Abi1 (abl-interactor 1) - Rat Genome Database

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Gene: Abi1 (abl-interactor 1) Rattus norvegicus
Analyze
Symbol: Abi1
Name: abl-interactor 1
RGD ID: 621008
Description: Predicted to enable SH3 domain binding activity; protein tyrosine kinase activator activity; and signaling adaptor activity. Involved in postsynapse to nucleus signaling pathway. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ABI1 (abl interactor 1); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: abelson interactor 1; abi-1; abl interactor 1; E3b1; eps8 binding protein (e3B1), alternatively spliced; eps8 SH3 domain-binding protein; eps8-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21785,098,837 - 85,179,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,098,550 - 85,179,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,583,073 - 88,664,013 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01792,418,465 - 92,499,400 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01786,435,255 - 86,516,184 (-)NCBIRnor_WKY
Rnor_6.01789,951,662 - 90,033,334 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,951,752 - 90,033,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01791,617,052 - 91,698,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,576,331 - 96,648,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,587,163 - 96,659,522 (-)NCBI
Celera1783,715,811 - 83,796,579 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chloroprene  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
potassium cyanide  (ISO)
resveratrol  (EXP,ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell leading edge  (ISO)
cytoskeleton  (IEA)
filopodium  (IEA)
filopodium tip  (ISO)
glutamatergic synapse  (EXP,IDA,IEP,IMP)
growth cone  (IEA)
lamellipodium  (IBA,IEA,ISO)
neuron projection  (IEA,ISO)
nucleus  (IEA)
postsynaptic density  (IDA,IEP)
SCAR complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Ito H, etal., Mol Psychiatry. 2010 Oct;15(10):976-86. doi: 10.1038/mp.2010.69. Epub 2010 Jun 8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. Proepper C, etal., EMBO J. 2007 Mar 7;26(5):1397-409. Epub 2007 Feb 15.
7. Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology. Proepper C, etal., PLoS One. 2011;6(11):e27045. doi: 10.1371/journal.pone.0027045. Epub 2011 Nov 15.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. Ziemnicka-Kotula D, etal., J Biol Chem 1998 May 29;273(22):13681-92.
Additional References at PubMed
PMID:10995551   PMID:11516653   PMID:12477932   PMID:12672821   PMID:15755804   PMID:16831833   PMID:17101133   PMID:17664349   PMID:18560548   PMID:19056867   PMID:19200726   PMID:19798448  
PMID:21107423   PMID:21464958   PMID:21795692   PMID:25297099   PMID:25468996   PMID:30053369  


Genomics

Comparative Map Data
Abi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21785,098,837 - 85,179,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,098,550 - 85,179,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,583,073 - 88,664,013 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01792,418,465 - 92,499,400 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01786,435,255 - 86,516,184 (-)NCBIRnor_WKY
Rnor_6.01789,951,662 - 90,033,334 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,951,752 - 90,033,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01791,617,052 - 91,698,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,576,331 - 96,648,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,587,163 - 96,659,522 (-)NCBI
Celera1783,715,811 - 83,796,579 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
ABI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381026,746,596 - 26,860,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1026,746,593 - 26,861,087 (-)EnsemblGRCh38hg38GRCh38
GRCh371027,035,525 - 27,149,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361027,075,531 - 27,189,965 (-)NCBINCBI36Build 36hg18NCBI36
Celera1026,743,902 - 26,858,351 (-)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1026,695,811 - 26,810,376 (-)NCBIHuRef
CHM1_11027,032,979 - 27,149,984 (-)NCBICHM1_1
T2T-CHM13v2.01026,768,504 - 26,882,882 (-)NCBIT2T-CHM13v2.0
Abi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39222,830,085 - 22,930,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl222,830,085 - 22,930,253 (-)EnsemblGRCm39 Ensembl
GRCm38222,940,073 - 23,040,241 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,940,073 - 23,040,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv37222,795,509 - 22,895,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,772,161 - 22,862,244 (-)NCBIMGSCv36mm8
Celera222,671,348 - 22,771,879 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.18NCBI
Abi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554292,682,343 - 2,783,752 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554292,682,341 - 2,783,752 (+)NCBIChiLan1.0ChiLan1.0
ABI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11027,227,960 - 27,339,434 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1027,227,960 - 27,339,434 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01026,863,648 - 26,975,376 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ABI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126,941,752 - 7,059,466 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26,941,900 - 7,057,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25,695,050 - 5,812,623 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,131,485 - 5,249,349 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,131,464 - 5,249,349 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,508,861 - 4,626,433 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024,587,702 - 4,705,303 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024,752,811 - 4,870,263 (+)NCBIUU_Cfam_GSD_1.0
Abi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934425,925,448 - 26,028,891 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364842,088,927 - 2,194,109 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364842,090,605 - 2,194,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1048,939,446 - 49,069,441 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11048,939,407 - 49,069,269 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ABI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1926,377,822 - 26,495,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl926,379,516 - 26,495,676 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605132,373,606 - 32,493,129 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247962,312,005 - 2,431,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abi1
116 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:145
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000057572
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat

Markers in Region
D17Rat51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,119,450 - 85,119,583 (-)MAPPERmRatBN7.2
Rnor_6.01790,012,592 - 90,012,722NCBIRnor6.0
Rnor_5.01791,677,997 - 91,678,127UniSTSRnor5.0
RGSC_v3.41796,587,775 - 96,587,905UniSTSRGSC3.4
RGSC_v3.41796,587,774 - 96,587,905RGDRGSC3.4
RGSC_v3.11796,598,608 - 96,598,738RGD
Celera1783,775,845 - 83,775,971UniSTS
RH 3.4 Map17848.7RGD
RH 3.4 Map17848.7UniSTS
RH 2.0 Map17730.2RGD
SHRSP x BN Map1747.5399RGD
FHH x ACI Map1768.73RGD
Cytogenetic Map17q12.3UniSTS
RH127345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,099,165 - 85,099,348 (-)MAPPERmRatBN7.2
Rnor_6.01790,032,823 - 90,033,005NCBIRnor6.0
Rnor_5.01791,698,228 - 91,698,410UniSTSRnor5.0
Celera1783,796,068 - 83,796,250UniSTS
RH 3.4 Map17841.2UniSTS
Cytogenetic Map17q12.3UniSTS
RH137994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,176,056 - 85,176,305 (-)MAPPERmRatBN7.2
Rnor_6.01789,955,200 - 89,955,448NCBIRnor6.0
Rnor_5.01791,620,605 - 91,620,853UniSTSRnor5.0
RGSC_v3.41796,645,056 - 96,645,304UniSTSRGSC3.4
Celera1783,719,259 - 83,719,507UniSTS
RH 3.4 Map17863.7UniSTS
Cytogenetic Map17q12.3UniSTS
AI009242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,145,642 - 85,145,846 (-)MAPPERmRatBN7.2
Rnor_6.01789,986,322 - 89,986,525NCBIRnor6.0
Rnor_5.01791,651,727 - 91,651,930UniSTSRnor5.0
RGSC_v3.41796,614,187 - 96,614,390UniSTSRGSC3.4
Celera1783,749,643 - 83,749,846UniSTS
RH 3.4 Map17844.3UniSTS
Cytogenetic Map17q12.3UniSTS
AU049482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,171,263 - 85,171,421 (-)MAPPERmRatBN7.2
Rnor_6.01789,960,404 - 89,960,561NCBIRnor6.0
Rnor_5.01791,625,809 - 91,625,966UniSTSRnor5.0
RGSC_v3.41796,639,806 - 96,639,963UniSTSRGSC3.4
Celera1783,724,076 - 83,724,236UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 9 74 35 38 11 8
Low 1 2 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF176784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB725283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000057572   ⟹   ENSRNOP00000054381
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,098,845 - 85,179,753 (-)Ensembl
Rnor_6.0 Ensembl1789,951,752 - 90,033,328 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091023   ⟹   ENSRNOP00000071079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,098,550 - 85,179,777 (-)Ensembl
Rnor_6.0 Ensembl1789,951,815 - 90,032,186 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093928   ⟹   ENSRNOP00000081022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,098,852 - 85,179,792 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103736   ⟹   ENSRNOP00000085236
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,098,845 - 85,179,753 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108948   ⟹   ENSRNOP00000093871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,098,555 - 85,179,746 (-)Ensembl
RefSeq Acc Id: NM_024397   ⟹   NP_077373
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,753 (-)NCBI
Rnor_6.01789,951,752 - 90,033,334 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
RGSC_v3.41796,576,331 - 96,648,752 (-)RGD
Celera1783,715,811 - 83,796,579 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254353   ⟹   XP_006254415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,825 (-)NCBI
Rnor_6.01789,951,681 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254354   ⟹   XP_006254416
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,825 (-)NCBI
Rnor_6.01789,951,681 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254355   ⟹   XP_006254417
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,825 (-)NCBI
Rnor_6.01789,951,681 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254356   ⟹   XP_006254418
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,824 (-)NCBI
Rnor_6.01789,951,681 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254357   ⟹   XP_006254419
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,825 (-)NCBI
Rnor_6.01789,951,681 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254358   ⟹   XP_006254420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,824 (-)NCBI
Rnor_6.01789,951,682 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254359   ⟹   XP_006254421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,824 (-)NCBI
Rnor_6.01789,951,682 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254360   ⟹   XP_006254422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,829 (-)NCBI
Rnor_6.01789,951,662 - 90,033,158 (+)NCBI
Rnor_5.01791,617,052 - 91,698,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096101   ⟹   XP_038952029
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,825 (-)NCBI
RefSeq Acc Id: XM_039096102   ⟹   XP_038952030
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,179,825 (-)NCBI
RefSeq Acc Id: XM_039096103   ⟹   XP_038952031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,098,837 - 85,158,169 (-)NCBI
RefSeq Acc Id: XM_039096104   ⟹   XP_038952032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,103,829 - 85,179,825 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_077373   ⟸   NM_024397
- UniProtKB: A2VD09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254422   ⟸   XM_006254360
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006254418   ⟸   XM_006254356
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006254415   ⟸   XM_006254353
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006254420   ⟸   XM_006254358
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZQS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254416   ⟸   XM_006254354
- Peptide Label: isoform X2
- UniProtKB: Q9QZM5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254417   ⟸   XM_006254355
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UQ93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254419   ⟸   XM_006254357
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006254421   ⟸   XM_006254359
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: ENSRNOP00000054381   ⟸   ENSRNOT00000057572
RefSeq Acc Id: ENSRNOP00000071079   ⟸   ENSRNOT00000091023
RefSeq Acc Id: XP_038952029   ⟸   XM_039096101
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AGM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952030   ⟸   XM_039096102
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A0X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952031   ⟸   XM_039096103
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038952032   ⟸   XM_039096104
- Peptide Label: isoform X11
RefSeq Acc Id: ENSRNOP00000081022   ⟸   ENSRNOT00000093928
RefSeq Acc Id: ENSRNOP00000093871   ⟸   ENSRNOT00000108948
RefSeq Acc Id: ENSRNOP00000085236   ⟸   ENSRNOT00000103736
Protein Domains
SH3   t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZM5-F1-model_v2 AlphaFold Q9QZM5 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700617
Promoter ID:EPDNEW_R11140
Type:initiation region
Name:Abi1_1
Description:abl-interactor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01789,951,725 - 89,951,785EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621008 AgrOrtholog
BioCyc Gene G2FUF-8481 BioCyc
Ensembl Genes ENSRNOG00000031325 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000054381 ENTREZGENE
  ENSRNOP00000054381.4 UniProtKB/TrEMBL
  ENSRNOP00000071079 ENTREZGENE
  ENSRNOP00000071079.2 UniProtKB/TrEMBL
  ENSRNOP00000081022 ENTREZGENE
  ENSRNOP00000081022.1 UniProtKB/TrEMBL
  ENSRNOP00000085236 ENTREZGENE
  ENSRNOP00000085236.1 UniProtKB/TrEMBL
  ENSRNOP00000093871 ENTREZGENE
  ENSRNOP00000093871.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057572 ENTREZGENE
  ENSRNOT00000057572.5 UniProtKB/TrEMBL
  ENSRNOT00000091023 ENTREZGENE
  ENSRNOT00000091023.2 UniProtKB/TrEMBL
  ENSRNOT00000093928 ENTREZGENE
  ENSRNOT00000093928.1 UniProtKB/TrEMBL
  ENSRNOT00000103736 ENTREZGENE
  ENSRNOT00000103736.1 UniProtKB/TrEMBL
  ENSRNOT00000108948 ENTREZGENE
  ENSRNOT00000108948.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192971 IMAGE-MGC_LOAD
InterPro ABI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABI1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Abi1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Abl-interactor_HHR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79249 UniProtKB/TrEMBL
MGC_CLONE MGC:156634 IMAGE-MGC_LOAD
NCBI Gene 79249 ENTREZGENE
PANTHER PTHR10460 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10460:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abi_HHR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abi1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0X0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UQ93 ENTREZGENE, UniProtKB/TrEMBL
  A2VD09 ENTREZGENE, UniProtKB/TrEMBL
  ABI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Abi1  abl-interactor 1    eps8 binding protein (e3B1), alternatively spliced  Name updated 1299863 APPROVED
2002-08-07 Abi1  eps8 binding protein (e3B1), alternatively spliced      Symbol and Name status set to provisional 70820 PROVISIONAL