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Gene: Top3a (DNA topoisomerase III alpha) Rattus norvegicus
Symbol: Top3a
Name: DNA topoisomerase III alpha
RGD ID: 1309320
Description: Predicted to have DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA topological change; chromosome separation; and mitochondrial DNA metabolic process. Predicted to localize to PML body. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha); PARTICIPATES IN homologous recombination pathway of double-strand break repair; INTERACTS WITH bisphenol A; (S)-colchicine (ortholog); 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA topoisomerase 3-alpha; LOC303194; topoisomerase (DNA) III alpha
Homo sapiens (human) : TOP3A (DNA topoisomerase III alpha)  HGNC  Alliance
Mus musculus (house mouse) : Top3a (topoisomerase (DNA) III alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top3a (DNA topoisomerase III alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP3A (DNA topoisomerase III alpha)
Canis lupus familiaris (dog) : TOP3A (DNA topoisomerase III alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top3a (DNA topoisomerase III alpha)
Sus scrofa (pig) : TOP3A (DNA topoisomerase III alpha)
Chlorocebus sabaeus (African green monkey) : TOP3A (DNA topoisomerase III alpha)
Heterocephalus glaber (naked mole-rat) : Top3a (DNA topoisomerase III alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01046,980,646 - 47,018,728 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,981,958 - 47,018,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,753,640 - 46,790,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,886,319 - 46,923,435 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11046,899,953 - 46,910,769 (-)NCBI
Celera1044,674,374 - 44,711,934 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Top3a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309320
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.