Gene: Top3a (DNA topoisomerase III alpha) Rattus norvegicus
Symbol: Top3a
Name: DNA topoisomerase III alpha
Description: ENCODES a protein that exhibits DNA topoisomerase type I activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN chromosome separation (ortholog); DNA topological change (ortholog); mitochondrial DNA metabolic process (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Chromosome 17, Trisomy 17p11 2 (ortholog); MICROCEPHALY, GROWTH RESTRICTION, AND INCREASED SISTER CHROMATID EXCHANGE 2 (ortholog); mitochondrial metabolism disease (ortholog); FOUND IN PML body (ortholog); INTERACTS WITH bisphenol A; (S)-colchicine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA topoisomerase 3-alpha; LOC303194; topoisomerase (DNA) III alpha
Homo sapiens (human) : TOP3A (DNA topoisomerase III alpha)  HGNC  Alliance
Mus musculus (house mouse) : Top3a (topoisomerase (DNA) III alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top3a (DNA topoisomerase III alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP3A (DNA topoisomerase III alpha)
Canis lupus familiaris (dog) : TOP3A (DNA topoisomerase III alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top3a (DNA topoisomerase III alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01046,980,646 - 47,018,728 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01046,753,640 - 46,790,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,886,319 - 46,923,435 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11046,899,953 - 46,910,769 (-)NCBI
Celera1044,674,374 - 44,711,934 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Top3a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309320
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2018-10-09
Status: ACTIVE