. 2012 Apr;122(4):1519-28. doi: 10.1172/JCI59743. Epub 2012 Mar 12.
11. Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis. Dyckman AJ, etal., Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. doi: 10.1016/j.bmcl.2010.10.133. Epub 2010 Oct 31.
12. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
13. NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. Fontan E, etal., FEBS J. 2007 May;274(10):2540-51. Epub 2007 Apr 10.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. Gillooly KM, etal., J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Gupte AA, etal., Diabetes. 2009 Mar;58(3):567-78. doi: 10.2337/db08-1070. Epub 2008 Dec 10.
18. Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats. Gupte AA, etal., J Appl Physiol (1985). 2009 Apr;106(4):1425-34. doi: 10.1152/japplphysiol.91210.2008. Epub 2009 Jan 29.
19. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
20. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
21. IKK mediates ischemia-induced neuronal death. Herrmann O, etal., Nat Med. 2005 Dec;11(12):1322-9. Epub 2005 Nov 13.
22. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Ho RC, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C794-801. Epub 2005 May 11.
23. NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. Hu WH, etal., J Biol Chem. 2005 Aug 12;280(32):29233-41. Epub 2005 Jun 10.
24. Elevated expression of tumor necrosis factor-alpha signaling molecules in colonic tumors of Zucker obese (fa/fa) rats. Jain SS and Bird RP, Int J Cancer. 2010 Nov 1;127(9):2042-50. doi: 10.1002/ijc.25232.
25. NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. Je JH, etal., FEBS Lett. 2004 May 21;566(1-3):183-9.
26. Experimental study on early protective effect of ischemic preconditioning on rat kidney graft. Jia RP, etal., Transplant Proc. 2009 Jan-Feb;41(1):69-72. doi: 10.1016/j.transproceed.2008.11.001.
27. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Kang YM, etal., Cardiovasc Res. 2009 Jun 1;82(3):503-12. doi: 10.1093/cvr/cvp073. Epub 2009 Feb 25.
28. Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels. Kumar S, etal., J Cell Physiol. 2012 Apr;227(4):1408-19. doi: 10.1002/jcp.22855.
29. Measurement of IKK activity in primary rat T cells: rapid activation and inactivation. Kupfer R and Scheinman RI, J Immunol Methods. 2002 Aug 1;266(1-2):155-64.
30. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Ling J, etal., Cancer Cell. 2012 Jan 17;21(1):105-20. doi: 10.1016/j.ccr.2011.12.006.
31. IKK2 inhibition attenuates laser-induced choroidal neovascularization. Lu H, etal., PLoS One. 2014 Jan 28;9(1):e87530. doi: 10.1371/journal.pone.0087530. eCollection 2014.
32. Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. Maniati E, etal., J Clin Invest. 2011 Dec;121(12):4685-99. doi: 10.1172/JCI45797. Epub 2011 Nov 7.
33. Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. Meng QH, etal., Pharmazie. 2013 Nov;68(11):904-8.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. Donor antigen-loaded IKK2dn gene-modified dendritic cells prolong allograft survival. Ouyang J, etal., Scand J Immunol. 2010 May;71(5):336-44.
38. IKKbeta leads to an inflammatory skin disease resembling interface dermatitis. Page A, etal., J Invest Dermatol. 2010 Jun;130(6):1598-610. doi: 10.1038/jid.2010.28. Epub 2010 Mar 4.
39. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Pasparakis M, etal., Nature. 2002 Jun 20;417(6891):861-6.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. [Influence of electroacupuncture intervention on hippocampal IL-1beta content and I kappa B kinase beta expression in focal cerebral ischemia/reperfusion rats]. Qin WY, etal., Zhen Ci Yan Jiu. 2013 Aug;38(4):271-6.
44. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Rajendrasozhan S, etal., Pulm Pharmacol Ther. 2010 Jun;23(3):172-81. doi: 10.1016/j.pupt.2010.01.002. Epub 2010 Jan 18.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Xanthine oxidase-induced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats. Romagnoli M, etal., Free Radic Biol Med. 2010 Jul 15;49(2):171-7. doi: 10.1016/j.freeradbiomed.2010.03.024. Epub 2010 Mar 31.
49. Apigenin blocks IKKa activation and suppresses prostate cancer progression. Shukla S, etal., Oncotarget. 2015 Oct 13;6(31):31216-32. doi: 10.18632/oncotarget.5157.
50. Genetic variation in genes involved in hormones, inflammation, and energetic factors and breast cancer risk in an admixed population. Slattery M, etal., Carcinogenesis. 2012 May 4.
51. Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis. Stratis A, etal., J Invest Dermatol. 2006 Mar;126(3):614-20.
52. Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Suzuki K and Verma IM, Cell. 2008 Aug 8;134(3):485-95. doi: 10.1016/j.cell.2008.05.050.
53. Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules. Tando Y, etal., Digestion. 2002;66(4):237-45. doi: 10.1159/000068364.
54. The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. Van Gammeren D, etal., FASEB J. 2009 Feb;23(2):362-70. doi: 10.1096/fj.08-114249. Epub 2008 Sep 30.
55. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
56. Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b] pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066). Watterson SH, etal., Bioorg Med Chem Lett. 2011 Dec 1;21(23):7006-12. doi: 10.1016/j.bmcl.2011.09.111. Epub 2011 Oct 5.
57. Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase. Wu L, etal., J Hypertens. 2006 Jan;24(1):123-30.
58. Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. Yang J, etal., Mol Cancer Ther. 2009 Mar;8(3):636-47. doi: 10.1158/1535-7163.MCT-08-0749. Epub 2009 Mar 10.
59. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. Zhang F, etal., J Pharmacol Exp Ther. 2010 Jun;333(3):822-33. doi: 10.1124/jpet.110.165829. Epub 2010 Feb 26.
60. Repression of AIM-1 kinase mRNA as part of a program of genes regulated by Mpl ligand. Zhang Y, etal., Biochem Biophys Res Commun 2001 Apr 6;282(3):844-9.
61. Targeting I¿B Kinase ß/NF-¿B Signaling in Human Prostate Cancer by a Novel I¿B Kinase ß Inhibitor CmpdA. Zhang Y, etal., Mol Cancer Ther. 2016 Jul;15(7):1504-14. doi: 10.1158/1535-7163.MCT-15-0999. Epub 2016 Apr 8.
62. [An experimental study on the reverse mechanism of PPAR-gamma agonist rosiglitazone in rats with non-alcoholic steatohepatitis]. Zhao CY, etal., Zhonghua Gan Zang Bing Za Zhi. 2007 Jun;15(6):450-5.
Additional References at PubMed
PMID:9819420   PMID:12235208   PMID:12492477   PMID:12857501   PMID:14743216   PMID:15084260   PMID:15383541   PMID:15684432   PMID:15790681   PMID:16079148   PMID:16079150   PMID:16319058  
PMID:17009244   PMID:17318081   PMID:17954568   PMID:18981174   PMID:19088076   PMID:19362079   PMID:19386987   PMID:19569009   PMID:20434986   PMID:20614026   PMID:20646420   PMID:20930169  
PMID:21399639   PMID:21423167   PMID:22982470   PMID:23016877   PMID:23091055   PMID:23418625   PMID:23453807   PMID:23563696   PMID:23613522   PMID:23776175   PMID:23776406   PMID:24135021  
PMID:24825147   PMID:25636800   PMID:25816133   PMID:26212789   PMID:26514267   PMID:28060742   PMID:28673900   PMID:29785049   PMID:30337470   PMID:30988283   PMID:31297885   PMID:31549412  
PMID:34073390   PMID:35132967  


Genomics

Comparative Map Data
Ikbkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,319,487 - 69,373,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,593,277 - 74,646,961 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01678,025,765 - 78,078,546 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01673,274,913 - 73,327,717 (+)NCBIRnor_WKY
Rnor_6.01674,177,233 - 74,230,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,809,854 - 73,863,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,804,730 - 73,858,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,805,346 - 73,858,348 (+)NCBI
Celera1667,214,025 - 67,266,348 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
IKBKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,271,302 - 42,332,460 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl842,271,302 - 42,332,460 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,128,820 - 42,189,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,247,986 - 42,309,122 (+)NCBINCBI36Build 36hg18NCBI36
Build 34842,247,985 - 42,309,122NCBI
Celera841,077,798 - 41,138,835 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,656,604 - 40,717,697 (+)NCBIHuRef
CHM1_1842,177,451 - 42,238,764 (+)NCBICHM1_1
T2T-CHM13v2.0842,545,654 - 42,606,501 (+)NCBIT2T-CHM13v2.0
Ikbkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,149,221 - 23,196,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,149,228 - 23,196,605 (-)EnsemblGRCm39 Ensembl
GRCm38822,659,205 - 22,706,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,659,212 - 22,706,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,769,677 - 23,817,055 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,125,308 - 24,172,108 (-)NCBIMGSCv36mm8
Celera824,149,472 - 24,196,863 (-)NCBICelera
Cytogenetic Map8A2NCBI
Ikbkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536612,774 - 658,647 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955536611,965 - 658,647 (-)NCBIChiLan1.0ChiLan1.0
IKBKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,960,594 - 39,020,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,960,594 - 39,020,971 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,515,613 - 41,576,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IKBKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,359,551 - 23,419,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,359,813 - 23,419,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,864,109 - 23,923,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,108,158 - 25,167,347 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,108,158 - 25,167,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,479,268 - 23,538,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,042,615 - 24,101,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,093,332 - 24,152,694 (-)NCBIUU_Cfam_GSD_1.0
Ikbkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,401,726 - 46,450,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785356,168 - 406,773 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936785358,128 - 406,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,289,690 - 11,348,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,289,607 - 11,348,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,063,170 - 13,101,270 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IKBKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,267,532 - 40,325,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,268,079 - 40,326,381 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,461,878 - 1,520,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780923,744 - 970,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624780922,524 - 978,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ikbkb
382 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:468
Count of miRNA genes:251
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000025851
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
RH131248  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,372,599 - 69,372,802 (+)MAPPERmRatBN7.2
Rnor_6.01674,230,158 - 74,230,360NCBIRnor6.0
Rnor_5.01673,862,985 - 73,863,187UniSTSRnor5.0
RGSC_v3.41673,857,859 - 73,858,061UniSTSRGSC3.4
Celera1667,265,697 - 67,265,899UniSTS
RH 3.4 Map16691.7UniSTS
Cytogenetic Map16q12.5UniSTS
RH138696  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,370,092 - 69,370,227 (+)MAPPERmRatBN7.2
Rnor_6.01674,227,651 - 74,227,785NCBIRnor6.0
Rnor_5.01673,860,478 - 73,860,612UniSTSRnor5.0
RGSC_v3.41673,855,352 - 73,855,486UniSTSRGSC3.4
Celera1667,263,190 - 67,263,324UniSTS
RH 3.4 Map16663.21UniSTS
Cytogenetic Map16q12.5UniSTS
RH139961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,372,999 - 69,373,186 (+)MAPPERmRatBN7.2
Rnor_6.01674,230,558 - 74,230,744NCBIRnor6.0
Rnor_5.01673,863,385 - 73,863,571UniSTSRnor5.0
RGSC_v3.41673,858,259 - 73,858,445UniSTSRGSC3.4
Celera1667,266,097 - 67,266,283UniSTS
RH 3.4 Map16691.4UniSTS
Cytogenetic Map16q12.5UniSTS
BF390838  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,330,561 - 69,330,719 (+)MAPPERmRatBN7.2
Rnor_6.01674,188,233 - 74,188,390NCBIRnor6.0
Rnor_5.01673,820,854 - 73,821,011UniSTSRnor5.0
RGSC_v3.41673,815,730 - 73,815,887UniSTSRGSC3.4
Celera1667,225,025 - 67,225,182UniSTS
RH 3.4 Map16665.92UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 53 37 19 37 3 66 35 34 11
Low 8 4 4 4 8 8 8 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025851   ⟹   ENSRNOP00000025851
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)Ensembl
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097362   ⟹   ENSRNOP00000077348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)Ensembl
RefSeq Acc Id: NM_053355   ⟹   NP_445807
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21669,319,555 - 69,373,251 (+)NCBI
Rnor_6.01674,177,233 - 74,230,809 (+)NCBI
Rnor_5.01673,809,854 - 73,863,636 (+)NCBI
RGSC_v3.41673,804,730 - 73,858,510 (+)RGD
Celera1667,214,025 - 67,266,348 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094867   ⟹   XP_038950795
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21669,319,487 - 69,362,366 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445807 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950795 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF21978 (Get FASTA)   NCBI Sequence Viewer  
  EDM09011 (Get FASTA)   NCBI Sequence Viewer  
  EDM09012 (Get FASTA)   NCBI Sequence Viewer  
  Q9QY78 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445807   ⟸   NM_053355
- UniProtKB: Q9QY78 (UniProtKB/Swiss-Prot),   G3V8H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025851   ⟸   ENSRNOT00000025851
RefSeq Acc Id: XP_038950795   ⟸   XM_039094867
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000077348   ⟸   ENSRNOT00000097362
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY78-F1-model_v2 AlphaFold Q9QY78 1-757 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700184
Promoter ID:EPDNEW_R10708
Type:initiation region
Name:Ikbkb_1
Description:inhibitor of nuclear factor kappa B kinase subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,177,222 - 74,177,282EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621375 AgrOrtholog
BioCyc Gene G2FUF-10881 BioCyc
Ensembl Genes ENSRNOG00000019073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025851 ENTREZGENE
  ENSRNOP00000025851.2 UniProtKB/TrEMBL
  ENSRNOP00000077348.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025851 ENTREZGENE
  ENSRNOT00000025851.5 UniProtKB/TrEMBL
  ENSRNOT00000097362.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84351 ENTREZGENE
Pfam IKBKB_SDD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ikbkb PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IKKbetaNEMObind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZJG2_RAT UniProtKB/TrEMBL
  G3V8H5 ENTREZGENE, UniProtKB/TrEMBL
  IKKB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Ikbkb  inhibitor of nuclear factor kappa B kinase subunit beta  Ikbkb  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Ikbkb  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  Ikbkb  inhibitor of kappaB kinase beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ikbkb  inhibitor of kappaB kinase beta    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  Name updated 1299863 APPROVED
2002-08-07 Ikbkb  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in megakaryocytes 633167
gene_expression expressed in rat liver and spleen cells 70526
gene_function cytosolic fragment interacts physically with p53 and prevents the nuclear translocation of p53  
gene_physical_interaction cytosolic fragment interacts physically with p53 and prevents the nuclear translocation of p53 70526
gene_process regulates growth 70526
gene_process forms a complex with p53 and the dissociation of this complex results in growth suppression by Tgf-b1, apoptosis, stress, hypoxia, DNA damage and UV radiation  
gene_regulation forms a complex with p53 and the dissociation of this complex results in growth suppression by Tgf-b1, apoptosis, stress, hypoxia, DNA damage and UV radiation 70526