Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) - Rat Genome Database

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Gene: Hadhb (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Rattus norvegicus
Analyze
Symbol: Hadhb
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
RGD ID: 620513
Description: Enables acetyl-CoA C-acyltransferase activity. Involved in fatty acid beta-oxidation. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency 2. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta); PARTICIPATES IN fatty acid metabolic pathway; carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit; mitochondrial trifunctional protein, beta subunit; TP-beta; trifunctional enzyme subunit beta, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,873,404 - 31,907,557 (-)NCBIGRCr8
GRCr8 Ensembl631,873,404 - 31,907,835 (-)EnsemblGRCr8 Ensembl
mRatBN7.2626,153,572 - 26,187,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,153,578 - 26,184,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,446,205 - 26,480,303 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,762,089 - 26,796,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,241,472 - 26,275,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,555,408 - 27,589,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,555,412 - 27,582,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,366,082 - 37,400,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,139,397 - 26,173,428 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera625,630,447 - 25,664,546 (-)NCBICelera
RGSC_v3.1626,142,349 - 26,169,900 (-)NCBI
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
Azoxymethane  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
ciprofibrate  (EXP)
clofibrate  (EXP,ISO)
Clofop  (ISO)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
flutamide  (ISO)
folic acid  (ISO)
furfural  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
indometacin  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (EXP)
perfluorobutyric acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
phenobarbital  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac  (EXP)
tacrolimus hydrate  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis. Asano J, etal., Cancer Sci. 2010 Apr;101(4):869-75. Epub 2009 Dec 8.
2. Identification of novel mutations of the HADHA and HADHB genes in patients with mitochondrial trifunctional protein deficiency. Choi JH, etal., Int J Mol Med. 2007 Jan;19(1):81-7.
3. The mitochondrial trifunctional protein: centre of a beta-oxidation metabolon? Eaton S, etal., Biochem Soc Trans. 2000 Feb;28(2):177-82.
4. Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB). Frackowiak J, etal., Brain Res. 2001 Jul 13;907(1-2):44-53.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular cloning of the cDNAs for the subunits of rat mitochondrial fatty acid beta-oxidation multienzyme complex. Structural and functional relationships to other mitochondrial and peroxisomal beta-oxidation enzymes. Kamijo T, etal., J Biol Chem 1993 Dec 15;268(35):26452-60.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. Uchida Y, etal., J Biol Chem. 1992 Jan 15;267(2):1034-41.
18. Molecular characterization of mitochondrial trifunctional protein deficiency: formation of the enzyme complex is important for stabilization of both alpha- and beta-subunits. Ushikubo S, etal., Am J Hum Genet. 1996 May;58(5):979-88.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:15240869   PMID:15489334   PMID:17116638   PMID:18063578   PMID:18614015   PMID:18640292   PMID:21527675   PMID:22658674   PMID:23376485   PMID:24625528  
PMID:29476059   PMID:29867124   PMID:33450132   PMID:35352799  


Genomics

Comparative Map Data
Hadhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,873,404 - 31,907,557 (-)NCBIGRCr8
GRCr8 Ensembl631,873,404 - 31,907,835 (-)EnsemblGRCr8 Ensembl
mRatBN7.2626,153,572 - 26,187,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,153,578 - 26,184,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,446,205 - 26,480,303 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,762,089 - 26,796,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,241,472 - 26,275,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,555,408 - 27,589,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,555,412 - 27,582,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,366,082 - 37,400,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,139,397 - 26,173,428 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera625,630,447 - 25,664,546 (-)NCBICelera
RGSC_v3.1626,142,349 - 26,169,900 (-)NCBI
Cytogenetic Map6q14NCBI
HADHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,244,939 - 26,290,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,243,170 - 26,290,465 (+)EnsemblGRCh38hg38GRCh38
GRCh37226,467,807 - 26,513,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,321,120 - 26,366,837 (+)NCBINCBI36Build 36hg18NCBI36
Build 34226,379,471 - 26,424,983NCBI
Celera226,307,847 - 26,353,565 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,213,206 - 26,249,388 (+)NCBIHuRef
CHM1_1226,397,520 - 26,443,240 (+)NCBICHM1_1
T2T-CHM13v2.0226,280,280 - 26,325,829 (+)NCBIT2T-CHM13v2.0
Hadhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,360,251 - 30,389,591 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,360,246 - 30,389,591 (+)EnsemblGRCm39 Ensembl
GRCm38530,155,253 - 30,184,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,155,248 - 30,184,593 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,481,862 - 30,511,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,486,109 - 30,515,370 (+)NCBIMGSCv36mm8
Celera527,672,860 - 27,702,121 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.04NCBI
Hadhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,233,980 - 8,274,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,233,980 - 8,272,149 (+)NCBIChiLan1.0ChiLan1.0
HADHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,227,901 - 100,273,502 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,231,866 - 100,277,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,240,365 - 26,285,982 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,334,043 - 26,379,059 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,334,043 - 26,379,059 (+)Ensemblpanpan1.1panPan2
HADHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,355,778 - 20,399,869 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,251,473 - 20,294,727 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,678,487 - 20,721,816 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11720,365,181 - 20,408,616 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,376,149 - 20,419,589 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,422,834 - 20,465,929 (+)NCBIUU_Cfam_GSD_1.0
Hadhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,656,832 - 64,699,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,137,970 - 6,182,792 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,139,717 - 6,182,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,704,024 - 112,753,086 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,712,894 - 112,753,121 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,651,210 - 119,676,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HADHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,361,735 - 81,411,588 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,361,612 - 81,411,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604530,746,759 - 30,796,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadhb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,384,830 - 8,424,163 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,384,789 - 8,420,994 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hadhb
117 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000014637
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
D6Got20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,182,289 - 26,182,548 (+)MAPPERmRatBN7.2
Rnor_6.0627,584,161 - 27,584,419NCBIRnor6.0
Rnor_5.0637,394,832 - 37,395,090UniSTSRnor5.0
RGSC_v3.4626,168,118 - 26,168,377RGDRGSC3.4
RGSC_v3.4626,168,119 - 26,168,377UniSTSRGSC3.4
Celera625,659,169 - 25,659,427UniSTS
RGSC_v3.1626,171,072 - 26,171,330RGD
RH 3.4 Map6117.99RGD
RH 3.4 Map6117.99UniSTS
Cytogenetic Map6q14UniSTS
RH134632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,153,712 - 26,153,897 (+)MAPPERmRatBN7.2
Rnor_6.0627,555,549 - 27,555,733NCBIRnor6.0
Rnor_5.0637,366,220 - 37,366,404UniSTSRnor5.0
RGSC_v3.4626,139,534 - 26,139,718UniSTSRGSC3.4
Celera625,630,588 - 25,630,772UniSTS
RH 3.4 Map6118.4UniSTS
Cytogenetic Map6q14UniSTS
BE100255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,187,268 - 26,187,482 (+)MAPPERmRatBN7.2
Rnor_6.0627,589,140 - 27,589,353NCBIRnor6.0
Rnor_5.0637,399,811 - 37,400,024UniSTSRnor5.0
RGSC_v3.4626,173,098 - 26,173,311UniSTSRGSC3.4
Celera625,664,147 - 25,664,360UniSTS
RH 3.4 Map6118.2UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC060545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM038662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM050540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM105991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM118580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014637   ⟹   ENSRNOP00000014637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,873,404 - 31,907,835 (-)Ensembl
mRatBN7.2 Ensembl626,153,578 - 26,184,869 (-)Ensembl
Rnor_6.0 Ensembl627,555,412 - 27,582,995 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085613   ⟹   ENSRNOP00000072480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,873,404 - 31,907,500 (-)Ensembl
mRatBN7.2 Ensembl626,153,578 - 26,184,869 (-)Ensembl
Rnor_6.0 Ensembl627,555,689 - 27,582,985 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107159   ⟹   ENSRNOP00000095235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,876,896 - 31,907,500 (-)Ensembl
mRatBN7.2 Ensembl626,157,064 - 26,184,869 (-)Ensembl
RefSeq Acc Id: NM_133618   ⟹   NP_598302
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,404 - 31,907,500 (-)NCBI
mRatBN7.2626,153,572 - 26,187,668 (-)NCBI
Rnor_6.0627,555,408 - 27,589,539 (-)NCBI
Rnor_5.0637,366,082 - 37,400,364 (-)NCBI
RGSC_v3.4626,139,397 - 26,173,428 (-)RGD
Celera625,630,447 - 25,664,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239786   ⟹   XP_006239848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,907,317 (-)NCBI
mRatBN7.2626,153,575 - 26,187,642 (-)NCBI
Rnor_6.0627,555,411 - 27,589,530 (-)NCBI
Rnor_5.0637,366,082 - 37,400,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111746   ⟹   XP_038967674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,907,466 (-)NCBI
mRatBN7.2626,153,581 - 26,187,642 (-)NCBI
RefSeq Acc Id: XM_063261519   ⟹   XP_063117589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,907,317 (-)NCBI
RefSeq Acc Id: XM_063261520   ⟹   XP_063117590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,907,463 (-)NCBI
RefSeq Acc Id: XM_063261521   ⟹   XP_063117591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,904,701 (-)NCBI
RefSeq Acc Id: XM_063261522   ⟹   XP_063117592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,907,386 (-)NCBI
RefSeq Acc Id: XM_063261523   ⟹   XP_063117593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,873,407 - 31,907,557 (-)NCBI
RefSeq Acc Id: NP_598302   ⟸   NM_133618
- Peptide Label: precursor
- UniProtKB: Q60587 (UniProtKB/Swiss-Prot),   A6HAE3 (UniProtKB/TrEMBL),   A0A0G2K330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239848   ⟸   XM_006239786
- Peptide Label: isoform X2
- UniProtKB: Q60587 (UniProtKB/Swiss-Prot),   A6HAE3 (UniProtKB/TrEMBL),   A0A0G2K330 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014637   ⟸   ENSRNOT00000014637
Ensembl Acc Id: ENSRNOP00000072480   ⟸   ENSRNOT00000085613
RefSeq Acc Id: XP_038967674   ⟸   XM_039111746
- Peptide Label: isoform X2
- UniProtKB: Q60587 (UniProtKB/Swiss-Prot),   A6HAE3 (UniProtKB/TrEMBL),   A0A0G2K330 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095235   ⟸   ENSRNOT00000107159
RefSeq Acc Id: XP_063117593   ⟸   XM_063261523
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117590   ⟸   XM_063261520
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117592   ⟸   XM_063261522
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117589   ⟸   XM_063261519
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117591   ⟸   XM_063261521
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP13 (UniProtKB/TrEMBL)
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60587-F1-model_v2 AlphaFold Q60587 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694467
Promoter ID:EPDNEW_R4992
Type:single initiation site
Name:Hadhb_1
Description:hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complexsubunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0627,582,998 - 27,583,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620513 AgrOrtholog
BioCyc Gene G2FUF-38303 BioCyc
Ensembl Genes ENSRNOG00000010800 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014637.7 UniProtKB/Swiss-Prot
  ENSRNOT00000085613 ENTREZGENE
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918791 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:171155 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72701 IMAGE-MGC_LOAD
NCBI Gene 171155 ENTREZGENE
PANTHER ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot
  TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PhenoGen Hadhb PhenoGen
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot
  THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010800 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A0G2K330 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP13 ENTREZGENE, UniProtKB/TrEMBL
  A6HAE1_RAT UniProtKB/TrEMBL
  A6HAE3 ENTREZGENE, UniProtKB/TrEMBL
  ECHB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-19 Hadhb  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta  Hadhb  hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Hadhb  hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit  Hadhb  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hadhb  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hadhb  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function has long chain 3-ketoacyl-CoA thiolase activity 632874
gene_protein encodes a 51,413-Da precursor and a 47,583-Da mature subunit 632874