Cd55 (CD55 molecule (Cromer blood group)) - Rat Genome Database

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Gene: Cd55 (CD55 molecule (Cromer blood group)) Rattus norvegicus
Analyze
Symbol: Cd55
Name: CD55 molecule (Cromer blood group)
RGD ID: 620651
Description: Enables enzyme inhibitor activity. Involved in several processes, including maternal process involved in parturition; negative regulation of complement activation; and response to peptide hormone. Located in apical plasma membrane. Used to study neuroblastoma and proteinuria. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)); PARTICIPATES IN complement system pathway; coagulation cascade pathway; myocarditis pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD55 antigen; CD55 molecule, decay accelerating factor for complement; complement decay-accelerating factor; Daf; Daf1; decay accelarating factor 1; decay accelerating factor 1; decay accelerating factor GPI-form; decay-accelarating factor; glycosylphophatidylinositol-anchored form
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cd55em6Mcwi   Cd55em4Mcwi  
Genetic Models: SD-Cd55em4Mcwi SD-Cd55em6Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,409,574 - 44,438,913 (-)NCBIGRCr8
mRatBN7.21341,857,242 - 41,885,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1341,857,395 - 41,885,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,456,356 - 44,482,601 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01345,744,470 - 45,770,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01342,999,115 - 43,025,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,125,156 - 47,153,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,126,741 - 47,154,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,177,543 - 52,206,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,322,246 - 43,348,334 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,344,956 - 43,362,318 (-)NCBI
Celera1342,209,852 - 42,236,220 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
butyric acid  (EXP)
cadmium selenide  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlormequat chloride  (EXP)
chloroprene  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
etoposide  (ISO)
fenoldopam  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
niclosamide  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
torcetrapib  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes. Bao L, etal., Kidney Int. 2002 Dec;62(6):2010-21.
2. Potent oncolytic activity of human enteroviruses against human prostate cancer. Berry LJ, etal., Prostate. 2008 May 1;68(6):577-87.
3. CD59 expressed on a tumor cell surface modulates decay-accelerating factor expression and enhances tumor growth in a rat model of human neuroblastoma. Chen S, etal., Cancer Res. 2000 Jun 1;60(11):3013-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Decay-accelerating factor in the periovulatory rat ovary. Gieske MC, etal., J Endocrinol. 2005 Aug;186(2):303-13.
6. Gene expression profiling of rat uterus at different stages of parturition. Girotti M and Zingg HH, Endocrinology. 2003 Jun;144(6):2254-65.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Human and rodent decay-accelerating factors (CD55) are not species restricted in their complement-inhibiting activities. Harris CL, etal., Immunology. 2000 Aug;100(4):462-70.
9. Molecular cloning and functional characterization of the rat analogue of human decay-accelerating factor (CD55). Hinchliffe SJ, etal., J Immunol 1998 Nov 15;161(10):5695-703.
10. CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. Huang Y, etal., Inflammation. 2018 Feb;41(1):232-239. doi: 10.1007/s10753-017-0681-7.
11. Prognostic significance of CD55 expression in breast cancer. Ikeda J, etal., Clin Cancer Res. 2008 Aug 1;14(15):4780-6.
12. Inhibition of decay-accelerating factor (CD55) attenuates prostate cancer growth and survival in vivo. Loberg RD, etal., Neoplasia. 2006 Jan;8(1):69-78.
13. Loss of CD55 is associated with aggressive breast tumors. Madjd Z, etal., Clin Cancer Res. 2004 Apr 15;10(8):2797-803.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Alternative exon usage in the 3' region of a single gene generates glycosylphosphatidylinositol-anchored and transmembrane forms of rat decay-accelerating factor. Miwa T, etal., Immunogenetics 2000 Feb;51(2):129-37.
16. CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa. Mizuno M, etal., Mol Immunol. 2007 Mar;44(7):1613-22. Epub 2006 Sep 27.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Expression of decay accelerating factor in endometrial adenocarcinoma is inversely related to the stage of tumor. Nowicki S, etal., Am J Reprod Immunol. 2001 Aug;46(2):144-8.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Expression of the complement regulatory proteins decay accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59 in the normal human uterine cervix and in premalignant and malignant cervical disease. Simpson KL, etal., Am J Pathol. 1997 Nov;151(5):1455-67.
23. Postconditioning attenuates renal ischemia-reperfusion injury by preventing DAF down-regulation. Wang W, etal., J Urol. 2010 Jun;183(6):2424-31. Epub 2010 Apr 18.
24. Coxsackievirus B3-associated myocardial pathology and viral load reduced by recombinant soluble human decay-accelerating factor in mice. Yanagawa B, etal., Lab Invest. 2003 Jan;83(1):75-85.
Additional References at PubMed
PMID:6211481   PMID:7525274   PMID:8223854   PMID:9892684   PMID:11313396   PMID:12477932   PMID:12731067   PMID:15907827   PMID:16818763   PMID:17166698   PMID:17826908   PMID:18064521  
PMID:18947875   PMID:19199708   PMID:19299737   PMID:20458337   PMID:23376485   PMID:23533145   PMID:24377861   PMID:25284781   PMID:27662796   PMID:28657829   PMID:33387103  


Genomics

Comparative Map Data
Cd55
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,409,574 - 44,438,913 (-)NCBIGRCr8
mRatBN7.21341,857,242 - 41,885,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1341,857,395 - 41,885,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,456,356 - 44,482,601 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01345,744,470 - 45,770,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01342,999,115 - 43,025,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,125,156 - 47,153,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,126,741 - 47,154,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,177,543 - 52,206,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,322,246 - 43,348,334 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,344,956 - 43,362,318 (-)NCBI
Celera1342,209,852 - 42,236,220 (-)NCBICelera
Cytogenetic Map13q13NCBI
CD55
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,321,678 - 207,360,966 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,321,519 - 207,386,804 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,495,023 - 207,534,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,561,488 - 205,600,470 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,883,259 - 203,922,241NCBI
Celera1180,747,405 - 180,786,905 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1178,191,283 - 178,230,783 (+)NCBIHuRef
CHM1_11208,767,582 - 208,807,063 (+)NCBICHM1_1
T2T-CHM13v2.01206,586,974 - 206,626,269 (+)NCBIT2T-CHM13v2.0
Cd55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,357,526 - 130,390,513 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,366,764 - 130,390,481 (-)EnsemblGRCm39 Ensembl
GRCm381130,429,798 - 130,465,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,439,027 - 130,462,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,335,606 - 132,359,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,267,758 - 132,290,230 (-)NCBIMGSCv36mm8
Celera1133,067,523 - 133,091,208 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Cd55
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540642,773,368 - 42,796,205 (+)NCBIChiLan1.0ChiLan1.0
CD55
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,015,372 - 42,054,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1141,981,330 - 42,020,548 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,923,369 - 182,962,518 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,201,195 - 187,240,350 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1187,201,081 - 187,240,350 (+)Ensemblpanpan1.1panPan2
CD55
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,361,037 - 6,396,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,360,964 - 6,386,226 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,923,634 - 5,949,508 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.076,049,135 - 6,075,038 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl76,049,143 - 6,077,363 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,982,465 - 6,008,341 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.076,084,489 - 6,110,584 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.076,125,081 - 6,150,968 (+)NCBIUU_Cfam_GSD_1.0
Cd55
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,104,286 - 68,123,978 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365575,344,373 - 5,364,234 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD55
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1967,933,069 - 67,960,380 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,368,906 - 74,393,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2974,313,866 - 74,314,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD55
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,055,138 - 22,092,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,073,629 - 22,092,173 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,674,151 - 22,711,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd55
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,252,676 - 4,274,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd55
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:227
Count of miRNA genes:155
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000005284
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
RH132379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21341,859,101 - 41,859,262 (+)MAPPERmRatBN7.2
Rnor_6.01347,126,905 - 47,127,065NCBIRnor6.0
Rnor_5.01352,179,265 - 52,179,425UniSTSRnor5.0
RGSC_v3.41343,321,762 - 43,321,922UniSTSRGSC3.4
Celera1342,209,368 - 42,209,528UniSTS
RH 3.4 Map13108.0UniSTS
Cytogenetic Map13q13UniSTS
RH139453  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21341,868,081 - 41,868,201 (+)MAPPERmRatBN7.2
Rnor_6.01347,135,774 - 47,135,893NCBIRnor6.0
Rnor_5.01352,188,134 - 52,188,253UniSTSRnor5.0
RGSC_v3.41343,330,741 - 43,330,860UniSTSRGSC3.4
Celera1342,218,349 - 42,218,468UniSTS
RH 3.4 Map13108.8UniSTS
Cytogenetic Map13q13UniSTS
RH141317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21341,868,081 - 41,868,288 (+)MAPPERmRatBN7.2
Rnor_6.01347,135,774 - 47,135,980NCBIRnor6.0
Rnor_5.01352,188,134 - 52,188,340UniSTSRnor5.0
RGSC_v3.41343,330,741 - 43,330,947UniSTSRGSC3.4
Celera1342,218,349 - 42,218,555UniSTS
Cytogenetic Map13q13UniSTS


Genetic Models
This gene Cd55 is modified in the following models/strains:
SD-Cd55em4Mcwi     SD-Cd55em6Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB026900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB294577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB294578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF039583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF039584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB610207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005284   ⟹   ENSRNOP00000005284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1341,858,928 - 41,885,795 (-)Ensembl
Rnor_6.0 Ensembl1347,126,741 - 47,154,292 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097302   ⟹   ENSRNOP00000079102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1341,857,395 - 41,885,831 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101971   ⟹   ENSRNOP00000078089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1341,858,928 - 41,885,795 (-)Ensembl
RefSeq Acc Id: NM_022269   ⟹   NP_071605
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,411,858 - 44,438,101 (-)NCBI
mRatBN7.21341,859,586 - 41,885,831 (-)NCBI
Rnor_6.01347,127,278 - 47,153,521 (-)NCBI
Rnor_5.01352,177,543 - 52,206,137 (-)NCBI
RGSC_v3.41343,322,246 - 43,348,334 (-)RGD
Celera1342,209,852 - 42,236,220 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249717   ⟹   XP_006249779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,418,657 - 44,438,197 (-)NCBI
mRatBN7.21341,866,378 - 41,885,889 (-)NCBI
Rnor_6.01347,135,701 - 47,153,550 (-)NCBI
Rnor_5.01352,177,543 - 52,206,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249719   ⟹   XP_006249781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,411,193 - 44,438,197 (-)NCBI
mRatBN7.21341,858,921 - 41,885,861 (-)NCBI
Rnor_6.01347,127,609 - 47,153,546 (-)NCBI
Rnor_5.01352,177,543 - 52,206,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249723   ⟹   XP_006249785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,664 - 44,438,913 (-)NCBI
mRatBN7.21341,857,242 - 41,885,945 (-)NCBI
Rnor_6.01347,125,156 - 47,153,557 (-)NCBI
Rnor_5.01352,177,543 - 52,206,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769498   ⟹   XP_008767720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,411,193 - 44,438,174 (-)NCBI
mRatBN7.21341,858,921 - 41,885,907 (-)NCBI
Rnor_6.01347,127,609 - 47,153,547 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598923   ⟹   XP_017454412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,664 - 44,438,913 (-)NCBI
mRatBN7.21341,857,281 - 41,885,863 (-)NCBI
Rnor_6.01347,125,176 - 47,153,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598924   ⟹   XP_017454413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,664 - 44,438,913 (-)NCBI
mRatBN7.21341,857,242 - 41,885,966 (-)NCBI
Rnor_6.01347,125,158 - 47,153,556 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091062   ⟹   XP_038946990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,664 - 44,438,197 (-)NCBI
mRatBN7.21341,857,268 - 41,885,872 (-)NCBI
RefSeq Acc Id: XM_063272576   ⟹   XP_063128646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,418,657 - 44,438,913 (-)NCBI
RefSeq Acc Id: XM_063272577   ⟹   XP_063128647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,588 - 44,438,913 (-)NCBI
RefSeq Acc Id: XM_063272578   ⟹   XP_063128648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,574 - 44,438,197 (-)NCBI
RefSeq Acc Id: XM_063272579   ⟹   XP_063128649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,409,594 - 44,437,835 (-)NCBI
Protein Sequences
Protein RefSeqs NP_071605 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249779 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249781 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249785 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767720 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454412 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454413 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946990 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128646 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128647 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128648 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128649 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC77438 (Get FASTA)   NCBI Sequence Viewer  
  AAC77439 (Get FASTA)   NCBI Sequence Viewer  
  AAH61869 (Get FASTA)   NCBI Sequence Viewer  
  BAA88989 (Get FASTA)   NCBI Sequence Viewer  
  BAA88990 (Get FASTA)   NCBI Sequence Viewer  
  BAA88991 (Get FASTA)   NCBI Sequence Viewer  
  BAA88992 (Get FASTA)   NCBI Sequence Viewer  
  BAA88993 (Get FASTA)   NCBI Sequence Viewer  
  BAA88994 (Get FASTA)   NCBI Sequence Viewer  
  BAA92770 (Get FASTA)   NCBI Sequence Viewer  
  BAA92771 (Get FASTA)   NCBI Sequence Viewer  
  BAA92772 (Get FASTA)   NCBI Sequence Viewer  
  BAF94240 (Get FASTA)   NCBI Sequence Viewer  
  BAF94260 (Get FASTA)   NCBI Sequence Viewer  
  EDM09864 (Get FASTA)   NCBI Sequence Viewer  
  EDM09865 (Get FASTA)   NCBI Sequence Viewer  
  EDM09866 (Get FASTA)   NCBI Sequence Viewer  
  EDM09867 (Get FASTA)   NCBI Sequence Viewer  
  EDM09868 (Get FASTA)   NCBI Sequence Viewer  
  EDM09869 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005284.7
  ENSRNOP00000078089.1
  ENSRNOP00000079102.1
RefSeq Acc Id: NP_071605   ⟸   NM_022269
- Peptide Label: precursor
- UniProtKB: Q9Z0M0 (UniProtKB/TrEMBL),   G3V6H8 (UniProtKB/TrEMBL),   A0A9K3Y778 (UniProtKB/TrEMBL),   A0A0G2QC50 (UniProtKB/TrEMBL),   Q9QUN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249785   ⟸   XM_006249723
- Peptide Label: isoform X9
- UniProtKB: Q9QUN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249781   ⟸   XM_006249719
- Peptide Label: isoform X7
- UniProtKB: A6IBY0 (UniProtKB/TrEMBL),   Q9QUT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249779   ⟸   XM_006249717
- Peptide Label: isoform X2
- UniProtKB: Q9Z0L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767720   ⟸   XM_008769498
- Peptide Label: isoform X11
- UniProtKB: Q9QUT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454413   ⟸   XM_017598924
- Peptide Label: isoform X10
- UniProtKB: A9CMA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454412   ⟸   XM_017598923
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZMB7 (UniProtKB/TrEMBL),   A6IBX8 (UniProtKB/TrEMBL),   Q9QUN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005284   ⟸   ENSRNOT00000005284
RefSeq Acc Id: XP_038946990   ⟸   XM_039091062
- Peptide Label: isoform X6
- UniProtKB: Q9QUT3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078089   ⟸   ENSRNOT00000101971
Ensembl Acc Id: ENSRNOP00000079102   ⟸   ENSRNOT00000097302
RefSeq Acc Id: XP_063128648   ⟸   XM_063272578
- Peptide Label: isoform X5
- UniProtKB: A9CMA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128647   ⟸   XM_063272577
- Peptide Label: isoform X3
- UniProtKB: Q9QUN6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128649   ⟸   XM_063272579
- Peptide Label: isoform X8
- UniProtKB: A6IBX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128646   ⟸   XM_063272576
- Peptide Label: isoform X1
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2QC50-F1-model_v2 AlphaFold A0A0G2QC50 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698783
Promoter ID:EPDNEW_R9308
Type:initiation region
Name:Cd55_1
Description:CD55 molecule, decay accelerating factor for complement
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01347,153,498 - 47,153,558EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620651 AgrOrtholog
BioCyc Gene G2FUF-18375 BioCyc
Ensembl Genes ENSRNOG00000003927 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005284.7 UniProtKB/TrEMBL
  ENSRNOT00000097302.1 UniProtKB/TrEMBL
  ENSRNOT00000101971.1 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598916 IMAGE-MGC_LOAD
InterPro Compl-Cell_Adhes-Reg UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
KEGG Report rno:64036 UniProtKB/TrEMBL
MGC_CLONE MGC:72267 IMAGE-MGC_LOAD
NCBI Gene 64036 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/TrEMBL
  COMPLEMENT DECAY-ACCELERATING FACTOR UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cd55 PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003927 RatGTEx
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
UniProt A0A0G2QC50 ENTREZGENE
  A0A8I5XWT0_RAT UniProtKB/TrEMBL
  A0A8I5ZMB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y778 ENTREZGENE, UniProtKB/TrEMBL
  A6IBX8 ENTREZGENE, UniProtKB/TrEMBL
  A6IBX9 ENTREZGENE, UniProtKB/TrEMBL
  A6IBY0 ENTREZGENE, UniProtKB/TrEMBL
  A9CMA5 ENTREZGENE, UniProtKB/TrEMBL
  G3V6H8 ENTREZGENE
  Q9QUN6 ENTREZGENE, UniProtKB/TrEMBL
  Q9QUT3 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0L9 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0M0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2QC50 UniProtKB/TrEMBL
  G3V6H8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-02-02 Cd55  CD55 molecule, decay accelerating factor for complement  Cd55  Cd55 molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd55  Cd55 molecule  Cd55  CD55 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Cd55  CD55 antigen  Daf1  decay accelarating factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Daf1  decay accelarating factor 1  Daf  decay-accelarating factor  Symbol and Name updated 1299863 APPROVED
2002-08-07 Daf  decay-accelarating factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains four SCR domains and a serine/threonine rich-stretch that is heavily O glycosylated 632506
gene_protein 70-kDa glycosylphosphatidylinositol (GPI)-linked glycoprotein 632506